Katalin Susztak, MD, PhD

faculty photo
Professor of Medicine
Department: Medicine
Graduate Group Affiliations

Contact information
12-123 Smilow Center for Translational Research
3400 Civic Center Blvd
Philadelphia, PA 19104
Office: 215 898 2009
Lab: 215 898 2008
Education:
MD
Semmelweis University, Medical School, Budapest, Hungary, 1995.
PhD
Semmelweis University, Medical School, Budapest, Hungary, 1997.
MS
Albert Einstein College of Medicine, Bronx, NY, 2004.
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Description of Research Expertise

Research interest: Work in my laboratory is aimed toward the understanding of molecular pathways that govern chronic kidney disease development.

Research details

Work in my laboratory is aimed towards the understanding of molecular pathways that govern chronic kidney disease development. We have two general areas of interest: hypothesis generating (high trough-put, translational) and mechanistic studies. Over the past 10 years we banked and analyzed (combined genetic, epigenetic and genomic approaches) a large number of healthy and diseased human kidney tissue samples. We hypothesize that integrative analysis of epigenetic and genetic settings in diseased cells can provide a rational basis for more accurately modeling the critical biological pathways involved in mediating the progressive phenotype in individual patients. We also predict that epigenomic integrative analysis can be used to determine the identity of chromatin and transcription factors that contribute mechanistically to aberrant transcriptional programming in chronic kidney disease, and that this information can be used for designing therapeutic strategies. We are specifically interested in defining cis-regulatory modules (promoters, enhancers and repressors) that govern the normal and altered epithelial phenotype in diseased kidneys.
In addition, we use genetic approaches and mouse as a model organism to test the role of candidate signaling molecules and regulatory pathways directly in vivo. The Cre/loxP and tet inducible transgenic technologies allow us to analyze the function of particular factors by deleting or overexpressing genes that encode them in specific cell types in the kidney. Specifically, we are working on determining the role of the Notch and Wnt/beta-catenin pathway in chronic kidney disease development, renal epithelial cell homeostasis, renal stem or progenitor cell function and differentiation. Our recent results highlight the role of embryonic programs in adult disease development.

Rotation Projects
There are several; please speak with Dr. Susztak.

Lab Personnel:

Szu-Yu Li MD- Visiting Associate Professor
Kimberley Reidy MD- Adjunct Assistant Professor
Dorottya Laczko MD PhD - Postdoctoral fellow
Shizheng Huang PhD- Postdoctoral fellow
Jihwan Park PhD- Postdoctoral fellow
Caroline Gluck MD-Fellow
Yi-an Ko- Graduate Student
Chengxiang Qiu MS-Programmer
Frank Chinga- Research Specialist
Matthew Seasock- Research Specialist
Josh Bryer- Research Specialist

Selected Publications:

Transgenic expression of human APOL1 risk variants in podocytes induces kidney disease in mice.
Beckerman P, Bi-Karchin J, Park AS, Qiu C, Dummer PD, Soomro I, Boustany-Kari CM, Pullen SS, Miner JH, Hu CA, Rohacs T, Inoue K, Ishibe S, Saleem MA, Palmer MB, Cuervo AM, Kopp JB, Susztak K.
Nat Med. 2017 Feb 20. doi: 10.1038/nm.4287.

Sox9-Positive Progenitor Cells Play a Key Role in Renal Tubule Epithelial Regeneration in Mice.
Kang HM, Huang S, Reidy K, Han SH, Chinga F, Susztak K.
Cell Rep. 2016 Feb 2;14(4):861-71.

Defective fatty acid oxidation in renal tubular epithelial cells has a key role in kidney fibrosis development.
Kang HM, Ahn SH, Choi P, Ko YA, Han SH, Chinga F, Park AS, Tao J, Sharma K, Pullman J, Bottinger EP, Goldberg IJ, Susztak K.

