J. Cobb Scott, Ph.D.

faculty photo
Assistant Professor of Clinical Psychology in Psychiatry at the Hospital of the University of Pennsylvania
Department: Psychiatry

Contact information
Brain Behavior Laboratory
Department of Psychiatry
5th Floor, Suite 5B
3700 Hamilton Walk

University of Pennsylvania
Philadelphia, PA 19104-6085
Office: 215-662-7388
B.A. (Psychology)
Wesleyan University, 1999.
M.S. (Psychology)
San Diego State University, 2006.
Ph.D. (Clinical Psychology)
University of California, San Diego, 2009.
Permanent link
> Perelman School of Medicine   > Faculty   > Details

Selected Publications

Scott JC, Lynch KG, Cenkner DP, Kehle-Forbes SM, Polusny MA, Gur RC, Chen S, Foa EB, & Oslin DW: Neurocognitive Predictors of Treatment Outcomes in Psychotherapy for Comorbid PTSD and Substance Use Disorders. Journal of Consulting and Clinical Psychology 89(11): 937-946, Nov 2021.

Scott JC, Slomiak ST, Jones JD, Rosen AFG, Moore TM, Gur RC: Association of Cannabis with Cognitive Functioning in Adolescents and Young Adults: A Systematic Review and Meta-analysis. JAMA Psychiatry 75(6): 585-595, Jun 2018.

Scott JC, Rosen AFG, Moore TM, Roalf DR, Satterthwaite TD, Calkins ME, Ruparel K, Gur RE, & Gur RC: Cannabis Use in Youth is Associated with Limited Alterations in Brain Structure. Neuropsychopharmacology 44(8): 1362-1369, Jul 2019.

Abdallah CG, Wrocklage KM, Averill CL, Akiki T, Schweinsburg BC, Roy A, Martini B, Southwick SM, Krystal JH, & Scott JC: Anterior Hippocampal Dysconnectivity in Posttraumatic Stress Disorder: A Dimensional and Multimodal Approach. Translational Psychiatry 7(2): e1045, Feb 2017.

Van Pelt AE, Scott JC, Morales KH, Matshaba M, Gur RC, Tshume O, Thuto B, Lowenthal ED, Moore TM: Structural validity of a computerized neurocognitive battery for youth affected by human immunodeficiency virus in Botswana. Psychological Assessment 34(2): 139-146, Feb 2022.

Scott JC, Harb GC, Brownlow J, Greene J, Gur RC, & Ross RJ: Verbal Memory Functioning Moderates Psychotherapy Treatment Response for PTSD-Related Nightmares. Behaviour Research and Therapy 91: 24-32, Apr 2017.

Scott JC, Wolf DH, Calkins ME, Bach EC, Weidner J, Ruparel K, Moore TM, Jones JD, Jackson CT, Gur RE, & Gur RC: Cognitive Functioning in Adolescent and Young Adult Cannabis Users in the Philadelphia Neurodevelopmental Cohort. Psychology of Addictive Behaviors 31(4): 423-434, Jun 2017.

Scott JC, Matt GE, Wrocklage KM, Crnich C, Jordan J, Southwick SM, Krystal JH, Schweinsburg BC: A Quantitative Meta-Analysis of Neurocognitive Functioning in Posttraumatic Stress Disorder. Psychological Bulletin 141(1): 105-40, Jan 2015.

Wrocklage KM, Schweinsburg BC, Krystal JH, Trejo M, Roy A, Weisser V, Moore TM, Southwick SM, Scott JC: Neuropsychological Functioning in Veterans with Posttraumatic Stress Disorder: Associations with Performance Validity, Comorbidities, and Functional Outcomes. Journal of the International Neuropsychological Society 22(4): 399-411, Apr 2016.

Scott JC, Woods SP, Wrocklage KM, Schweinsburg BC, Southwick SM, Krystal JH: Prospective Memory in Posttraumatic Stress Disorder. Journal of the International Neuropsychological Society 22(7): 724-34, Aug 2016.

Scott JC, Moore TM, Stein DJ, Pretorius A, Zingela Z, Nagdee M, Ngqengelele L, King MC, McClellan JM, Port AM, Jackson C, Ruparel K, Susser ES, Gur RC: Adaptation and validation of a computerized neurocognitive battery in the Xhosa of South Africa. Neuropsychology 35(6): 581–594, Sep 2021.

Akiki TJ, Averill CL, Wrocklage KM, Scott JC, Averill LA, Schweinsburg B, Alexander-Bloch A, Martini B, Southwick SM, Krystal JH, & Abdallah CG: Default Mode Network Abnormalities in Posttraumatic Stress Disorder: A Novel Network-Restricted Topology Approach. NeuroImage 176: 489-498, Aug 2018.

