Benjamin L. Prosser, Ph.D
Associate Professor of Physiology
Associate Director, Pennsylvania Muscle Institute (PMI), Perelman School of Medicine
Director, Center for Epilepsy and NeuroDevelopment Disorders (ENDD)
Department: Physiology
Graduate Group Affiliations
Contact information
Clinical Research Building Rm 779
415 Curie Blvd.
Philadelphia, PA 19104
415 Curie Blvd.
Philadelphia, PA 19104
Office: 215-746-1488
Email:
bpros@mail.med.upenn.edu
bpros@mail.med.upenn.edu
Publications
Links
Search PubMed for articles
Prosser lab website
Center for Epilepsy and NeuroDevelopmental Disorders
Search PubMed for articles
Prosser lab website
Center for Epilepsy and NeuroDevelopmental Disorders
Education:
BS (Health and Exercise Science)
Wake Forest University, 2005.
Ph.D (Molecular Medicine)
University of Maryland School of Medicine, 2009.
Permanent linkBS (Health and Exercise Science)
Wake Forest University, 2005.
Ph.D (Molecular Medicine)
University of Maryland School of Medicine, 2009.
Description of Research Expertise
physiologymuscle biology
neurodevelopmental disorders
antisense oligonucleotides
heart failure
cytoskeleton
microtubules
RNA biology
Selected Publications
McKee JL, Magielski JH, Xian J, Cohen S, Toib J, Harrison A, Chen C, Kim D, Rathod A, Brimble E, Fitter N, Graglia JM, Helde KA, McKeown Ruggiero S, Boland MJ, Prosser BL, Sederman R, Helbig I.: Clinical signatures of SYNGAP1-related disorders through data integration. Genet Med.(101419), Mar 2025 Notes: doi: 10.1016/j.gim.2025.101419.Latchman NR, Stevens TL, Bedi KC, Prosser BL, Margulies KB, Elrod JW.: Ultrastructure analysis of mitochondria, lipid droplet and sarcoplasmic reticulum apposition in human heart failure. bioRxiv Jan 2025.
Pavlov DA, Heffler J, Suay-Corredera C, Dehghany M, Shen KM, Zuela-Sopilniak N, Randell R, Uchida K, Jain R, Shenoy V, Lammerding J, Prosser B.: Microtubule forces drive nuclear damage in LMNA cardiomyopathy. bioRxiv Oct 2024.
Pietsch N, Chen CY, Kupsch S, Bacmeister L, Geertz B, Herrera-Rivero M, Siebels B, Voß H, Krämer E, Braren I, Westermann D, Schlüter H, Mearini G, Schlossarek S, van der Velden J, Caporizzo M, Lindner D, Prosser BL, Carrier L.: Chronic Activation of Tubulin Tyrosination Improves Heart Function. Circ Res. 135(9), Sep 2024.
Felix AJ, Wilson T, Randell R, Marotta N, Uchida K, Boland MJ, Davidson BL, Prosser BL. : Generation of humanized mouse models to support therapeutic development for SYNGAP1 and STXBP1 disorders. bioRxiv Aug 2024.
Eaton DM, Lee BW, Caporizzo MA, Iyengar A, Chen CY, Uchida K, Marcellin G, Lannay Y, Vite A, Bedi KC Jr, Brady CF, Smolyak JN, Meldrum D, Dominic J, Weingarten N, Patel M, Belec A, Hached K, Atluri P, Van Der Laan S, Prosser BL*, Margulies KB*. *co-corresponding authors: Vasohibin inhibition improves myocardial relaxation in a rat model of heart failure with preserved ejection fraction. Sci Transl Med 16(756), Jul 2024.
Goss JR, Prosser BL, Helbig I, Son Rigby C.: STXBP1: fast-forward to a brighter future – a patient organization perspective. Ther Adv Rare Dis. 18(5), June 2024.
Aiste Liutkute, Benjamin L Prosser, Niels Voigt.: Microtubules: highway to … arrhythmia? Cardiovascular Research 120(7): 671-672, May 2024.
Yan G, Han Z, Kwon Y, Jousma J, Nukala SB, Prosser BL, Du X, Pinho S, Ong SB, Lee WH, Ong SG.: Integrated Stress Response Potentiates Ponatinib-Induced Cardiotoxicity. Circ Res. 134(5): 482-501, Mar 2024.
Thalwitzer KM, Xian J, deCampo D, Parthasarathy S, Magielski J, Sullivan KR, Goss J, Rigby CS, Boland M, Prosser B, Ruggiero SM, Syrbe S, Helbig I.: Early life seizures and epileptic spasms in STXBP1 -related disorders. Epilepsia 65(3), Mar 2024.