Hsiaoju Sharon Lee, PhD

faculty photo
Research Assistant Professor of Radiology
Director of Cyclotron Operation, PSOM
Department: Radiology

Contact information
Perelman School of Medicine
Department of Radiology
Radio Chemistry Lab
420 Curie Blvd
Philadelphia, PA 19104
Office: 3144588365
Lab: 2153495632
BS (Agricultural Chemistry)
National Taiwan University, 1994.
MS (Clinical Nutrition)
Drexel University, 1999.
PhD (Chemical Biology)
Washington University in St. Louis, 2008.
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Selected Publications

Iris K Lee, Daniel A Jacome, Joshua K Cho, Vincent Tu, Anthony J Young, Tiffany Dominguez, Justin D Northrup, Jean M Etersque, Hsiaoju S Lee, Andrew Ruff, Ouniol Aklilu, Kyle Bittinger, Laurel J Glaser, Daniel Dorgan, Denis Hadjiliadis, Rahul M Kohli, Robert H Mach, David A Mankoff, Robert K Doot, Mark A Sellmyer: Imaging sensitive and drug-resistant bacterial infection with [11C]-trimethoprim. J Clin Invest 132(18): e156679, Sep 2022.

Chia-Ju Hsieh, Catherine Hou, Yi Zhu, Ji Youn Lee, Neha Kohli, Evan Gallagher, Kuiying Xu, Hsiaoju Lee, Shihong Li, Meagan J McManus, Robert H Mach: [ 18 F]ROStrace detects oxidative stress in vivo and predicts progression of Alzheimer's disease pathology in APP/PS1 mice. EJNMMI Res 12(1): 43, Jul 2022.

Rong Zhou, Hoon Choi, Jianbo Cao, Austin Pantel, Mamta Gupta, Hsiaoju Lee, David Mankoff : 18 F-Fluciclovine PET Imaging of Glutaminase Inhibition in Breast Cancer Models. J Nucl Med Jun 2022.

Hsiaoju S Lee, Sally W Schwarz, Erin K Schubert, Delphine L Chen, Robert K Doot, Mehran Makvandi, Lilie L Lin, Elizabeth S McDonald, David A Mankoff, Robert H Mach: The Development of 18 F Fluorthanatrace: A PET Radiotracer for Imaging Poly (ADP-Ribose) Polymerase-1. Radiol Imaging Cancer 4(1): e210070, Jan 2022.

Hsiaoju Lee, Lisa J States: Glucagonlike Peptide-1 Receptor Imaging in Individuals with Type 2 Diabetes. J Nucl Med 63(5): 792-793, 2022.

Varsha Viswanath, Rong Zhou, Hsiaoju Lee, Shihong Li, Abigail Cragin, Robert K Doot, David A Mankoff, Austin R Pantel: Kinetic Modeling of 18 F-(2 S, 4 R)4-Fluoroglutamine in Mouse Models of Breast Cancer to Estimate Glutamine Pool Size as an Indicator of Tumor Glutamine Metabolism. J Nucl Med 62(8): 1154-1162, Aug 2021.

Robert W Pipal, Kenneth T Stout, Patricia Z Musacchio, Sumei Ren, Thomas J A Graham, Stefan Verhoog, Liza Gantert, Talakad G Lohith, Alexander Schmitz, Hsiaoju S Lee, David Hesk, Eric D Hostetler, Ian W Davies, David W C MacMillan: Metallaphotoredox aryl and alkyl radiomethylation for PET ligand discovery. Nature 589(7843): 542-547, Jan 2021.

Michael Tran Duong, Yin Jie Chen, Robert K Doot, Anthony J Young, Hsiaoju Lee, Jenny Cai, Arun Pilania, David A Wolk, Ilya M Nasrallah: Astrocyte activation imaging with 11C-acetate and amyloid PET in mild cognitive impairment due to Alzheimer pathology. Nucl Med Commun 42(11): 1261-1269, 2021.

Hsiaoju Lee, Naresh Damuka, John A Katzenellenbogen, Bhuddhika Liyana Pathirannahel, Jinbin Xu, Robert H Mach, Kiran Kumar Solingapuram Sai: Initial Biological Evaluations of [18F]KS-7-51 to Image PPAR-γ in Tumor Mice Model. Journal of Radiology and Radiation Therapy 8: 1086, Sep 2020.

Robert K Doot, Anthony J Young, Margaret E Daube-Witherspoon, David Alexoff, Kyle J Labban, Hwan Lee, Zehui Wu, Zhihao Zha, Seok R Choi, Karl H Ploessl, Erin K Schubert, Hsiaoju Lee, Lin Zhu, Janet S Reddin, Joel S Karp, Hank Kung, Daniel A Pryma: Biodistribution, dosimetry, and temporal signal-to-noise ratio analyses of normal and cancer uptake of [ 68 Ga]Ga-P15-041, a gallium-68 labeled bisphosphonate, from first-in-human studies. Nucl Med Biol 86-87: 1-8, Jul-Aug 2020.

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Last updated: 12/02/2022
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