Luca Busino, Ph.D.

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Associate Professor of Cancer Biology
Department: Cancer Biology

Contact information
421 Curie Blvd
Philadelphia, PA 19104-6160
Lab: 215-746-2569
B.S. (Medical Biotechnology)
Università di Napoli, Federico II, 1999.
M.S. (Medical Biotechnology)
Università di Napoli, Federico II, 2001.
Ph.D. (Experimental Oncology)
European Institute of Oncology, 2008.
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Selected Publications

Busino L, Donzelli M, Chiesa M, Guardavaccaro D, Ganoth D, Dorrello NV, Hershko A, Pagano M, Draetta GF: Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage. Nature 426(6962): 87-91, November 2003.

Busino L, Chiesa M, Draetta GF, Donzelli M: Cdc25A phosphatase: combinatorial phosphorylation, ubiquitylation and proteolysis. Oncogene 23(11): 2050-6, March 2004.

Donzelli M, Busino L, Chiesa M, Ganoth D, Hershko A, Draetta GF: Hierarchical order of phosphorylation events commits Cdc25A to betaTrCP-dependent degradation. Cell Cycle 3(4): 469-71, April 2004.

Busino L, Bassermann F, Maiolica A, Lee C, Nolan PM, Godinho SI, Draetta GF, Pagano M: SCFFbxl3 Controls the Oscillation of the Circadian Clock by Directing the Degradation of Cryptochrome Proteins. Science 316(5826): 900-4, May 2007.

Busino L, Millman SE, Kyratsous C, Scotto L, Basrur V, Hoffmann A, O’Connor O, Elenitoba- Johnson K, Pagano M: SCFFbxw7-mediated degradation of p100 is a pro-survival mechanism in multiple myeloma. Nature Cell Biology 14(4): 375-85, March 2012.

Xing W, Busino L, Hinds TR, Marionni ST, Saifee NH, Bush MF, Pagano M, Zheng N: SCF(FBXL3) ubiquitin ligase targets cryptochromes at their cofactor pocket. Nature 496(7443): 64-8, April 2013.

Choi J, Lee K, Ingvarsdottir K, Bonasio R, Saraf A, Florens L, Washburn MP, Tadros S, Green MR, Busino L: Loss of KLHL6 promotes DLBCL growth and survival via stabilization of the mRNA decay factor Roquin2. Nature Cell Biology 20(5): 586-596, April 2018.

Choi J, Saraf A, Florens L, Washburn MP, Busino L: PTPN14 regulates Roquin2 stability by tyrosine dephosphorylation. Cell Cycle 17(18): 2243–2255, September 2018.

Zhou N, Uzquiza AG, Zheng XY, Vogl D, Garfall AL, Bernabei L, Saraf A, Florens L, Washburn MP, Illendula A, Bushweller JH, Busino L: RUNX proteins desensitize multiple myeloma to lenalidomide via protecting IKZFs from degradation. Leukemia 33(8): 2006-2021, August 2019.

Guillamot M, Ouazia D, Dolgalev I, Kourtis N, Dai Y, Corrigan K, Yeung S, Zea-Redondo L, Saraf A, Florens L, Washburn MP, Tikhonova AN, Gong Y, Tsirigos A, Park C, Barbieri C, Khanna K, Busino L*, Aifantis I* (*co-last and co-corresponding authors): The E3 ubiquitin ligase SPOP controls resolution of systemic inflammation by triggering MyD88 degradation. Nature Immunology 20(9): 1196-1207, September 2019.

Saffie R, Rolland DCM, Onder O, Basrur V, Elenitoba-Johnson KSJ, Capell BC, Busino L: FBXW7 triggers degradation of KMT2D to favor growth of mature B-type malignant cells. Cancer Research 80(12): 2498-2511, June 2020.

Simoneschi D, Rona G, Zhou N, Jeong YT, Jiang S, Milletti G, Arbini AA, O'Sullivan A, Wang AA, Nithikasem S, Keegan S, Siu Y, Cianfanelli V, Maiani E, Nazio F, Cecconi F, Boccalatte F, Fenyö D, Jones DR, Busino L*, Pagano M* (*co-last and co-corresponding authors): CRL4-AMBRA1 is a master regulator of D-type cyclins. Nature 592(7856): 789-793, April 2021.

Zhou N, Choi J, Grothusen G, Kim BJ, Ren D, Cao Z, Liu Y, Li Q, Inamdar A, Beer T, Tang HY, Perkey E, Maillard I, Bonasio R, Shi J, Ruella M, Wan L, Busino L.: DLBCL associated NOTCH2 mutations escape ubiquitin-dependent degradation and promote chemoresistance. Blood 142(11): 973-988, Sep 14 2023.

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Last updated: 10/20/2023
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