David H. Jang, MD, MSc

faculty photo
Assistant Professor of Emergency Medicine at the Hospital of the University of Pennsylvania and the Presbyterian Medical Center of Philadelphia
Department: Emergency Medicine

Contact information
3620 Hamilton Walk
Eckmann Lab-John Morgan Building Room 12
Philadelphia, PA 19104
Fax: 215-898-0868
Education:
BS (Magna cum laude with Department Honors, Psychology and Neuroscience)
University of Massachusetts-Amherst, 2001.
MD (Doctor of Medicine)
Tufts University School of Medicine, 2006.
N/A (Emergency Medicine)
University of Pittsburgh, 2009.
N/A (Medical Toxicology)
New York University School of Medicine, 2011.
MSc (Clinical Investigation in Translational Research)
New York University CTSI, 2013.
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Description of Clinical Expertise

Emergency Medicine
University of Pittsburgh-2009

Medical Toxicology
New York University Medical Toxicology Fellowship-2011

Description of Other Expertise

Attending physician in the Division of Medical Toxicology and Critical Care Medicine (ResCCU)

Investigator, Penn Acute Care Collaboration (PARC), University of Pennsylvania
-Mitochondrial bioenergetics and dynamics in Emergency Medicine (MitoEM)

Description of Research Expertise

Abnormal Mitochondrial Bioenergetic and Motility Signatures in Acute Care Illness in a Translational Approach from Bench to Bedside

We are interested in studying the interaction of mitochondrial bioenergetics and dynamics in the area of acute care that includes sepsis and acute toxicologic poisoning. We are currently taking a translational approach studying the mitochondria at a cell-based level all the way to the clinical setting actively enrolling patients with these acute medical conditions with the goal to develop better prognostic measures with the potential for mitochondrial-directed therapy.

The Eckmann lab has both the latest model of the O2k-FluoRespirometer (O2k-Series H - new)x2 and Seahorse XFe24 to study mitochondrial respiration in both intact and permeabilized cells. In addition we also study mitochondrial dynamics examining both mitochondrial motility and fusion/fission events with microscopy. Combining these elements we aim to better understand the complex interactions of both bioenergetics and motility in issues of acute care to better improve patient care and outcomes.

Our other area of interest includes research objectives relevant to the Office of Naval Research (ONR) where we leverage our expertise in this area to study cellular dysfunction in response to decompression injuries from the cell to clinical in a translational fashion. Our research in this area is also to study more effective treatments directed at the mitochondrial-level to improve function which will result in better safety and performance in naval personnel.

This work is supported by:
1. K08HL136858 (Jang, PI)
2. K12HL109005-Completed
2. Penn Acute Research Collaboration (PARC)
http://www.uphs.upenn.edu/surgery/Research/trauma/PARC/PARC_home.html

Selected Publications

David H. Jang, John C. Greenwood, Shawn Owiredu, Abhay Ranganathan and David M. Eckmann: Mitochondrial Networking in Human Blood Cells with Application in Acute Care Illnesses. Mitochondrion November 2017.

David H Jang, Sarah C Seeger, Martha E Grady, Frances S Shofer, and David M Eckmann: Mitochondrial dynamics and respiration within cells with increased open pore cytoskeletal meshes. Biology Open Nov 17 2017.

David H. Jang, MD, MSc, Matthew Kelly, MD, David Lambert, MD, Kevin Hardy, MD, Frances Shofer, PhD, David M. Eckmann, PhD, MD: A preliminary study in the alterations of mitochondrial respiration in patients with carbon monoxide poisoning measured in blood cells. Clinical Toxicology 2017.

David H. Jang, MD, MSc John C. Greenwood, MD Meghan B. Spyres, MD David M. Eckmann, PhD, MD : Measurement of Mitochondrial Respiration and Motility in Acute Care: Sepsis, Trauma, and Poisoning. Journal of Intensive Care Medicine July 2016.

David H. Jang, Frances S. Shofer, Scott L. Weiss, Lance B. Becker: Impairment of Mitochondrial Respiration Following Ex-vivo Cyanide Exposure in Peripheral Blood Mononuclear Cells. Clinical Toxicology Taylor & Francis, February 2016 Notes: Epub ahead of print.

Jang DH, Lampe J, Becker LB. : The Potential Application of Mitochondrial Medicine in Toxicologic Poisoning. Journal of Medical Toxicology 11(2): 201-207, June 2015.

Jang DH, Donovan S, Nelson LS, Bania TC, Hoffman RS, Chu J.: Efficacy of Methylene Blue in an Experimental Model of Calcium Channel Blocker Induced Shock. Annals of Emergency Medicine 65(4): 410-415, October 2014.

Jang DH, Weaver MD, Pizon AF.: In Vitro Study of N-acetylcysteine on Coagulation Factors in Plasma Samples from Healthy Subjects. Journal of Medical Toxicology 9(1): 49-53, March 2013.

David Jang, Sean Donovan, Theodore Bania, Lewis Nelson, Robert Hoffman, Jason Chu: The novel development of an experimental model of dihydropyridine calcium channel blocker poisoning using intravenous amlodipine. International Journal of Cardiovascular Research 2(2): 1000121, March 2013.

Anthony F. Pizon, MD, David H. Jang, MD, and Henry E. Wang, MD: The In Vitro Effect of N-Acetylcysteineon Prothrombin Time in Plasma Samples From Healthy Subjects. Academic Emergency Medicne 18(4): 351-354, April 2011.

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Last updated: 12/12/2017
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