Selected Publications

Scott PJH, VanBrocklin HF, Cumming RC, Dick DW, Ignace C, Bunning S, Cutler CS, Lee H, Schwarz SW, Zigler SS.: FDA Investigator Training for PET Drug Manufacturing Inspections. J Nucl Med Page: jnumed.125.271221, Nov 2025 Notes: doi: 10.2967/jnumed.125.271221. Epub ahead of print.

Young AJ, Doot RK, Cho JK, Pham JM, Ordonez AA, Del Castillo AF, Dominguez TL, Dugyala S, Schubert EK, Lee H, Pantel AR, Mach RH, Mankoff DA, Sellmyer MA.: First-in-Human Biodistribution and Dosimetry of [(11)C]Trimethoprim. Mol Imaging Biol Nov 2025 Notes: doi: 10.1007/s11307-025-02064-7. Epub ahead of print.

Chia-Ju Hsieh; Dinahlee Saturnino Guarino; Anthony J. Young; Andrew D. Siderowf; Ilya Nasrallah; Alexander Schmitz; Carol Garcia; Ho Young Kim; Erin K. Schubert; Hsiaoju Lee; Joel S. Perlmutter; Robert H. Mach: Pilot Study of [11C]HY-2-15: A Mixed Alpha-Synuclein and Tau PET Radiotracer. Cells 14(15): 1157, Jul 2025.

Bunning S, Christodoulou D, Cohen JE, Cutler CS, Dick DW, Ghosh K, Ignace C, Kasliwal RK, Lee H, Marzella L, Pohlhaus T, Scott PJH, Schwarz SW, Syed IA, VanBrocklin HF, Wasil LR, Zigler SS.: Proceedings: PET Drugs-A 2023 Workshop on Product Quality, Regulatory Submissions, Facility Inspections, and Benefit-Risk Considerations. J Nucl Med 66(9): 1480-1492, Jul 2025 Notes: doi: 10.2967/jnumed.125.270011.

Dubroff JG, Hsieh CJ, Wiers CE, Lee H, Schmitz A, Li EJ, Schubert EK, Mach RH, Kranzler HR.: [(11)C]Carfentanil PET Whole-Body Imaging of μ-Opioid Receptors: A First in-Human Study. J Nucl Med 66: 1112-1118, Jul 2025.

Tian GL, Hsieh CJ, Guarino DS, Graham TJA, Lengyel-Zhand Z, Schmitz A, Chia WK, Young AJ, Crosby JG, Plakas K, Huang T, Jiang H, Yu Y, Hou C, Lee H, Petersson EJ, Giannakoulias S, O'Shea J, Kotzbauer P, Tu Z, Mathis CA, Mach RH.: The development of a PET radiotracer for imaging alpha synuclein aggregates in Parkinson's disease. RSC Med Chem Apr 2025 Notes: doi: 10.1039/d5md00057b. Epub ahead of print.

Plakas K, Hsieh CJ, Saturnino Guarino D, Hou C, Chia WK, Young A, Schmitz A, Ho YP, Weng CC, Lee H, Li S, Graham TJA, Mach RH.: Toward a Small-Molecule Antagonist Radioligand for Positron Emission Tomography Imaging of the Mu Opioid Receptor. ACS Chem Neurosci 16(8): 1592-1603, Apr 2025 Notes: DOI: 10.1021/acschemneuro.5c00140.

Evan Gallagher, Shihong Li,Hsiaoju Lee, Hong Xu, Virginia M.-Y. Lee,Robert H. Mach, and Meagan J. McManus: Noninvasive Detection of Oxidative Stress in a Mouse Model of 4R Tauopathy via Positron Emission Tomography with [18F]ROStrace. Int. J. Mol. Sci. 26(5): 1845, Feb 2025.

Hoon Choi, Mamta Gupta, Arjun Sengupta, Emma E. Furth, Christopher Hensley, Aalim M. Weljie, Hsiaoju Lee, Yu-Ting Lu, Austin Pantel, David Mankoff, Rong Zhou: Disruption of redox balance in glutaminolytic triple negative breast cancer by inhibition of glutaminase and glutamate export. Neoplasia 61, 2025 Notes: https://doi.org/10.1016/j.neo.2025.101136.

Young, A. J., Pantel, A. R., Kiani, M., Doot, R. K., Bagheri, S., Pryma, D. A., Farwell, M. D., Li, S., Lee, H., Schubert, E. K., Secreto, A., Zuckerman, S. P., Nayak, A., Choi, H., Carlin, S., DeMichele, A., Mankoff, D. A., Zhou, R., Mach, R. H., McDonald, E. S.: Kinetic Analysis and Metabolism of Poly(Adenosine Diphosphate-Ribose) Polymerase-1-Targeted (18)F-Fluorthanatrace PET in Breast Cancer. J Nucl Med 65(12): 1862-1868, Dec 2024 Notes: doi: 10.2967/jnumed.124.268254.