David H. Jang, MD, MSc

faculty photo
Assistant Professor of Emergency Medicine at the Hospital of the University of Pennsylvania and the Presbyterian Medical Center of Philadelphia
Department: Emergency Medicine

Contact information
3620 Hamilton Walk
Eckmann Lab-John Morgan Building Room 12
Philadelphia, PA 19104
Fax: 215-898-0868
Education:
BS (Magna cum laude with Department Honors, Psychology and Neuroscience)
University of Massachusetts-Amherst, 2001.
MD (Doctor of Medicine)
Tufts University School of Medicine, 2006.
N/A (Emergency Medicine)
University of Pittsburgh, 2009.
N/A (Medical Toxicology)
New York University School of Medicine, 2011.
MSc (Clinical Investigation in Translational Research)
New York University CTSI, 2013.
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Description of Clinical Expertise

Emergency Medicine
University of Pittsburgh-2009

Medical Toxicology
New York University Medical Toxicology Fellowship-2011

Description of Other Expertise

Attending physician in the Division of Medical Toxicology and Critical Care Medicine (ResCCU)

Investigator, Penn Acute Care Collaboration (PARC), University of Pennsylvania
-Mitochondrial bioenergetics and dynamics in Emergency Medicine (MitoEM)

Description of Research Expertise

"Abnormal Mitochondrial Bioenergetic and Motility Signatures in Acute Care Illness in a Translational Approach from Bench to Bedside."

We are interested in studying the interaction of mitochondrial bioenergetics and dynamics in the area of acute care that includes sepsis and acute toxicological poisoning. We are currently taking a translational approach studying the mitochondria at a cell-based level all the way to the clinical setting actively enrolling patients with these acute medical conditions with the goal to develop better prognostic measures with the potential for mitochondrial-directed therapy.

We have both the latest model of the O2k-FluoRespirometer (O2k-Series H) and Seahorse XFe24 to study mitochondrial respiration in both intact and permeabilized cells. In addition we also study mitochondrial dynamics examining both mitochondrial motility and fusion/fission events with microscopy while also examining other mitochondrial functions such as membrane potential and ROS. Combining these elements we aim to better understand the complex interactions of both bioenergetics and motility in issues of acute care to better improve patient care and outcomes.

Our other area of interest includes research objectives relevant to the Office of Naval Research (ONR) where we leverage our expertise in this area to study cellular dysfunction in response to decompression injuries from the cell to clinical in a translational fashion. Our research in this area is also to study more effective treatments directed at the mitochondrial-level to improve function which will result in better safety and performance in naval personnel.

This work is supported by:
1. K08HL136858 (Jang, PI)
2. K12HL109005-Completed
3. Penn Acute Research Collaboration (PARC)

http://www.uphs.upenn.edu/surgery/Research/trauma/PARC/PARC_home.html

Selected Publications

David H. Jang, Clinton J. Orloski, Shawn Owiredu, Frances S. Shofer, John C. Greenwood and David M. Eckmann: Alterations in mitochondrial function in blood cells obtained from patients with sepsis presenting to an emergency department. Shock: Injury, Inflammation, and Sepsis: Laboratory and Clinical Approaches June 2018.

David H. Jang, Utsha G. Khatri, Anita Mudan, Jennifer S. Love, Shawn Owiredu and David M. Eckmann: Translational application of measuring mitochondrial functions in blood cells obtained from patients with acute poisoning. Journal of Medical Toxicology February 2018.

David H. Jang, MD, MSc, Utsha G. Khatri, MD, Brenna P Shortal, BS, Matthew Kelly, MD, David Lambert, MD, Kevin Hardy, MD, David M. Eckmann, PhD, MD: Alterations in mitochondrial respiration and reactive oxygen species in patients poisoned with carbon monoxide treated with hyperbaric oxygen. Intensive Care Medicine Experimental January 2018.

David H. Jang, John C. Greenwood, Shawn Owiredu, Abhay Ranganathan and David M. Eckmann: Mitochondrial Networking in Human Blood Cells with Application in Acute Care Illnesses. Mitochondrion December 2017.

David H Jang, Sarah C Seeger, Martha E Grady, Frances S Shofer, and David M Eckmann: Mitochondrial dynamics and respiration within cells with increased open pore cytoskeletal meshes. Biology Open Nov 17 2017.

David H. Jang, MD, MSc, Matthew Kelly, MD, David Lambert, MD, Kevin Hardy, MD, Frances Shofer, PhD, David M. Eckmann, PhD, MD: A preliminary study in the alterations of mitochondrial respiration in patients with carbon monoxide poisoning measured in blood cells. Clinical Toxicology 2017.

David H. Jang, MD, MSc, John C. Greenwood, MD, Meghan B. Spyres, MD, David M. Eckmann, PhD, MD : Measurement of Mitochondrial Respiration and Motility in Acute Care: Sepsis, Trauma, and Poisoning. Journal of Intensive Care Medicine July 2016.

David H. Jang, Frances S. Shofer, Scott L. Weiss, Lance B. Becker: Impairment of Mitochondrial Respiration Following Ex-vivo Cyanide Exposure in Peripheral Blood Mononuclear Cells. Clinical Toxicology Taylor & Francis, February 2016 Notes: Epub ahead of print.

David H. Jang, Joshua W. Lampe, Lance Becker: The Potential Application of Mitochondrial Medicine in Toxicologic Poisoning. Journal of Medical Toxicology 11(2): 201-207, June 2015.

David H. Jang, Sean Donovan, Lewis S. Nelson, Theodore C. Bania, Robert S. Hoffman, Jason Chu: Efficacy of Methylene Blue in an Experimental Model of Calcium Channel Blocker Induced Shock. Annals of Emergency Medicine 65(4): 410-415, October 2014.

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Last updated: 06/05/2018
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