Russell Takeshi Shinohara, Ph.D.
Professor of Biostatistics and Epidemiology
Senior Scholar, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania Perelman School of Medicine
Affiliated Faculty, Center for Neuromodulation in Depression and Stress (CNDS), Department of Psychiatry, University of Pennsylvania Perelman School of Medicine
Affiliated Faculty , Center for Biomedical Imaging Computing and Analytics (CBICA), University of Pennsylvania Perelman School of Medicine
Full Member , Institute for Translational Medicine and Therapeutics (ITMAT), University of Pennsylvania Perelman School of Medicine
Senior Fellow, Institute for Biomedical Informatics (IBI), University of Pennsylvania Perelman School of Medicine
Director, Penn Statistics in Imaging and Visualization Center, University of Pennsylvania Perelman School of Medicine
Department: Biostatistics and Epidemiology
Graduate Group Affiliations
Contact information
Center for Clinical Epidemiology and Biostatistics
Department of Biostatistics, Epidemiology and Informatics
Perelman School of Medicine
University of Pennsylvania
217 Blockley Hall
423 Guardian Drive
Philadelphia, PA 19104-6021
Department of Biostatistics, Epidemiology and Informatics
Perelman School of Medicine
University of Pennsylvania
217 Blockley Hall
423 Guardian Drive
Philadelphia, PA 19104-6021
Office: 215-746-1090
Fax: 215-573-1050
Fax: 215-573-1050
Email:
rshi@pennmedicine.upenn.edu
rshi@pennmedicine.upenn.edu
Education:
Honors BSc (Probability and Statistics)
McGill University, 2006.
MSc (Mathematics and Statistics)
McGill University, 2007.
PhD (Biostatistics)
The Johns Hopkins University, 2012.
Permanent linkHonors BSc (Probability and Statistics)
McGill University, 2006.
MSc (Mathematics and Statistics)
McGill University, 2007.
PhD (Biostatistics)
The Johns Hopkins University, 2012.
Selected Publications
Ripart M, Spitzer H, Williams LZJ, Walger L, Chen A, Napolitano A, Rossi- Espagnet C, Foldes ST, Hu W, Mo J, Likeman M, Rüber T, Caligiuri ME, Gambardella A, Guttler C, Tietze A, Lenge M, Guerrini R, Cohen NT, Wang I, Kloster A, Pinborg LH, Hamandi K, Jackson G, Tortora D, Tisdall M, Conde-Blanco E, Pariente JC, Perez-Enriquez C, Gonzalez-Ortiz S, Mullatti N, Vecchiato K, Liu Y, Kalviainen R, Sokol D, Shetty J, Sinclair B, Vivash L, Willard A, Winston GP, Yasuda C, Cendes F, Shinohara RT, Duncan JS, Cross JH, Baldeweg T, Robinson EC, Iglesias JE, Adler S, Wagstyl K; MELD FCD writing group; Fawaz A, De Benedictis A, De Palma L, Zhang K, Labate A, Barba C, You X, Gaillard WD, Tang Y, Wang S, Davies S, Semmelroch M, Severino M, Striano P, Chari A, D'Arco F, Mankad K, Bargallo N, Pascual-Diaz S, Delgado-Martinez I, O'Muircheartaigh J, Abela E, Kandasamy J, McLellan A, Desmond P, Lui E, O'Brien TJ, Whitaker K: Detection of Epileptogenic Focal Cortical Dysplasia Using Graph Neural Networks: A MELD Study. JAMA Neurology Page: e245406, Feb 2025 Notes: doi: 10.1001/jamaneurol.2024.5406. Epub ahead of print.Martin ML, Cao Q, Luskin E, Renner B, Daboul L, O'Donnell CM, Rodrigues P, Derbyshire J, Azevedo CJ, Bar-Or A, Caverzasi E, Calabresi P, Cree BAC, Freeman L, Henry RG, Longbrake EE, Oh J, Papinutto N, Pelletier D, Prchkovska V, Ramos M, Samudralwar RD, Schindler MK, Sotirchos ES, Sicotte NL, Solomon AJ, Reich DS, Ontaneda D, Shinohara RT, Sati P: Reliability of Central Vein Sign Imaging With 3T FLAIR* in a Multicenter Study. Journal of Neuroimaging 35(1): e70011, Jan-Feb 2025.
