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Haochang Shou, Ph.D.
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Associate Professor of Biostatistics in Biostatistics and Epidemiology at the Hospital of the University of Pennsylvania
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Affiliated Faculty, Center for Biomedical Image Computing and Analytics (CBICA), University of Pennsylvania Perelman School of Medicine
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Senior Scholar, Center for Clinical Epidemiology (CCEB), University of Pennsylvania Perelman School of Medicine
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Affiliated Faculty, Center for Statistics in Big Data (CSBD), Department of Biostatistics, Epidemiology and Informatics
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Associate Director, Penn Statistics in Imaging and Visualization Center (PennSIVE), Department of Biostatistics, Epidemiology and Informatics
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Affiliated Faculty, Center For AI And Data Science For Integrated Diagnostics (AI2D), University of Pennsylvania Perelman School of Medicine
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Department: Biostatistics and Epidemiology
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Graduate Group Affiliations
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Contact information
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Department of Biostatistics, Epidemiology and Informatics
35 University of Pennsylvania School of Medicine
33 D006 Richards Medical Research Laboratories
35 3700 Hamilton Walk
Philadelphia, PA 19104
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35 University of Pennsylvania School of Medicine
33 D006 Richards Medical Research Laboratories
35 3700 Hamilton Walk
Philadelphia, PA 19104
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Office: 215-573-6534
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Email:
hshou@pennmedicine.upenn.edu
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hshou@pennmedicine.upenn.edu
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Education:
21 a B.Sc. 17 (Statistics) c
31 Peking University, China, 2009.
21 a Ph.D. 1a (Biostatistics) c
48 Johns Hopkins Bloomberg School of Public Health, 2014.
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Permanent link21 a B.Sc. 17 (Statistics) c
31 Peking University, China, 2009.
21 a Ph.D. 1a (Biostatistics) c
48 Johns Hopkins Bloomberg School of Public Health, 2014.
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Description of Research Expertise
1ac Dr. Shou’s methodological research mainly focuses on functional data analysis with complex structures. She is particularly interested in novel statistical modeling and estimation techniques for multimodal functional and longitudinal measurements, including neuroimaging and human activity data. Her collaborations span brain disorder studies, mental health, and biomarker evaluation for chronic kidney disease.e 29
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67 Tassopoulou V, Stamouli C, Shou H, Pappas GJ, Davatzikos C. 113 : Uncertainty-calibrated prediction of randomly-timed biomarker trajectories with conformal bands. The Thirty-ninth Annual Conference on Neural Information Processing Systems (NeurIPS) Dec 2025 Notes: https://openreview.net/forum?id=jusQeCotOF.
17d Holmqvist S, Shou H, Halberstadter K, Kaplan M, Chaturvedi R, Rhodes E, Giovannetti T: Bidirectional associations of daily mood and subjective cognition in older adults using Ecological Momentary Assessment. Aging Ment Health 29: 1-10, Dec 2025 Notes: doi: 10.1080/13607863.2025.2606875. Epub ahead of print.
73 Wen J, Skampardoni I, Tian YE, Yang Z, Cui Y, Erus G, Hwang G, Varol E, 14b Boquet-Pujadas A, Chand GB, Nasrallah I, Satterthwaite TD, Shou H, Shen L, Toga AW, Zalesky A, Davatzikos C: Neuroimaging-AI endophenotypes reveal underlying mechanisms and genetic factors contributing to progression and development of four brain disorders. Nat Biomed Eng 9(11): 1920-1937, Nov 2025.
322 Xiao W, Woodham RD, Cui Y, Wen J, Antoniades M, Srinivasan D, Fan Y, Erus G, Garcia JA, Arnott SR, Chen T, Choi KS, Chin Fatt C, Frey BN, Frokjaer VG, Ganz M, Godlewska BR, Hassel S, Ho K, McIntosh AM, Qin K, Rotzinger S, Sacchet MD, Savitz J, Shou H, Singh A, Stolicyn A, Strigo I, Strother SC, Tosun D, Wei D, Anderson IM, Craighead WE, Deakin JFW, Dunlop BW, Elliott R, Gong Q, Gotlib IH, Harmer CJ, Kennedy SH, Knudsen GM, Mayberg HS, Paulus MP, Qiu J, Trivedi MH, Whalley HC, Yan CG, Young AH, Davatzikos C, Fu CHY.: Neuroanatomical dimensions in major depression linked to cognition, adverse life events, self-harm, metabolomics and genetics. Commun Med Nov 2025 Notes: doi: 10.1038/s43856-025-01219-5. Epub ahead of print.
