Benjamin L. Prosser, Ph.D

faculty photo
Assistant Professor of Physiology
Department: Physiology

Contact information
Clinical Research Building Rm 726
415 Curie Blvd.
Philadelphia, PA 19104
Office: 215-746-1488
Education:
BS (Health and Exercise Science)
Wake Forest University, 2005.
Ph.D (Molecular Medicine)
University of Maryland School of Medicine, 2009.
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Description of Research Expertise

myocyte biology
mechanobiology
heart failure
cytoskeleton
microtubules
excitation-contraction coupling

Selected Publications

Chen Christina Yingxian, Salomon Alexander K, Caporizzo Matthew Alexander, Curry Sam, Kelly Neil A, Bedi Kenneth C, Bogush Alexey I, Krämer Elisabeth, Schlossarek Saskia, Janiak Philip, Moutin Marie-Jo, Carrier Lucie, Margulies Kenneth B, Prosser Benjamin L: Depletion of Vasohibin 1 Speeds Contraction and Relaxation in Failing Human Cardiomyocytes. Circulation research Apr 2020.

Caporizzo Matthew A, Chen Christina Yingxian, Bedi Ken, Margulies Kenneth B, Prosser Benjamin L: Microtubules Increase Diastolic Stiffness in Failing Human Cardiomyocytes and Myocardium. Circulation 141(11): 902-915, Jan 2020.

Heffler Julie, Shah Parisha P, Robison Patrick, Phyo Sai, Veliz Kimberly, Uchida Keita, Bogush Alexey, Rhoades Joshua, Jain Rajan, Prosser Benjamin L: A Balance Between Intermediate Filaments and Microtubules Maintains Nuclear Architecture in the Cardiomyocyte. Circulation research 126(3): e10-e26, Jan 2020.

Caporizzo MA, Chen CY, Prosser BL: Cardiac microtubules in health and heart disease. Experimental Biology and Medicine August 2019.

Cho S, Vashisth M, Abbas A, Majkut S, Vogel K, Xia Y, Ivanovska IL, Irianto J, Tewari M, Zhu K, Tichy ED, Mourkioti F, Tang HY, Greenberg RA, Prosser BL, Discher DE.: Mechanosensing by the lamina protects against nuclear rupture, DNA damage, and cell-cycle arrest. Developmental Cell 49(6): 920-935, June 2019.

Caporizzo Matthew Alexander, Chen Christina Yingxian, Salomon Alexander Koizumi, Margulies Kenneth B, Prosser Benjamin L: Microtubules Provide a Viscoelastic Resistance to Myocyte Motion. Biophysical journal Sep 2018.

Chen Christina Yingxian, Caporizzo Matthew A, Bedi Kenneth, Vite Alexia, Bogush Alexey I, Robison Patrick, Heffler Julie G, Salomon Alex K, Kelly Neil A, Babu Apoorva, Morley Michael P, Margulies Kenneth B, Prosser Benjamin L: Suppression of detyrosinated microtubules improves cardiomyocyte function in human heart failure. Nature medicine 24(8): 1225-1233, Aug 2018.

Nemani Neeharika, Carvalho Edmund, Tomar Dhanendra, Dong Zhiwei, Ketschek Andrea, Breves Sarah L, Jaña Fabián, Worth Alison M, Heffler Julie, Palaniappan Palaniappan, Tripathi Aparna, Subbiah Ramasamy, Riitano Massimo F, Seelam Ajay, Manfred Thomas, Itoh Kie, Meng Shuxia, Sesaki Hiromi, Craigen William J, Rajan Sudarsan, Shanmughapriya Santhanam, Caplan Jeffrey, Prosser Benjamin L, Gill Donald L, Stathopulos Peter B, Gallo Gianluca, Chan David C, Mishra Prashant, Madesh Muniswamy: MIRO-1 Determines Mitochondrial Shape Transition upon GPCR Activation and Ca Stress. Cell reports 23(4): 1005-1019, Apr 2018.

Hu Li-Yen R, Ackermann Maegen A, Hecker Peter A, Prosser Benjamin L, King Brendan, O'Connell Kelly A, Grogan Alyssa, Meyer Logan C, Berndsen Christopher E, Wright Nathan T, Jonathan Lederer W, Kontrogianni-Konstantopoulos Aikaterini: Deregulated Ca(2+) cycling underlies the development of arrhythmia and heart disease due to mutant obscurin. Science advances 3(6): e1603081, Jun 2017.

Robison P, Prosser BL: Microtubule mechanics in the working myocyte. Journal of Physiology Epub, Jan 2017.

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Last updated: 10/27/2020
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