Hsiaoju Sharon Lee, PhD

faculty photo
Research Assistant Professor of Radiology
Director of Cyclotron Operation, PSOM
Department: Radiology

Contact information
Perelman School of Medicine
Department of Radiology
Radio Chemistry Lab
420 Curie Blvd
Philadelphia, PA 19104
Office: 3144588365
Lab: 2153495632
BS (Agricultural Chemistry)
National Taiwan University, 1994.
MS (Clinical Nutrition)
Drexel University, 1999.
PhD (Chemical Biology)
Washington University in St. Louis, 2008.
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Selected Publications

Ho Young Kim 1, Wai Kit Chia 1, Chia-Ju Hsieh 1, Dinahlee Saturnino Guarino 1, Thomas J A Graham 1, Zsofia Lengyel-Zhand 1, Mark Schneider 1, Cosette Tomita 1, Marshall G Lougee 2, Hee Jong Kim 3, Vinayak V Pagar 2, Hsiaoju Lee 1, Catherine Hou 1, Benjamin A Garcia 3, E James Petersson 2, Jennifer O'Shea 4, Paul T Kotzbauer 4, Chester A Mathis 5, Virginia M-Y Lee 6, Kelvin C Luk 6, Robert H Mach 1: A Novel Brain PET Radiotracer for Imaging Alpha Synuclein Fibrils in Multiple System Atrophy. J. Med. Chem. 66(17): 12185-12201, Sep 2023.

Reagan R Wetherill, Robert K Doot, Anthony J Young, Hsiaoju Lee, Erin K Schubert, Corinde E Wiers, Frank T Leone, Robert H Mach, Henry R Kranzler, Jacob G Dubroff: Molecular Imaging of Pulmonary Inflammation in Users of Electronic and Combustible Cigarettes: A Pilot Study. J Nucl Med 64(5): 797-802, May 2023.

Rong Zhou 1, Hoon Choi 2, Jianbo Cao 2, Austin Pantel 2, Mamta Gupta 2, Hsiaoju S Lee 2, David Mankoff 1: 18F-Fluciclovine PET Imaging of Glutaminase Inhibition in Breast Cancer Models. J Nucl Med 64(1): 131-136, Jan 2023.

Iris K Lee, Daniel A Jacome, Joshua K Cho, Vincent Tu, Anthony J Young, Tiffany Dominguez, Justin D Northrup, Jean M Etersque, Hsiaoju S Lee, Andrew Ruff, Ouniol Aklilu, Kyle Bittinger, Laurel J Glaser, Daniel Dorgan, Denis Hadjiliadis, Rahul M Kohli, Robert H Mach, David A Mankoff, Robert K Doot, Mark A Sellmyer: Imaging sensitive and drug-resistant bacterial infection with [11C]-trimethoprim. J Clin Invest 132(18): e156679, Sep 2022.

Chia-Ju Hsieh, Catherine Hou, Yi Zhu, Ji Youn Lee, Neha Kohli, Evan Gallagher, Kuiying Xu, Hsiaoju Lee, Shihong Li, Meagan J McManus, Robert H Mach: [ 18 F]ROStrace detects oxidative stress in vivo and predicts progression of Alzheimer's disease pathology in APP/PS1 mice. EJNMMI Res 12(1): 43, Jul 2022.

Rong Zhou, Hoon Choi, Jianbo Cao, Austin Pantel, Mamta Gupta, Hsiaoju Lee, David Mankoff : 18 F-Fluciclovine PET Imaging of Glutaminase Inhibition in Breast Cancer Models. J Nucl Med Jun 2022.

Hsiaoju S Lee, Sally W Schwarz, Erin K Schubert, Delphine L Chen, Robert K Doot, Mehran Makvandi, Lilie L Lin, Elizabeth S McDonald, David A Mankoff, Robert H Mach: The Development of 18 F Fluorthanatrace: A PET Radiotracer for Imaging Poly (ADP-Ribose) Polymerase-1. Radiol Imaging Cancer 4(1): e210070, Jan 2022.

Hsiaoju Lee, Lisa J States: Glucagonlike Peptide-1 Receptor Imaging in Individuals with Type 2 Diabetes. J Nucl Med 63(5): 792-793, 2022.

Varsha Viswanath, Rong Zhou, Hsiaoju Lee, Shihong Li, Abigail Cragin, Robert K Doot, David A Mankoff, Austin R Pantel: Kinetic Modeling of 18 F-(2 S, 4 R)4-Fluoroglutamine in Mouse Models of Breast Cancer to Estimate Glutamine Pool Size as an Indicator of Tumor Glutamine Metabolism. J Nucl Med 62(8): 1154-1162, Aug 2021.

Robert W Pipal, Kenneth T Stout, Patricia Z Musacchio, Sumei Ren, Thomas J A Graham, Stefan Verhoog, Liza Gantert, Talakad G Lohith, Alexander Schmitz, Hsiaoju S Lee, David Hesk, Eric D Hostetler, Ian W Davies, David W C MacMillan: Metallaphotoredox aryl and alkyl radiomethylation for PET ligand discovery. Nature 589(7843): 542-547, Jan 2021.

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Last updated: 10/10/2023
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