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Katalin Susztak, MD, PhD

Katalin Susztak, MD, PhD

faculty photo
Associate Professor of Medicine
Department: Medicine
Graduate Group Affiliations

Contact information
Renal Electrolyte and Hypertension Division
415 Curie Boulevard
Clinical Research Building 405B
Philadelphia, PA 19104
Office: 215 898 2009
Lab: 215 898 2008
Education:
MD
Semmelweis University, Medical School, Budapest, Hungary, 1995.
PhD
Semmelweis University, Medical School, Budapest, Hungary, 1997.
MS
Albert Einstein College of Medicine, Bronx, NY, 2004.
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Description of Research Expertise

Research interest
Work in my laboratory is aimed toward the understanding of molecular pathways that govern chronic kidney disease development.

Keywords
Chronic Kidney Disease
Diabetic Kidney Disease
Tissue fibrosis
Genomics
Epigenomics
Notch, Wnt/Ctnnb1
Epithelial cell differentiation

Research details

Work in my laboratory is aimed towards the understanding of molecular pathways that govern chronic kidney disease development. We have two general areas of interest: hypothesis generating (high trough-put, translational) and mechanistic studies. Over the past 10 years we banked and analyzed (combined genetic, epigenetic and genomic approaches) a large number of healthy and diseased human kidney tissue samples. We hypothesize that integrative analysis of epigenetic and genetic settings in diseased cells can provide a rational basis for more accurately modeling the critical biological pathways involved in mediating the progressive phenotype in individual patients. We also predict that epigenomic integrative analysis can be used to determine the identity of chromatin and transcription factors that contribute mechanistically to aberrant transcriptional programming in chronic kidney disease, and that this information can be used for designing therapeutic strategies. We are specifically interested in defining cis-regulatory modules (promoters, enhancers and repressors) that govern the normal and altered epithelial phenotype in diseased kidneys.
In addition, we use genetic approaches and mouse as a model organism to test the role of candidate signaling molecules and regulatory pathways directly in vivo. The Cre/loxP and tet inducible transgenic technologies allow us to analyze the function of particular factors by deleting or overexpressing genes that encode them in specific cell types in the kidney. Specifically, we are working on determining the role of the Notch and Wnt/beta-catenin pathway in chronic kidney disease development, renal epithelial cell homeostasis, renal stem or progenitor cell function and differentiation. Our recent results highlight the role of embryonic programs in adult disease development.

Rotation Projects
There are several; please speak with Dr. Susztak.

Lab Personnel:

Jianling Tao MD- Visiting Associate Professor
Kimberley Reidy MD- Adjunct Assistant Professor
Esther Park MD - Postdoctoral fellow
Hyun Mi Kang PhD- Postdoctoral fellow
Mariya Sweetwyne PhD- Postdoctoral fellow
Laura Malaga MD, PhD-Fellow
Yi-an Ko- Graduate Student
Frank Chinga- Research Specialist
Nora Ledo- Research Specialist

Selected Publications:

Niranjan T, Bielesz B, Gruenwald A, Ponda MP, Kopp JB, Thomas DB, Susztak K.
The Notch pathway in podocytes plays a role in the development of glomerular disease. Nat Med. 2008 Mar;14(3):290-8. Epub 2008 Mar 2. PMID: 18311147

Kato H, Gruenwald A, Suh JH, Miner JH, Barisoni-Thomas L, Taketo MM, Faul C, Millar SE, Holzman LB, Susztak K. Wnt/β-catenin pathway in podocytes integrates cell adhesion, differentiation, and survival. J Biol Chem. 2011 Jul 22;286(29):26003-15. PMID: 21613219

Bielesz B, Sirin Y, Si H, Niranjan T, Gruenwald A, Ahn S, Kato H, Pullman J, Gessler M, Haase VH, Susztak K. Epithelial Notch signaling regulates interstitial fibrosis development in the kidneys of mice and humans. J Clin Invest. 2010 Nov;120(11):4040-54. PMID: 20978353

Sirin Y, Susztak K. Notch in the kidney: development and disease.
J Pathol. 2012 Jan;226(2):394-403 Review.