Solomon AJ, Weinstein S, Shinohara RT, Aoun SM, Schmidt H, Solari A: Diagnostic Delay and Misdiagnosis of Symptoms Reported by Patients with Multiple Sclerosis Participating in a Research Registry. Multiple Sclerosis Journal – Experimental, Translational and Clinical In press 2025.
Thompson EW, Dong NJ, Kim JS, Bhattaru A, Vu P, Hu F, Shinohara RT, Swago S, Donnelly E, Zhang X, Loth A, Vuthuri L, Lanzilotta K, Whitehead KK, Duda J, Gee J, Almasy L, Goldmuntz E, Fogel MA, Witschey WR: Cardiovascular Magnetic Resonance Imaging Traits Associated with Adverse Right Ventricular Remodeling in Repaired Tetralogy of Fallot. J Cardiovasc Magn Reson 2025.
Parkes L, Kim JZ, Stiso J, Brynildsen JK, Cieslak M, Covitz S, Gur RE, Gur RC, Pasqualetti F, Shinohara RT, Zhou D, Satterthwaite TD, Bassett DS: Using network control theory to study the dynamics of the structural connectome. Nature Protocols 19(12): 3721-3749, Dec 2024.
Desai, N; Baladandayuthapani, V; Shinohara, R; Morris, J: Covariance Assisted Multivariate Penalized Additive Regression (CoMPAdRe). Journal of Computational and Graphical Statistics Page: 1-10, Nov 2024 Notes: https://doi.org/10.1080/10618600.2024.2407453.
Kwak S, Akbari H, Garcia JA, Mohan S, Dicker Y, Sako C, Matsumoto Y, Nasrallah MP, Shalaby M, O'Rourke DM, Shinohara RT, Liu F, Badve C, Barnholtz-Sloan JS, Sloan AE, Lee M, Jain R, Cepeda S, Chakravarti A, Palmer JD, Dicker AP, Shukla G, Flanders AE, Shi W, Woodworth GF, Davatzikos C: Predicting peritumoral glioblastoma infiltration and subsequent recurrence using deep-learning-based analysis of multi-parametric magnetic resonance imaging. Journal of Medical Imaging (Bellingham) 11(5): 054001, Sep 2024.
Hu, F; Lucas, A; Chen, A; Coleman, K; Horng, H; Ng, R; Tustison, NJ; Davis, K; Shou, H; Li, M; Shinohara, R; The Alzheimer’s Disease Neuroimaging Initiative: DeepComBat: A Statistically Motivated, Hyperparameter-Robust, Deep Learning Approach to Harmonization of Neuroimaging Data. Human Brain Mapping 45(11): e26708, Aug 2024.
Chen, A; Clark, K; Dewey, B; DuVal, A; Pellegrini, N; Bhagavatheeshwaran, G; Jalke, Y; Khalil, S; Zurawski, J; Calabresi, P; Reich, D; Bakshi, R; Shou, H*; Shinohara, R*; for the Alzheimer’s Disease Neuroimaging Initiativec, and for the North American Imaging in Multiple Sclerosis Cooperative: PARE: A framework for removal of confounding effects from any distance-based dimension reduction method. PLOS Computational Biology 20(7): e1012241, Jul 2024 Notes: *Co-senior authorship.
Chao, A; Agarwal, K; Zhou, Y; Grilo, CM; Gur, R; Joseph, P; Shinohara, R; Richmond, T; Wadden, T: Neural Responses to Auditory Food Stimuli Following Cognitive Behavioral Therapy for Binge-Eating Disorder. International Journal of Eating Disorders Jul 2024 Notes: doi: 10.1002/eat.24244. Epub ahead of print.