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Kyra S. O'Brien, MD, MSHP
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Assistant Professor of Neurology at the Hospital of the University of Pennsylvania
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Senior Fellow, Penn Leonard Davis Institute of Health Economics
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Associate Program Director, Penn Cognitive and Behavioral Neurology Fellowship, University of Pennsylvania, Philadelphia, PA
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Medical Director, Penn Medicine GUIDE Program, Penn Medicine
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Department: Neurology
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Contact information
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Penn Neuroscience Center - Neurology
1e 3400 Civic Center Blvd
3c 2nd Floor, South Pavilion
Philadelphia, PA 19104
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1e 3400 Civic Center Blvd
3c 2nd Floor, South Pavilion
Philadelphia, PA 19104
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Education:
21 7 BS 14 (Biology) c
28 Yale University, 2012.
21 7 MD 15 (Medicine) c
56 Perelman School of Medicine at the University of Pennsylvania, 2016.
21 9 MSHP 25 (Health services research) c
4f University of Pennsylvania Perelman School of Medicine, 2024.
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Permanent link21 7 BS 14 (Biology) c
28 Yale University, 2012.
21 7 MD 15 (Medicine) c
56 Perelman School of Medicine at the University of Pennsylvania, 2016.
21 9 MSHP 25 (Health services research) c
4f University of Pennsylvania Perelman School of Medicine, 2024.
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Description of Clinical Expertise
93 Dementia, mild cognitive impairment, Alzheimer's disease, memory disorders, cognitive evaluation, dementia diagnosis, dementia care71
Description of Research Expertise
40 Dementia care delivery, health services researche 29
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166 Kyra O'Brien, Cameron Coykendall, Kristin Harkins, Xingmei Wang, Abigail Perelman, Megan Zhang, Jason Karlawish: Study of the utility and impact of a plasma p-tau181 Alzheimer’s biomarker (SUITABLE). Alzheimer's & Dementia: Translational Research & Clinical Interventions March 2026.
179 Kyra O’Brien, Sydney Pugh, Cameron Coykendall, Matthew Hill, Sy Hwang, Rachel Wu, Kuk Jang, Stacy Iannone, Karen O’Connor, Eric Eaton, and Kevin Johnson: WATCH: Warning Assessment and Alerting Tool for Cognitive Health. Poster session presented at the fourth annual a2 National Symposium March 2026.
b0 Sydney Pugh, Matthew Hill, Sy Hwang, Rachel Wu, Kuk Jang, Stacy Iannone, Karen O’Connor, Kyra O’Brien, Eric Eaton, Kevin Johnson c2 : WATCH-SS: A Trustworthy and Explainable Modular Framework for Detecting Cognitive Impairment from Spontaneous Speech. Pacific Symposium on Biocomputing Jan 2026.
1b5 Katheryn A Q Cousins, Rory Boyle, Colleen Morse, Anurag Verma, Christopher A Brown, Kyra S O'Brien, Marina Serper, Nadia Dehghani, Penn Medicine BioBank, Corey T McMillan, Edward B Lee, Leslie M Shaw, David A Wolk: Electronic Health Records to Test Multimorbidity Influences to Plasma Biomarker Interpretation for Alzheimer's Disease. Annals of Neurology Dec 2025.
140 Kyra O'Brien and Jason Karlawish: Alzheimer’s Disease: New Diagnostic Technologies and Treatments - The Role of Neuroimaging in Diagnosis of Alzheimer Disease. American Geriatrics Society. Harper GM (eds.). American Geriatrics Society, Nov 2025.
186 Kyra O’Brien, Wheeler Maxwell, Stacy Iannone, Jason Karlawish, Joseph Teel, Robert Burke: Implementation of an Electronic Health Record-Integrated Cognitive Assessment Pathway in Primary Care. Poster session presented at the 2025 Patient-Centered Outcomes Research Institute Annual Meeting, Washington, DC Oct 2025.
148 Nessen SJ, Chary AN, Bhananker AR, Muir KJ, Southerland LT, O'Brien K, and Friedman AB: NOTICE-ED: Nurse or Technician Insights Into Cognitive Evaluations in the Emergency Department. Journal of the American Geriatrics Society 73(8): 2503-2511, Aug 2025.
