Beverly L. Davidson, Ph.D.

faculty photo
Professor of Pathology and Laboratory Medicine
Arthur V. Meigs Chair in Pediatrics, Children's Hospital of Philadelphia
Director, Raymond G. Perelman Center for Cellular and Molecular Therapeutics, Children's Hospital of Philadelphia
Chief Scientific Strategy Officer (CSS), Children's Hospital of Philadelphia Research Institute
Department: Pathology and Laboratory Medicine
Graduate Group Affiliations

Contact information
The Children's Hospital of Philadelphia
3501 Civic Center Boulevard, 5060 CTRB
Philadelphia, PA 19104
Office: 267-426-0929
Fax: 215-590-3660
Education:
B.S. (Biology Major/Chemistry Minor; High Distinction)
Nebraska Wesleyan University, 1981.
Ph.D. (Biological Chemistry)
University of Michigan, 1987.
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Description of Research Expertise

Keywords:
Neurodegenerative Disease
RNA biology
Gene therapy
Animal models
Human treatment

Our lab is focused on genetic diseases that affect the brain. We study the mechanisms by which mutant gene products contribute to disease, and why certain brain regions are more susceptible. The team employs advanced molecular methods, sequencing and imaging modalities in animal models. The lab is also engaged in the development of next generation therapeutics for inherited disorders, including the engineering of novel gene therapy vector capsids and cargo to approach tissue and cell type specific treatments.

Selected Publications

St-Cyr S, Child DD, Giaime E, Smith AR, Pascua CJ, Hahm S, Saiah E, Davidson BL: Huntington's disease phenotypes are improved via mTORC1 modulation by small molecule therapy. PLoS One 17(8): e0273710, August 2022 Notes: doi: 10.1371/journal.pone.0273710.

Sabatino DE,, Bushman FD (Chair), Chandler RJ, Crystal RG, Davidson BL, Dolmetsch R, Eggan KC, Gao G, Gil-Farina I, Kay MA, McCarty DM, Montini E, Ndu A, Yuan J: Evaluating the State of the Science for Adeno-Associated Virus (AAV) Integration:An Integrated Perspective. Mol Ther S1525-0016(22)00364-1, June 2022 Notes: doi: 10.1016/j.ymthe.2022.06.004.

Davidson BL, Gao G, Berry-Kravis E, Bradbury A, Bonnemann C, Buxbaum JD, Corcoran GR, Gray SJ, Gray-Edwards H, Kleiman RJ, Shaywitz A, Wang D, Zoghbi HY, Flotte TR, Tauscher-Wisniewski S, Tifft CF, Sahin M; Gene Therapy Workship Faculty: Gene-based therapeutics for rare genetic neurodevelopmental psychiatric disorders. Mol Ther Page: S1525-0016(22)00312-4, May 2022.

St-cyr S, Smith AR, Davidson BL: Temporal phenotypic changes in HD models for preclinical studies. Presented at the 25th annual meeting of the American Society for Gene and Cell Therapy Page: Poster #M-148, May 2022.

Tecedor L, Chen YH, Ranum PT, Keiser MS, Leib D, Cheng C, Lysenko E, Davidson BL: Evolved AAV capsids for gene therapy of CLN2 disease. Presented at the 25th annual meeting of the American Society for Gene and Cell Therapy Page: Poster #M-147, May 2022.

Robbins AB, Carrell EM, Keiser MS, Davidson BL: Combined over expression of hATXN1L and mutant ATXN1 knockdown rescues motor phenotypes and disease-related gene expression changes in B05 mice. Presented at the 25th annual meeting of the American Society for Gene and Cell Therapy, Washington, DC Page: Poster M-109, May 2022.

Carrell EM, Carrell ST, Davidson BL: Disease-responsive therapy for the treatment of myotonic dystrophy. Presented at the 25th annual meeting of the American Society for Gene and Cell Therapy Page: Oral presentation, May 2022.

Fagan K, Keiser M, Davidson B: Gene editing strategies to treat spinocerebellar ataxia type 1. Presented at the 25th annual meeting of the Society for Cell and Gene Therapy, Washington DC Page: Poster M-140, May 2022.

Arora S, Vu A, Kulhankova K, Weaver M, Excoffon K, Liu X, vanderLoo JC, McCray PB, Davidson BL: Development of a stable cell line and downstream process for improved titer of GP64-pseudotyped lentivurus particle. Presented at the 25th annual meeting of the American Society for Gene and Cell Therapy, Washington, DC Page: Poster W-268, May 2022.

Yrigollen CM, Simpson B, Lim E, Chen YH, Davidson B: The molecular and behavioral phenotypes altered in CGG knock-in mice edited using CRISPR. Presented at the 25th annual meeting of the American Society for Gene and Cell Therapy, Washington, DC Page: Poster M-160, May 2022.

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Last updated: 09/08/2022
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