77 Hu F, Ren Z, Chen L, Valcarcel AM, Dworkin J, Renner B, Daboul L, O'Donnell 4e CM, Verter ED, Manning AR, Clark KA, Bae E, Chen C, Lou C, Satterthwaite TD, 4d Shou H, Bilello M, Nakamura K, Bar-Or A, Calabresi PA, Freeman L, Henry RG, f1 Longbrake EE, Oh J, Schindler MK, Absinta M, Solomon AJ, Sicotte NL, Ontaneda D, Reich DS, Sati P, Shinohara RT: Automated segmentation of multiple sclerosis lesions, paramagnetic rims, and central vein sign on MRI provides reliable 76 diagnostic biomarkers. Imaging Neurosci 3: IMAG.a.932, Oct 2025 Notes: doi:10.1162/IMAG.a.932.
262 Hu F, Ren Z, Chen L, Valcarcel AM, Dworkin J, Renner B, Daboul L, O'Donnell CM, Verter ED, Manning AR, Clark KA, Bae E, Chen C, Lou C, Satterthwaite TD, Shou H, Bilello M, Nakamura K, Bar-Or A, Calabresi PA, Freeman L, Henry RG, Longbrake EE, Oh J, Schindler MK, Absinta M, Solomon AJ, Sicotte NL, Ontaneda D, Reich DS, Sati P, Shinohara RT: Automated segmentation of multiple sclerosis lesions, paramagnetic rims, and central vein sign on MRI provides reliable diagnostic biomarkers. Imaging Neurosci (Camb) 10(3): IMAG.a.932, Oct 2025.
78 Anagnostakis F, Kokkorakis M, Walker KA, Skampardoni I, Wen J, Erus G, Tosun 15f D, Tassopoulou V, Cui Y, Govindarajan ST, Srinivasan D, Melhem R, Mamourian E, Shou H, Nasrallah IM, Mantzoros CS, Davatzikos C: Radiomic and proteomic signatures of body mass index on brain ageing and Alzheimer's-like patterns of brain atrophy. EBioMedicine 116(105763), Jun 2025 Notes: doi:10.1016/j.ebiom.2025.105763.
147 Holmqvist S, Kaplan M, Chaturvedi R, Shou H, Giovannetti T: Longitudinal and combined smartwatch and ecological momentary assessment in racially diverse older adults: feasibility, adherence, and acceptability study. JMIR Hum Factors 12: e69952, Apr 2025.
173 Tassopoulou V, Shou H*, Davatzikos C*: Adaptive shrinkage estimation for personalized deep kernel regression in modeling brain trajectories. The Thirteenth International Conference on Learning Representations (ICLR) Apr 2025 Notes: https://openreview.net/forum?id=peX9zpWgg4. *co-senior authorship.
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Selected Publications
e5 Zhang J, Cui E, Li H, Shou H.: INTACT: A method for integration of longitudinal physical activity data from multiple sources. Biometrics Nov 2025, accepted.67 Tassopoulou V, Stamouli C, Shou H, Pappas GJ, Davatzikos C. 113 : Uncertainty-calibrated prediction of randomly-timed biomarker trajectories with conformal bands. The Thirty-ninth Annual Conference on Neural Information Processing Systems (NeurIPS) Dec 2025 Notes: https://openreview.net/forum?id=jusQeCotOF.
17d Holmqvist S, Shou H, Halberstadter K, Kaplan M, Chaturvedi R, Rhodes E, Giovannetti T: Bidirectional associations of daily mood and subjective cognition in older adults using Ecological Momentary Assessment. Aging Ment Health 29: 1-10, Dec 2025 Notes: doi: 10.1080/13607863.2025.2606875. Epub ahead of print.
