Adam Christian Naj, PhD

faculty photo
Assistant Professor of Epidemiology in Biostatistics and Epidemiology at the Hospital of the University of Pennsylvania
Department: Biostatistics and Epidemiology

Contact information
229 Blockley Hall
423 Guardian Drive
Philadelphia, PA 19104
Office: (215) 746-4180
Fax: (215) 573-1050
Lab: (215) 746-4180
Education:
BA (Biology (Genetics)/Psychology)
University of Chicago, 2000.
PhD (Epidemiology (Human Genetics))
The Johns Hopkins University Bloomberg School of Public Health, 2008.
Permanent link
 
> Perelman School of Medicine   > Faculty   > Details

Description of Research Expertise

Dr. Naj is an Assistant Professor of Epidemiology in the Department of Biostatistics, Epidemiology, and Informatics, and the Department of Pathology and Laboratory Medicine at the University of Pennsylvania Perelman School of Medicine. His research focuses primarily on the genetics of Alzheimer’s Disease (AD) and neurodegeneration, including his genome-wide association analyses in the Alzheimer’s Disease Genetics Consortium (ADGC) which resulted in a first-author paper that was the most cited Alzheimer’s study of 2011. Joining Penn in 2012, Dr. Naj has extended his roles in analysis and data management in the ADGC, and has been actively co-leading quality control and case-control analysis working groups in the Alzheimer’s Disease Sequencing Project (ADSP), which has collected data on nearly 600 whole genomes and more than 10,500 whole exomes of AD cases and controls to identify rare risk-increasing and protective genomic variants contributing to AD. Of late his work has included guiding development of a quality control pipeline for next-generation sequence data as part of the Genomic Center on Alzheimer’s Disease (GCAD). Dr. Naj is also one of several Penn co-founders and organizers of the annual Symposium on Advances in Genetic Epidemiology and Statistics (SAGES), promoting the development of methods to analyze genomic datasets. He has recently expanded his research portfolio to include studies examining genetic loci contributing to multiple neurodegenerative diseases and phenotypes including AD, Parkinson’s disease, and progressive supranuclear palsy, among others, aspiring to identify key genetic contributors to the pathologies underlying neurodgeneration.

Selected Publications

Jun GR, Chung J, Mez J, Barber R, Beecham GW, Bennett DA, Buxbaum JD, Byrd GS, Carrasquillo MM, Crane PK, Cruchaga C, De Jager P, Ertekin-Taner N, Evans D, Fallin MD, Foroud TM, Friedland RP, Goate AM, Graff-Radford NR, Hendrie H, Hall KS, Hamilton-Nelson KL, Inzelberg R, Kamboh MI, Kauwe JSK, Kukull WA, Kunkle BW, Kuwano R, Larson EB, Logue MW, Manly JJ, Martin ER, Montine TJ, Mukherjee S, Naj A, Reiman EM, Reitz C, Sherva R, St George-Hyslop PH, Thornton T, Younkin SG, Vardarajan BN, Wang L-S, Wendlund JR, Winslow AR, Haines J, Mayeux R, Pericak-Vance MA, Schellenberg G, Lunetta KL, Farrer LA; Alzheimer's Disease Genetics Consortium: Transethnic genome-wide scan identifies novel Alzheimer's disease loci. Alzheimer's & dementia : the journal of the Alzheimer's Association February 2017.

Naj AC, Martin ER, and DeStefano AL: Quality Control (QC) and Multi-Pipeline Genotype Consensus Calling Strategies for 578 whole genomes and 10,692 whole exomes in the Alzheimer’s Disease Sequencing Project (ADSP). Alzheimer's Disease Sequencing Project (ADSP) Workshop, National Institutes of Health (NIH), Bethesda, MD January 2017.

Naj AC, Schellenberg GD: Genomic variants, genes, and pathways of Alzheimer's disease: An overview. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 174(1): 5-26, January 2017.

