Luca Busino, Ph.D.

faculty photo
Assistant Professor of Cancer Biology
Department: Cancer Biology

Contact information
421 Curie Blvd
Philadelphia, PA 19104-6160
Lab: 215-746-2569
B.S. (Medical Biotechnology)
Università di Napoli, Federico II, 1999.
M.S. (Medical Biotechnology)
Università di Napoli, Federico II, 2001.
Ph.D. (Experimental Oncology)
European Institute of Oncology, 2008.
Permanent link
> Perelman School of Medicine   > Faculty   > Details

Selected Publications

Xing W, Busino L, Hinds TR, Marionni ST, Saifee NH, Bush MF, Pagano M, Zheng N: SCF(FBXL3) ubiquitin ligase targets cryptochromes at their cofactor pocket. Nature 496(7443): 64-8, April 2013.

Busino L, Millman SE, Pagano M: SCF-mediated degradation of p100 (NF-κB2): mechanisms and relevance in multiple myeloma. Science Signaling 5(253): pt14, December 2012.

Busino L, Millman SE, Kyratsous C, Scotto L, Basrur V, Hoffmann A, O’Connor O, Elenitoba- Johnson K, Pagano M: SCFFbxw7-mediated degradation of p100 is a pro-survival mechanism in multiple myeloma. Nature Cell Biology 14(4): 375-85, March 2012.

Cotto-Rios XM, Jones MJK, Busino L, Pagano M, Huang TT: APC/CCdh1-dependent proteolysis of USP1 regulates the response to UV mediated DNA damage. The Journal of Cell Biology 194(2), July 2011.

Bashir T, Pagan JK, Busino L, Pagano M: Phosphorylation of Ser72 is dispensable for Skp2 assembly into an active SCF ubiquitin ligase and its subcellular localization. Cell Cycle 9(5): 971-4, March 2011.

Mateo F, Vidal-Laliena M, Canela N, Busino L, Martinez-Balbas MA, Pagano M, Agell N, Bachs O: Degradation of cyclin A is regulated by acetylation. Oncogene 28(29): 2654-66, July 2009.

Bassermann F, Frescas D, Guardavaccaro D, Busino L, Peschiaroli A, Pagano M: Cdc14BCdh1-Plk1 axis controls the G2 DNA damage response checkpoint. Cell 134(2): 256-67, July 2008.

Godinho SI, Maywood ES, Shaw L, Tucci V, Barnard AR, Busino L, Pagano M, Kendall R, Quwailid MM, Romero MR, O'neill J, Chesham JE, Brooker D, Lalanne Z, Hastings MH, Nolan PM: The after-hours mutant reveals a role for Fbxl3 in determining mammalian circadian period. Science 316(5826): 897-900, May 2007.

Busino L, Bassermann F, Maiolica A, Lee C, Nolan PM, Godinho SI, Draetta GF, Pagano M: SCFFbxl3 Controls the Oscillation of the Circadian Clock by Directing the Degradation of Cryptochrome Proteins. Science 316(5826): 900-4, May 2007.

Donzelli M, Busino L, Chiesa M, Ganoth D, Hershko A, Draetta GF: Hierarchical order of phosphorylation events commits Cdc25A to betaTrCP-dependent degradation. Cell Cycle 3(4): 469-71, April 2004.

back to top
Last updated: 05/01/2017
The Trustees of the University of Pennsylvania