Selected Publications

Sonal Sharma, Sergey Magnitsky, Emily Reesey, Mitchell Schwartz, Suraiya Haroon, Manuela Lavorato, Sherine Chan, Rui Xiao, Benjamin J. Wilkins, Daniel Martinez, Christoph Seiler, and Marni J. Falk : Novel Development of Magnetic Resonance Imaging to Quantify the Structural Anatomic Growth of Diverse Organs in Adult and Mutant Zebrafish. Zebrafish Page: doi: 10.1089, Aug 2023 Notes: epub ahead of print.

Sonal Sharma, Sergey Magnitsky, Emily Reesey, Mitchell Schwartz, Suraya Haroon, Manuela Lavorato, Sherine Chan, Rui Xiao, Benjamin J. Wilkins, Daniel Martinez, Christoph Seiler, Marni J. Falk: Novel development of magnetic resonance imaging (MRI) to study structural anatomic differences in diverse organs of primary mitochondrial disease in adult zebrafish animal models United Mitochondrial Disease Foundation, Charlotte NC June 2023 Notes: Poster.

Haroon S, Yoon H, Seiler C, Osei-Frimpong B, He J, Nair RM, Mathew ND, Burg L, Kose M, Venkata CRM, Anderson VE, Nakamaru-Ogiso E, Falk MJ.: N-acetylcysteine and cysteamine bitartrate prevent azide-induced neuromuscular decompensation by restoring glutathione balance in two novel surf1-/- zebrafish deletion models of Leigh syndrome. Human Molecular Genetics 32(12): 1988-2004, Jun 2023.

Shannon Schrope, Kelsey Keith, Ryan Mendel, Suraiya Haroon, Prabhjot Kaur, Eiko Nakamaru-Ogiso, Neal D. Mathew, and Marni J. Falk: High-throughput pre-clinical evaluation of candidate therapies using RNA interference of DLD-based Primary Mitochondrial Disease in Caenorhabditis elegans. United Mitochondrial Disease Foundation, Charlotte NC June 2023 Notes: Poster.

Mendel R, Cheng Y, Tara Z, Schrope S, Keith K, Mathew N, Ogiso E, Falk MJ and Haroon S.: Identification of two mitophagy modulators that rescue mitochondrial stress in a heteroplasmic single large-scale mtDNA deletion (SLSMD) C. elegans animal model. United Mitochondrial Disease Foundation, Charlotte NC June 2023 Notes: Podium Presentation (Talk).

Lavorato M, Remes C, Haroon S, Elzanfali S, Mendel R, Mathew ND, Nakamaru-Ogiso E, Falk MJ: Therapeutic modeling in human fibroblast and C. elegans models of C12ORF65 primary mitochondrial disease United Mitochondrial Disease Foundation, Charlotte NC Jun 2023 Notes: Poster.

Claire Chung, Bert M Verheijen, Zoe Navapanich, Eric G McGann,g Sarah Shemtov, Guan-Ju Lai, Payal Arora, Atif Towheed, Suraiya Haroon, Agnes Holczbauer, Sharon Chang, Zarko Manojlovic, Stephen Simpson, Kelley W Thomas, Craig Kaplan, Peter van Hasselt, Marc Timmers, Dorothy Erie, Lin Chen, Jean-Franćois Gout, Marc Vermulst: Evolutionary conservation of the fidelity of transcription Nature Communications 14(1): 1547, Mar 2023.

Ryan Mendel, Zahra Tara, Yi Cheng, Neal Mathew, Eiko Ogiso, Marni J. Falk, and Suraiya Haroon: High-throughput screening of mitophagy modulating drug library in a C. elegans model of single large-scale mitochondrial DNA deletion disease to develop therapies. Wellcome Trust Genome Mitochondrial Medicine - Therapeutic Development Conference, Virtual Nov 2022 Notes: Abstract Book.

Suraiya Haroon#, Heeyong Yoon#, Christoph Seiler, Bruce Osei-Frimpong, Jie He, Rohini M. Nair, Neal Mathew, Leonard Burg, Chavali Venkata, Vernon E. Anderson, Eiko Nakamaru-Ogiso, Marni J. Falk. (# equal contribution): N-acetylcysteine and cysteamine bitartrate antioxidant therapies prevent neuromuscular decompensation in two novel surf1-/- zebrafish models of Leigh Syndrome. Wellcome Trust Genome Mitochondrial Medicine - Therapeutic Development Conference, Virtual Nov 2022 Notes: Podium Presentation (Talk).

Zahra Tara, Erin Haus, Christie Campbell, Seinn Wei, Ryan Mendel, Neal Mathew, Christoph Seiler, Sherine Chen, Eiko Ogiso, Marni J Falk, and Suraiya Haroon: High-throughput drug screening in a humanized C. elegans model identified potential therapeutic compounds for OPA1 disease. Wellcome Trust Genome Mitochondrial Medicine - Therapeutic Development Conference, Virtual Nov 2022 Notes: Abstract Book.