David H. Jang, MD, MSc FACMT

faculty photo
Assistant Professor of Emergency Medicine
Department: Emergency Medicine

Contact information
Department of Emergency Medicine Research Offices
Blockley Hall
423 Guardian Drive, Room 415

Lab:
Anesthesia and Critical Care Mitochondrial Unit (ACMU)
Colket Translational Research Building
Lab 6200
3501 Civic Center Blvd
Philadelphia, PA 19104
Philadelphia, PA 19104
Fax: 215-898-0868
Education:
BS (Magna cum laude with Department Honors, Psychology and Neuroscience)
University of Massachusetts-Amherst, 2001.
MD (Doctor of Medicine)
Tufts University School of Medicine, 2006.
MSc (Clinical Investigation)
New York University CTSI, 2013.
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Description of Clinical Expertise

Emergency Medicine
University of Pittsburgh
2009

Medical Toxicology
New York University School of Medicine
2011

Description of Other Expertise

Attending physician in the Division of Medical Toxicology

Description of Research Expertise

"Abnormal Mitochondrial Function in Acute Care Illness in a Translational Approach from Bench to Bedside."

We are interested in studying the interaction of mitochondrial function in the area of acute care that includes sepsis and acute poisoning. We are currently taking a translational approach studying the mitochondria at a cell-based level, to various animal models, all the way to the clinical setting actively enrolling patients with these acute medical conditions with the goal to develop better prognostic measures with the potential for mitochondrial-directed therapy.

Our lab has the latest models of the O2k-FluoRespirometer (O2k-Series H), Western blotting, confocal microscopy to study mitochondrial function in both in vitro and in vivo models with a focus on mitochondrial-directed therapies using substrate prodrugs. Relevant in vivo platforms include zebrafish, murine and porcine models of acute critical care illnesses that also combine state of the art physiological monitoring such as PV loop catheters providing realtime physiological data to be linked with cellular function. Our other interests also utilize the use of blood cells as proxy of organ cellular function as a type of biomarker which may provide prognostic function and allow clinicians to better gauge response to therapy.

Combining these elements we aim to better understand the complex interactions of both bioenergetics in issues of acute care to better improve patient care and outcomes.

This work is supported by:
1. K08HL136858 (Jang, PI)
2. R03HL154232 (Jang, PI)
3. R21ES031243 (Jang, PI)
4. R56HL158696 (Jang, PI)

Selected Publications

Jang DH, Piel S, Greenwood JC, Kelly M, Mazandi VM, Ranganathan A, Lin Y, Starr J, Hallowell T, Shofer FS, Baker WB, Lafontant A, Andersen K, Ehinger J, Kilbaugh TJ, : Alterations in cerebral and cardiac mitochondrial function in a porcine model of acute carbon monoxide poisoning Clinical Toxicology Jan 2021.

Owiredu S, Ranganathan A, Greenwood JC, Piel S, Janowska JI, Eckmann D, Kelly M, Ehinger J, Kilbaugh TJ, Jang DH: In vitro Comparison of Hydroxocobalamin (B12a) and the Mitochondrial Directed therapy by a Succinate Prodrug in a Cellular Model of Cyanide Poisoning. Toxicology Reports September 2020.

Mudan A, Greenwood JC, Shofer FS, Zhou V, Jang DH: The Managing Poisoned Patients in an ED-Based Resuscitation and Critical Care Unit (ResCCU) American Journal of Emergency Medicine June 2020.

Owiredu S, Ranganathan A, Eckmann DM, Shofer FS, Hardy K, Lambert DS, Kelly M, and Jang DH: Ex vivo use of cell-permeable succinate prodrug attenuates mitochondrial dysfunction in blood cells obtained from carbon monoxide poisoned individuals. Am J Physiol Cell Physiol May 7 2020.

Janowska JI, Piel S, Saliba N, Kim CD, Jang DH, Karlsson M, Kilbaugh TJ, Ehinger JK: N-methyl carbamate-induced mitochondrial respiratory chain complex I dysfunction ex vivo can be alleviated with a cell-permeable succinate prodrug. Toxicol In Vitro Feb 2020.

Jang David H, Khatri Utsha G, Shortal Brenna P, Kelly Matthew, Hardy Kevin, Lambert David S, Eckmann David M: Alterations in mitochondrial respiration and reactive oxygen species in patients poisoned with carbon monoxide treated with hyperbaric oxygen. Intensive care medicine experimental 6(1): 4, Jan 2018.

Jang David H, Orloski Clinton J, Owiredu Shawn, Shofer Frances S, Greenwood John C, Eckmann David M: Alterations in Mitochondrial Function in Blood Cells Obtained from Patients with Sepsis Presenting to an Emergency Department. Shock (Augusta, Ga.) Jun 2018.

Jang David H, Kelly Matthew, Hardy Kevin, Lambert David S, Shofer Frances S, Eckmann David M: A preliminary study in the alterations of mitochondrial respiration in patients with carbon monoxide poisoning measured in blood cells. Clinical toxicology (Philadelphia, Pa.) 55(6): 579-584, Jul 2017.

Jang DH, Piel S, Greenwood JC, Ehinger JK, Kilbaugh TJ: Emerging Cellular-Based Therapies in Carbon Monoxide Poisoning. Am J Physiol Cell Physiol. June 2021.

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Last updated: 10/08/2021
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