Deborah G Murdock, PhD
Research Associate Professor of Pediatrics (Human Genetics)
Department: Pediatrics
Contact information
Children's Hospital of Philadelphia
Center for Mitochondrial and Epigenomic Medicine
3501 Civic Center Boulevard Colket Translational Research Building, Room 6062
Philadelphia, PA 19104
Center for Mitochondrial and Epigenomic Medicine
3501 Civic Center Boulevard Colket Translational Research Building, Room 6062
Philadelphia, PA 19104
Office: 2674250122
Lab: 6155792116
Lab: 6155792116
Education:
BS (Biology)
University of Georgia, 1988.
PhD (Biological Science)
Carnegie Mellon University, 1996.
Permanent linkBS (Biology)
University of Georgia, 1988.
PhD (Biological Science)
Carnegie Mellon University, 1996.
Selected Publications
Joseph W Guarnieri 1, Jeffrey A Haltom 1, Yentli E Soto Albrecht 2, Timothy Lie 3, Arnold Z Olali 1, Gabrielle A Widjaja 1, Sujata S Ranshing 1, Alessia Angelin 1, Deborah Murdock 1, Douglas C Wallace 4: SARS-CoV-2 mitochondrial metabolic and epigenomic reprogramming in COVID-19. Pharmacol Res 204: 107170, April 2024.Joseph W Guarnieri 1 2 3, Joseph M Dybas 2 3, Hossein Fazelinia 2 3, Man S Kim 1 2 3 4, Justin Frere 5, Yuanchao Zhang 1 2 3, Yentli Soto Albrecht 1 2 3, Deborah G Murdock 1 2, Alessia Angelin 1 2, Larry N Singh 1 2 3, Scott L Weiss 1 2, Sonja M Best 3 6, Marie T Lott 1 2, Shiping Zhang 1 2, Henry Cope 7, Victoria Zaksas 3 8 9, Amanda Saravia-Butler 3 10 11, Cem Meydan 3 12, Jonathan Foox 12, Christopher Mozsary 12, Yaron Bram 12, Yared Kidane 3 13, Waldemar Priebe 3 14, Mark R Emmett 3 15, Robert Meller 3 16, Sam Demharter 17, Valdemar Stentoft-Hansen 17, Marco Salvatore 17, Diego Galeano 3 18, Francisco J Enguita 3 19, Peter Grabham 20, Nidia S Trovao 3 21, Urminder Singh 3 22, Jeffrey Haltom 1 2 3 22, Mark T Heise 23, Nathaniel J Moorman 23, Victoria K Baxter 23, Emily A Madden 23, Sharon A Taft-Benz 23, Elizabeth J Anderson 23, Wes A Sanders 23, Rebekah J Dickmander 23, Stephen B Baylin 3 24, Eve Syrkin Wurtele 3 22, Pedro M Moraes-Vieira 3 25, Deanne Taylor 1 2 3, Christopher E Mason 3 12 26, Jonathan C Schisler 3 23, Robert E Schwartz 3 12, Afshin Beheshti 3 27 28, Douglas C Wallace 1 2 3 : Core mitochondrial genes are down-regulated during SARS-CoV-2 infection of rodent and human hosts. Sci Transl Med 15(15): 708, august 2023.
Guarnieri JW, Angelin A, Murdock DG, Schaefer P, Portluri P, Lie T, Huang J, Wallace DC: SARS-COV-2 viroporins activate the NLRP3-inflammasome by the mitochondrial permeability transition pore. Front Immunol 14(3): 1064293, Feb 2023 Notes: doi: 10.3389/fimmu.2023.1064293. eCollection 2023.
Schaefer PM, Scherer Alves L, Lvova M, Huang J, Rathi K, Janssen K, Butic A, Yardeni T, Morrow R, Lott M, Murdock D, Song A, Keller K, Garcia BA, Francomano CA, Wallace DC: Combination of common mtDNA variants results in mitochondrial dysfunction and a connective tissue dysregulation. Proc Natl Acad Sci U S A 119(45): e2212417119, Nov 2022 Notes: doi: 10.1073/pnas.2212417119.
Guarnieri JW, Dybas JM, Fazelinia H, Kim MS, Frere J, Zhang Y, Albrecht YS, Murdock DG, Angelin A, Singh LN, Weiss SL, Best SM, Lott MT, Cope H, Zaksas V, Saravia-Butler A, Meydan C, Foox J, Mozsary C, Kidane YH, Priebe W, Emmett MR, Meller R, Singh U, Bram Y, tenOever BR, Heise MT, Moorman NJ, Madden EA, Taft-Benz SA, Anderson EJ, Sanders WA, Dickmander RJ, Baxter VK, Baylin SB, Wurtele ES, Moraes-Vieira PM, Taylor D, Mason CE, Schisler JC, Schwartz RE, Beheshti A, Wallace DC: Targeted Down Regulation Of Core Mitochondrial Genes During SARS-CoV-2 Infection. bioRxiv Feb 2022 Notes: doi: 10.1101/2022.02.19.481089. ecollection.
Rossidis AC, Angelin A, Lawrence KM, Baumgarten HD, Kim AG, Mejaddam AY, Coons BE, Hartman HA, Hwang G, Monos S, Peranteau WH, Davey MG, Murdock D, Wallace DC, Flake AW: Premature Lambs Exhibit Normal Mitochondrial Respiration after Long-Term Extrauterine Support. Fetal Diagn Ther 46(5): 306-312, Nov 2019 Notes: doi: 10.1159/000496232. Epub 2019 Mar 12.
Weiss SL, Zhang D, Bush J, Graham K, Starr J, Tuluc F, Henrickson S, Kilbaugh T, Deutschman CS, Murdock D, McGowan FX Jr, Becker L, Wallace DC: Persistent Mitochondrial Dysfunction Linked to Prolonged Organ Dysfunction in Pediatric Sepsis. Crit Care Med 47(10): 1433-1441, Oct 2019 Notes: doi: 10.1097/CCM.0000000000003931.
Yardeni T, Tanes CE, Bittinger K, Mattei LM, Schaefer PM, Singh LN, Wu GD, Murdock DG, Wallace DC : Host mitochondria influence gut microbiome diversity: A role for ROS. Sci Signal 12(588): eaaw3159, Jul 2019 Notes: doi: 10.1126/scisignal.aaw3159.
Kallianpur AR, Gerschenson M, Hulgan T, Kaur H, Clifford DB, Haas DW, Murdock DG, McArthur JC, Samuels DC, Simpson DM : Hemochromatosis (HFE) Gene Variants Are Associated with Increased Mitochondrial DNA Levels During HIV-1 Infection and Antiretroviral Therapy. AIDS Res Hum Retroviruses 34(11): 942-949, Nov 2018 Notes: doi: 10.1089/AID.2018.0025. Epub 2018 Aug 22.
Smieszek S, Mitchell SL, Farber-Eger EH, Veatch OJ, Wheeler NR, Goodloe RJ, Wells QS, Murdock DG, Crawford DC : Hi-MC: a novel method for high-throughput mitochondrial haplogroup classification. PeerJ 6(3): e5149, Jun 2018 Notes: doi: 10.7717/peerj.5149. eCollection 2018.