Sims R*, van der Lee SJ*, Naj AC*, Bellenguez C*, Badarinarayan N, Jakobsdottir J, Kunkle BW, Boland A, Raybould R, Bis JC, Martin ER, Grenier-Boley B, Heilmann-Heimbach S, Chouraki V, Partch A, Sleegers K, Vronskaya M, Ruiz A, Graham RR, Olaso R, Hoffmann P, Grove ML, Vardarajan BN, Hiltunen M, Nöthen MM, White CC, Hamilton-Nelson KL, Epelbaum J, Maier W, Choi S-H, Beecham GW, Dulary C, Herms S, Smith AV, Funk CC, Derbois C, Forstner AJ, Ahmad S, Li H, Bacq D, Harold D, Satizabal CL, Valladares O, Squassina A, Thomas R, Brody JA, Qu L, Sanchez-Juan P, Morgan T, Wolters FJ, Zhao Y, Garcia FS, Denning N, Fornage M, Malamon J, Naranjo MCD, Majounie E, Mosley TH, Dombroski B, Wallon D, Lupton MK, Dupuis J, Whitehead PL, Fratiglioni L, Medway C, Jian X, Mukherjee S, Keller L, Brown K, Lin H, Cantwell LB, Panza F, McGuinness B, Moreno-Grau S, Burgess JD, Solfrizzi V, Proitsi P, Adams HH, Allen M, Seripa D, Pastor P, Cupples LA, Price ND, Hannequin D, Frank-García A, Levy D, Chakrabarty P, Caffarra P, Giegling I, Beiser AS, Giedraitis V, Hampel H, Garcia ME, Wang X, Lannfelt L, Mecocci P, Eiriksdottir G, Crane PK, Pasquier F, Boccardi V, Henández I, Barber RC, Scherer M, Tarraga L, Adams PM, Leber M, Chen Y, Albert MS, Riedel-Heller S, Emilsson V, Beekly D, Braae A, Schmidt R, Blacker D, Masullo C, Schmidt H, Doody RS, Spalletta G, Longstreth Jr WT, Fairchild TJ, Bossù P, Lopez OL, Frosch MP, Sacchinelli E, Ghetti B, Sánchez-Juan P, Yang Q, Huebinger RM, Jessen F, Li S, Kamboh MI, Morris J, Sotolongo-Grau O, Katz MJ, Corcoran C, Himali JJ, Keene CD, Tschanz J, Fitzpatrick AL, Kukull WA, Norton M, Aspelund T, Larson EB, Munger R, Rotter JI, Lipton RB, Bullido MJ, Hofman A, Montine TJ, Coto E, Boerwinkle E, Petersen RC, Alvarez V, Rivadeneira F, Reiman EM, Gallo M, O’Donnell CJ, Reisch JS, Bruni AC, Royall DR, Dichgans M, Sano M, Galimberti D, St George-Hyslop P, Scarpini E, Tsuang DW, Mancuso M, Wendland JR, Bonuccelli U, Winslow AR, Daniele A, Wu C-K, GERAD/PERADES, CHARGE, ADGC, EADI, Peters O, Nacmias B, Riemenschneider M, Heun R, Brayne C, Rubinsztein DC, Bras J, Guerreiro R, Hardy J, Al-Chalabi A, Shaw CE, Collinge J, Mann D, Tsolaki M, Clarimón J, Sussams R, Lovestone S, O'Donovan MC, Owen MJ, Behrens TW, Mead S, Goate AM, Uitterlinden AG, Holmes C, Cruchaga C, Ingelsson M, Bennett DA, Powell J, Golde TE, Graff C, De Jager PL, Morgan K, Ertekin-Taner N, Cambarros O, Psaty BM, Passmore P, Younkin SG, Berr C, Gudnason V, Rujescu D, Dickson DW, Dartigues J-F, DeStefano AL, Ortega-Cubero S, Hakonarson H, Campion D, Boada M, Kauwe JSK, Farrer LA, Van Broeckhoven C, Ikram MA, Jones L, Haines JL, Tzourio C, Launer LJ, Escott-Price V, Mayeux RP, Deleuze J-F, Amin N, Holmans PA, Pericak-Vance MA, Amouyel P, van Duijn CM, Ramirez A, Wang L-S, Lambert J-C, Seshadri S, Williams J, Schellenberg GD (*co-first authors): Novel rare coding variants in PLCG2, ABI3 and TREM2 implicate microglial-mediated innate immunity in Alzheimer’s disease. Nature Genetics (in press) 2017.