Cytosine methylation changes in enhancer regions of core pro-fibrotic genes characterize kidney fibrosis development.
Ko YA, Mohtat D, Suzuki M, Park AS, Izquierdo MC, Han SY, Kang HM, Si H, Hostetter T, Pullman JM, Fazzari M, Verma A, Zheng D, Greally JM, Susztak K.
Genome Biol. 2013;14(10):R108.

The Notch pathway in podocytes plays a role in the development of glomerular disease.
Niranjan T, Bielesz B, Gruenwald A, Ponda MP, Kopp JB, Thomas DB, Susztak K.
Nat Med. 2008 Mar;14(3):290-8.

Epithelial Notch signaling regulates interstitial fibrosis development in the kidneys of mice and humans.
Bielesz B, Sirin Y, Si H, Niranjan T, Gruenwald A, Ahn S, Kato H, Pullman J, Gessler M, Haase VH, Susztak K.
J Clin Invest. 2010 Nov;120(11):4040-54

Selected Publications

Tin Adrienne, Marten Jonathan, Halperin Kuhns Victoria L, Li Yong, Wuttke Matthias, Kirsten Holger, Sieber Karsten B, Qiu Chengxiang, Gorski Mathias, Yu Zhi, Giri Ayush, Sveinbjornsson Gardar, Li Man, Chu Audrey Y, Hoppmann Anselm, O'Connor Luke J, Prins Bram, Nutile Teresa, Noce Damia, Akiyama Masato, Cocca Massimiliano, Ghasemi Sahar, van der Most Peter J, Horn Katrin, Xu Yizhe, Fuchsberger Christian, Sedaghat Sanaz, Afaq Saima, Amin Najaf, Ärnlöv Johan, Bakker Stephan J L, Bansal Nisha, Baptista Daniela, Bergmann Sven, Biggs Mary L, Biino Ginevra, Boerwinkle Eric, Bottinger Erwin P, Boutin Thibaud S, Brumat Marco, Burkhardt Ralph, Campana Eric, Campbell Archie, Campbell Harry, Carroll Robert J, Catamo Eulalia, Chambers John C, Ciullo Marina, Concas Maria Pina, Coresh Josef, Corre Tanguy, Cusi Daniele, Felicita Sala Cinzia, de Borst Martin H, De Grandi Alessandro, de Mutsert Renée, de Vries Aiko P J, Delgado Graciela, Demirkan Ayşe, Devuyst Olivier, Dittrich Katalin, Eckardt Kai-Uwe, Ehret Georg, Endlich Karlhans, Evans Michele K, Gansevoort Ron T, Gasparini Paolo, Giedraitis Vilmantas, Gieger Christian, Girotto Giorgia, Gögele Martin, Gordon Scott D, Gudbjartsson Daniel F, Gudnason Vilmundur, Haller Toomas, Hamet Pavel, Harris Tamara B, Hayward Caroline, Hicks Andrew A, Hofer Edith, Holm Hilma, Huang Wei, Hutri-Kähönen Nina, Hwang Shih-Jen, Ikram M Arfan, Lewis Raychel M, Ingelsson Erik, Jakobsdottir Johanna, Jonsdottir Ingileif, Jonsson Helgi, Joshi Peter K, Josyula Navya Shilpa, Jung Bettina, Kähönen Mika, Kamatani Yoichiro, Kanai Masahiro, Kerr Shona M, Kiess Wieland, Kleber Marcus E, Koenig Wolfgang, Kooner Jaspal S, Körner Antje, Kovacs Peter, Krämer Bernhard K, Kronenberg Florian, Kubo Michiaki, Kühnel Brigitte, La Bianca Martina, Lange Leslie A, Lehne Benjamin, Lehtimäki Terho, Liu Jun, Loeffler Markus, Loos Ruth J F, Lyytikäinen Leo-Pekka, Magi Reedik, Mahajan Anubha, Martin Nicholas G, März Winfried, Mascalzoni Deborah, Matsuda Koichi, Meisinger Christa, Meitinger Thomas, Metspalu Andres, Milaneschi Yuri, O'Donnell Christopher J, Wilson Otis D, Gaziano J Michael, Mishra Pashupati P, Mohlke Karen L, Mononen Nina, Montgomery Grant W, Mook-Kanamori Dennis O, Müller-Nurasyid Martina, Nadkarni Girish N, Nalls Mike A, Nauck Matthias, Nikus Kjell, Ning Boting, Nolte Ilja M, Noordam Raymond, O'Connell Jeffrey R, Olafsson Isleifur, Padmanabhan Sandosh, Penninx Brenda W J H, Perls Thomas, Peters Annette, Pirastu Mario, Pirastu Nicola, Pistis Giorgio, Polasek Ozren, Ponte Belen, Porteous David J, Poulain Tanja, Preuss Michael H, Rabelink Ton J, Raffield Laura M, Raitakari Olli T, Rettig Rainer, Rheinberger Myriam, Rice Kenneth M, Rizzi Federica, Robino Antonietta, Rudan Igor, Krajcoviechova Alena, Cifkova Renata, Rueedi Rico, Ruggiero Daniela, Ryan Kathleen A, Saba Yasaman, Salvi Erika, Schmidt Helena, Schmidt Reinhold, Shaffer Christian M, Smith Albert V, Smith Blair H, Spracklen Cassandra N, Strauch Konstantin, Stumvoll Michael, Sulem Patrick, Tajuddin Salman M, Teren Andrej, Thiery Joachim, Thio Chris H L, Thorsteinsdottir Unnur, Toniolo Daniela, Tönjes Anke, Tremblay Johanne, Uitterlinden André G, Vaccargiu Simona, van der Harst Pim, van Duijn Cornelia M, Verweij Niek, Völker Uwe, Vollenweider Peter, Waeber Gerard, Waldenberger Melanie, Whitfield John B, Wild Sarah H, Wilson James F, Yang Qiong, Zhang Weihua, Zonderman Alan B, Bochud Murielle, Wilson James G, Pendergrass Sarah A, Ho Kevin, Parsa Afshin, Pramstaller Peter P, Psaty Bruce M, Böger Carsten A, Snieder Harold, Butterworth Adam S, Okada Yukinori, Edwards Todd L, Stefansson Kari, Susztak Katalin, Scholz Markus, Heid Iris M, Hung Adriana M, Teumer Alexander, Pattaro Cristian, Woodward Owen M, Vitart Veronique, Köttgen Anna: Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels. Nature genetics Oct 2019.

