Ming-Lin Liu, MBBS, PhD
Research Associate Professor of Dermatology
Department: Dermatology
Contact information
Department of Dermatology
University of Pennsylvania Health System
Perelman School of Medicine
University of Pennsylvania
2 East. Gates Building, #2021
3600 Spruce Street
Philadelphia, PA 19104
University of Pennsylvania Health System
Perelman School of Medicine
University of Pennsylvania
2 East. Gates Building, #2021
3600 Spruce Street
Philadelphia, PA 19104
Email:
lium1@pennmedicine.upenn.edu
lium1@pennmedicine.upenn.edu
Publications
Education:
MBBS
Tianjin Medical University, 1986.
PhD
University of Helsinki, 2003.
Permanent linkMBBS
Tianjin Medical University, 1986.
PhD
University of Helsinki, 2003.
Description of Research Expertise
1) Expertise in the function of Extracellular Vesicles (EVs) and Neutrophil Extracellular Traps (NETs) as critical mediators of cell-to-cell communication and inflammation in health and disease.2) Mechanistic studies on programmed cell death (e.g., NETosis), regulation of EV generation and NET formation, and their roles in innate immunity and autoimmunity.
3) Pathogenesis of autoimmune diseases, including SLE, Dermatomyositis, and Vasculitis, as mediated by EVs and NETs, with their modulation by UV light and tobacco smoking.
4) Studies on the role of EVs in cardiometabolic and vascular pathology, and how tobacco smoking modulates EV release and function to drive the disease progression.
Selected Publications
Zhao Y, Lyu X, Wu X, Liu Y, Zhang N, Wei W*, Liu ML*: Novel Perspectives on Extracellular Vesicles in Autoimmune Diseases: Immunogenicity, Inflammation, and Immune Surveillance. Journal of Clinical Investigation 136(3), Feb 2026 Accepted (*Co-Corresponding authors).Singh J, Boettcher M, Dolling M, Jeuer A, Hohberger B, Leppkes M, Naschberger E, Schapher M, Schauer C, Schoen J, Sturzl M, Vitkov L, Wang H, Zlatar L, Schett GA, Pisetsky DS*, Liu ML*, Herrmann M*, Knopf J*.: Moonlighting chromatin: when DNA escapes nuclear control. Cell Death Differ. 30: 861-875, February 2023 (*Co-senior authors). Notes: doi: 10.1038/s41418-023-01124-1
Li MH, Lyu X, Liao J, Werth VP, Liu ML*: Rho Kinase regulates neutrophil NET formation that is involved in UVB-induced skin inflammation (doi: 10.7150/thno.66457). Theranostics. 12(5): 2133, Feburary 2022.
Li YB, Li MH, Weigel B, Mall M, Werth VP, Liu ML*: Nuclear envelope rupture and NET formation is driven by PKCα-mediated lamin B disassembly (doi: 10.15252/embr.201948779). EMBO Reports 21(8): e48779, June 2020 (*Corresponding Author)
Zhao Y, Wei W*, Liu ML*: Extracellular Vesicles and Lupus Nephritis - New insights into pathophysiology and clinical implications (doi: 10.1016/j.jaut.2020.102540). Journal of Autoimmunity. Elsevier, 113, September 2020 (*Co-corresponding Authors).
Liu ML*: Functional actin cytoskeleton is required in early stage of NETosis induction. (Letter-to-the-editor). Proc. Natl. Acad. Sci. U.S.A. 117(37): 22653-22654, September 2020 (*Corresponding Author)
Luan J, Chen W, Fan J, Wang S, Zhang X, Zai W, Jin X, Wang Y, Feng Z, Zhang J, Liu ML*, Ju D*.: GSDMD membrane pore is critical for IL-1β release and antagonizing IL-1β by hepatocyte-specific nanobiologics is a promising therapeutics for murine alcoholic steatohepatitis. Biomaterials 227(119570), January 2020 (* Co-corresponding Authors)
Wu X, Liu Y, Wei W*, Liu ML* : Extracellular Vesicles in Autoimmune Vasculitis - Little dirts light the fire in blood vessels. Autoimmunity Reviews 18(6): 593-606, June 2019 (* Co-corresponding Authors).
ML Liu*, KJ Williams, VP Werth: Microvesicles in Autoimmune Diseases. (Invited Review Article). Advances in Clinical Chemistry 77: 125-175 Jul 2016 (* Corresponding Author).
Liu ML*, Reilly MP, Peter Casasanto, McKenzie SE, Williams KJ*.: Cholesterol Enrichment of Human Monocyte/Macrophages Induces Surface Exposure of Phosphatidylserine and the Release of Biologically-Active Tissue Factor-Positive Microvesicles. Arteriosclerosis, Thrombosis, and Vascular Biology. 27(2): 430-5, 2007 (* Co-corresponding Authors).