Benjamin L. Prosser, Ph.D

faculty photo
Assistant Professor of Physiology
Department: Physiology

Contact information
Clinical Research Building Rm 726
415 Curie Blvd.
Philadelphia, PA 19104
Office: 215-746-1488
Education:
BS (Health and Exercise Science)
Wake Forest University, 2005.
Ph.D (Molecular Medicine)
University of Maryland School of Medicine, 2009.
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Description of Research Expertise

cardiac electrophysiology
excitation-contraction coupling
calcium signaling
mechanotransduction
redox signaling

Selected Publications

Caporizzo MA, Chen CY, Prosser BL: Cardiac microtubules in health and heart disease. Experimental Biology and Medicine August 2019.

Cho S, Vashisth M, Abbas A, Majkut S, Vogel K, Xia Y, Ivanovska IL, Irianto J, Tewari M, Zhu K, Tichy ED, Mourkioti F, Tang HY, Greenberg RA, Prosser BL, Discher DE.: Mechanosensing by the lamina protects against nuclear rupture, DNA damage, and cell-cycle arrest. Developmental Cell 49(6): 920-935, June 2019.

Caporizzo Matthew Alexander, Chen Christina Yingxian, Salomon Alexander Koizumi, Margulies Kenneth B, Prosser Benjamin L: Microtubules Provide a Viscoelastic Resistance to Myocyte Motion. Biophysical journal Sep 2018.

Chen Christina Yingxian, Caporizzo Matthew A, Bedi Kenneth, Vite Alexia, Bogush Alexey I, Robison Patrick, Heffler Julie G, Salomon Alex K, Kelly Neil A, Babu Apoorva, Morley Michael P, Margulies Kenneth B, Prosser Benjamin L: Suppression of detyrosinated microtubules improves cardiomyocyte function in human heart failure. Nature medicine 24(8): 1225-1233, Aug 2018.

Nemani Neeharika, Carvalho Edmund, Tomar Dhanendra, Dong Zhiwei, Ketschek Andrea, Breves Sarah L, Jaña Fabián, Worth Alison M, Heffler Julie, Palaniappan Palaniappan, Tripathi Aparna, Subbiah Ramasamy, Riitano Massimo F, Seelam Ajay, Manfred Thomas, Itoh Kie, Meng Shuxia, Sesaki Hiromi, Craigen William J, Rajan Sudarsan, Shanmughapriya Santhanam, Caplan Jeffrey, Prosser Benjamin L, Gill Donald L, Stathopulos Peter B, Gallo Gianluca, Chan David C, Mishra Prashant, Madesh Muniswamy: MIRO-1 Determines Mitochondrial Shape Transition upon GPCR Activation and Ca Stress. Cell reports 23(4): 1005-1019, Apr 2018.

Hu Li-Yen R, Ackermann Maegen A, Hecker Peter A, Prosser Benjamin L, King Brendan, O'Connell Kelly A, Grogan Alyssa, Meyer Logan C, Berndsen Christopher E, Wright Nathan T, Jonathan Lederer W, Kontrogianni-Konstantopoulos Aikaterini: Deregulated Ca(2+) cycling underlies the development of arrhythmia and heart disease due to mutant obscurin. Science advances 3(6): e1603081, Jun 2017.

Robison P, Prosser BL: Microtubule mechanics in the working myocyte. Journal of Physiology Epub, Jan 2017.

Chiou Kevin K, Rocks Jason W, Chen Christina Yingxian, Cho Sangkyun, Merkus Koen E, Rajaratnam Anjali, Robison Patrick, Tewari Manorama, Vogel Kenneth, Majkut Stephanie F, Prosser Benjamin L, Discher Dennis E, Liu Andrea J: Mechanical signaling coordinates the embryonic heartbeat. Proceedings of the National Academy of Sciences of the United States of America 113(32): 8939-44, Aug 2016.

Robison Patrick, Caporizzo Matthew A, Ahmadzadeh Hossein, Bogush Alexey I, Chen Christina Yingxian, Margulies Kenneth B, Shenoy Vivek B, Prosser Benjamin L: Detyrosinated microtubules buckle and bear load in contracting cardiomyocytes. Science (New York, N.Y.) 352(6284): aaf0659, Apr 2016.

Saritu Limbu, Tuan M Honag-Trong, Benjamin L Prosser, W Jonathan Lederer, and M Saleet Jafri: Modeling Local X-ROS and Calcium Signaling in the Heart. Biophysical Journal 109(10): 2037-2050, November 2015.

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Last updated: 11/01/2019
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