Haineng Xu, Ph.D.
Research Assistant Professor of Obstetrics and Gynecology
Department: Obstetrics and Gynecology
Contact information
Ovarian Cancer Research Center, University of Pennsylvania
421 Curie Blvd., Biomedical Research Building II/III 1214
Philadelphia, PA 19104
421 Curie Blvd., Biomedical Research Building II/III 1214
Philadelphia, PA 19104
Office: 832-705-3657
Publications
Education:
Bachelor (Biotechnology)
Anhui Normal University, 2007.
Ph.D. (Cancer Biology)
Chinese Academy of Sciences, 2013.
Permanent linkBachelor (Biotechnology)
Anhui Normal University, 2007.
Ph.D. (Cancer Biology)
Chinese Academy of Sciences, 2013.
Selected Publications
Xu H#, George E#, Kinose Y, Kim H, Shah JB, Peake JD, Ferman B, Medvedev S, Murtha T, Barger CJ, Devins KM, D'Andrea K, Wubbenhorst B, Schwartz LE, Hwang WT, Mills GB, Nathanson KL, Karpf AR, Drapkin R, Brown EJ, Simpkins F : CCNE1 copy number is a biomarker for response to combination WEE1-ATR inhibition in ovarian and endometrial cancer models. Cell Rep Med 2(9): 100394, 2021 Notes: (# Equal Contribution).Kim H#, Xu H#, George E, Hallberg D, Kumar S, Jagannathan V, Medvedev S, Kinose Y, Devins K, Verma P, Ly K, Wang Y, Greenberg RA, Schwartz L, Johnson N, Scharpf RB, Mills GB, Zhang R, Velculescu VE, Brown EJ, Simpkins F : Combining PARP with ATR inhibition overcomes PARP inhibitor and platinum resistance in ovarian cancer models. Nat Commun 11(1): 3726, 2020 Notes: (# Equal Contribution).
Gitto SB, Kim H, Rafail S, Omran DK, Medvedev S, Kinose Y, Rodriguez-Garcia A, Flowers AJ, Xu H, Schwartz LE, Powell DJ Jr, Simpkins F: An autologous humanized patient-derived-xenograft platform to evaluate immunotherapy in ovarian cancer. Gynecol Oncol 156(1): 222-232, 2020.
Liu T#, Ma W#, Xu H#, Huang M, Zhang D, He Z, Zhang L, Brem S, O'Rourke DM, Gong Y, Mou Y, Zhang Z, Fan Y: PDGF-mediated mesenchymal transformation renders endothelial resistance to anti-VEGF treatment in glioblastoma. Nat Commun 9(1): 3439, 2018 Notes: (# Equal Contribution).
Liu T#, Xu H#, Huang M, Ma W, Saxena D, Lustig RA, Alonso-Basanta M, Zhang Z, O'Rourke DM, Zhang L, Gong Y, Kao GD, Dorsey JF, Fan Y: Circulating Glioma Cells Exhibit Stem Cell-like Properties. Cancer Res 78(23): 6632-6642, 2018 Notes: (# Equal Contribution).
Wang Q, He Z, Huang M, Liu T, Wang Y, Xu H, Duan H, Ma P, Zhang L, Zamvil SS, Hidalgo J, Zhang Z, O'Rourke DM, Dahmane N, Brem S, Mou Y, Gong Y, Fan Y: Vascular niche IL-6 induces alternative macrophage activation in glioblastoma through HIF-2alpha. Nat Commun 9(1): 559, 2018.
Wang Y, Xu H, Liu T, Huang M, Butter PP, Li C, Zhang L, Kao GD, Gong Y, Maity A, Koumenis C, Fan Y: Temporal DNA-PK activation drives genomic instability and therapy resistance in glioma stem cells. JCI Insight 3(3), 2018.