Benjamin L. Prosser, Ph.D
Associate Professor of Physiology
Associate Director, Pennsylvania Muscle Institute (PMI), Perelman School of Medicine
Department: Physiology
Graduate Group Affiliations
Contact information
Clinical Research Building Rm 726
415 Curie Blvd.
Philadelphia, PA 19104
415 Curie Blvd.
Philadelphia, PA 19104
Office: 215-746-1488
Email:
bpros@mail.med.upenn.edu
bpros@mail.med.upenn.edu
Publications
Education:
BS (Health and Exercise Science)
Wake Forest University, 2005.
Ph.D (Molecular Medicine)
University of Maryland School of Medicine, 2009.
Permanent linkBS (Health and Exercise Science)
Wake Forest University, 2005.
Ph.D (Molecular Medicine)
University of Maryland School of Medicine, 2009.
Description of Research Expertise
myocyte biologymechanobiology
heart failure
cytoskeleton
microtubules
excitation-contraction coupling
Selected Publications
Scarborough EA, Uchida K, Vogel M, Erlitzki N, Iyer M, Phyo SA, Bogush A, Kehat I, Prosser BL.: Microtubules orchestrate local translation to enable cardiac growth. Nat Commun 12: 1547, Mar 2021.Margulies KB, Prosser BL.: Tubulin Detyrosination: An Emerging Therapeutic Target in Hypertrophic Cardiomyopathy. Circ Heart Fail 14: e008006, Jan 2021.
Shah PP, Lv W, Rhoades JH, Poleshko A, Abbey D, Caporizzo MA, Linares-Saldana R, Heffler JG, Sayed N, Thomas D, Wang Q, Stanton LJ, Bedi K, Morley MP, Cappola TP, Owens AT, Margulies KB, Frank DB, Wu JC, Rader DJ, Yang W, Prosser BL, Musunuru K, Jain R.: Pathogenic LMNA variants disrupt cardiac lamina-chromatin interactions and de-repress alternative fate genes. Cell Stem Cell ell Stem Cell, 2021.
Chen Christina Yingxian, Salomon Alexander K, Caporizzo Matthew Alexander, Curry Sam, Kelly Neil A, Bedi Kenneth C, Bogush Alexey I, Krämer Elisabeth, Schlossarek Saskia, Janiak Philip, Moutin Marie-Jo, Carrier Lucie, Margulies Kenneth B, Prosser Benjamin L: Depletion of Vasohibin 1 Speeds Contraction and Relaxation in Failing Human Cardiomyocytes. Circulation research Apr 2020.
Caporizzo Matthew A, Chen Christina Yingxian, Bedi Ken, Margulies Kenneth B, Prosser Benjamin L: Microtubules Increase Diastolic Stiffness in Failing Human Cardiomyocytes and Myocardium. Circulation 141(11): 902-915, Jan 2020.
Heffler Julie, Shah Parisha P, Robison Patrick, Phyo Sai, Veliz Kimberly, Uchida Keita, Bogush Alexey, Rhoades Joshua, Jain Rajan, Prosser Benjamin L: A Balance Between Intermediate Filaments and Microtubules Maintains Nuclear Architecture in the Cardiomyocyte. Circulation research 126(3): e10-e26, Jan 2020.
Caporizzo MA, Chen CY, Prosser BL: Cardiac microtubules in health and heart disease. Experimental Biology and Medicine August 2019.
Cho S, Vashisth M, Abbas A, Majkut S, Vogel K, Xia Y, Ivanovska IL, Irianto J, Tewari M, Zhu K, Tichy ED, Mourkioti F, Tang HY, Greenberg RA, Prosser BL, Discher DE.: Mechanosensing by the lamina protects against nuclear rupture, DNA damage, and cell-cycle arrest. Developmental Cell 49(6): 920-935, June 2019.
Caporizzo Matthew Alexander, Chen Christina Yingxian, Salomon Alexander Koizumi, Margulies Kenneth B, Prosser Benjamin L: Microtubules Provide a Viscoelastic Resistance to Myocyte Motion. Biophysical journal Sep 2018.
Chen Christina Yingxian, Caporizzo Matthew A, Bedi Kenneth, Vite Alexia, Bogush Alexey I, Robison Patrick, Heffler Julie G, Salomon Alex K, Kelly Neil A, Babu Apoorva, Morley Michael P, Margulies Kenneth B, Prosser Benjamin L: Suppression of detyrosinated microtubules improves cardiomyocyte function in human heart failure. Nature medicine 24(8): 1225-1233, Aug 2018.