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Tiffanie Jones, MD, MPH, MSCE
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Assistant Professor of Medicine (Pulmonary, Allergy and Critical Care) at the Hospital of the University of Pennsylvania
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Senior Scholar, Center for Clinical Epidemiology and Biostatistics (CCEB)
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Co-Director, Master of Science in Clinical Epidemiology (MSCE) Program
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Center for Clinical Epidemiology and Biostatistics (CCEB)
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Department: Medicine
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Contact information
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Hospital of the University of Pennsylvania
1b 5048 Gates Building
35 3400 Spruce Street
Philadelphia, PA 19104
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1b 5048 Gates Building
35 3400 Spruce Street
Philadelphia, PA 19104
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Office: 215-662-3202
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Links
aa Department of Biostatistics, Epidemiology, and Informatics (DBEI)
a1 Center for Clinical Epidemiology and Biostatistics (CCEB)
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aa Department of Biostatistics, Epidemiology, and Informatics (DBEI)
a1 Center for Clinical Epidemiology and Biostatistics (CCEB)
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Education:
21 7 AB 14 (Biology) c
2b Harvard University, 2007.
21 8 MPH 29 (Chronic Disease Epidemiology) c
28 Yale University, 2012.
21 7 MD 15 (Medicine) c
28 Yale University, 2012.
21 9 MSCE 1b (Human Genetics) c
33 University of Pennsylvania, 2018.
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Permanent link21 7 AB 14 (Biology) c
2b Harvard University, 2007.
21 8 MPH 29 (Chronic Disease Epidemiology) c
28 Yale University, 2012.
21 7 MD 15 (Medicine) c
28 Yale University, 2012.
21 9 MSCE 1b (Human Genetics) c
33 University of Pennsylvania, 2018.
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Description of Clinical Expertise
16a Dr. Jones is an intensivist who serves as an attending physician in the Medical Intensive Care Unit (MICU) and the Critical Care Outreach and Procedure Service (CCOPS) at the Hospital of the University of Pennsylvania. Her clinical expertise is the management of critical illness including sepsis, shock, respiratory failure, and cardiac arrest.71
Description of Research Expertise
26c Dr. Jones is a physician-epidemiologist who investigates the risk factors for respiratory failure during critical illness with a focus on the determinants of acute respiratory distress syndrome (ARDS). She conducts studies that apply her knowledge in pulmonary and critical care medicine, clinical epidemiology, genetic epidemiology, and public health. The purpose of her research is to identify novel genetic determinants of ARDS to elucidate the underlying biology, identify new targets for disease-specific pharmacotherapy, and advance a precision medicine paradigm for treatment of critical illness.e 29
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1d0 Cosgriff CV, Miano TA, Mathew D, Huang AC, Giannini HM, Kuri-Cervantes L, Pampena MB, Ittner CAG, Weisman AR, Agyekum RS, Dunn TG, Oniyide O, Turner AP, D'Andrea K, Adamski S, Greenplate AR, Anderson BJ, Harhay MO, Jones TK, Reilly JP, Mangalmurti NS, Shashaty MGS, Betts MR, Wherry EJ, Meyer NJ.: Validating a Proteomic Signature of Severe COVID-19. Crit Care Explor 4(12): e0800, Dec 2022.
28c Hernandez-Beeftink T, Guillen-Guio B, Lorenzo-Salazar JM, Corrales A, Suarez-Pajes E, Feng R, Rubio-Rodríguez LA, Paynton ML, Cruz R, García-Laorden MI, Prieto-González M, Rodríguez-Pérez A, Carriedo D, Blanco J, Ambrós A, González-Higueras E, Espinosa E, Muriel A, Tamayo E, Martin MM, Lorente L, Domínguez D, de Lorenzo AG, Giannini HM, Reilly JP, Jones TK, Añón JM, Soro M, Carracedo Á, Wain LV, Meyer NJ, Villar J, Flores C; Genetics of Sepsis (GEN-SEP) Network.: A genome-wide association study of survival in patients with sepsis. Crit Care 26(1): 341, Nov 2022.
1e4 Miano TA, Hennessy S, Yang W, Dunn TG, Weisman AR, Oniyide O, Agyekum RS, Turner AP, Ittner CAG, Anderson BJ, Wilson FP, Townsend R, Reilly JP, Giannini HM, Cosgriff CV, Jones TK, Meyer NJ, Shashaty MGS.: Association of vancomycin plus piperacillin-tazobactam with early changes in creatinine versus cystatin C in critically ill adults: a prospective cohort study. Intensive Care Med 48(9): 1144-1155, Sep 2022.
1ed Belvitch P, Casanova N, Sun X, Camp SM, Sammani S, Brown ME, Mascarhenas J, Lynn H, Adyshev D, Siegler J, Desai A, Seyed-Saadat L, Rizzo A, Bime C, Shekhawat GS, Dravid VP, Reilly JP, Jones TK, Feng R, Letsiou E, Meyer NJ, Ellis N, Garcia JGN, Dudek SM.: A cortactin CTTN coding SNP contributes to lung vascular permeability and inflammatory disease severity in African descent subjects. Transl Res 244: 56-74, Jun 2022.