Jones JD, Calkins ME, Scott JC, Bach EC, & Gur RE: Cannabis Use, Polysubstance Use, and Psychosis Spectrum Symptoms in a Community-Based Sample of US Youth. Journal of Adolescent Health 60(6): 653-659, Jun 2017.

Scott JC, Woods SP, Vigil O, Heaton RK, Schweinsburg BC, Ellis RJ, Grant I, Marcotte TD: A Neuropsychological Investigation of Multitasking in HIV Infection: Implications for Everyday Functioning. Neuropsychology 25(4): 511-9, Jul 2011.

Wen Z, Hammoud MZ, Scott JC, Jimmy J, Brown L, Marin MF, Asnaani A, Gur RC, Foa EB, Milad MR.: Impact of exogenous estradiol on task-based and resting-state neural signature during and after fear extinction in healthy women. Neuropsychopharmacology 46(13): 2278-2287, Dec 2021.

Moore TM, Butler ER, Cobb Scott J, Port AM, Ruparel K, Njokweni LJ, Gur RE, Gur RC: When CAT is not an Option: Complementary Methods of Test Abbreviation for Neurocognitive Batteries. Cognitive Neuropsychiatry 26(1): 35-54, Jan 2021.

Wrocklage KM, Averill LA, Scott JC, Averill CL, Schweinsburg BC, Trejo M, Roy A, Weisser V, Kelly C, Martini B, Harpaz-Rotem I, Southwick SM, Krystal JH, & Abdallah CG : Cortical Thickness Reduction in Combat Exposed U.S. Veterans With and Without PTSD. European Neuropsychopharmacology 27(5): 515-525, May 2017.

Moore TM, Martin IK, Gur OM, Jackson CT, Scott JC, Calkins ME, Ruparel K, Port AM, Nivar I, Krinsky HD, Gur RE, & Gur RC: Characterizing Social Environment’s Association with Neurocognition Using Census and Crime Data Linked to the Philadelphia Neurodevelopmental Cohort. Psychological Medicine 46: 599-610, Feb 2016.

Scott JC, Woods SP, Carey CL, Weber E, Bondi MW, Grant I: Neurocognitive Consequences of HIV Infection in Older Adults: An Evaluation of the "Cortical" Hypothesis. AIDS and Behavior 15(6): 1187-96, Aug 2011.

Moore TM, Scott JC, Reise SP, Port AM, Jackson CT, Ruparel K, Savitt AP, Gur RE, Gur RC: Development of an Abbreviated Form of the Penn Line Orientation Test Using Large Samples and Computerized Adaptive Test Simulation. Psychological Assessment 27(3): 955-64, Sep 2015.

Scott JC, Pietrzak RH, Southwick SM, Jordan J, Silliker N, Brandt CA, Haskell SG: Military Sexual Trauma Interacts with Combat Exposure to Increase Risk for Posttraumatic Stress Symptomatology in Female Iraq and Afghanistan Veterans. The Journal of Clinical Psychiatry 75(6): 637-43, Jun 2014.

Pietrzak RH, Scott JC, Neumeister A, Lim YY, Ames D, Ellis KA, Harrington K, Lautenschlager NT, Szoeke C, Martins RN, Masters CL, Villemagne VL, Rowe CC, Maruff P; Australian Imaging, Biomarkers and Lifestyle (AIBL) Research Group.: Anxiety Symptoms, Cerebral Amyloid Burden and Memory Decline in Healthy Older Adults Without Dementia: 3-year Prospective Cohort Study. The British Journal of Psychiatry 204: 400-1, May 2014.

Scott JC, Woods SP, Vigil O, Heaton RK, Grant I, Ellis RJ, Marcotte TD: Script Generation of Activities of Daily Living in HIV-Associated Neurocognitive Disorders. Journal of the International Neuropsychological Society 17(4): 740-5, Jul 2011.

Tsai J, Whealin JM, Scott JC, Harpaz-Rotem I, Pietrzak RH: Examining the Relation Between Combat-Related Concussion, a Novel 5-Factor Model of Posttraumatic Stress Symptoms, and Health-Related Quality of Life in Iraq and Afghanistan Veterans. The Journal of Clinical Psychiatry 73(8): 1110-8, Aug 2012.

Scott JC, Pietrzak RH, Mattocks K, Southwick SM, Brandt C, Haskell S: Gender Differences in the Correlates of Hazardous Drinking Among Iraq and Afghanistan Veterans. Drug and Alcohol Dependence 127(1-3): 15-22, Jan 2013.

Morgan EE, Woods SP, Smith C, Weber E, Scott JC, Grant I: Lower Cognitive Reserve Among Individuals with Syndromic HIV-Associated Neurocognitive Disorders (HAND). AIDS and Behavior 16(8): 2279-85, Nov 2012.