Woroniecka KI, Park AS, Mohtat D, Thomas DB, Pullman JM, Susztak K. Transcriptome analysis of human diabetic kidney disease. Diabetes. 2011 Sep;60(9):2354-69.

Selected Publications

Teumer Alexander, Tin Adrienne, Sorice Rossella, Gorski Mathias, Yeo Nan Cher, Chu Audrey Y, Li Man, Li Yong, Mijatovic Vladan, Ko Yi-An, Taliun Daniel, Luciani Alessandro, Chen Ming-Huei, Yang Qiong, Foster Meredith C, Olden Matthias, Hiraki Linda T, Tayo Bamidele O, Fuchsberger Christian, Dieffenbach Aida Karina, Shuldiner Alan R, Smith Albert V, Zappa Allison M, Lupo Antonio, Kollerits Barbara, Ponte Belen, Stengel Bénédicte, Krämer Bernhard K, Paulweber Bernhard, Mitchell Braxton D, Hayward Caroline, Helmer Catherine, Meisinger Christa, Gieger Christian, Shaffer Christian M, Müller Christian, Langenberg Claudia, Ackermann Daniel, Siscovick David, Boerwinkle Eric, Kronenberg Florian, Ehret Georg B, Homuth Georg, Waeber Gerard, Navis Gerjan, Gambaro Giovanni, Malerba Giovanni, Eiriksdottir Gudny, Li Guo, Wichmann H Erich, Grallert Harald, Wallaschofski Henri, Völzke Henry, Brenner Herrmann, Kramer Holly, Leach I Mateo, Rudan Igor, Hillege J L, Beckmann Jacques S, Lambert Jean Charles, Luan Jian'an, Zhao Jing Hua, Chalmers John, Coresh Josef, Denny Joshua C, Butterbach Katja, Launer Lenore J, Ferrucci Luigi, Kedenko Lyudmyla, Haun Margot, Metzger Marie, Woodward Mark, Hoffman Matthew J, Nauck Matthias, Waldenberger Melanie, Pruijm Menno, Bochud Murielle, Rheinberger Myriam, Verweij N, Wareham Nicholas J, Endlich Nicole, Soranzo Nicole, Polasek Ozren, van der Harst P, Pramstaller Peter Paul, Vollenweider Peter, Wild Philipp S, Gansevoort R T, Rettig Rainer, Biffar Reiner, Carroll Robert J, Katz Ronit, Loos Ruth J F, Hwang Shih-Jen, Coassin Stefan, Bergmann Sven, Rosas Sylvia E, Stracke Sylvia, Harris Tamara B, Corre Tanguy, Zeller Tanja, Illig Thomas, Aspelund Thor, Tanaka Toshiko, Lendeckel Uwe, Völker Uwe, Gudnason Vilmundur, Chouraki Vincent, Koenig Wolfgang, Kutalik Zoltan, O'Connell Jeffrey R, Parsa Afshin, Heid Iris M, Paterson Andrew D, de Boer Ian H, Devuyst Olivier, Lazar Jozef, Endlich Karlhans, Susztak Katalin, Tremblay Johanne, Hamet Pavel, Jacob Howard J, Böger Carsten A, Fox Caroline S, Pattaro Cristian, Köttgen Anna: Genome-wide Association Studies Identify Genetic Loci Associated with Albuminuria in Diabetes. Diabetes 65(3): 803-17, Mar 2016.

Reiner Alex P, Susztak Katalin: APOL1 Variants: From Parasites to Kidney Function to Cardiovascular Disease. Arteriosclerosis, thrombosis, and vascular biology 36(2): 219-20, Feb 2016.

Li SY, Susztak K.: : Fat burning problem in cystic kidneys: an emerging common mechanism of chronic kidney disease eBioMedicine February 2016.