182 Jones TK, Reilly JP, Anderson BJ, Miano TA, Dunn TG, Weisman AR, Agyekum R, Feng R, Ittner CAG, Shashaty MGS, Meyer NJ.: Elevated Plasma Levels of Matrix Metalloproteinase-3 and Tissue-Inhibitor of Matrix Metalloproteinases-1 Associate with Organ Dysfunction and Mortality in Sepsis. Shock 57(1): 41-47, Jan 2022.
236 Jones Tiffanie K, Feng Rui, Kerchberger V Eric, Reilly John P, Anderson Brian J, Shashaty Michael G S, Wang Fan, Dunn Thomas G, Riley Thomas R, Abbott Jason, Ittner Caroline A G, Christiani David C, Mikacenic Carmen, Wurfel Mark M, Ware Lorraine B, Calfee Carolyn S, Matthay Michael A, Christie Jason D, Meyer Nuala J: Plasma sRAGE Acts as Genetically Regulated Causal Intermediate in Sepsis-Associated ARDS. American journal of respiratory and critical care medicine 201(1): 47-56, Jan 2020.
338 Guillen-Guio Beatriz, Lorenzo-Salazar Jose M, Ma Shwu-Fan, Hou Pei-Chi, Hernandez-Beeftink Tamara, Corrales Almudena, García-Laorden M Isabel, Jou Jonathan, Espinosa Elena, Muriel Arturo, Domínguez David, Lorente Leonardo, Martín María M, Rodríguez-Gallego Carlos, Solé-Violán Jordi, Ambrós Alfonso, Carriedo Demetrio, Blanco Jesús, Añón José M, Reilly John P, Jones Tiffanie K, Ittner Caroline Ag, Feng Rui, Schöneweck Franziska, Kiehntopf Michael, Noth Imre, Scholz Markus, Brunkhorst Frank M, Scherag André, Meyer Nuala J, Villar Jesús, Flores Carlos: Sepsis-associated acute respiratory distress syndrome in individuals of European ancestry: a genome-wide association study. The Lancet. Respiratory medicine 8(3): 258-266, Mar 2020.
27d Reilly John P, Wang Fan, Jones Tiffanie K, Palakshappa Jessica A, Anderson Brian J, Shashaty Michael G S, Dunn Thomas G, Johansson Erik D, Riley Thomas R, Lim Brian, Abbott Jason, Ittner Caroline A G, Cantu Edward, Lin Xihong, Mikacenic Carmen, Wurfel Mark M, Christiani David C, Calfee Carolyn S, Matthay Michael A, Christie Jason D, Feng Rui, Meyer Nuala J: Plasma angiopoietin-2 as a potential causal marker in sepsis-associated ARDS development: evidence from Mendelian randomization and mediation analysis. Intensive care medicine 44(11): 1849-1858, Nov 2018.
29d Wu Ann Chen, Kiley James P, Noel Patricia J, Amur Shashi, Burchard Esteban G, Clancy John P, Galanter Joshua, Inada Maki, Jones Tiffanie K, Kropski Jonathan A, Loyd James E, Nogee Lawrence M, Raby Benjamin A, Rogers Angela J, Schwartz David A, Sin Don D, Spira Avrum, Weiss Scott T, Young Lisa R, Himes Blanca E: Current Status and Future Opportunities in Lung Precision Medicine Research with a Focus on Biomarkers. An American Thoracic Society/National Heart, Lung, and Blood Institute Research Statement. American journal of respiratory and critical care medicine 198(12): e116-e136, Dec 2018.
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Selected Publications
157 Jones TK, Reilly JP, Anderson BJ, Miano TA, Dunn TG, Turner AP, Agyekum RS, Feng R, Ittner CAG, Shashaty MGS, Meyer NJ.: ARDS Mediates the Association Between Early Plasma sRAGE Concentrations and Mortality in Sepsis. Am J Respir Crit Care Med 208(5): 628-630, Sep 2023.1d0 Cosgriff CV, Miano TA, Mathew D, Huang AC, Giannini HM, Kuri-Cervantes L, Pampena MB, Ittner CAG, Weisman AR, Agyekum RS, Dunn TG, Oniyide O, Turner AP, D'Andrea K, Adamski S, Greenplate AR, Anderson BJ, Harhay MO, Jones TK, Reilly JP, Mangalmurti NS, Shashaty MGS, Betts MR, Wherry EJ, Meyer NJ.: Validating a Proteomic Signature of Severe COVID-19. Crit Care Explor 4(12): e0800, Dec 2022.
