Rebecca A Hubbard, Ph.D.

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Professor of Biostatistics in Biostatistics and Epidemiology at the Hospital of the University of Pennsylvania
Department: Biostatistics and Epidemiology

Contact information
Department of Biostatistics, Epidemiology & Informatics
University of Pennsylvania School of Medicine
604 Blockley Hall
423 Guardian Drive
Philadelphia, PA 19104
Office: 215-898-3311
Fax: 215-573-4865
B.S. (Ecology & Evolution, summa cum laude)
University of Pittsburgh, Pittsburgh, PA, 1999.
M.Sc. (Epidemiology)
University of Edinburgh, Edinburgh, UK, 2001.
M.Sc. (Applied Statistics, with honors)
Oxford University, Oxford, UK, 2002.
Ph.D. (Biostatistics)
University of Washington, Seattle, WA , 2007.
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Description of Research Expertise

Dr. Hubbard's research focuses on development and application of statistical methodology for studies using observational data from community medical practice. This work encompasses evaluation of screening and diagnostic test performance, methods for comparative effectiveness studies, and health services research. A wealth of data on healthcare utilization, performance, and outcomes are available from electronic medical records. However, the complex observation scheme giving rise to these data necessitates careful study design and analysis to ensure that inference is valid. Dr. Hubbard’s methodological research emphasizes development of statistical tools for such inference and has been applied to studies of cancer screening, aging and dementia, pharmacoepidemiology, women’s health, and behavioral health.

Selected Publications

Hubbard RA, Tong J, Duan R, Chen Y: Reducing bias due to outcome misclassification for epidemiologic studies using EHR-derived probabilistic phenotypes. Epidemiology 31(4): 542-550, July 2020.

Conant EF, Zuckerman S, McDonald ES, Weinstein SP, Korhonen K, Synnestvedt MB, Schnall MD, Hubbard RA: Five consecutive years of screening with digital breast tomosynthesis: Outcomes by screening year and round. Radiology 295(2): 285-293, May 2020.

Mahmud N, Hubbard RA, Kaplan DE, Taddei TH, Goldberg DS: Risk prediction scores for acute on chronic liver failure development and mortality. Liver International 40(5): 1159-1167, May 2020.

Xie S, Hubbard RA*, Himes BE*: Neighborhood-level measures of socioeconomic status are more correlated with individual-level measures in urban areas compared to less urban areas. Annals of Epidemiology 43: 37-43, March 2020 Notes: *Equal contribution.

Bittermann T, Hubbard RA, Goldberg D: The proportion of Model for End-stage Liver Disease Sodium score attributable to creatinine independently predicts post-transplant survival and renal complications. Clinical Transplantation 34: e13817, February 2020.

Tong J, Huang J, Chubak J, Wang X, Hubbard RA, Chen Y: An augmented estimation procedure for EHR-based association studies accounting for differential misclassification. Journal of the American Medical Informatics Association 27(2): 244-253, February 2020.

Upshaw JN, Finkelman B, Hubbard RA, Smith AM, Narayan H, Arndt L, Domchek S, DeMichele A, Fox K, Shah P, Clark A, Bradbury A, Matro J, Adusumalli S, Carver JR, Ky B: Comprehensive assessment of changes in left ventricular diastolic function with contemporary breast cancer therapy. Journal of the American College of Cardiology: Cardiovascular Imaging 13(1): 198-210, January 2020.

Demissei BG, Hubbard RA, Zhang L, Smith AM, Sheline K, McDonald C, Narayan V, Domchek SM, DeMichele A, Shah P, Clark AS, Fox K, Matro J, Bradbury A, Knollman H, Getz K, Armenian S, Januzzi J, Tang WH, Liu P, Ky B: Changes in cardiovascular biomarkers with breast cancer therapy and associations with cardiac dysfunction. Journal of the American Heart Association 9: e014708, January 2020.

Kenyon CC, Maltenfort MG, Hubbard RA, Schinazi L, de Roos A, Henrickson S, Forrest CB: Variability in diagnosed asthma in young children in a large pediatric primary care network. Academic Pediatrics In press, 2020.

Tom SE, Phadke M, Crane PL, Hubbard RA, Stern Y, Larson EB: Trends in incident dementia and early life socioeconomic status by birth cohort. JAMA Network Ope In press, 2020.

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Last updated: 06/20/2020
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