Pedro Gonzalez-Alegre, MD, PhD

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Professor of Neurology at the Pennsylvania Hospital
Department: Neurology

Contact information
University of Pennsylvania
Department of Neurology
800 Spruce Street
Philadelphia, PA 19107
University of Malaga Medical School, Málaga (Spain), 1996.
PhD (Neuroscience)
University of Malaga Medical School, Málaga (Spain), 2009.
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Description of Clinical Expertise

Dr. Pedro Gonzalez-Alegre is a physician-scientist certified by the American Board of Psychiatry and Neurology and with subspecialty training in Movement Disorders/Neurogenetics. After completing his residency and fellowship training at the University of Iowa, he joined the faculty at that institution where he reached the rank of Associate Professor with tenure. In 2014, he was recruited to the Department of Neurology at the University of Pennsylvania. He has been elected to the Best Doctors in America list every year since 2009. He is the founding director of the Penn HD Center since 2015, gaining designation as a Center of Excellence of the HDSA (Huntington’s Disease Society of America) in 2016. He also launched a new Neurogenetics Clinic at Penn in 2015.

Description of Other Expertise

Dr. Gonzalez-Alegre has devoted significant efforts to education. He has been the advisor of several graduate students that successfully obtained their PhD, mentored numerous undergraduate and medical students, neurology residents and fellows, and participated in multiple local, national and international educational programs related to neurology. He was named Associate Director of the Neurology Residency Program at the University of Iowa in 2009, Residency Program Director and acting Vice-Chair for Education in 2012, Chair of the Seminar Committee and Member of the Executive Committee of the Interdisciplinary Program in Neuroscience at the University of Iowa in 2012. His educational efforts were rewarded by the 2009 and 2012 Medical Education Faculty Award in Neurology of the Carver College of Medicine at the University of Iowa and the 2014 Best Teacher Award from the Neurology Residents at UI.

Description of Research Expertise

Dr. Gonzalez-Alegre is a highly committed clinician-scientist who directs a laboratory devoted to the investigation of the neurobiological bases and therapeutics of dystonia. For his research efforts, funded through federal and private sources, he has been recognized with 2003 S Weir Mitchell Award of the American Academy of Neurology, the 2004 Junior Award for Excellence in Basic Science Research from the Movement Disorders Society, the 2012 Jon Stolk Award in Movement Disorders from the American Academy of Neurology, and the 2012 Stanley Fahn Award from the Dystonia Medical Research Foundation. He is also Co-Director for Clinical Programs of the Raymond G. Perelman Center for Cellular & Molecular Therapy at the Children Hospital of Philadelphia, involved in translational efforts to advance novel molecular therapies for various neurological diseases to early phase clinical trials.

Selected Publications

73. Tropea TF, Amari N, Han N, Rick J, Suh E, Akhtar RS, Dahodwala N, Deik A, Gonzalez-Alegre P, Hurtig H, Siderowf A, Spindler M, Stern M, Thenganatt MA, Weintraub D, Willis AW, Van Deerlin V, Chen-Plotkin A. : Whole Clinic Research Enrollment in Parkinson's Disease: The Molecular Integration in Neurological Diagnosis (MIND) Study. J Parkinsons Dis 2021.

75. Isonaka R, Goldstein DS, Zhu W, Yoon E, Ehrlich D, Schindler AB, Kokkinis AD, Sabir MS, Scholz SW, Bandres-Ciga S, Blauwendraat C, Gonzalez-Alegre P, Lopez G, Sidransky E, Narendra DP. : α-Synuclein deposition in sympathetic nerve fibers in genetic forms of Parkinson’s Disease. Mov Disord 2021.

Klapper J, Bardakjian T, Sigal I, Muralidharan K, Gonzalez-Alegre P. : Healthcare Delivery via Telehealth during the COVID-19 Pandemic: the Experience of a Huntington’s Disease Center. Clin Parkinsonism Relat Disord 2021.