Chung Ki Wung, Dhillon Poonam, Huang Shizheng, Sheng Xin, Shrestha Rojesh, Qiu Chengxiang, Kaufman Brett A, Park Jihwan, Pei Liming, Baur Joseph, Palmer Matthew, Susztak Katalin: Mitochondrial Damage and Activation of the STING Pathway Lead to Renal Inflammation and Fibrosis. Cell metabolism 30(4): 784-799.e5, Oct 2019.

Park Jihwan, Liu Chang Linda, Kim Junhyong, Susztak Katalin: Understanding the kidney one cell at a time. Kidney international 96(4): 862-870, Oct 2019.

Salem Rany M, Todd Jennifer N, Sandholm Niina, Cole Joanne B, Chen Wei-Min, Andrews Darrell, Pezzolesi Marcus G, McKeigue Paul M, Hiraki Linda T, Qiu Chengxiang, Nair Viji, Di Liao Chen, Cao Jing Jing, Valo Erkka, Onengut-Gumuscu Suna, Smiles Adam M, McGurnaghan Stuart J, Haukka Jani K, Harjutsalo Valma, Brennan Eoin P, van Zuydam Natalie, Ahlqvist Emma, Doyle Ross, Ahluwalia Tarunveer S, Lajer Maria, Hughes Maria F, Park Jihwan, Skupien Jan, Spiliopoulou Athina, Liu Andrew, Menon Rajasree, Boustany-Kari Carine M, Kang Hyun M, Nelson Robert G, Klein Ronald, Klein Barbara E, Lee Kristine E, Gao Xiaoyu, Mauer Michael, Maestroni Silvia, Caramori Maria Luiza, de Boer Ian H, Miller Rachel G, Guo Jingchuan, Boright Andrew P, Tregouet David, Gyorgy Beata, Snell-Bergeon Janet K, Maahs David M, Bull Shelley B, Canty Angelo J, Palmer Colin N A, Stechemesser Lars, Paulweber Bernhard, Weitgasser Raimund, Sokolovska Jelizaveta, Rovīte Vita, Pīrāgs Valdis, Prakapiene Edita, Radzeviciene Lina, Verkauskiene Rasa, Panduru Nicolae Mircea, Groop Leif C, McCarthy Mark I, Gu Harvest F, Möllsten Anna, Falhammar Henrik, Brismar Kerstin, Martin Finian, Rossing Peter, Costacou Tina, Zerbini Gianpaolo, Marre Michel, Hadjadj Samy, McKnight Amy J, Forsblom Carol, McKay Gareth, Godson Catherine, Maxwell A Peter, Kretzler Matthias, Susztak Katalin, Colhoun Helen M, Krolewski Andrzej, Paterson Andrew D, Groop Per-Henrik, Rich Stephen S, Hirschhorn Joel N, Florez Jose C: Genome-Wide Association Study of Diabetic Kidney Disease Highlights Biology Involved in Glomerular Basement Membrane Collagen. Journal of the American Society of Nephrology : JASN 30(10): 2000-2016, Oct 2019.

Teumer Alexander, Li Yong, Ghasemi Sahar, Prins Bram P, Wuttke Matthias, Hermle Tobias, Giri Ayush, Sieber Karsten B, Qiu Chengxiang, Kirsten Holger, Tin Adrienne, Chu Audrey Y, Bansal Nisha, Feitosa Mary F, Wang Lihua, Chai Jin-Fang, Cocca Massimiliano, Fuchsberger Christian, Gorski Mathias, Hoppmann Anselm, Horn Katrin, Li Man, Marten Jonathan, Noce Damia, Nutile Teresa, Sedaghat Sanaz, Sveinbjornsson Gardar, Tayo Bamidele O, van der Most Peter J, Xu Yizhe, Yu Zhi, Gerstner Lea, Ärnlöv Johan, Bakker Stephan J L, Baptista