Hsiaoju Sharon Lee, PhD

Research Assistant Professor of Radiology
Director of Cyclotron Operation, PSOM
Department: Radiology
Contact information
Perelman School of Medicine
Department of Radiology
Radio Chemistry Lab
420 Curie Blvd
Philadelphia, PA 19104
Department of Radiology
Radio Chemistry Lab
420 Curie Blvd
Philadelphia, PA 19104
Office: 3144588365
Lab: 2153495632
Lab: 2153495632
Education:
BS (Agricultural Chemistry)
National Taiwan University, 1994.
MS (Clinical Nutrition)
Drexel University, 1999.
PhD (Chemical Biology)
Washington University in St. Louis, 2008.
Permanent linkBS (Agricultural Chemistry)
National Taiwan University, 1994.
MS (Clinical Nutrition)
Drexel University, 1999.
PhD (Chemical Biology)
Washington University in St. Louis, 2008.
Selected Publications
Iris K Lee, Daniel A Jacome, Joshua K Cho, Vincent Tu, Anthony J Young, Tiffany Dominguez, Justin D Northrup, Jean M Etersque, Hsiaoju S Lee, Andrew Ruff, Ouniol Aklilu, Kyle Bittinger, Laurel J Glaser, Daniel Dorgan, Denis Hadjiliadis, Rahul M Kohli, Robert H Mach, David A Mankoff, Robert K Doot, Mark A Sellmyer: Imaging sensitive and drug-resistant bacterial infection with [11C]-trimethoprim. J Clin Invest 132(18): e156679, Sep 2022.Chia-Ju Hsieh, Catherine Hou, Yi Zhu, Ji Youn Lee, Neha Kohli, Evan Gallagher, Kuiying Xu, Hsiaoju Lee, Shihong Li, Meagan J McManus, Robert H Mach: [ 18 F]ROStrace detects oxidative stress in vivo and predicts progression of Alzheimer's disease pathology in APP/PS1 mice. EJNMMI Res 12(1): 43, Jul 2022.
Rong Zhou, Hoon Choi, Jianbo Cao, Austin Pantel, Mamta Gupta, Hsiaoju Lee, David Mankoff : 18 F-Fluciclovine PET Imaging of Glutaminase Inhibition in Breast Cancer Models. J Nucl Med Jun 2022.
Hsiaoju S Lee, Sally W Schwarz, Erin K Schubert, Delphine L Chen, Robert K Doot, Mehran Makvandi, Lilie L Lin, Elizabeth S McDonald, David A Mankoff, Robert H Mach: The Development of 18 F Fluorthanatrace: A PET Radiotracer for Imaging Poly (ADP-Ribose) Polymerase-1. Radiol Imaging Cancer 4(1): e210070, Jan 2022.
Hsiaoju Lee, Lisa J States: Glucagonlike Peptide-1 Receptor Imaging in Individuals with Type 2 Diabetes. J Nucl Med 63(5): 792-793, 2022.
Varsha Viswanath, Rong Zhou, Hsiaoju Lee, Shihong Li, Abigail Cragin, Robert K Doot, David A Mankoff, Austin R Pantel: Kinetic Modeling of 18 F-(2 S, 4 R)4-Fluoroglutamine in Mouse Models of Breast Cancer to Estimate Glutamine Pool Size as an Indicator of Tumor Glutamine Metabolism. J Nucl Med 62(8): 1154-1162, Aug 2021.
Robert W Pipal, Kenneth T Stout, Patricia Z Musacchio, Sumei Ren, Thomas J A Graham, Stefan Verhoog, Liza Gantert, Talakad G Lohith, Alexander Schmitz, Hsiaoju S Lee, David Hesk, Eric D Hostetler, Ian W Davies, David W C MacMillan: Metallaphotoredox aryl and alkyl radiomethylation for PET ligand discovery. Nature 589(7843): 542-547, Jan 2021.
Michael Tran Duong, Yin Jie Chen, Robert K Doot, Anthony J Young, Hsiaoju Lee, Jenny Cai, Arun Pilania, David A Wolk, Ilya M Nasrallah: Astrocyte activation imaging with 11C-acetate and amyloid PET in mild cognitive impairment due to Alzheimer pathology. Nucl Med Commun 42(11): 1261-1269, 2021.
Hsiaoju Lee, Naresh Damuka, John A Katzenellenbogen, Bhuddhika Liyana Pathirannahel, Jinbin Xu, Robert H Mach, Kiran Kumar Solingapuram Sai: Initial Biological Evaluations of [18F]KS-7-51 to Image PPAR-γ in Tumor Mice Model. Journal of Radiology and Radiation Therapy 8: 1086, Sep 2020.
Robert K Doot, Anthony J Young, Margaret E Daube-Witherspoon, David Alexoff, Kyle J Labban, Hwan Lee, Zehui Wu, Zhihao Zha, Seok R Choi, Karl H Ploessl, Erin K Schubert, Hsiaoju Lee, Lin Zhu, Janet S Reddin, Joel S Karp, Hank Kung, Daniel A Pryma: Biodistribution, dosimetry, and temporal signal-to-noise ratio analyses of normal and cancer uptake of [ 68 Ga]Ga-P15-041, a gallium-68 labeled bisphosphonate, from first-in-human studies. Nucl Med Biol 86-87: 1-8, Jul-Aug 2020.