George L Anesi, MD, MSCE, MBE
Assistant Professor of Medicine (Pulmonary, Allergy and Critical Care) at the Hospital of the University of Pennsylvania
Attending Physician, Division of Pulmonary, Allergy, and Critical Care, Department of Medicine, Hospital of the University of Pennsylvania
Director, Medical Critical Care Bioresponse Program, and Medical Director, Special Pathogen Treatment Unit, Hospital of the University of Pennsylvania
Core Faculty, PAIR (Palliative and Advanced Illness Research) Center, University of Pennsylvania Perelman School of Medicine
Faculty Fellow, Center for Clinical Epidemiology and Biostatistics (CCEB), University of Pennsylvania Perelman School of Medicine
Senior Fellow, Leonard Davis Institute of Health Economics (LDI), University of Pennsylvania (Initial appointment 2019; Reappointments 2022, 2025)
Senior Fellow, Center for Public Health Initiatives (CPHI), University of Pennsylvania
Department: Medicine
Contact information
3400 Spruce Street, 5037 Gates Building
Philadelphia, PA 19104
Philadelphia, PA 19104
Office: 215-908-4563
Publications
Education:
BS (Chemistry and Biological Chemistry)
University of Chicago, 2006.
MD (Medicine)
Case Western Reserve University, 2011.
MBE (Bioethics)
Case Western Reserve University, 2011.
MSCE (Clinical Epidemiology)
University of Pennsylvania Perelman School of Medicine, 2017.
Permanent linkBS (Chemistry and Biological Chemistry)
University of Chicago, 2006.
MD (Medicine)
Case Western Reserve University, 2011.
MBE (Bioethics)
Case Western Reserve University, 2011.
MSCE (Clinical Epidemiology)
University of Pennsylvania Perelman School of Medicine, 2017.
Description of Clinical Expertise
Critical care; sepsis; acute respiratory failure; shock; multi-system organ failure; influenza and respiratory viral infections; COVID-19; global healthDescription of Other Expertise
hospital operations; preparedness and response; hospital capacity strainDescription of Research Expertise
My research interests focus on hospital preparedness and the evaluation of critical care and acute care resources during times of strain to the system, including situations of dynamic strain (i.e., random variation in demand, seasonal trends, epidemics, and disasters) and fixed strain (i.e., critical illness in resource-limited settings domestically and globally).Selected Publications
Anesi GL: Approach to Hospital Preparedness for Acute Surge Events Due to Emerging Infectious Diseases. JAMA 332(18), Oct 2024.Anesi GL, Savarimuthu SM, Invernizzi J, Hyman R, Ramkillawan A, Eddey C, Wise RD, Smith MTD: ICU Mortality Across Prepandemic and Pandemic Cohorts in a Resource-Limited Setting: A Critical Care Resiliency Analysis From South Africa. CHEST Critical Care 1(1): 100005, Jun 2023.
Anesi GL, Degnan K, Dutcher L, Saw S, Maguire C, Binkley A, Patel S, Athans V, Barton TD, Binkley S, Candeloro CL, Herman DJ, Kasbekar N, Kennedy L, Millstein JH, Meyer NJ, Talati NJ, Patel H, Pegues DA, Sayre PJ, Tebas P, Terico AT, Murphy KM, O’Donnell JA, White M, Hamilton KW: The Penn Medicine COVID-19 Therapeutics Committee—Reflections on a Model for Rapid Evidence Review and Dynamic Practice Recommendations During a Public Health Emergency. Open Forum Infect Dis 10(8): ofad428, Aug 2023 Notes: https://doi.org/10.1093/ofid/ofad428.
Anesi GL, Andrews A, Bai H, Bhatraju PK, Brett-Major DM, Broadhurst MJ, Campbell ES, Cobb JP, Gonzalez M, Homami S, Hypes CD, Irwin A, Kratochvil CJ, Krolikowski K, Kumar VK, Landsittel D, Lee RA, Liebler JM, Lutrick K, Marts LT, Mosier JM, Mukherjee V, Postelnicu R, Rodina V, Segal LN, Sevransky JE, Spainhour C, Srivastava A, Uyeki TM, Wurfel MM, Wyles D, Evans L for the Severe Acute Respiratory Infection – Preparedness (SARI-PREP) Study Group: Perceived Hospital Stress, Severe Acute Respiratory Syndrome Coronavirus 2 Activity, and Care Process Temporal Variance During the COVID-19 Pandemic. Crit Care Med 51(4): 445-459, Apr 2023.
Anesi GL, Dress E, Chowdhury M, Wang W, Small DS, Delgado MK, Bayes B, Barreda FX, Halpern SD, Liu VX: Hospital Strain and Variation in Sepsis ICU Admission Practices and Associated Outcomes. Crit Care Explor 4(2): e0858, Feb 2023.
Anesi GL, Xiong R, Delgado MK: Frequency and Trends of Pre-Pandemic Surge Periods in U.S. Emergency Departments, 2006–2019. Crit Care Explor 5(8): e1023, Aug 2023.
Anesi GL, Dress E, Chowdhury M, Wang W, Small DS, Delgado MK, Bayes B, Szymczak JE, Glassman LW, Barreda FX, Weiner JZ, Escobar GJ, Halpern SD, Liu VX: Among-Hospital Variation in ICU Admission Practices and Associated Outcomes for Patients with Acute Respiratory Failure. Ann Am Thorac Soc 20(3): 406-413, Mar 2023 Notes: Accompanied by an editorial (PMID: 36856718).
Anesi GL, Liu VX, Chowdhury M, Small DS, Wang W, Delgado MK, Bayes B, Dress E, Escobar GJ, Halpern SD: Association of Intensive Care Unit Admission and Outcomes in Sepsis and Acute Respiratory Failure. Am J Respir Crit Care Med 205(5): 520-528, Apr 2022 Notes: doi.org/10.1164/rccm.202106-1350OC.
Anesi GL, Jablonski J, Harhay MO, Atkins JH, Bajaj J, Baston C, Brennan PJ, Candeloro CL, Catalano LM, Cereda MF, Chandler JM, Christie JD, Collins T, Courtright KR, Fuchs BD, Gordon E, Greenwood JC, Gudowski S, Hanish A, Hanson CW, Heuer M, Kinniry P, Kornfield ZN, Kruse GB, Lane-Fall M, Martin ND, Mikkelsen ME, Negoianu D, Pascual JL, Patel MB, Pugliese SC, Qasim ZA, Reilly JP, Salmon J, Schweickert WD, Scott MJ, Shashaty MGS, Sicoutris CP, Wang JK, Wani AA, Anderson BJ, Gutsche JT: Characteristics, Outcomes, and Trends of Patients With COVID-19–Related Critical Illness at a Learning Health System in the United States. Ann Intern Med 174(5): 613-621, Jan 2021 Notes: https://doi.org/10.7326/M20-5327.
Anesi GL, Chowdhury M, Small DS, Delgado MK, Kohn R, Bayes B, Wang W, Dress E, Escobar GJ, Halpern SD, Liu VX: Association of a Novel Index of Hospital Capacity Strain on Admission to Intensive Care Units. Ann Am Thorac Soc 17(11): 1440-1447, Nov 2020.