Lingshu Yin, PhD, DABR
Assistant Professor of Clinical Radiation Oncology
Department: Radiation Oncology
Contact information
3400 Civic Center Boulevard
2 West
Philadelphia, PA 19104
2 West
Philadelphia, PA 19104
Education:
B.Sc., (Physics)
Nanjing University, Nanjing, China, 2006.
Ph.D. (Medical Physics )
University of British Columbia, 2011.
Permanent linkB.Sc., (Physics)
Nanjing University, Nanjing, China, 2006.
Ph.D. (Medical Physics )
University of British Columbia, 2011.
Description of Clinical Expertise
Machine Quality Assurance• Performed daily, monthly and annual QA for Varian Clinac 2300iX, Truebeam with OBI/CBCT/Calypso and Siemens Oncor machines
Treatment Planning
• Extensive treatment planning experience with Varian Eclipse system
o 3D-CRT, IMRT and RapidArc: CNS, GI/GU, Lung, GYN, Breast, Lymphoma, Sarcoma, Head and Neck
o Special treatment planning including electrons and TBI
Patient Treatment Quality Assurance
• Extensive experience with IMRT and RapidArc patient specific QA using MapCheck2 and ArcCheck
Cyberknife Robotic Radiosurgery System
• Performed daily, monthly and annual QA for Accuray Cyberknife VSI system
Brachytherapy Treatment
• Experience with Varian BrachyVision using Ir-192, performed monthly QA and source exchange calibration of the HDR unit
o Treatment planning and delivery of GYN cases with tandem and ovoid, vaginal cylinders, syed and capri applicators
General Clinical Practice and Projects
• Initial chart checking under the supervision of staff physicists
• On call physicist for after hour emergency treatments and machines issues
• Commissioning of RadCalc (Sun Nuclear) for secondary MU check of 3D-CRT, IMRT and RapidArc
• Commissioning of RapidArc (machine testing, treatment planning and patient specific QA) at the Pennsylvania Hospital
• Monthly QA for Siemens CT (Somatom Definition AS)
• Extensive experience with Varian Aria for paperless charting and R&V
• in vivo dosimetry measurements for Total Body Irradiation treatments using OneDose MOSFET and microStar OSLD
CLINICAL EXPERIENCE – PROTON THERAPY
Acceptance and Commissioning of Cone Beam CT system for proton gantry machine
• Collaboration with IBA on acceptance and commissioning of the first proton therapy specific cone beam CT solution.
• Developing new tools and concepts for image guided proton therapy (IGPT) with CBCT using IBA imageX platform
Acceptance and Commissioning of adaPTinsightTM
• Collaboration with IBA on testing and feedback of this image guidance software platform
• Acceptance and commissioning as the first site implementing this platform
Proton Therapy Machine Quality Assurance
• Daily, monthly, annual machine QA for double scattering, uniform scanning and pencil beam scanning rooms
o Beam quality test (range, modulation and output) tests and absolute dose calibration with IBA Bluephantom and Zebra
o Absolute dose calibration (TRS 398) for pencil beam scanning proton therapy and spot pattern QA with Lynx scintillation detector
Proton Therapy Patient Specific Quality Assurance
• Double scattering patient QA: output and range/modulation measurement using IBA Bluephantom and MatrixX
• Uniform scanning and pencil beam scanning patient QA using IBA Zebra and MatrixX
Daily physics duties
• Provides support for dosimetry on treatment planning
• Initial, weekly chart checks and ends of treatment check
• Provides physics support for therapists during the 1st and 2nd shift
Description of Research Expertise
Applications for Image Guided Proton Therapy with CBCTCommissioning and absolute dosimetry for proton therapy
Monte Carlo simulation and beam modeling for proton therapy
Software development for translational clinical applications including:
- Eclipse Scripting for clinical automation
- In-house dual energy CT calibration program
- Secondary MU check for pencil beam scanning proton therapy
Selected Publications
Yuting Peng, Youfang Lai, Lingshu Yin, Yujie Chi, Heng Li and Xun Jia: Investigating radical yield variations in FLASH and conventional proton irradiation via microscopic Monte Carlo simulations. Physics in Medicine & Biology 70(10), May 2025.Lingshu Yin, Daniel Sforza, Devin Miles, Masumi Umezawa, Kan Ota, Xun Jia and Heng Li: Commissioning of a 142.4 MeV ultra-high dose rate (UHDR) proton beamline in a synchrotron-based proton therapy system. Medical Physics 2025 Notes: Tentatively accepted.
Yin L, Masumi U, Ota K, Sforza DM, Miles D, Rezaee M, Wong JW, Jia X, Li H: Feasibility of Synchrotron-Based Ultra-High Dose Rate (UHDR) Proton Irradiation with Pencil Beam Scanning for FLASH Research. Cancers (Basel) 16(1): 221, Jan 2024.
Yin L, Zou W, Kim M, Avery S, Wiersma R, Teo BK, Dong L, Diffenderfer E: Evaluation of two-voltage and three-voltage linear methods for deriving ion recombination correction factors in proton FLASH irradiation. IEEE Transactions on Radiation and Plasma Medical Sciences 6(3): 263-270, Mar 2022.
Kassaee A, Cheng C, Yin L, Zou W, Li T, Lin A, Swisher-McClure S, Lukens JN, Lustig RA, O'Reilly S, Dong L, Ms RH, Teo BK: Dual-Energy Computed Tomography Proton-Dose Calculation with Scripting and Modified Hounsfield Units. Int J Part Ther 8(1): 62-72, Jun 2021.
Zou W, Diffenderfer ES, Cengel KA, Kim MM, Avery S, Konzer J, Cai Y, Boisseu P, Ota K, Yin L, Wiersma R, Carlson DJ, Fan Y, Busch TM, Koumenis C, Lin A, Metz JM, Teo BK, Dong L: Current delivery limitations of proton PBS for FLASH. Radiother Oncol 155: 212-218, Feb 2021.
Xie Y, Petzoldt J, Janssens G, O'Grady F, Yin L, Bentefour EH, Smeets J, Prieels D, Lustig RA, Lin A, Teo BK: Prompt gamma imaging for the identification of regional proton range deviations due to anatomic change in a heterogeneous region. Br J Radiol 93(1116): 20190619, Dec 2020.
O'Reilly S, Jain V, Huang Q, Cheng C, Teo BK, Yin L, Zhang M, Diffenderfer E, Li T, Levin W, Xiao Y, Dong L, Feigenberg S, Berman AT, Zou W: Dose to Highly Functional Ventilation Zones Improves Prediction of Radiation Pneumonitis for Proton and Photon Lung Cancer Radiation Therapy. Int J Radiat Oncol Biol Phys 107(1): 79-87, May 2020.
Lalonde A, Xie Y, Burgdorf B, O'Reilly S, Ingram WS, Yin L, Zou W, Dong L, Bouchard H, Teo BK: Influence of intravenous contrast agent on dose calculation in proton therapy using dual energy CT. Phys Med Biol 64(12): 125024, Jun 2019.
Arscott WT, Thompson RF, Yin L, Burgdorf B, Kirk M, Ben-Josef E: Stereotactic body proton therapy for liver tumors: Dosimetric advantages and their radiobiological and clinical implications. Phys Imaging Radiat Oncol 8: 17-22, Nov 2018.