Description of Clinical Expertise

Dr. Landstrom is Professor of Pediatrics at the Perelman School of Medicine at the University of Pennsylvania, Director of Translational Research for the Children's Hospital of Philadelphia Cardiovascular Institute, and a pediatric cardiologist and cardiovascular geneticist specializing in the care of children and families with inherited cardiovascular disease. His clinical expertise focuses on inherited arrhythmia syndromes, cardiomyopathies, sudden cardiac arrest, sudden cardiac death, and cardiovascular genetic disorders. He directs comprehensive evaluation and management strategies for patients with conditions including long QT syndrome, catecholaminergic polymorphic ventricular tachycardia (CPVT), Brugada syndrome, arrhythmogenic cardiomyopathy, dilated cardiomyopathy, hypertrophic cardiomyopathy, and other heritable heart diseases. Dr. Landstrom integrates cardiovascular genetics, genomic medicine, advanced cardiac imaging, electrophysiology, and precision medicine approaches to guide individualized risk assessment, diagnosis, and treatment. His clinical practice emphasizes the use of genetic testing and genomic data to identify disease risk, refine prognostic assessment, inform family screening, and develop personalized management strategies aimed at preventing heart failure, malignant arrhythmias, sudden cardiac arrest, and sudden cardiac death. Through his leadership in cardiovascular genetics and inherited heart disease programs, he works to translate advances in genomic medicine and precision therapeutics into improved outcomes for patients and families affected by rare and heritable cardiovascular disorders.

Description of Other Expertise

Dr. Landstrom is committed to advancing the clinical, scientific, and educational foundations of cardiovascular genetics, genomic medicine, precision medicine, and gene-based therapies. In addition to his clinical and research programs, he plays a leadership role in developing clinical practice guidelines, scientific statements, consensus documents, and research best practices that guide the implementation of genetic and genomic medicine for inherited cardiovascular disease. His work focuses on establishing evidence-based approaches to genetic testing, variant interpretation, genomic data integration, precision therapeutics, clinical trial design, and translating emerging discoveries into clinical care for inherited arrhythmia syndromes, cardiomyopathies, and sudden cardiac death–predisposing disorders. Through leadership positions in national and international scientific organizations, professional societies, and collaborative research networks, Dr. Landstrom works to advance standards of care, accelerate therapeutic development, and promote the responsible integration of genomics into cardiovascular medicine. He is also deeply committed to physician-scientist training, mentorship, and medical education, developing educational programs in cardiovascular genetics, inherited heart disease, and precision cardiovascular medicine for learners ranging from students and trainees to practicing clinicians. Internationally, he collaborates with academic medical centers, healthcare systems, scientific organizations, and biotechnology partners throughout Southeast Asia to expand access to genomic medicine, improve rare disease diagnosis, advance cardiovascular genetics research, and support the education and training of physicians, genetic counselors, scientists, and healthcare professionals. Through these efforts, he seeks to strengthen global capacity in inherited cardiovascular disease, cardiovascular genomics, precision medicine, and translational cardiovascular research.

Description of Research Expertise

Dr. Landstrom is a physician-scientist whose research focuses on defining the genetic, molecular, and cellular mechanisms that drive inherited cardiovascular disease, with particular emphasis on inherited arrhythmia syndromes, cardiomyopathies, heart failure, and sudden cardiac death. His laboratory integrates human genomics, functional genomics, patient-derived induced pluripotent stem cell–derived cardiomyocytes (iPSC-CMs), engineered cardiac tissues, and animal models to identify disease mechanisms and therapeutic targets for rare and heritable heart disorders. His work has contributed to the discovery of novel genetic causes of inherited cardiovascular disease, the characterization of mechanisms underlying arrhythmias and cardiomyopathies, and the development of precision medicine approaches for cardiovascular genetics. A major focus of his research program is the development of mechanism-based therapies, including small-molecule, genomic, and gene-based therapeutic strategies designed to prevent disease progression and life-threatening arrhythmias. In parallel, his group develops genomic prediction models that integrate genetic, molecular, and clinical data to improve disease prediction, risk stratification, and personalized treatment. The overarching goal of his research is to translate discoveries in cardiovascular genetics and genomic medicine into precision therapeutics that prevent heart failure, sudden cardiac arrest, and sudden cardiac death.