Haochang Shou, Ph.D.

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Associate Professor of Biostatistics in Biostatistics and Epidemiology at the Hospital of the University of Pennsylvania
Affiliated Faculty, Center for Biomedical Image Computing and Analytics (CBICA), University of Pennsylvania Perelman School of Medicine
Senior Scholar, Center for Clinical Epidemiology (CCEB), University of Pennsylvania Perelman School of Medicine
Affiliated Faculty, Center for Statistics in Big Data (CSBD), Department of Biostatistics, Epidemiology and Informatics
Associate Director, Penn Statistics in Imaging and Visualization Center (PennSIVE), Department of Biostatistics, Epidemiology and Informatics
Affiliated Faculty, Center For AI And Data Science For Integrated Diagnostics (AI2D), University of Pennsylvania Perelman School of Medicine
Department: Biostatistics and Epidemiology

Contact information
Department of Biostatistics, Epidemiology and Informatics
University of Pennsylvania School of Medicine
219 Blockley Hall
423 Guardian Drive
Philadelphia, PA 19104
Office: 215-573-6534
B.Sc. (Statistics)
Peking University, China, 2009.
Ph.D. (Biostatistics)
Johns Hopkins Bloomberg School of Public Health, 2014.
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Description of Research Expertise

Dr. Shou’s methodological research mainly focuses on functional data analysis with complex structures. She is particularly interested in novel statistical modeling and estimation techniques for multimodal functional and longitudinal measurements, including neuroimaging and human activity data. Her collaborations span brain disorder studies, mental health, and biomarker evaluation for chronic kidney disease.

Selected Publications

Skampardoni I, Nasrallah IM, Abdulkadir A, Wen J, Melhem R, Mamourian E, Erus G, Doshi J, Singh A, Yang Z, Cui Y, Hwang G, Ren Z, Pomponio R, Srinivasan D, Govindarajan ST, Parmpi P, Wittfeld K, Grabe HJ, Bülow R, Frenzel S, Tosun D, Bilgel M, An Y, Marcus DS, LaMontagne P, Heckbert SR, Austin TR, Launer LJ, Sotiras A, Espeland MA, Masters CL, Maruff P, Fripp J, Johnson SC, Morris JC, Albert MS, Bryan RN, Yaffe K, Völzke H, Ferrucci L, Benzinger TLS, Ezzati A, Shinohara RT, Fan Y, Resnick SM, Habes M, Wolk D, Shou H, Nikita K, Davatzikos C: Genetic and Clinical Correlates of AI-Based Brain Aging Patterns in Cognitively Unimpaired Individuals. JAMA Psychiatry Feb 2024 Notes: doi: 10.1001/jamapsychiatry.2023.5599. Epub ahead of print.

Yang Z, Wen J, Abdulkadir A, Cui Y, Erus G, Mamourian E, Melhem R, Srinivasan D, Govindarajan ST, Chen J, Habes M, Masters CL, Maruff P, Fripp J, Ferrucci L, Albert MS, Johnson SC, Morris JC, LaMontagne P, Marcus DS, Benzinger TLS, Wolk DA, Shen L, Bao J, Resnick SM, Shou H, Nasrallah IM, Davatzikos C: Gene-SGAN: discovering disease subtypes with imaging and genetic signatures via multi-view weakly-supervised deep clustering. Nature Communications 15(1): 354, Jan 2024 Notes: doi: 10.1038/s41467-023-44271-2.

Song I, Thompson EW, Verma A, MacLean MT, Duda J, Elahi A, Tran R, Raghupathy P, Swago S, Hazim M, Bhattaru A, Schneider C, Vujkovic M, Torigian DA, Kahn CE, Gee JC, Borthakur A, Kripke CM, Carson CC, Carr R, Jehangir Q, Ko YA, Litt H, Rosen M, Mankoff DA, Schnall MD, Shou H, Chirinos J, Damrauer SM, Serper M, Chen J, Rader DJ; Penn Medicine BioBank; Witschey WRT, Sagreiya H: Clinical correlates of CT imaging-derived phenotypes among lean and overweight patients with hepatic steatosis. Scientific Reports 14(1): 53, Jan 2024 Notes: doi: 10.1038/s41598-023-49470-x.

