Selected Publications

Cristina Remes1, Neal D. Mathew1, Victoria Miranda1, Suraiya Haroon1,2, Tyler O’Hara1, Vernon E. Anderson1, Manuela Lavorato1,2, Kelsey Keith3, Rui Xiao4, Eiko Nakamaru-Ogiso1,2, Marni J. Falk1,2*: Dichloroacetate improves animal survival, growth, neuromuscular activity, mitochondrial stress and physiology, and increased lactate in C. elegans pdha-1 and dld-1 models of pyruvate dehydrogenase complex deficiency (PDCD). JIMD accepted 2026.

Sarah J Shemtov 1, Eric McGann 1, Lucy Carrillo 1, Sangmin Lee 1, Herbert Anson 1, Claire S Chung 1, Maria-Eleni Anagnostou 1, Guan-Ju D Lai 2, Bert M Verheijen 3, Junxiang Wan 1, Ivetta Vorobyova 1 2 3 4 5 6 7, Monica Sanchez-Contreras 4, Cheryl A Conover 5, Max A Thorwald 1, Pinchas Cohen 1, Scott R Kennedy 4, Jean-François Gout 6, Suraiya Haroon 7, Marc Vermulst 1: The longevity effects of reduced IGF-1 signaling depend on the stability of the mitochondrial genome. Science Advance accepted 2026.

Mendel R1, Cheng Y1, Tara Z1, Schrope S1, Keith K3, Matsuno S1, O’Hara TO1, Mathew N1, Nakamaru-Ogiso E1, Falk MJ1,2, and Haroon S1,2: Identification of FDA-Approved Compounds That Rescue Mitochondrial Stress in a Heteroplasmic Single LargeScale mtDNA Deletion (SLSMD) C. Elegans Animal Model UMDF June 2025.

Melis Kose1, Suraiya Haroon1,2, Elizabeth McCormick1, Eiko Nakamaru-Ogiso1,2, Marni J. Falk1,2: Cockayne Syndrome Human Cell and C. elegans Models Exhibit Pronounced Mitochondrial Dysfunction, Oxidative Stress Sensitivity, and Developmental Defects Rescued by Antioxidant Therapies. UMDF June 2025.

O’Hara TG1, Lu A1, Tara Z1, Haus E1, Campbell C1, Wei S1, Mendel R1, Mathew N1, Keith K2 Seiler C3, Chen S4,Nakamaru-Ogiso E1, Falk MJ1,5, and Haroon S1,5 : Therapy Development for OPA1 Disease Using Worm Models, With Validation in Zebrafish and Patient Fibroblast Models. UMDF June 2025.

Burg L1, O’Hara T1, Haroon S1, Reesey Gretzmacher E1, Magnitsky S2, Seiler C3, Nakamaru-Ogiso E1, Falk MJ1,4: Characterization of a Zebrafish surf1-/- Model of Leigh Syndrome. UMDF June 2025.

Kelsey Keith, Neal D. Matthew, Shannon Schrope, Ryan Mendel, Cristina Remes, Eiko Nakamaru-Ogiso, Suraiya Haroon, Marni J. Falk : A Disease-Agnostic High-Throughput Screening Platform for PMD Candidate Drug Therapies and Mitotoxicants UMDF Conference June 2024.

Alex Lu, Tyler O’Hara, Zahra Tara, Ryan Mendel, Neal Mathew, Kelsey Keith, Christoph Seiler, Sherine Chen, Eiko Ogiso, Marni J. Falk, and Suraiya Haroon: High-throughput drug screening in a humanized C. elegans model identified potential therapeutic compounds for OPA1 disease. Metabolism, Aging, Pathogenesis, Stress and Small RNAs in C. elegans June 2024.

Ryan Mendel, Sofie Matsuno, Shannon Schrope, Kelsey Keith, Neal Mathew, Marni J. Falk, and Suraiya Haroon : Identification of FDA-approved compounds that rescue mitochondrial stress in a heteroplasmic single large-scale mtDNA deletion (SLSMD) C. elegans animal model Metabolism, Aging, Pathogenesis, Stress and Small RNAs in C. elegans Conference June 2024.

Melis Kose1, Suraiya Haroon1,2, Elizabeth McCormick1, Eiko Nakamaru-Ogiso1,2, Marni J. Falk1,2 : Cockayne syndrome cells display pronounced mitochondrial dysfunction with acute stress sensitivity that is rescued by N-acetylcysteine. UMDF Conference June 2024.