Naj AC, Zhao Y, Qu L, van der Lee SJ, Hamilton-Nelson KL, Kunkle BW, Kuzma A, Valladares O, Reitz C, Beecham GW, Martin ER, Wang L-S, Haines JL, Mayeux R, Farrer LA, Pericak-Vance MA, Schellenberg GD, Alzheimer's Disease Genetics Consortium: High-resolution imputation of rare variants identifies novel rare variant candidate loci in late-onset Alzheimer’s disease: The Alzheimer’s Disease Genetics Consortium. American Society of Human Genetics (ASHG) Annual Meeting, Vancouver, BC, Canada October 2016.

Adam Naj on behalf of the ADSP Case-Control Working Group: Alzheimer’s Disease Sequencing Project (ADSP) Case-Control Analysis. American Society of Human Genetics (ASHG) Annual Meeting, Vancouver, BC, Canada October 2016.

Wang L-S, Gangadharan P, Kuzma A, Valladares O, Greenfest-Allen E, Childress DM, Cweibel R, Malamon J, Lin H, Zhao Y, Qu L, Leung YY, Naj A, Stoeckert Jr. CJ, Schellenberg G: NIA Genetics of Alzheimer’s Disease Data Storage site (NIAGADS): 2016 update. American Society of Human Genetics (ASHG) Annual Meeting, Vancouver, BC, Canada October 2016.

Malamon J, Naj AC, Schmidt M, Vardarajan BN, Ma Y, Lancour D, Kuzma A, Valladares O, Qu L, Lin H, Martin ER, Wang L-S, Haines JL, Mayeux R, Farrer LA, Pericak-Vance MA, Schellenberg GD, Coordinating Center for Genetics and Genomics of Alzheimer's Disease: Post-variant calling quality control (QC) pipeline and multi-pipeline genotype consensus caller for large-scale whole genome and whole exome sequencing studies. American Society of Human Genetics (ASHG) Annual Meeting, Vancouver, BC, Canada October 2016.

Jakobsdottir J, van der Lee SJ, Bis JC, Chouraki V, Li-Kroeger D, Yamamoto S, Grove ML, Naj A, Vronskaya M, Salazar JL, DeStefano AL, Brody JA, Smith AV, Amin N, Sims R, Ibrahim-Verbaas CA, Choi S-H, Satizabal CL, Lopez OL, Beiser A, Ikram MA, Garcia ME, Hayward C, Varga TV, Ripatti S, Franks PW, Hallmans G, Rolandsson O, Jansson J-H, Porteous DJ, Salomaa V, Eiriksdottir G, Rice KM, Bellen HJ, Levy D, Uitterlinden AG, Emilsson V, Rotter JI, Aspelund T, O'Donnell CJ, Fitzpatrick AL, Launer LJ, Hofman A, Wang L-S, Williams J, Schellenberg GD, Boerwinkle E, Psaty BM, Seshadri S, Shulman JM, Gudnason V, van Duijn CM: Rare Functional Variant in TM2D3 is Associated with Late-Onset Alzheimer's Disease. PLoS Genetics 12(10): e1006327, October 2016.

Prabhakaran Gangadharan, MS; Amanda B Partch, MS; Otto Valladares, MS; Emily Greenfest-Allen, PhD; Daniel Micah Childress, AS; Rebecca Cweibel; John Malamon, BSE; Han-Jen Lin; Yi Zhao; Mugdha Khaladkar; Adam C. Naj, PhD; Christian J Stoeckert Jr., PhD1;Gerard D Schellenberg, PhD and Li-San Wang, PhD: NIA Genetics of Alzheimer’s Disease Data Storage Site (NIAGADS): 2016 Update. Alzheimer's Association International Conference (AAIC), Toronto, ON, Canada July 2016.

back to top
Last updated: 07/12/2017
The Trustees of the University of Pennsylvania