Robert H Mach, Ph.D.

faculty photo
Britton Chance Professor of Radiology
Department: Radiology
Graduate Group Affiliations

Contact information
Department of Radiology
Chemistry Building
231 S. 34th Street
Philadelphia, PA 19104
Office: 215-746-8233
Education:
B.A. (Chemistry)
State University of New York, College at Potsdam, 1978.
Ph.D. (Medical Chemistry)
State University of New York at Buffalo, Buffalo, NY, 1985.
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Selected Publications

Makvandi, M., Pantel, A., Schwartz, L., Schubert, E., Xu, K., Hsieh, C. J., Hou, C., Kim, H., Weng, C. C., Winters, H., Doot, R., Farwell, M. D., Pryma, D. A., Greenberg, R. A., Mankoff, D. A., Simpkins, F., Mach, R. H., Lin, L. L.: A PET imaging agent for evaluating PARP-1 expression in ovarian cancer. J Clin Invest 128(5): 2116-2126, 2018.

Mach, R. H., Luedtke, R. R.: Challenges in the development of dopamine D2- and D3-selective radiotracers for PET imaging studies. J Labelled Comp Radiopharm 61(3): 291-298, 2018.

Lu, H. D., Wang, L. Z., Wilson, B. K., McManus, S. A., Jumai'an, J., Padakanti, P. K., Alavi, A., Mach, R. H., Prud'homme, R. K.: Copper Loading of Preformed Nanoparticles for PET-Imaging Applications. ACS Appl Mater Interfaces 10(4): 3191-3199, 2018.

Hou, C., Hsieh, C. J., Li, S., Lee, H., Graham, T. J., Xu, K., Weng, C. C., Doot, R. K., Chu, W., Chakraborty, S. K., Dugan, L. L., Mintun, M. A., Mach, R. H.: Development of a Positron Emission Tomography Radiotracer for Imaging Elevated Levels of Superoxide in Neuroinflammation. ACS Chem Neurosci 9(3): 578-586, 2018.

Yue, X., Dhavale, D. D., Li, J., Luo, Z., Liu, J., Yang, H., Mach, R. H., Kotzbauer, P. T., Tu, Z.: Design, synthesis, and in vitro evaluation of quinolinyl analogues for alpha-synuclein aggregation. Bioorg Med Chem Lett 28(6): 1011-1019, 2018.

Sun, Y. T., Wang, G. F., Yang, Y. Q., Jin, F., Wang, Y., Xie, X. Y., Mach, R. H., Huang, Y. S.: Synthesis and pharmacological evaluation of 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline derivatives as sigma-2 receptor ligands. Eur J Med Chem 147: 227-237, 2018.

Reilly, S. W., Puentes, L. N., Wilson, K., Hsieh, C. J., Weng, C. C., Makvandi, M., Mach, R. H.: Examination of Diazaspiro Cores as Piperazine Bioisosteres in the Olaparib Framework Shows Reduced DNA Damage and Cytotoxicity. J Med Chem 61(12): 5367-5379, 2018.

Reilly, S. W., Puentes, L. N., Hsieh, C. J., Makvandi, M., Mach, R. H.: Altering Nitrogen Heterocycles of AZD2461 Affords High Affinity Poly(ADP-ribose) Polymerase-1 Inhibitors with Decreased P-Glycoprotein Interactions. ACS Omega 3(8): 9997-10001, 2018.

Reilly, S. W., Makvandi, M., Xu, K., Mach, R. H.: Rapid Cu-Catalyzed [(211)At]Astatination and [(125)I]Iodination of Boronic Esters at Room Temperature. Org Lett 20(7): 1752-1755, 2018.

Powell, G. L., Bonadonna, J. P., Vannan, A., Mach, R. H., Luedtke, R. R., Neisewander, J. L.: Dopamine D3 receptor partial agonist LS-3-134 attenuates cocaine-motivated behaviors. Pharmacol Biochem Behav 2018.

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Last updated: 10/16/2018
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