Ledo N, Susztak K and Palmer M: Cell Phenotype Transitions in Renal Fibrosis. Current Pathobiology Reports February 2016.

Hakimi A Ari, Ostrovnaya Irina, Jacobsen Anders, Susztak Katalin, Coleman Jonathan A, Russo Paul, Winer Andrew G, Mano Roy, Sankin Alexander I, Motzer Robert J, Voss Martin H, Offit Kenneth, Purdue Mark, Pomerantz Mark, Freedman Matthew, Choueiri Toni K, Hsieh James J, Klein Robert J: Validation and genomic interrogation of the MET variant rs11762213 as a predictor of adverse outcomes in clear cell renal cell carcinoma. Cancer 122(3): 402-10, Feb 2016.

Kang Hyun Mi, Huang Shizheng, Reidy Kimberly, Han Seung Hyeok, Chinga Frank, Susztak Katalin: Sox9-Positive Progenitor Cells Play a Key Role in Renal Tubule Epithelial Regeneration in Mice. Cell reports 14(4): 861-71, Feb 2016.

Pattaro Cristian, Teumer Alexander, Gorski Mathias, Chu Audrey Y, Li Man, Mijatovic Vladan, Garnaas Maija, Tin Adrienne, Sorice Rossella, Li Yong, Taliun Daniel, Olden Matthias, Foster Meredith, Yang Qiong, Chen Ming-Huei, Pers Tune H, Johnson Andrew D, Ko Yi-An, Fuchsberger Christian, Tayo Bamidele, Nalls Michael, Feitosa Mary F, Isaacs Aaron, Dehghan Abbas, d'Adamo Pio, Adeyemo Adebowale, Dieffenbach Aida Karina, Zonderman Alan B, Nolte Ilja M, van der Most Peter J, Wright Alan F, Shuldiner Alan R, Morrison Alanna C, Hofman Albert, Smith Albert V, Dreisbach Albert W, Franke Andre, Uitterlinden Andre G, Metspalu Andres, Tonjes Anke, Lupo Antonio, Robino Antonietta, Johansson Åsa, Demirkan Ayse, Kollerits Barbara, Freedman Barry I, Ponte Belen, Oostra Ben A, Paulweber Bernhard, Krämer Bernhard K, Mitchell Braxton D, Buckley Brendan M, Peralta Carmen A, Hayward Caroline, Helmer Catherine, Rotimi Charles N, Shaffer Christian M, Müller Christian, Sala Cinzia, van Duijn Cornelia M, Saint-Pierre Aude, Ackermann Daniel, Shriner Daniel, Ruggiero Daniela, Toniolo Daniela, Lu Yingchang, Cusi Daniele, Czamara Darina, Ellinghaus David, Siscovick David S, Ruderfer Douglas, Gieger Christian, Grallert Harald, Rochtchina Elena, Atkinson Elizabeth J, Holliday Elizabeth G, Boerwinkle Eric, Salvi Erika, Bottinger Erwin P, Murgia Federico, Rivadeneira Fernando, Ernst Florian, Kronenberg Florian, Hu Frank B, Navis Gerjan J, Curhan Gary C, Ehret George B, Homuth Georg, Coassin Stefan, Thun Gian-Andri, Pistis Giorgio, Gambaro Giovanni, Malerba Giovanni, Montgomery Grant W, Eiriksdottir Gudny, Jacobs Gunnar, Li Guo, Wichmann H-Erich, Campbell Harry, Schmidt Helena, Wallaschofski Henri, Völzke Henry, Brenner Hermann, Kroemer Heyo K, Kramer Holly, Lin Honghuang, Mateo Leach I, Ford Ian, Guessous Idris, Rudan Igor, Prokopenko Inga, Borecki Ingrid, Heid Iris M, Kolcic Ivana, Persico Ivana, Jukema J Wouter, Wilson James F, Felix Janine F, Divers Jasmin, Lambert Jean-Charles, Stafford Jeanette M, Gaspoz Jean-Michel, Smith Jennifer A, Faul Jessica D, Wang Jie Jin, Ding Jingzhong, Hirschhorn Joel N, Attia