Schweinsburg BC, Scott JC, Schweinsburg AD, Jacobus J, Theilmann RJ, Frank LR, Weber E, Grant I, Woods SP: Altered Prefronto-Striato-Parietal Network Response to Mental Rotation in HIV. Journal of Neurovirology 18(1): 74-9, Feb 2012.

Iudicello JE, Woods SP, Vigil O, Scott JC, Cherner M, Heaton RK, Atkinson JH, Grant I: Longer Term Improvement in Neurocognitive Functioning and Affective Distress Among Methamphetamine Users Who Achieve Stable Abstinence. Journal of Clinical and Experimental Neuropsychology 32(7): 704-18, Aug 2010.

Morgan EE, Woods SP, Scott JC, Childers M, Beck JM, Ellis RJ, Grant I, Heaton RK: Predictive Validity of Demographically Adjusted Normative Standards for the HIV Dementia Scale. Journal of Clinical and Experimental Neuropsychology 30(1): 83-90, Jan 2008.

Scott JC, Woods SP, Matt GE, Meyer RA, Heaton RK, Atkinson JH, Grant I: Neurocognitive Effects of Methamphetamine: A Critical Review and Meta-Analysis. Neuropsychology Review 17(3): 275-97, Sep 2007.

Woods SP, Delis DC, Scott JC, Kramer JH, Holdnack JA: The California Verbal Learning Test--Second Edition: Test-Retest Reliability, Practice Effects, and Reliable Change Indices for the Standard and Alternate Forms. Archives of Clinical Neuropsychology 21(5): 413-20, Aug 2006.

Scott JC, Woods SP, Patterson KA, Morgan EE, Heaton RK, Grant I, Marcotte TD: Recency Effects in HIV-Associated Dementia are Characterized by Deficient Encoding. Neuropsychologia 44(8): 1336-43, 2006.

Neylan TC, Jasiukaitis PA, Lenoci M, Scott JC, Metzler TJ, Weiss DS, Schoenfeld FB, Marmar CR: Temporal Instability of Auditory and Visual Event-Related Potentials in Posttraumatic Stress Disorder. Biological Psychiatry 53(3): 216-25, Feb 2003.

Casaletto KB, Umlauf A, Moore DJ, Woods SP, Scott JC, Heaton RK: Abbreviated Goal Management Training Shows Preliminary Evidence as a Neurorehabilitation Tool for HIV-associated Neurocognitive Disorders among Substance Users. The Clinical Neuropsychologist 30: 107-30, Jan 2016.

Kalkstein S, Scott JC, Biester R, Brownlow JA, Harpaz-Rotem I, Gur RC: Comparison of Blast-Exposed OEF/OIF Veterans With and Without a History of TBI Symptoms on a Brief Computerized Neuropsychological Battery. Applied Neuropsychology: Adult Page: 92-97, Feb 2017.

Jones JD, Scott JC, Calkins ME, Ruparel K, Moore TM, Gur RC, & Gur RE: Correspondence Between Adolescent and Informant Reports of Substance Use: Findings from the Philadelphia Neurodevelopment Cohort. Addictive Behaviors 65: 13-18, Sep 2016.

Akiki TJ, Averill CL, Wrocklage KM, Schweinsburg BC, Scott JC, Martini B, Averill LA, Southwick SM, Krystal JH, & Abdallah CG: The Association of PTSD Symptom Severity with Localized Hippocampus and Amygdala Atrophy. Chronic Stress 1: 1-10, Feb 2017.

Gur RE, Moore TM, Rosen AFG, Barzilay R, Roalf DR, Calkins ME, Ruparel K, Scott JC, Almasy L, Satterthwaite TD, Shinohara RT, Gur RC: Burden of Environmental Adversity Affecting Psychopathology, Maturation and Brain-Behavior Parameters in Youth. JAMA Psychiatry 76(9): 966-975, May 2019.

Scott JC, Van Pelt AE, Port AM, Njokweni L, Gur RC, Moore TM, Phoi O, Tshume O, Matshaba M, Ruparel K, Chapman J, & Lowenthal ED: Study Design and Protocol for the Ntemoga Study: Development of a Computerized Neurocognitive Battery for Children and Adolescents with HIV in Botswana. BMJ Open 10(8): e041099, Aug 2020.

Xu A, Larsen B, Henn A, Baller EB, Scott JC, Sharma V, Adebimpe A, Basbaum AI, Corder G, Dworkin RH, Edwards RR, Woolf CJ, Eickhoff SB, Eickhoff CR, & Satterthwaite TD: Brain responses to noxious stimuli in patients with chronic pain: A meta analysis. JAMA Network Open 4(1): e2032236, Jan 2020.

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Last updated: 05/10/2024
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