Tiffanie K. Jones, MD, MPH, MSCE
Assistant Professor of Medicine at the Hospital of the University of Pennsylvania
Senior Scholar, Center for Clinical Epidemiology and Biostatistics
Department: Medicine
Contact information
Hospital of the University of Pennsylvania
5048 Gates Building
3400 Spruce Street
Philadelphia, PA 19104
5048 Gates Building
3400 Spruce Street
Philadelphia, PA 19104
Office: 215-662-3202
Links
Department of Biostatistics, Epidemiology, and Informatics (DBEI)
Center for Clinical Epidemiology and Biostatistics (CCEB)
Department of Biostatistics, Epidemiology, and Informatics (DBEI)
Center for Clinical Epidemiology and Biostatistics (CCEB)
Education:
AB (Biology)
Harvard University, 2007.
MPH (Chronic Disease Epidemiology)
Yale University, 2012.
MD (Medicine)
Yale University, 2012.
MSCE (Human Genetics)
University of Pennsylvania, 2018.
Permanent linkAB (Biology)
Harvard University, 2007.
MPH (Chronic Disease Epidemiology)
Yale University, 2012.
MD (Medicine)
Yale University, 2012.
MSCE (Human Genetics)
University of Pennsylvania, 2018.
Description of Clinical Expertise
Dr. Jones is an intensivist who serves as an attending physician in the Medical Intensive Care Unit (MICU) and the Critical Care Outreach and Procedure Service (CCOPS) at the Hospital of the University of Pennsylvania. Her clinical expertise is the management of critical illness including sepsis, shock, respiratory failure, and cardiac arrest.Description of Research Expertise
Dr. Jones is a physician-epidemiologist who investigates the risk factors for respiratory failure during critical illness with a focus on the determinants of acute respiratory distress syndrome (ARDS). She conducts studies that apply her knowledge in pulmonary and critical care medicine, clinical epidemiology, genetic epidemiology, and public health. The purpose of her research is to identify novel genetic determinants of ARDS to elucidate the underlying biology, identify new targets for disease-specific pharmacotherapy, and advance a precision medicine paradigm for treatment of critical illness.Selected Publications
Cosgriff CV, Miano TA, Mathew D, Huang AC, Giannini HM, Kuri-Cervantes L, Pampena MB, Ittner CAG, Weisman AR, Agyekum RS, Dunn TG, Oniyide O, Turner AP, D'Andrea K, Adamski S, Greenplate AR, Anderson BJ, Harhay MO, Jones TK, Reilly JP, Mangalmurti NS, Shashaty MGS, Betts MR, Wherry EJ, Meyer NJ.: Validating a Proteomic Signature of Severe COVID-19. Crit Care Explor 4: e0800, Dec 2022.Hernandez-Beeftink T, Guillen-Guio B, Lorenzo-Salazar JM, Corrales A, Suarez-Pajes E, Feng R, Rubio-Rodríguez LA, Paynton ML, Cruz R, García-Laorden MI, Prieto-González M, Rodríguez-Pérez A, Carriedo D, Blanco J, Ambrós A, González-Higueras E, Espinosa E, Muriel A, Tamayo E, Martin MM, Lorente L, Domínguez D, de Lorenzo AG, Giannini HM, Reilly JP, Jones TK, Añón JM, Soro M, Carracedo Á, Wain LV, Meyer NJ, Villar J, Flores C; Genetics of Sepsis (GEN-SEP) Network.: A genome-wide association study of survival in patients with sepsis. Crit Care 26: 341, Nov 2022.
Miano TA, Hennessy S, Yang W, Dunn TG, Weisman AR, Oniyide O, Agyekum RS, Turner AP, Ittner CAG, Anderson BJ, Wilson FP, Townsend R, Reilly JP, Giannini HM, Cosgriff CV, Jones TK, Meyer NJ, Shashaty MGS.: Association of vancomycin plus piperacillin-tazobactam with early changes in creatinine versus cystatin C in critically ill adults: a prospective cohort study. Intensive Care Med 2022.
Belvitch P, Casanova N, Sun X, Camp SM, Sammani S, Brown ME, Mascarhenas J, Lynn H, Adyshev D, Siegler J, Desai A, Seyed-Saadat L, Rizzo A, Bime C, Shekhawat GS, Dravid VP, Reilly JP, Jones TK, Feng R, Letsiou E, Meyer NJ, Ellis N, Garcia JGN, Dudek SM.: A cortactin CTTN coding SNP contributes to lung vascular permeability and inflammatory disease severity in African descent subjects. Transl Res 2022.