John, Whitfield John B, Chalmers John, Viikari Jorma, Coresh Josef, Denny Joshua C, Karjalainen Juha, Fernandes Jyotika K, Endlich Karlhans, Butterbach Katja, Keene Keith L, Lohman Kurt, Portas Laura, Launer Lenore J, Lyytikäinen Leo-Pekka, Yengo Loic, Franke Lude, Ferrucci Luigi, Rose Lynda M, Kedenko Lyudmyla, Rao Madhumathi, Struchalin Maksim, Kleber Marcus E, Cavalieri Margherita, Haun Margot, Cornelis Marilyn C, Ciullo Marina, Pirastu Mario, de Andrade Mariza, McEvoy Mark A, Woodward Mark, Adam Martin, Cocca Massimiliano, Nauck Matthias, Imboden Medea, Waldenberger Melanie, Pruijm Menno, Metzger Marie, Stumvoll Michael, Evans Michele K, Sale Michele M, Kähönen Mika, Boban Mladen, Bochud Murielle, Rheinberger Myriam, Verweij Niek, Bouatia-Naji Nabila, Martin Nicholas G, Hastie Nick, Probst-Hensch Nicole, Soranzo Nicole, Devuyst Olivier, Raitakari Olli, Gottesman Omri, Franco Oscar H, Polasek Ozren, Gasparini Paolo, Munroe Patricia B, Ridker Paul M, Mitchell Paul, Muntner Paul, Meisinger Christa, Smit Johannes H, Kovacs Peter, Wild Philipp S, Froguel Philippe, Rettig Rainer, Mägi Reedik, Biffar Reiner, Schmidt Reinhold, Middelberg Rita P S, Carroll Robert J, Penninx Brenda W, Scott Rodney J, Katz Ronit, Sedaghat Sanaz, Wild Sarah H, Kardia Sharon L R, Ulivi Sheila, Hwang Shih-Jen, Enroth Stefan, Kloiber Stefan, Trompet Stella, Stengel Benedicte, Hancock Stephen J, Turner Stephen T, Rosas Sylvia E, Stracke Sylvia, Harris Tamara B, Zeller Tanja, Zemunik Tatijana, Lehtimäki Terho, Illig Thomas, Aspelund Thor, Nikopensius Tiit, Esko Tonu, Tanaka Toshiko, Gyllensten Ulf, Völker Uwe, Emilsson Valur, Vitart Veronique, Aalto Ville, Gudnason Vilmundur, Chouraki Vincent, Chen Wei-Min, Igl Wilmar, März Winfried, Koenig Wolfgang, Lieb Wolfgang, Loos Ruth J F, Liu Yongmei, Snieder Harold, Pramstaller Peter P, Parsa Afshin, O'Connell Jeffrey R, Susztak Katalin, Hamet Pavel, Tremblay Johanne, de Boer Ian H, Böger Carsten A, Goessling Wolfram, Chasman Daniel I, Köttgen Anna, Kao W H Linda, Fox Caroline S: Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function. Nature communications(7), 10023, Jan 21 2016.

Huang Shizheng, Susztak Katalin: Epithelial Plasticity versus EMT in Kidney Fibrosis. Trends in molecular medicine 22(1): 4-6, Jan 2016.

Jin JS and Susztak K: Are podocytes the weakest link in diabetic kidney disease? Current Diabetes Reports in press 2016.

Lin Jennie, Zhang Xuan, Xue Chenyi, Zhang Hanrui, Shashaty Michael G S, Gosai Sager J, Meyer Nuala, Grazioli Alison, Hinkle Christine, Caughey Jennifer, Li Wenjun, Susztak Katalin, Gregory Brian D, Li Mingyao, Reilly Muredach P: The long noncoding RNA landscape in hypoxic and inflammatory renal epithelial injury. American journal of physiology. Renal physiology 309(11): F901-13, Dec 2015.

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Last updated: 04/19/2016
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