Zech M, Jech R, Boesch S, Škorvánek M, Weber S, Wagner M, Zhao C, Jochim A, Necpál J, Dincer Y, Vill K, Distelmaier F, Stoklosa M, Krenn M, Grunwald S, Bock-Bierbaum T, Fečíková A, Havránková P, Roth J, Příhodová I, Adamovičová M, Ulmanová O, Bechyně K, Danhofer P, Veselý B, Haň V, Pavelekova P, Gdovinová Z, Mantel T, Meindl T, Sitzberger A, Schröder S, Blaschek A, Roser T, Bonfert MV, Haberlandt E, Plecko B, Leineweber B, Berweck S, Herberhold T, Langguth B, Švantnerová J, Minár M, Ramos-Rivera GA, Wojcik MH, Pajusalu S, Õunap K, Schatz UA, Pölsler L, Milenkovic I, Laccone F, Pilshofer V, Colombo R, Patzer S, Iuso A, Vera J, Troncoso M, Fang F, Prokisch H, Wilbert F, Eckenweiler M, Graf E, Westphal DS, Riedhammer KM, Brunet T, Alhaddad B, Berutti R, Strom TM, Hecht M, Baumann M, Wolf M, Telegrafi A, Person RE, Zamora FM, Henderson LB, Weise D, Musacchio T, Volkmann J, Szuto A, Becker J, Cremer K, Sycha T, Zimprich F, Kraus V, Makowski C, Gonzalez-Alegre P, Bardakjian TM, Ozelius LJ, Vetro A, Guerrini R, Maier E, Borggraefe I, Kuster A, Wortmann SB, Hackenberg A, Steinfeld R, Assmann B, Staufner C, Opladen T, Růžička E, Cohn RD, Dyment D, Chung WK, Engels H, Ceballos-Baumann A, Ploski R, Daumke O, Haslinger B, Mall V, Oexle K, Winkelmann J.: Monogenic variants in dystonia: an exome-wide sequencing study. Lancet Neurol 19(11): 908-918, Nov 2020.

Robbins, N. M., Ozmore, J. R., Winder, T. L., Gonzalez-Alegre, P., Bardakjian, T. M.: A Novel SPAST/SPG4 Splice-Site Variant in a Family with Dominant Hereditary Spastic Paraplegia. Case Rep Neurol Med 2020: 7219514, Aug 2020.

Zech M, Bardakjian TM, Stoklosa M, Ploski R, Jech R, Gonzalez-Alegre P, Winkelmann J.: A Neurodevelopmental Disorder With Dystonia and Chorea Resulting From Clustering CAMK4 Variants. Mov Disord in press, 2020.

Ogilvie AC, Gonzalez-Alegre P, Schultz JL: Diabetes Mellitus Is Associated With an Earlier Age of Onset of Huntington's Disease. Mov Disord 2020.

Walker IM, Riboldi GM, Drummond P, Saade-Lemus S, Martin-Saavedra JS, Frucht S, Bardakjian TM, Gonzalez-Alegre P, Deik A.: PPP2R5D Genetic Mutations and Early-Onset Parkinsonism. Ann Neurol in press, 2020.

Hamedani A, Bardakjian T, Balcer L, Gonzalez-Alegre P. : Inpatient gastrostomy in Huntington's disease: Nationwide analysis of utilization and outcomes compared to amyotrophic lateral sclerosis. Clin Parkinsonism Relat Disord in press, 2020.

Rodriguez Losada N, Wendelbo R; Ocaña Fratan MC; Díaz Casares A; Guzman de Villoria R; Aguirre JA; Arraez MA; Gonzalez-Alegre P; Medina MA; Arenas E; Narvaez-Bueno JA.: Graphene oxide and reduced derivatives, as powder or film scaffolds, differentially promote dopaminergic neuron differentiation and survival. Front Neurosci in press, 2020.

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Last updated: 04/15/2021
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