73 Wen J, Skampardoni I, Tian YE, Yang Z, Cui Y, Erus G, Hwang G, Varol E, 14b Boquet-Pujadas A, Chand GB, Nasrallah I, Satterthwaite TD, Shou H, Shen L, Toga AW, Zalesky A, Davatzikos C: Neuroimaging-AI endophenotypes reveal underlying mechanisms and genetic factors contributing to progression and development of four brain disorders. Nat Biomed Eng 9(11): 1920-1937, Nov 2025.
322 Xiao W, Woodham RD, Cui Y, Wen J, Antoniades M, Srinivasan D, Fan Y, Erus G, Garcia JA, Arnott SR, Chen T, Choi KS, Chin Fatt C, Frey BN, Frokjaer VG, Ganz M, Godlewska BR, Hassel S, Ho K, McIntosh AM, Qin K, Rotzinger S, Sacchet MD, Savitz J, Shou H, Singh A, Stolicyn A, Strigo I, Strother SC, Tosun D, Wei D, Anderson IM, Craighead WE, Deakin JFW, Dunlop BW, Elliott R, Gong Q, Gotlib IH, Harmer CJ, Kennedy SH, Knudsen GM, Mayberg HS, Paulus MP, Qiu J, Trivedi MH, Whalley HC, Yan CG, Young AH, Davatzikos C, Fu CHY.: Neuroanatomical dimensions in major depression linked to cognition, adverse life events, self-harm, metabolomics and genetics. Commun Med Nov 2025 Notes: doi: 10.1038/s43856-025-01219-5. Epub ahead of print.
77 Hu F, Ren Z, Chen L, Valcarcel AM, Dworkin J, Renner B, Daboul L, O'Donnell 4e CM, Verter ED, Manning AR, Clark KA, Bae E, Chen C, Lou C, Satterthwaite TD, 4d Shou H, Bilello M, Nakamura K, Bar-Or A, Calabresi PA, Freeman L, Henry RG, f1 Longbrake EE, Oh J, Schindler MK, Absinta M, Solomon AJ, Sicotte NL, Ontaneda D, Reich DS, Sati P, Shinohara RT: Automated segmentation of multiple sclerosis lesions, paramagnetic rims, and central vein sign on MRI provides reliable 76 diagnostic biomarkers. Imaging Neurosci 3: IMAG.a.932, Oct 2025 Notes: doi:10.1162/IMAG.a.932.
262 Hu F, Ren Z, Chen L, Valcarcel AM, Dworkin J, Renner B, Daboul L, O'Donnell CM, Verter ED, Manning AR, Clark KA, Bae E, Chen C, Lou C, Satterthwaite TD, Shou H, Bilello M, Nakamura K, Bar-Or A, Calabresi PA, Freeman L, Henry RG, Longbrake EE, Oh J, Schindler MK, Absinta M, Solomon AJ, Sicotte NL, Ontaneda D, Reich DS, Sati P, Shinohara RT: Automated segmentation of multiple sclerosis lesions, paramagnetic rims, and central vein sign on MRI provides reliable diagnostic biomarkers. Imaging Neurosci (Camb) 10(3): IMAG.a.932, Oct 2025.
78 Anagnostakis F, Kokkorakis M, Walker KA, Skampardoni I, Wen J, Erus G, Tosun 15f D, Tassopoulou V, Cui Y, Govindarajan ST, Srinivasan D, Melhem R, Mamourian E, Shou H, Nasrallah IM, Mantzoros CS, Davatzikos C: Radiomic and proteomic signatures of body mass index on brain ageing and Alzheimer's-like patterns of brain atrophy. EBioMedicine 116(105763), Jun 2025 Notes: doi:10.1016/j.ebiom.2025.105763.
147 Holmqvist S, Kaplan M, Chaturvedi R, Shou H, Giovannetti T: Longitudinal and combined smartwatch and ecological momentary assessment in racially diverse older adults: feasibility, adherence, and acceptability study. JMIR Hum Factors 12: e69952, Apr 2025.
173 Tassopoulou V, Shou H*, Davatzikos C*: Adaptive shrinkage estimation for personalized deep kernel regression in modeling brain trajectories. The Thirteenth International Conference on Learning Representations (ICLR) Apr 2025 Notes: https://openreview.net/forum?id=peX9zpWgg4. *co-senior authorship.
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