Zoltan Pierre Arany, MD, PhD

faculty photo
Samuel Bellet Professor of Cardiology
Department: Medicine
Graduate Group Affiliations

Contact information
Perelman School of Medicine
University of Pennsylvania
11th floor Smilow Translational Research Center
34th and Civic Center Blvd
Philadelphia, PA 19014
Office: 215-898-3482
BA (Biochemical Sciences (Summa Cum Laude)
Harvard College, 1989.
PhD (Biological and Biomedical Sciences )
Harvard Graduate School, 1995.
MD (Medicine)
Harvard Medical School, 1998.
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Description of Research Expertise

The Arany lab focuses on cardiovascular metabolism. Such unfocused focus has led us to study a wide range of projects in the heart, liver, fat, and many other tissues, and has led us to use all techniques we can get out hands on, including human genetics, genetically engineered mouse models, cell culture, metabolomics, in vivo isotope metabolic tracing, and many more. In essence, the lab aims to ask fundamental questions within the (wide) space of cardiovascular metabolism, and leverages all available state-of-the-art approaches to do so.

For more details see www.med.upenn.edu/aranylab/

Selected Publications

Murashige D, Jang C, Neinast M, Edwards JJ, Cowan A, Hyman MC, Rabinowitz JD, Frankel DS, Arany Z.: Comprehensive quantification of fuel use by the failing and nonfailing human heart. Science 370: 364-368, Oct 2020.

Ibrahim A, Yucel N, Kim B, Arany Z: Local Mitochondrial ATP Production Regulates Endothelial Fatty Acid Uptake and Transport. Cell Metabolism 4(32): 309-319, Aug 2020.

Hoshino Atsushi, Wang Wei-Jia, Wada Shogo, McDermott-Roe Chris, Evans Chantell S, Gosis Bridget, Morley Michael P, Rathi Komal S, Li Jian, Li Kristina, Yang Steven, McManus Meagan J, Bowman Caitlyn, Potluri Prasanth, Levin Michael, Damrauer Scott, Wallace Douglas C, Holzbaur Erika L F, Arany Zoltan: The ADP/ATP translocase drives mitophagy independent of nucleotide exchange. Nature 575(7782): 375-379, Nov 2019.

Neinast Michael D, Jang Cholsoon, Hui Sheng, Murashige Danielle S, Chu Qingwei, Morscher Raphael J, Li Xiaoxuan, Zhan Le, White Eileen, Anthony Tracy G, Rabinowitz Joshua D, Arany Zoltan: Quantitative Analysis of the Whole-Body Metabolic Fate of Branched-Chain Amino Acids. Cell metabolism 29(2): 417-429.e4, Nov 2018.

Das Abhirup, Huang George X, Bonkowski Michael S, Longchamp Alban, Li Catherine, Schultz Michael B, Kim Lynn-Jee, Osborne Brenna, Joshi Sanket, Lu Yuancheng, TreviƱo-Villarreal Jose Humberto, Kang Myung-Jin, Hung Tzong-Tyng, Lee Brendan, Williams Eric O, Igarashi Masaki, Mitchell James R, Wu Lindsay E, Turner Nigel, Arany Zolt, Guarente Leonard, Sinclair David A: Impairment of an Endothelial NAD-HS Signaling Network Is a Reversible Cause of Vascular Aging. Cell 173(1): 74-89.e20, Mar 2018.

Kim Boa, Jang Cholsoon, Dharaneeswaran Harita, Li Jian, Bhide Mohit, Yang Steven, Li Kristina, Arany Zolt: Endothelial pyruvate kinase M2 maintains vascular integrity. The Journal of clinical investigation 128(10): 4543-4556, Oct 2018.

Ware JS, Li J, Mazaika E, Yasso CM, DeSouza T, Cappola TP, Tsai EJ, Hilfiker-Kleiner D, Kamiya CA, Mazzarotto F, Cook SA, Halder I, Prasad SK, Pisarcik J, Hanley-Yanez K, Alharethi R, Damp J, Hsich E, Elkayam U, Sheppard R, Kealey A, Alexis J, Ramani G, Safirstein J, Boehmer J, Pauly DF, Wittstein IS, Thohan V, Zucker MJ, Liu P, Gorcsan J, McNamara DM, Seidman CE, Seidman JG, Arany Z: Shared Genetic Predisposition in Peripartum and Dilated Cardiomyopathies. The New England journal of medicine 374(3): 233-41, Jan 2016.

Jang C, Oh SF, Wada S, Rowe GC, Liu L, Chan MC, Rhee J, Hoshino A, Kim B, Ibrahim A, Baca LG, Kim E, Ghosh CC, Parikh SM, Jiang A, Chu Q, Forman DE, Lecker SH, Krishnaiah S, Rabinowitz JD, Weljie AM, Baur JA, Kasper DL, Arany Z: A branched-chain amino acid metabolite drives vascular fatty acid transport and causes insulin resistance. Nature medicine 22(4): 421-6, Apr 2016.

Patten IS, Rana S, Shahul S, Rowe GC, Jang C, Liu L, Hacker MR, Rhee JS, Mitchell J, Mahmood , Hess P, Farrell C, Koulisis N , Khankin EV, Burke SD, Tudorache I, Bauersachs J, del Monte F, Hilfiker-Kleiner D, Karumanchi SA, Arany Z: Cardiac angiogenic imbalance leads to peripartum cardiomyopathy. Nature 485(7398): 333-8, May 2012.

Arany Z, Foo S-Y, Ma Y, Ruas JL, Bommi-Reddy A, Girnun G, Cooper M, Laznik D, Chinsomboon J, Rangwala SM, Baek KH, Rosenzweig A, Spiegelman BM: HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1alpha. Nature 451(7181): 1008-12, Feb 2008 Notes: editorials in NEJM, Dev. Cell, and Science STK.

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Last updated: 08/11/2021
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