Christopher D Watt, MD, PhD

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Associate Professor of Clinical Pathology and Laboratory Medicine
Department: Pathology and Laboratory Medicine

Contact information
Department of Pathology and Laboratory Medicine
Hospital of the University of Pennsylvania
3400 Spruce Street
Philadelphia, PA 19104
Education:
B.S. (Biology)
University of Kentucky, 1996.
M.D. (Medicine)
Perelman School of Medicine at the University of Pennsylvania, 2005.
Ph.D. (Cell and Molecular Biology)
Perelman School of Medicine at the University of Pennsylvania, 2005.
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Description of Clinical Expertise

Molecular Pathology

Selected Publications

Gentile C, Richard-Greenblatt M, Fink J, Elkan M, Harris RM, Van Deerlin VM, Glaser L, Watt CD, Herlihy SE : A Practical Comparison of Seven Molecular SARS-CoV-2 Methods. The Journal of Molecular Diagnostics 22(11): S33, Nov 2020 Notes: Association for Molecular Pathology 2020 Annual Meeting Abstract [ID22]

Zhang Q, Orlando EJ, Wang HY, Bogusz AM, Liu X, Lacey SF, Strauser HT, Nunez-Cruz S, Nejati R, Zhang P, Brooks S, Watt CD, Melenhorst JJ, June CH, Schuster SJ, Wasik MA : Transdifferentiation of lymphoma into sarcoma associated with profound reprogramming of the epigenome. Blood 136(17): 1980-1983, Oct 2020.

Herlihy SE, Carlin A, Nasrallah NP, Watt CD and Van Deerlin VM: Evaluation of a Targeted Realtime Assay for Rapid Identification of IDH1 and IDH2 Disease-Associated Variants in Brain Tumors. The Journal of Molecular Diagnostics 21(6): 1201, Nov 2019 Notes: Association for Molecular Pathology 2019 Annual Meeting Abstract [ST059]

Garces S, Nelson N, Watt CD, and Priore S: FLT3 Variants Near Codon 835: An Institutional Experience Comparing Rapid Restriction Digest Testing with Massively Parallel Sequencing. The Journal of Molecular Diagnostics 21(6): 1230, Nov 2019 Notes: Association for Molecular Pathology 2019 Annual Meeting Abstract [TT012]

McMahon C, Ferng T, Canaani J, Wang E, Morrissette J, Eastburn D, Pellegrino M, Durruthy-Durruthy R, Watt CD, Asthana S, Lasater E, DeFilippis RA, Peretz C, McGary L, Deihimi S, Logan A, Luger S, Shah N, Carroll M, Smith C, and Perl A: Clonal selection with Ras pathway activation mediates secondary clinical resistance to selective FLT3 inhibition in acute myeloid leukemia. Cancer Discovery 9(8): 1050-1063, Aug 2019.

Brown JT, Beldorth IJ, Laosinchai-Wolf W, Fahey ME, Jefferson KL, Ruskin AK, Roth JJ, Cai L, Watt CD, Press RD, Yang F, Hedges JB, and Andruss BF: Analytical validation of a highly sensitive, multiplexed chronic myeloid leukemia monitoring system targeting BCR-ABL1 RNA. The Journal of Molecular Diagnostics 21(4): 718-733, July 2019.

McMahon CM, Canaani J, Rea B, Sargent R, Watt CD, Morrissette JJD, Carroll M, and Perl AE: Gilteritinib induces differentiation in relapsed and refractory FLT3-mutated acute myeloid leukemia. Blood Advances 3(10): 1581-1585, May 2019.

Nasrallah MP, Binder ZA, Oldridge DA, Zhao J, Lieberman DB, Roth JJ, Watt CD, Sukhadia S, Klinman E, Daber RD, Desai A, O’Rourke DM, and Morrissette JJD: Molecular neuropathology in practice: Clinical profiling and integrative analysis of molecular alterations in glioblastoma. Academic Pathology 6: epub, May 2019.

Nelson W, Bagley S, Watt CD, and Nasrallah M: An institutional experience with pyrosequencing for MGMT promoter methylation analysis. Modern Pathology 32(supplement 2): 29, Mar 2019 Notes: United States and Canadian Academy of Pathology 2019 Annual Meeting Abstract.

Belman J, Gentile C, Lake JI, Roth JJ and Watt CD: Optimizing RNA extraction to facilitate BCR/ABL1 quantitative testing. The Journal of Molecular Diagnostics 20(6): 1031, Nov 2018 Notes: Association for Molecular Pathology 2018 Annual Meeting Abstract [TT049]

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Last updated: 04/01/2021
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