Selected Publications

Chia-Ju Hsieh; Dinahlee Saturnino Guarino; Anthony J. Young; Andrew D. Siderowf; Ilya Nasrallah; Alexander Schmitz; Carol Garcia; Ho Young Kim; Erin K. Schubert; Hsiaoju Lee; Joel S. Perlmutter; Robert H. Mach: Pilot Study of [11C]HY-2-15: A Mixed Alpha-Synuclein and Tau PET Radiotracer. Cells 14(15): 1157, Jul 2025.

Bunning S, Christodoulou D, Cohen JE, Cutler CS, Dick DW, Ghosh K, Ignace C, Kasliwal RK, Lee H, Marzella L, Pohlhaus T, Scott PJH, Schwarz SW, Syed IA, VanBrocklin HF, Wasil LR, Zigler SS.: Proceedings: PET Drugs-A 2023 Workshop on Product Quality, Regulatory Submissions, Facility Inspections, and Benefit-Risk Considerations. J Nucl Med Jul 2025.

Dubroff JG, Hsieh CJ, Wiers CE, Lee H, Schmitz A, Li EJ, Schubert EK, Mach RH, Kranzler HR.: [(11)C]Carfentanil PET Whole-Body Imaging of μ-Opioid Receptors: A First in-Human Study. J Nucl Med 66: 1112-1118, Jul 2025.

Tian GL, Hsieh CJ, Guarino DS, Graham TJA, Lengyel-Zhand Z, Schmitz A, Chia WK, Young AJ, Crosby JG, Plakas K, Huang T, Jiang H, Yu Y, Hou C, Lee H, Petersson EJ, Giannakoulias S, O'Shea J, Kotzbauer P, Tu Z, Mathis CA, Mach RH.: The development of a PET radiotracer for imaging alpha synuclein aggregates in Parkinson's disease. RSC Med Chem Apr 2025.

Plakas K, Hsieh CJ, Saturnino Guarino D, Hou C, Chia WK, Young A, Schmitz A, Ho YP, Weng CC, Lee H, Li S, Graham TJA, Mach RH.: Toward a Small-Molecule Antagonist Radioligand for Positron Emission Tomography Imaging of the Mu Opioid Receptor. ACS Chem Neurosci 16: 1592-1603, Apr 2025.

Evan Gallagher, Shihong Li,Hsiaoju Lee, Hong Xu, Virginia M.-Y. Lee,Robert H. Mach, and Meagan J. McManus: Noninvasive Detection of Oxidative Stress in a Mouse Model of 4R Tauopathy via Positron Emission Tomography with [18F]ROStrace. Int. J. Mol. Sci. 26(5): 1845, Feb 2025.

Hoon Choi, Mamta Gupta, Arjun Sengupta, Emma E. Furth, Christopher Hensley, Aalim M. Weljie, Hsiaoju Lee, Yu-Ting Lu, Austin Pantel, David Mankoff, Rong Zhou: Disruption of redox balance in glutaminolytic triple negative breast cancer by inhibition of glutaminase and glutamate export. Neoplasia 61, 2025 Notes: https://doi.org/10.1016/j.neo.2025.101136.

Gallagher, E., Hou, C., Zhu, Y., Hsieh, C. J., Lee, H., Li, S., Xu, K., Henderson, P., Chroneos, R., Sheldon, M., Riley, S., Luk, K. C., Mach, R. H., McManus, M. J.: Positron Emission Tomography with [(18)F]ROStrace Reveals Progressive Elevations in Oxidative Stress in a Mouse Model of Alpha-Synucleinopathy. Int J Mol Sci 25(9), 2024.

Young, A. J., Pantel, A. R., Kiani, M., Doot, R. K., Bagheri, S., Pryma, D. A., Farwell, M. D., Li, S., Lee, H., Schubert, E. K., Secreto, A., Zuckerman, S. P., Nayak, A., Choi, H., Carlin, S., DeMichele, A., Mankoff, D. A., Zhou, R., Mach, R. H., McDonald, E. S.: Kinetic Analysis and Metabolism of Poly(Adenosine Diphosphate-Ribose) Polymerase-1-Targeted (18)F-Fluorthanatrace PET in Breast Cancer. J Nucl Med 2024.

Li, S., Schmitz, A., Lu, Y. T., Pal, R., Sarkar, S., Sellmyer, M. A., Mach, R. H., Lee, H.: Automation of simplified two-step radiolabeling via ditosylate synthon for (18)F-labeled radiotracers using AllinOne module. Nucl Med Biol 138-139: 108948, 2024.