Daniela, Biggs Mary L, Boerwinkle Eric, Brenner Hermann, Burkhardt Ralph, Carroll Robert J, Chee Miao-Li, Chee Miao-Ling, Chen Mengmeng, Cheng Ching-Yu, Cook James P, Coresh Josef, Corre Tanguy, Danesh John, de Borst Martin H, De Grandi Alessandro, de Mutsert Renée, de Vries Aiko P J, Degenhardt Frauke, Dittrich Katalin, Divers Jasmin, Eckardt Kai-Uwe, Ehret Georg, Endlich Karlhans, Felix Janine F, Franco Oscar H, Franke Andre, Freedman Barry I, Freitag-Wolf Sandra, Gansevoort Ron T, Giedraitis Vilmantas, Gögele Martin, Grundner-Culemann Franziska, Gudbjartsson Daniel F, Gudnason Vilmundur, Hamet Pavel, Harris Tamara B, Hicks Andrew A, Holm Hilma, Foo Valencia Hui Xian, Hwang Shih-Jen, Ikram M Arfan, Ingelsson Erik, Jaddoe Vincent W V, Jakobsdottir Johanna, Josyula Navya Shilpa, Jung Bettina, Kähönen Mika, Khor Chiea-Chuen, Kiess Wieland, Koenig Wolfgang, Körner Antje, Kovacs Peter, Kramer Holly, Krämer Bernhard K, Kronenberg Florian, Lange Leslie A, Langefeld Carl D, Lee Jeannette Jen-Mai, Lehtimäki Terho, Lieb Wolfgang, Lim Su-Chi, Lind Lars, Lindgren Cecilia M, Liu Jianjun, Loeffler Markus, Lyytikäinen Leo-Pekka, Mahajan Anubha, Maranville Joseph C, Mascalzoni Deborah, McMullen Barbara, Meisinger Christa, Meitinger Thomas, Miliku Kozeta, Mook-Kanamori Dennis O, Müller-Nurasyid Martina, Mychaleckyj Josyf C, Nauck Matthias, Nikus Kjell, Ning Boting, Noordam Raymond, Connell Jeffrey O', Olafsson Isleifur, Palmer Nicholette D, Peters Annette, Podgornaia Anna I, Ponte Belen, Poulain Tanja, Pramstaller Peter P, Rabelink Ton J, Raffield Laura M, Reilly Dermot F, Rettig Rainer, Rheinberger Myriam, Rice Kenneth M, Rivadeneira Fernando, Runz Heiko, Ryan Kathleen A, Sabanayagam Charumathi, Saum Kai-Uwe, Schöttker Ben, Shaffer Christian M, Shi Yuan, Smith Albert V, Strauch Konstantin, Stumvoll Michael, Sun Benjamin B, Szymczak Silke, Tai E-Shyong, Tan Nicholas Y Q, Taylor Kent D, Teren Andrej, Tham Yih-Chung, Thiery Joachim, Thio Chris H L, Thomsen Hauke, Thorsteinsdottir Unnur, Tönjes Anke, Tremblay Johanne, Uitterlinden André G, van der Harst Pim, Verweij Niek, Vogelezang Suzanne, Völker Uwe, Waldenberger Melanie, Wang Chaolong, Wilson Otis D, Wong Charlene, Wong Tien-Yin, Yang Qiong, Yasuda Masayuki, Akilesh Shreeram, Bochud Murielle, Böger Carsten A, Devuyst Olivier, Edwards Todd L, Ho Kevin, Morris Andrew P, Parsa Afshin, Pendergrass Sarah A, Psaty Bruce M, Rotter Jerome I, Stefansson Kari, Wilson James G, Susztak Katalin, Snieder Harold, Heid Iris M, Scholz Markus, Butterworth Adam S, Hung Adriana M, Pattaro Cristian, Köttgen Anna: Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria. Nature communications 10(1): 4130, Sep 2019.

