Deborah G Murdock, PhD
Research Associate Professor of Pediatrics (Human Genetics)
Department: Pediatrics
Contact information
Children's Hospital of Philadelphia
Center for Mitochondrial and Epigenomic Medicine
3501 Civic Center Boulevard Colket Translational Research Building, Room 6062
Philadelphia, PA 19104
Center for Mitochondrial and Epigenomic Medicine
3501 Civic Center Boulevard Colket Translational Research Building, Room 6062
Philadelphia, PA 19104
Office: 2674250122
Education:
BS (Biology)
University of Georgia, 1988.
PhD (Biological Science)
Carnegie Mellon University, 1996.
Permanent linkBS (Biology)
University of Georgia, 1988.
PhD (Biological Science)
Carnegie Mellon University, 1996.
Selected Publications
Guarnieri JW, Angelin A, Murdock DG, Schaefer P, Portluri P, Lie T, Huang J, Wallace DC: SARS-COV-2 viroporins activate the NLRP3-inflammasome by the mitochondrial permeability transition pore. Front Immunol 14(3): 1064293, Feb 2023 Notes: doi: 10.3389/fimmu.2023.1064293. eCollection 2023.Schaefer PM, Scherer Alves L, Lvova M, Huang J, Rathi K, Janssen K, Butic A, Yardeni T, Morrow R, Lott M, Murdock D, Song A, Keller K, Garcia BA, Francomano CA, Wallace DC: Combination of common mtDNA variants results in mitochondrial dysfunction and a connective tissue dysregulation. Proc Natl Acad Sci U S A 119(45): e2212417119, Nov 2022 Notes: doi: 10.1073/pnas.2212417119.
Guarnieri JW, Dybas JM, Fazelinia H, Kim MS, Frere J, Zhang Y, Albrecht YS, Murdock DG, Angelin A, Singh LN, Weiss SL, Best SM, Lott MT, Cope H, Zaksas V, Saravia-Butler A, Meydan C, Foox J, Mozsary C, Kidane YH, Priebe W, Emmett MR, Meller R, Singh U, Bram Y, tenOever BR, Heise MT, Moorman NJ, Madden EA, Taft-Benz SA, Anderson EJ, Sanders WA, Dickmander RJ, Baxter VK, Baylin SB, Wurtele ES, Moraes-Vieira PM, Taylor D, Mason CE, Schisler JC, Schwartz RE, Beheshti A, Wallace DC: Targeted Down Regulation Of Core Mitochondrial Genes During SARS-CoV-2 Infection. bioRxiv Feb 2022 Notes: doi: 10.1101/2022.02.19.481089. ecollection.
Rossidis AC, Angelin A, Lawrence KM, Baumgarten HD, Kim AG, Mejaddam AY, Coons BE, Hartman HA, Hwang G, Monos S, Peranteau WH, Davey MG, Murdock D, Wallace DC, Flake AW: Premature Lambs Exhibit Normal Mitochondrial Respiration after Long-Term Extrauterine Support. Fetal Diagn Ther 46(5): 306-312, Nov 2019 Notes: doi: 10.1159/000496232. Epub 2019 Mar 12.
Weiss SL, Zhang D, Bush J, Graham K, Starr J, Tuluc F, Henrickson S, Kilbaugh T, Deutschman CS, Murdock D, McGowan FX Jr, Becker L, Wallace DC: Persistent Mitochondrial Dysfunction Linked to Prolonged Organ Dysfunction in Pediatric Sepsis. Crit Care Med 47(10): 1433-1441, Oct 2019 Notes: doi: 10.1097/CCM.0000000000003931.
Yardeni T, Tanes CE, Bittinger K, Mattei LM, Schaefer PM, Singh LN, Wu GD, Murdock DG, Wallace DC : Host mitochondria influence gut microbiome diversity: A role for ROS. Sci Signal 12(588): eaaw3159, Jul 2019 Notes: doi: 10.1126/scisignal.aaw3159.
Kallianpur AR, Gerschenson M, Hulgan T, Kaur H, Clifford DB, Haas DW, Murdock DG, McArthur JC, Samuels DC, Simpson DM : Hemochromatosis (HFE) Gene Variants Are Associated with Increased Mitochondrial DNA Levels During HIV-1 Infection and Antiretroviral Therapy. AIDS Res Hum Retroviruses 34(11): 942-949, Nov 2018 Notes: doi: 10.1089/AID.2018.0025. Epub 2018 Aug 22.
Smieszek S, Mitchell SL, Farber-Eger EH, Veatch OJ, Wheeler NR, Goodloe RJ, Wells QS, Murdock DG, Crawford DC : Hi-MC: a novel method for high-throughput mitochondrial haplogroup classification. PeerJ 6(3): e5149, Jun 2018 Notes: doi: 10.7717/peerj.5149. eCollection 2018.
Morrow RM, Picard M, Derbeneva O, Leipzig J, McManus MJ, Gouspillou G, Barbat-Artigas S, Dos Santos C, Hepple RT, Murdock DG, Wallace DC: Mitochondrial energy deficiency leads to hyperproliferation of skeletal muscle mitochondria and enhanced insulin sensitivity. Proc Natl Acad Sci U S A 114(10): 2705-2710, Mar 2017 Notes: 10.1073/pnas.1700997114. Epub 2017 Feb 21.
Clay HB, Parl AK, Mitchell SL, Singh L, Bell LN, Murdock DG : Altering the Mitochondrial Fatty Acid Synthesis (mtFASII) Pathway Modulates Cellular Metabolic States and Bioactive Lipid Profiles as Revealed by Metabolomic. PLoS One 11(3): e0151171, Mar 2016 Notes: 10.1371/journal.pone.0151171. eCollection 2016.