Adam Christian Naj, PhD

faculty photo
Assistant Professor of Epidemiology in Biostatistics and Epidemiology at the Hospital of the University of Pennsylvania
Department: Biostatistics and Epidemiology

Contact information
229 Blockley Hall
423 Guardian Drive
Philadelphia, PA 19104
Office: (215) 746-4180
Fax: (215) 573-1050
Lab: (215) 746-4180
Education:
BA (Biology (Genetics)/Psychology)
University of Chicago, 2000.
PhD (Epidemiology (Human Genetics))
The Johns Hopkins University Bloomberg School of Public Health, 2008.
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Description of Research Expertise

Dr. Naj is an Assistant Professor of Epidemiology in the Department of Biostatistics, Epidemiology, and Informatics, and the Department of Pathology and Laboratory Medicine at the University of Pennsylvania Perelman School of Medicine. His research focuses primarily on the genetics of Alzheimer’s Disease (AD) and neurodegeneration, including his genome-wide association analyses in the Alzheimer’s Disease Genetics Consortium (ADGC) which resulted in a first-author paper that was the most cited Alzheimer’s study of 2011. Joining Penn in 2012, Dr. Naj has extended his roles in analysis and data management in the ADGC, and has been actively co-leading quality control and case-control analysis working groups in the Alzheimer’s Disease Sequencing Project (ADSP), which has collected data on nearly 600 whole genomes and more than 10,500 whole exomes of AD cases and controls to identify rare risk-increasing and protective genomic variants contributing to AD. Of late his work has included guiding development of a quality control pipeline for next-generation sequence data as part of the Genomic Center on Alzheimer’s Disease (GCAD). Dr. Naj is also one of several Penn co-founders and organizers of the annual Symposium on Advances in Genetic Epidemiology and Statistics (SAGES), promoting the development of methods to analyze genomic datasets. He has recently expanded his research portfolio to include studies examining genetic loci contributing to multiple neurodegenerative diseases and phenotypes including AD, Parkinson’s disease, and progressive supranuclear palsy, among others, aspiring to identify key genetic contributors to the pathologies underlying neurodgeneration.

Selected Publications

Naj AC, Sha J, Leonenko G, Chen Y, Chouraki V, Leber M, Sims R, Grenier-Boley B, Bis JC, Zhao Y, Kuzma A, Kunkle B, Comic H, van der Lee SJ, Bellenguez C, Frizzati A, Holmans P, Dupuis J, Wang L-S, Farrer LA, van Duijn C, Haines JL, DeStefano AL, Pericak-Vance MA, Ramirez A, Amouyel P, Lambert J-C, Seshadri S, Williams J, Schellenberg GD; International Genomics of Alzheimer's Project (IGAP): Genome-wide rare variant imputation in 60,178 subjects identifies novel rare variant candidate loci in Late-Onset Alzheimer’s Disease (LOAD): The International Genomics of Alzheimer’s Project (IGAP). American Society of Human Genetics (ASHG) Annual Meeting, San Diego, CA October 2018.

Greenfest-Allen E, Gangadharan P, Kuzma A, Qu L, Valladares O, Leung YY, Bush W, Naj A, Schellenberg GD, Stoeckert Jr. CJ, Wang L-S: NIA Genetics of Alzheimer’s Disease Data Storage Site (NIAGADS) Alzheimer’s genomics database: 2018 update. American Society of Human Genetics (ASHG) Annual Meeting, San Diego, CA October 2018.

Naj AC, Sha J, Leonenko G, Chen Y, Chouraki V, Leber M, Sims R, Grenier-Boley B, Bis JC, Zhao Y, Kuzma A, Kunkle BW, Comic H, van der Lee SJ, Bellenguez C, Frizzati A, Holmans P, Dupuis J, Wang L-S, Farrer LA, van Duijn C, Haines JL, DeStefano AL, Pericak-Vance MA, Ramirez A, Amouyel P, Lambert J-C, Seshadri S, Williams J, Schellenberg GD; International Genomics of Alzheimer's Project (IGAP): Genome-Wide Rare Variant Imputation in 60,178 Subjects Identifies Novel Rare Variant Candidate Loci in Late-Onset Alzheimer’s Disease: The International Genomics of Alzheimer’s Project (IGAP). American Society of Human Genetics (ASHG) Annual Meeting, San Diego, CA October 2018.

Guerreiro R, Orme T, Naj AC, Kuzma AB, Schellenberg GD, Bras J: Is APOE ε4 required for Alzheimer's disease to develop in TREM2 p.R47H variant carriers? Neuropathology and Applied Neurobiology Page: In Press, September 2018.

McMillan CT, Lee EB, Jefferson-George K, Naj A, Van Deerlin VM, Trojanowski JQ, Wolk DA: Alzheimer's genetic risk is reduced in primary age-related tauopathy: a potential model of resistance? Annals of Clinical and Translational Neurology 5(8): 927-934, August 2018.