28c Hernandez-Beeftink T, Guillen-Guio B, Lorenzo-Salazar JM, Corrales A, Suarez-Pajes E, Feng R, Rubio-Rodríguez LA, Paynton ML, Cruz R, García-Laorden MI, Prieto-González M, Rodríguez-Pérez A, Carriedo D, Blanco J, Ambrós A, González-Higueras E, Espinosa E, Muriel A, Tamayo E, Martin MM, Lorente L, Domínguez D, de Lorenzo AG, Giannini HM, Reilly JP, Jones TK, Añón JM, Soro M, Carracedo Á, Wain LV, Meyer NJ, Villar J, Flores C; Genetics of Sepsis (GEN-SEP) Network.: A genome-wide association study of survival in patients with sepsis. Crit Care 26(1): 341, Nov 2022.
1e4 Miano TA, Hennessy S, Yang W, Dunn TG, Weisman AR, Oniyide O, Agyekum RS, Turner AP, Ittner CAG, Anderson BJ, Wilson FP, Townsend R, Reilly JP, Giannini HM, Cosgriff CV, Jones TK, Meyer NJ, Shashaty MGS.: Association of vancomycin plus piperacillin-tazobactam with early changes in creatinine versus cystatin C in critically ill adults: a prospective cohort study. Intensive Care Med 48(9): 1144-1155, Sep 2022.
1ed Belvitch P, Casanova N, Sun X, Camp SM, Sammani S, Brown ME, Mascarhenas J, Lynn H, Adyshev D, Siegler J, Desai A, Seyed-Saadat L, Rizzo A, Bime C, Shekhawat GS, Dravid VP, Reilly JP, Jones TK, Feng R, Letsiou E, Meyer NJ, Ellis N, Garcia JGN, Dudek SM.: A cortactin CTTN coding SNP contributes to lung vascular permeability and inflammatory disease severity in African descent subjects. Transl Res 244: 56-74, Jun 2022.
182 Jones TK, Reilly JP, Anderson BJ, Miano TA, Dunn TG, Weisman AR, Agyekum R, Feng R, Ittner CAG, Shashaty MGS, Meyer NJ.: Elevated Plasma Levels of Matrix Metalloproteinase-3 and Tissue-Inhibitor of Matrix Metalloproteinases-1 Associate with Organ Dysfunction and Mortality in Sepsis. Shock 57(1): 41-47, Jan 2022.
236 Jones Tiffanie K, Feng Rui, Kerchberger V Eric, Reilly John P, Anderson Brian J, Shashaty Michael G S, Wang Fan, Dunn Thomas G, Riley Thomas R, Abbott Jason, Ittner Caroline A G, Christiani David C, Mikacenic Carmen, Wurfel Mark M, Ware Lorraine B, Calfee Carolyn S, Matthay Michael A, Christie Jason D, Meyer Nuala J: Plasma sRAGE Acts as Genetically Regulated Causal Intermediate in Sepsis-Associated ARDS. American journal of respiratory and critical care medicine 201(1): 47-56, Jan 2020.
338 Guillen-Guio Beatriz, Lorenzo-Salazar Jose M, Ma Shwu-Fan, Hou Pei-Chi, Hernandez-Beeftink Tamara, Corrales Almudena, García-Laorden M Isabel, Jou Jonathan, Espinosa Elena, Muriel Arturo, Domínguez David, Lorente Leonardo, Martín María M, Rodríguez-Gallego Carlos, Solé-Violán Jordi, Ambrós Alfonso, Carriedo Demetrio, Blanco Jesús, Añón José M, Reilly John P, Jones Tiffanie K, Ittner Caroline Ag, Feng Rui, Schöneweck Franziska, Kiehntopf Michael, Noth Imre, Scholz Markus, Brunkhorst Frank M, Scherag André, Meyer Nuala J, Villar Jesús, Flores Carlos: Sepsis-associated acute respiratory distress syndrome in individuals of European ancestry: a genome-wide association study. The Lancet. Respiratory medicine 8(3): 258-266, Mar 2020.
27d Reilly John P, Wang Fan, Jones Tiffanie K, Palakshappa Jessica A, Anderson Brian J, Shashaty Michael G S, Dunn Thomas G, Johansson Erik D, Riley Thomas R, Lim Brian, Abbott Jason, Ittner Caroline A G, Cantu Edward, Lin Xihong, Mikacenic Carmen, Wurfel Mark M, Christiani David C, Calfee Carolyn S, Matthay Michael A, Christie Jason D, Feng Rui, Meyer Nuala J: Plasma angiopoietin-2 as a potential causal marker in sepsis-associated ARDS development: evidence from Mendelian randomization and mediation analysis. Intensive care medicine 44(11): 1849-1858, Nov 2018.
29d Wu Ann Chen, Kiley James P, Noel Patricia J, Amur Shashi, Burchard Esteban G, Clancy John P, Galanter Joshua, Inada Maki, Jones Tiffanie K, Kropski Jonathan A, Loyd James E, Nogee Lawrence M, Raby Benjamin A, Rogers Angela J, Schwartz David A, Sin Don D, Spira Avrum, Weiss Scott T, Young Lisa R, Himes Blanca E: Current Status and Future Opportunities in Lung Precision Medicine Research with a Focus on Biomarkers. An American Thoracic Society/National Heart, Lung, and Blood Institute Research Statement. American journal of respiratory and critical care medicine 198(12): e116-e136, Dec 2018.
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