Aranyi Tamas, Susztak Katalin: Cytosine Methylation Studies in Patients with Diabetic Kidney Disease. Current diabetes reports 19(10): 91, Aug 2019.

Hellwege Jacklyn N, Velez Edwards Digna R, Giri Ayush, Qiu Chengxiang, Park Jihwan, Torstenson Eric S, Keaton Jacob M, Wilson O D, Robinson-Cohen Cassianne, Chung Cecilia P, Roumie Christianne L, Klarin Derek, Damrauer Scott M, DuVall Scott L, Siew Edward, Akwo Elvis A, Wuttke Matthias, Gorski Mathias, Li Man, Li Yong, Gaziano J Michael, Wilson Peter W F, Tsao Philip S, O'Donnell Christopher J, Kovesdy Csaba P, Pattaro Cristian, Köttgen Anna, Susztak Katalin, Edwards Todd L, Hung Adriana M: Mapping eGFR loci to the renal transcriptome and phenome in the VA Million Veteran Program. Nature communications 10(1): 3842, Aug 2019.

Huang Shizheng, Sheng Xin, Susztak Katalin: The kidney transcriptome, from single cells to whole organs and back. Current opinion in nephrology and hypertension 28(3): 219-226, May 2019.

Li Szu-Yuan, Chu Pao-Hsien, Huang Po-Hsun, Hsieh Tsung-Han, Susztak Katalin, Tarng Der-Cherng: FHL2 mediates podocyte Rac1 activation and foot process effacement in hypertensive nephropathy. Scientific reports 9(1): 6693, Apr 2019.

Li Szu-Yuan, Park Jihwan, Guan Yuting, Chung Kiwung, Shrestha Rojesh, Palmer Matthew B, Susztak Katalin: DNMT1 in Progenitor Cells Is Essential for Transposable Element Silencing and Kidney Development. Journal of the American Society of Nephrology : JASN 30(4): 594-609, Apr 2019.

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Last updated: 10/20/2019
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