Eliot Graham Peyster, MD, MSc

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Assistant Professor of Medicine (Cardiovascular Medicine) at the Hospital of the University of Pennsylvania
Member, Cardiovascular Research Institute
Department: Medicine

Contact information
3400 Civic Center Blvd
Philadelphia, PA 19104
BA (Physical Chemistry)
Williams College, 2005.
MD (Medicine)
Drexel University College of Medicine, 2012.
MSc (Translational Research)
University of Pennsylvania, 2019.
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Description of Clinical Expertise

Advanced Heart Failure and Transplant Cardiology
Inflammatory Cardiomyopathies

Description of Research Expertise

My research focuses on applying sophisticated computational methods to multidimensional diagnostic data in order to enhance the understanding of cardiovascular diseases. With clinical training in advanced heart failure/transplant medicine and scientific training in translational research, my work focuses on designing rigorous experiments that facilitate the translation of innovative technologies into patient care. I have led multiple first-in-field investigations leveraging ‘machine learning’ computer-vision technology to diagnose and predict diseases of both the native and transplanted heart. As a result of these efforts, I have received multiple national research awards, been awarded several US patents, presented at numerous national conferences, and serve as key personnel on multiple NIH-funded projects. Current areas of active research focus on multi-modal data integration, combining digital pathology analysis with other data types to develop novel diagnostic and prognostic platforms. These include utilizing ‘histo-immunologic’ data to predict transplanted heart rejection, ‘histo-clinical’ data to predict long-term transplanted heart failure, and ‘histo-proteomic’ data to improve donor organ harvest and allocation decisions. Ultimately, the goal of my research is to identify and integrate promising analytical methods to improve disease understanding and enhance precision medical practices.

Selected Publications

Kobashigawa J, Hall S, Shah P, Fine B, Halloran P, Jackson AM, Khush KK, Margulies KB, Sani MM, Patel JK, Patel N, Peyster E.: The Evolving Use of Biomarkers in Heart Transplantation: Consensus of an Expert Panel. Am J Transplant. 23, Mar 2023.

Carissa E. Livingston, Dale Daniel Kim, Lacey Serletti, Andrea Jin, Eliot Peyster: PREDICTING TRANSIENT VS SUSTAINED RV FAILURE AFTER LVAD IMPLANTATION: A NOVEL APPROACH. ACC Scientific Sessions 2023.

Nicholas K. Brown, Eliot G. Peyster, Thanh-Mai Bui : R for HLA Data: A Suite of Tools for Managing and Analyzing Data from Clinical HLA Laboratory Information Systems American Transplant Congress Annual Meeting 2023.

Chaitanya Rojulpote, Abhijit Bhattaru, Christopher Jean, Sarah L Adams, Vandan Patel, Mahesh K Vidula, Senthil Selvaraj, Jacob Dubroff, Eliot Peyster, Caitlin B Clancy, Karen Patterson, Francis E Marchlinski, Milton Rossman, Lee Goldberg, Paco E Bravo : Effect of Immunosuppressive Therapy and Biopsy Status in Monitoring Therapy Response in Suspected Cardiac Sarcoidosis JACC Cardiovascular Imaging 15(11), November 2022.

Eliot G. Peyster, Andrew Janowczyk, Abigail Swamidoss, Samhith Kethireddy, Michael D. Feldman, Kenneth B. Margulies: Computational Analysis of Routine Biopsies Improves Diagnosis and Prediction of Cardiac Allograft Vasculopathy. Circulation April 2022.

L. Holzhauser M. Norris M. Molina S. Chambers K. Gala T. Fallah T. Bittermann P. Atluri R. McLean E. Peyster: A Transplant Center Experience with Basiliximab Induction Strategies - A Double Edged Sword? International Society of Heart and Lung Transplantation Annual Meeting April 2022.

Peyster E, ArabYarmohommadi S, Janowczyk A, Azarianpour-Esfahani S, Sekulic M, Cassol C, Blower L, Parwani A, Lal P, Feldman M, Margulies K, Madabhushi A : An Automated Computational Image Analysis Pipeline for Histologic Grading of Cardiac Allograft Rejection. Eur Heart J Page: ehab241, May 2021 Notes: online ahead of print.

Duong Van Huyen JP, Fedrigo M, Fishbein GA, Leone O, Neil D, Marboe C, Peyster E, von der Thüsen J, Loupy A, Mengel M, Revelo MP, Adam B, Bruneval P, Angelini A, Miller DV, Berry, GJ: The XVth Banff Conference on Allograft Pathology The Banff Workshop Heart Report: Improving the Diagnostic Yield from Endomyocardial Biopsies and Quilty Effect Revisited. Am J Transplant 20(12): 3308-3318, Jun 2020.

Peyster EG, Margulies KB: Is it Time for Trials on Preventing Immune-Mediated Myocardial Damage? JACC Basic Transl Sci 28(6): 543-545, Jun 2021.

Peyster Eliot, Wang Chichung, Ishola Felicia, Remeniuk Bethany, Hoyt Clifford, Feldman Michael D, Margulies Kenneth B: In Situ Immune Profiling of Heart Transplant Biopsies Improves Diagnostic Accuracy and Rejection Risk Stratification. JACC: Basic to Translational Science 5(4): 328-340, Apr 2020.

Nirschl JJ, Janowczyk A, Peyster EG, Frank R, Margulies KB, Feldman MD, Madabhushi A: A deep-learning classifier identifies patients with clinical heart failure using whole-slide images of H&E tissue. PLoS One 13(4): e0192726, Apr 2018.

Peyster EG, Madabhushi A, Margulies KB: Advanced Morphologic Analysis for Diagnosing Allograft Rejection: The Case of Cardiac Transplant Rejection. Transplantation 102(8): 1230-1239, Aug 2018.

Peyster E, Chen J, Feldman HI, Go AS, Gupta J, Mitra N, Pan Q, Porter A, Rahman M, Raj D, Reilly M, Wing MR, Yang W, Townsend RR: Inflammation and Arterial Stiffness in Chronic Kidney Disease: Findings From the CRIC Study. Am J Hypertens 30(4): 400-408, Apr 2017.

Fenning RS, Burgert ME, Hamamdzic D, Peyster EG, Mohler ER, Kangovi S, Jucker BM, Lenhard SC, Macphee CH, WilenskY RL: Atherosclerotic plaque inflammation varies between vascular sites and correlates with response to inhibition of lipoprotein-associated phospholipase A2. JAHA 4(2), Feb 2015.

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Last updated: 09/15/2023
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