Stewart A Anderson, MD
Abramson Research Center
Philadelphia, PA 19147
BA (Neuroscience and Psychology)
Amherst College, Amherst, MA, 1984.
University of Connecticut, Storrs, CT, 1989.
Description of Clinical ExpertiseI am a psychiatrist who worked mainly with treatment-resistant outpatients suffering from schizophrenia. Since moving in July, 2012 from Cornell Medical College to UPenn/The Children's Hospital of Philadelphia, I am not seeing patients as I focus on laboratory research into the causes of neuropsychiatric illnesses.
Description of Research ExpertiseI am a Children's Hospital of Philadelphia-based faculty in the Department of Psychiatry at UPenn.
The focus of my laboratory concerns the molecular and cellular mechanisms that govern the development of the mammalian forebrain. We use mouse genetics, forebrain slice and dissociated culture techniques, as well as mouse and human pluripotent stem cells in cell culture and transplantation experiments to study the fate determination of interneurons of the cerebral cortex. We are particularly interested in understanding the molecular underpinnings behind the fate determination of subclasses of GABAergic interneurons implicated in the neuropathology of autism and schizophrenia. In addition, we are using mouse and human stem cell-derived interneurons in animal models of cell-based therapies for seizures, psychosis, and as tools for the study of gene-gene and gene-environment interactions in neuropsychiatric disease. Additional projects include the study of mitochondria in stem cell derived neurons derived from people with the 22q11.2 deletion syndrome and schizophrenia, and the study of human stem cell derived microglia infected with HIV.
For more information, please visit the Anderson lab website at:
Selected PublicationsTischfield DJ, Kim J, Anderson SA: Atypical PKC and Notch Inhibition Differentially Modulate Cortical Interneuron Subclass Fate from Embryonic Stem Cells. Stem Cell Reports 8(5): 1135-43, 2017.
Tischfield DJ, Saraswat DK, Furash A, Fowler SC, Fuccillo MV, Anderson SA.: Loss of the neurodevelopmental gene Zswim6 alters striatal morphology and motor regulation. Neurobiology of Disease 103: 174-183, 2017.
Dimidschstein J, Chen Q, Tremblay R, Rogers SL, Saldi GA, Guo L, Xu Q, Liu R, Lu C, Chu J, Grimley JS, Krostag AR, Kaykas A, Avery MC, Rashid MS, Baek M, Jacob AL, Smith GB, Wilson DE, Kosche G, Kruglikov I, Rusielewicz T, Kotak VC, Mowery TM, Anderson SA, Callaway EM, Dasen JS, Fitzpatrick D, Fossati V, Long MA, Noggle S, Reynolds JH, Sanes DH, Rudy B, Feng G, Fishell G: A viral strategy for targeting and manipulating interneurons across vertebrate species. Nature Neuroscience 19(12): 1743-49, 2016.
Donegan JJ, Tyson JA, Branch SY, Beckstead MJ, Anderson SA, Lodge DJ.: Stem cell-derived interneuron transplants as a treatment for schizophrenia: preclinical validation in a rodent model. Mol Psychiatry. epub ahead of print, 2016.
Lin-Hendel EG, McManus MJ, Wallace DC, Anderson SA*, Golden JA*. (*co-corresponding authors): Differential mitochondrial requirements for radially and non-radially migrating cortical neurons: implications for mitochondrial disorders. Cell Reports in press, 2016.
Chu J, Anderson SA : Development of Cortical Interneurons. Neuropsychopharmacology 40(1): 16-23, 2015.
Jaiswal MK, Keros S, Zhao Z, Inan M, Schwartz TH, Anderson SA, Homanics GE, Goldstein PA : Reduction in focal ictal activity following transplantation of MGE interneurons requires expression of the GABAA receptor α4 subunit. Frontiers in Cellular Neuroscience 9: 127-134, 2015.
Anderson SA, Parent JM (2015). : Reprogramming patient-derived cells to study the epilepsies. Nature Neuroscience 18(3): 360-366, 2015.
Tyson JA, Goldberg EM, Maroof AM, Xu Q, Petros TJ, Anderson SA.: Duration of culture and Sonic Hedgehog signaling differentially specify PV versus SST cortical interneuron fates from embryonic stem cells. Development 142(7): 1267-78. 2015.
Petros TJ, Bultje RS, Ross ME, Fishell G, Anderson SA.: Apical versus Basal Neurogenesis Directs Cortical Interneuron Subclass Fate. Cell reports 13(6): 1090-95, 2015.