18a Cameron Coykendall, Megan Zhang, Abigail Perelman, Kristin Harkins, Jason Karlawish, Kyra O'Brien: Study of the Utility and Impact of Plasma p-tau181 Alzheimer's Biomarkers - SUIT-ABLE: Patient and Care Partner Outcomes. Poster session presented at the 2025 Association International Conference, Toronto, Canada Jul 2025.
179 Kyra O'Brien, Wheeler Maxwell, Stacy Iannone, Jason Karlawish, Joseph Teel, Robert Burke: Building a cognitive screening and assessment pathway for primary care: The experience of one health care system. Poster session presented at the 2025 Association International Conference, Toronto, Canada Jul 2025.
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Selected Publications
17b Claire Erickson, Kyra S. O'Brien, Emily A. Largent, Kristin Harkins, Cameron Coykendall, Melanie Kleid, Justin T. Clapp, Jason Karlawish: Expert consensus on communicating tau PET results to persons living with MCI or dementia: Findings from a modified Delphi study. Alzheimer's & Dementia 22(4), Apr 2026.166 Kyra O'Brien, Cameron Coykendall, Kristin Harkins, Xingmei Wang, Abigail Perelman, Megan Zhang, Jason Karlawish: Study of the utility and impact of a plasma p-tau181 Alzheimer’s biomarker (SUITABLE). Alzheimer's & Dementia: Translational Research & Clinical Interventions March 2026.
179 Kyra O’Brien, Sydney Pugh, Cameron Coykendall, Matthew Hill, Sy Hwang, Rachel Wu, Kuk Jang, Stacy Iannone, Karen O’Connor, Eric Eaton, and Kevin Johnson: WATCH: Warning Assessment and Alerting Tool for Cognitive Health. Poster session presented at the fourth annual a2 National Symposium March 2026.
b0 Sydney Pugh, Matthew Hill, Sy Hwang, Rachel Wu, Kuk Jang, Stacy Iannone, Karen O’Connor, Kyra O’Brien, Eric Eaton, Kevin Johnson c2 : WATCH-SS: A Trustworthy and Explainable Modular Framework for Detecting Cognitive Impairment from Spontaneous Speech. Pacific Symposium on Biocomputing Jan 2026.
1b5 Katheryn A Q Cousins, Rory Boyle, Colleen Morse, Anurag Verma, Christopher A Brown, Kyra S O'Brien, Marina Serper, Nadia Dehghani, Penn Medicine BioBank, Corey T McMillan, Edward B Lee, Leslie M Shaw, David A Wolk: Electronic Health Records to Test Multimorbidity Influences to Plasma Biomarker Interpretation for Alzheimer's Disease. Annals of Neurology Dec 2025.
140 Kyra O'Brien and Jason Karlawish: Alzheimer’s Disease: New Diagnostic Technologies and Treatments - The Role of Neuroimaging in Diagnosis of Alzheimer Disease. American Geriatrics Society. Harper GM (eds.). American Geriatrics Society, Nov 2025.
186 Kyra O’Brien, Wheeler Maxwell, Stacy Iannone, Jason Karlawish, Joseph Teel, Robert Burke: Implementation of an Electronic Health Record-Integrated Cognitive Assessment Pathway in Primary Care. Poster session presented at the 2025 Patient-Centered Outcomes Research Institute Annual Meeting, Washington, DC Oct 2025.
148 Nessen SJ, Chary AN, Bhananker AR, Muir KJ, Southerland LT, O'Brien K, and Friedman AB: NOTICE-ED: Nurse or Technician Insights Into Cognitive Evaluations in the Emergency Department. Journal of the American Geriatrics Society 73(8): 2503-2511, Aug 2025.
18a Cameron Coykendall, Megan Zhang, Abigail Perelman, Kristin Harkins, Jason Karlawish, Kyra O'Brien: Study of the Utility and Impact of Plasma p-tau181 Alzheimer's Biomarkers - SUIT-ABLE: Patient and Care Partner Outcomes. Poster session presented at the 2025 Association International Conference, Toronto, Canada Jul 2025.
179 Kyra O'Brien, Wheeler Maxwell, Stacy Iannone, Jason Karlawish, Joseph Teel, Robert Burke: Building a cognitive screening and assessment pathway for primary care: The experience of one health care system. Poster session presented at the 2025 Association International Conference, Toronto, Canada Jul 2025.
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