Bis Joshua C, Jian Xueqiu, Kunkle Brian W, Chen Yuning, Hamilton-Nelson Kara L, Bush William S, Salerno William J, Lancour Daniel, Ma Yiyi, Renton Alan E, Marcora Edoardo, Farrell John J, Zhao Yi, Qu Liming, Ahmad Shahzad, Amin Najaf, Amouyel Philippe, Beecham Gary W, Below Jennifer E, Campion Dominique, Charbonnier Camille, Chung Jaeyoon, Crane Paul K, Cruchaga Carlos, Cupples L Adrienne, Dartigues Jean-François, Debette Stéphanie, Deleuze Jean-François, Fulton Lucinda, Gabriel Stacey B, Genin Emmanuelle, Gibbs Richard A, Goate Alison, Grenier-Boley Benjamin, Gupta Namrata, Haines Jonathan L, Havulinna Aki S, Helisalmi Seppo, Hiltunen Mikko, Howrigan Daniel P, Ikram M Arfan, Kaprio Jaakko, Konrad Jan, Kuzma Amanda, Lander Eric S, Lathrop Mark, Lehtimäki Terho, Lin Honghuang, Mattila Kari, Mayeux Richard, Muzny Donna M, Nasser Waleed, Neale Benjamin, Nho Kwangsik, Nicolas Gaël, Patel Devanshi, Pericak-Vance Margaret A, Perola Markus, Psaty Bruce M, Quenez Olivier, Rajabli Farid, Redon Richard, Reitz Christiane, Remes Anne M, Salomaa Veikko, Sarnowski Chloe, Schmidt Helena, Schmidt Michael, Schmidt Reinhold, Soininen Hilkka, Thornton Timothy A, Tosto Giuseppe, Tzourio Christophe, van der Lee Sven J, van Duijn Cornelia M, Vardarajan Badri, Wang Weixin, Wijsman Ellen, Wilson Richard K, Witten Daniela, Worley Kim C, Zhang Xiaoling, Bellenguez Celine, Lambert Jean-Charles, Kurki Mitja I, Palotie Aarno, Daly Mark, Boerwinkle Eric, Lunetta Kathryn L, Destefano Anita L, Dupuis Josée, Martin Eden R, Schellenberg Gerard D, Seshadri Sudha, Naj Adam C, Fornage Myriam, Farrer Lindsay A: Whole exome sequencing study identifies novel rare and common Alzheimer's-Associated variants involved in immune response and transcriptional regulation. Molecular Psychiatry August 2018.

Malamon JS, Naj AC, Schmidt M, Vardarajan BN, Ma Y, Lancour D, Kuzma A, Valladares O, Zhao Y, Chou Y-F, Leung YY, Qu L, Lin H, Martin ER, Wang L-S, Haines JL, Mayeux R, Farrer LA, Pericak-Vance MA, Schellenberg GD, for the Genome Center for Alzheimer's Disease (GCAD): Post-Variant Calling Quality Control (QC) Pipeline and Multi-Pipeline Genotype Consensus Caller for Large-Scale Whole Genome and Whole Exome Sequencing Studies. Alzheimer's Association International Conference (AAIC), Chicago, IL July 2018.

Deming Yuetiva, Dumitrescu Logan, Barnes Lisa L, Thambisetty Madhav, Kunkle Brian, Gifford Katherine A, Bush William S, Chibnik Lori B, Mukherjee Shubhabrata, De Jager Philip L, Kukull Walter, Huentelman Matt, Crane Paul K, Resnick Susan M, Keene C Dirk, Montine Thomas J, Schellenberg Gerard D, Haines Jonathan L, Zetterberg Henrik, Blennow Kaj, Larson Eric B, Johnson Sterling C, Albert Marilyn, Moghekar Abhay, Del Aguila Jorge L, Fernandez Maria Victoria, Budde John, Hassenstab Jason, Fagan Anne M, Riemenschneider Matthias, Petersen Ronald C, Minthon Lennart, Chao Michael J, Van Deerlin Vivianna M, Lee Virginia M-Y, Shaw Leslie M, Trojanowski John Q, Peskind Elaine R, Li Gail, Davis Lea K, Sealock Julia M, Cox Nancy J, Goate Alison M, Bennett David A, Schneider Julie A, Jefferson Angela L, Cruchaga Carlos, Hohman Timothy J: Sex-specific Genetic Predictors of Alzheimer's Disease Biomarkers. Acta Neuropathologica Page: In Press. July 2018.

Naj AC, Lin H, Vardarajan BN, White S, Lancour D, Ma Y, Schmidt M, Sun F, Butkiewicz M, Bush WS, Kunkle BW, Malamon J, Amin N, Choi SH, Hamilton-Nelson KL, van der Lee SJ, Gupta N, Koboldt DC, Saad M, Wang B, Nato AQ, Sohi HK, Kuzma A, Wang L-S, Cupples LA, van Duijn C, Seshadri S, Schellenberg GD, Boerwinkle E, Bis JC, Dupuis J, Salerno WJ, Wijsman EM, Martin ER, DeStefano AL: Quality control and integration of genotypes from two calling pipelines for whole genome sequence data in the Alzheimer's disease sequencing project. Genomics Page: In Press. May 2018.

Vardarajan Badri N, Barral Sandra, Jaworski James, Beecham Gary W, Blue Elizabeth, Tosto Giuseppe, Reyes-Dumeyer Dolly, Medrano Martin, Lantigua Rafael, Naj Adam, Thornton Timothy, DeStefano Anita, Martin Eden, Wang Li-San, Brown Lisa, Bush William, van Duijn Cornelia, Goate Allison, Farrer Lindsay, Haines Jonathan L, Boerwinkle Eric, Schellenberg Gerard, Wijsman Ellen, Pericak-Vance Margaret A, Mayeux Richard, Wang Li-San: Whole genome sequencing of Caribbean Hispanic families with late-onset Alzheimer's disease. Annals of Clinical and Translational Neurology 5(4): 406-417, April 2018.

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Last updated: 10/30/2018
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