Laughlin, AI; Cao, Q; Bryson, R; Haughey, V; Abdul-Salaam, R; Gonzenbach, V; Rudraraju, M; Eydman, I; Tweed, CM; Fala, GJ; Patel, K; Fox, KR; Hanson, CW; Bekelman, JE; Shou, H: Detection of Medication Taking using Wrist-worn Commercially Available Wearable Device. JCO Clinical Cancer Informatics Dec 2023.

Chen AA, Weinstein SM, Adebimpe A, Gur RC, Gur RE, Merikangas KR, Satterthwaite TD, Shinohara RT, Shou H: Similarity-based multimodal regression. Biostatistics Dec 2023 Notes: doi: 10.1093/biostatistics/kxad033. Epub ahead of print.

Wen J, Nasrallah IM, Abdulkadir A, Satterthwaite TD, Yang Z, Erus G, Robert-Fitzgerald T, Singh A, Sotiras A, Boquet-Pujadas A, Mamourian E, Doshi J, Cui Y, Srinivasan D, Skampardoni I, Chen J, Hwang G, Bergman M, Bao J, Veturi Y, Zhou Z, Yang S, Dazzan P, Kahn RS, Schnack HG, Zanetti MV, Meisenzahl E, Busatto GF, Crespo-Facorro B, Pantelis C, Wood SJ, Zhuo C, Shinohara RT, Gur RC, Gur RE, Koutsouleris N, Wolf DH, Saykin AJ, Ritchie MD, Shen L, Thompson PM, Colliot O, Wittfeld K, Grabe HJ, Tosun D, Bilgel M, An Y, Marcus DS, LaMontagne P, Heckbert SR, Austin TR, Launer LJ, Espeland M, Masters CL, Maruff P, Fripp J, Johnson SC, Morris JC, Albert MS, Bryan RN, Resnick SM, Fan Y, Habes M, Wolk D, Shou H, Davatzikos C: Genomic loci influence patterns of structural covariance in the human brain. Proceedings of the National Academy of Sciences of the United States of America 120(52), Dec 2023 Notes: doi: 10.1073/pnas.2300842120. Epub 2023 Dec 21.

Dubin RF, Deo R, Ren Y, Wang J, Zheng Z, Shou H, Go AS, Parsa A, Lash JP, Rahman M, Hsu CY, Weir MR, Chen J, Anderson A, Grams ME, Surapaneni A, Coresh J, Li H, Kimmel PL, Vasan RS, Feldman H, Segal MR, Ganz P; CRIC Study Investigators; CKD Biomarkers Consortium: Proteomics of CKD progression in the chronic renal insufficiency cohort. Nature Communications 14(1): 6340, Oct 2023 Notes: doi: 10.1038/s41467-023-41642-7.

Zhang, J; Basner, M; Jones, CW; Dinges, DF; Shou, H; Li, H : Mediation Analysis with Random Distribution as Mediator with an Application to iCOMPARE Trial. Statistics in Biosciences Aug 2023 Notes: https://doi-org.proxy.library.upenn.edu/10.1007/s12561-023-09383-9.

Basner M, Smith MG, Jones CW, Ecker AJ, Howard K, Schneller V, Cordoza M, Kaizi-Lutu M, Park-Chavar S, Stahn AC, Dinges DF, Shou H, Mitchell JA, Bhatnagar A, Smith T, Smith AE, Stopforth CK, Yeager R, Keith RJ: Associations of bedroom PM2.5, CO2, temperature, humidity, and noise with sleep: An observational actigraphy study. Sleep Health 9(3): 253-263, Jun 2023 Notes: doi: 10.1016/j.sleh.2023.02.010. Epub 2023 Apr 18.

Deo R, Dubin RF, Ren Y, Murthy AC, Wang J, Zheng H, Zheng Z, Feldman H, Shou H, Coresh J, Grams M, Surapaneni AL, Bhat Z, Cohen JB, Rahman M, He J, Saraf SL, Go AS, Kimmel PL, Vasan RS, Segal MR, Li H, Ganz P: Proteomic cardiovascular risk assessment in chronic kidney disease European Heart Journal 44(23): 2095-2110, Jun 2023 Notes: doi: 10.1093/eurheartj/ehad115.

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Last updated: 03/08/2024
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