Jones TK, Reilly JP, Anderson BJ, Miano TA, Dunn TG, Weisman AR, Agyekum R, Feng R, Ittner CAG, Shashaty MGS, Meyer NJ.: Elevated Plasma Levels of Matrix Metalloproteinase-3 and Tissue-Inhibitor of Matrix Metalloproteinases-1 Associate with Organ Dysfunction and Mortality in Sepsis. Shock Jul 2021.
Bange EM, Han NA, Wileyto P, Kim JY, Gouma S, Robinson J, Greenplate AR, Hwee MA, Porterfield F, Owoyemi O, Naik K, Zheng C, Galantino M, Weisman AR, Ittner CAG, Kugler EM, Baxter AE, Oniyide O, Agyekum RS, Dunn TG, Jones TK, Giannini HM, Weirick ME, McAllister CM, Babady NE, Kumar A, Widman AJ, DeWolf S, Boutemine SR, Roberts C, Budzik KR, Tollett S, Wright C, Perloff T, Sun L, Mathew D, Giles JR, Oldridge DA, Wu JE, Alanio C, Adamski S, Garfall AL, Vella LA, Kerr SJ, Cohen JV, Oyer RA, Massa R, Maillard IP, Maxwell KN, Reilly JP, Maslak PG, Vonderheide RH, Wolchok JD, Hensley SE, Wherry EJ, Meyer NJ, DeMichele AM, Vardhana SA, Mamtani R, Huang AC.: CD8(+) T cells contribute to survival in patients with COVID-19 and hematologic cancer. Nat Med 27(7):1280-1289, July 2021.
Sjoding MW, Taylor D, Motyka J, Lee E, Co I, Claar D, McSparron JI, Ansari S, Kerlin MP, Reilly JP, Shashaty MGS, Anderson BJ, Jones TK, Drebin HM, Ittner CAG, Meyer NJ, Iwashyna TJ, Ward KR, Gillies CE.: Deep learning to detect acute respiratory distress syndrome on chest radiographs: a retrospective study with external validation. Lancet Digit Health 2021.
Kuri-Cervantes, L., Pampena, M. B., Meng, W., Rosenfeld, A. M., Ittner, C. A. G., Weisman, A. R., Agyekum, R. S., Mathew, D., Baxter, A. E., Vella, L. A., Kuthuru, O., Apostolidis, S. A., Bershaw, L., Dougherty, J., Greenplate, A. R., Pattekar, A., Kim, J., Han, N., Gouma, S., Weirick, M. E., Arevalo, C. P., Bolton, M. J., Goodwin, E. C., Anderson, E. M., Hensley, S. E., Jones, T. K., Mangalmurti, N. S., Luning Prak, E. T., Wherry, E. J., Meyer, N. J., Betts, M. R.: Comprehensive mapping of immune perturbations associated with severe COVID-19. Sci Immunol 5(49): 1-15, Jul 2020.
Guillen-Guio Beatriz, Lorenzo-Salazar Jose M, Ma Shwu-Fan, Hou Pei-Chi, Hernandez-Beeftink Tamara, Corrales Almudena, García-Laorden M Isabel, Jou Jonathan, Espinosa Elena, Muriel Arturo, Domínguez David, Lorente Leonardo, Martín María M, Rodríguez-Gallego Carlos, Solé-Violán Jordi, Ambrós Alfonso, Carriedo Demetrio, Blanco Jesús, Añón José M, Reilly John P, Jones Tiffanie K, Ittner Caroline Ag, Feng Rui, Schöneweck Franziska, Kiehntopf Michael, Noth Imre, Scholz Markus, Brunkhorst Frank M, Scherag André, Meyer Nuala J, Villar Jesús, Flores Carlos: Sepsis-associated acute respiratory distress syndrome in individuals of European ancestry: a genome-wide association study. The Lancet. Respiratory medicine 8(3): 258-266, Mar 2020.
Jones Tiffanie K, Feng Rui, Kerchberger V Eric, Reilly John P, Anderson Brian J, Shashaty Michael G S, Wang Fan, Dunn Thomas G, Riley Thomas R, Abbott Jason, Ittner Caroline A G, Christiani David C, Mikacenic Carmen, Wurfel Mark M, Ware Lorraine B, Calfee Carolyn S, Matthay Michael A, Christie Jason D, Meyer Nuala J: Plasma sRAGE Acts as Genetically Regulated Causal Intermediate in Sepsis-Associated ARDS. American journal of respiratory and critical care medicine 201(1): 47-56, Jan 2020.