Ming-Lin Liu, MD, PhD

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Research Assistant Professor of Dermatology
Department: Dermatology

Contact information
Department of Dermatology
University of Pennsylvania Health System
Perelman School of Medicine
University of Pennsylvania
2 East. Gates Building, #2021
3600 Spruce Street
Philadelphia, PA 19104
Education:
MD
Tianjin Medical University, 1986.
PhD
University of Helsinki, 2003.
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Description of Research Expertise

1) Cell Death, Inflammation, Innate Immunity

2) Extracellular Vesicles, Extracellular Traps, and Innate Immune Responses

3) Extracellular Vesicles, Extracellular Traps, and Their Pathological Involvement in Human Diseases (i.e. Autoimmune, Cardiovascular and Metabolic Diseases)

4) UVB Exposure, and Its Involvement in Skin Inflammation and Autoimmune Diseases (i.e. lupus, dermatomyositis, etc).

Selected Publications

Li MH, Lyu X, Liao J, Werth VP, Liu ML: Rho Kinase regulates neutrophil NET formation that is involved in UVB-induced skin inflammation (doi: 10.7150/thno.66457). Theranostics 12(5): 2133-2149, Feburary 2022.

Li YB, Li MH, Weigel B, Mall M, Werth VP, Liu ML: Nuclear envelope rupture and NET formation is driven by PKCα-mediated lamin B disassembly (doi: 10.15252/embr.201948779). EMBO reports 21(8): e48779, June 2020

Zhao Y, Wei W*, Liu ML*: Extracellular Vesicles and Lupus Nephritis - New insights into pathophysiology and clinical implications (doi: 10.1016/j.jaut.2020.102540). Journal of Autoimmunity. Elsevier, 113, September 4 2020 (*Co-corresponding Authors).

Ming-Lin Liu: Functional actin cytoskeleton is required in early stage of NETosis induction. (Letter-to-the-editor). Proc. Natl. Acad. Sci. U.S.A. 117(37): 22653-22654, September 2020.

Luan J, Chen W, Fan J, Wang S, Zhang X, Zai W, Jin X, Wang Y, Feng Z, Zhang J, Liu ML*, Ju D*.: GSDMD membrane pore is critical for IL-1β release and antagonizing IL-1β by hepatocyte-specific nanobiologics is a promising therapeutics for murine alcoholic steatohepatitis. Biomaterials 227(119570), January 2020 (* Co-corresponding Authors)

Wu X, Liu Y, Wei W*, Liu ML* : Extracellular Vesicles in Autoimmune Vasculitis - Little dirts light the fire in blood vessels. Autoimmunity Reviews 18(6): 593-606, June 2019 (* Co-corresponding Authors).

ML Liu*, KJ Williams, VP Werth: Microvesicles in Autoimmune Diseases. Advances in Clinical Chemistry 77: 125-175 Jul 2016 (* Corresponding Author).

Liu ML*, Scalia R, Mehta JL, Williams KJ*: Cholesterol-induced membrane microvesicles as novel carriers of damage-associated molecular patterns: mechanisms of formation, action, and detoxification. Arteriosclerosis, Thrombosis, and Vascular Biology. 32(9): 2113-21, Sep 2012 (* Co-corresponding Authors) Notes:

Chen K, Liu ML, Schaffer L, Li MZ, Williams KJ: Type 2 diabetes in mice induces hepatic overexpression of sulfatase 2, a novel factor that suppresses uptake of remnant lipoproteins. Hepatology. 52: 1957-1967, 2010.

Liu ML*, Reilly MP, Peter Casasanto, McKenzie SE, Williams KJ*.: Cholesterol Enrichment of Human Monocyte/Macrophages Induces Surface Exposure of Phosphatidylserine and the Release of Biologically-Active Tissue Factor-Positive Microvesicles. Arteriosclerosis, Thrombosis, and Vascular Biology. 27(2): 430-5, 2007 (* Co-corresponding Authors).

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Last updated: 02/07/2022
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