Alexander Proekt, M.D. Ph.D.
Associate Professor of Anesthesiology and Critical Care
Attending Anesthesiologist, Hospital of the University of Pennsylvania
Attending Anesthesiologist, Penn Presbyterian Medical Center
Education Officer, Hospital of the University of Pennsylvania
Department: Anesthesiology and Critical Care
Graduate Group Affiliations
Contact information
Anesthesiology and Critical Care
University of Pennsylvania
331 John Morgan Building
Philadelphia, PA 19104
University of Pennsylvania
331 John Morgan Building
Philadelphia, PA 19104
Lab: 215 746 2370
Email:
proekta@uphs.upenn.edu
proekta@uphs.upenn.edu
Publications
Education:
B.S. (Biological Sciences)
Carnegie Mellon University, 1998.
M.D. Ph.D. (Neuroscience/Medicine)
Mount Sinai School of Medicine, 2006.
Permanent linkB.S. (Biological Sciences)
Carnegie Mellon University, 1998.
M.D. Ph.D. (Neuroscience/Medicine)
Mount Sinai School of Medicine, 2006.
Description of Clinical Expertise
General Anesthesia, Anesthesia for Neurosurgery, Neuromonitoring during AnesthesiaDescription of Research Expertise
Neuroscience, Neurophysiology, Computational Neuroscience, Systems NeuroscienceSelected Publications
Andrzej Z Wasilczuk, Cole Rinehart, Adeeti Aggarwal, Martha E Stone George A Mashour, Michael S Avidan, Max B Kelz1, Alex Proekt: Hormonal Basis of Sex Differences in Anesthetic Sensitivity. Proceedings of the National Academy of Sciences 121(3): e2312913120, JAN 2024 Notes: doi: 10.1073/pnas.2312913120. Epub 2024 Jan 8.C Brennan, A Proekt: Attractor dynamics with activity-dependent plasticity capture human working memory across time scales. Nature Communications Psychology 1(28), OCT 2023 Notes: DOI https://doi.org/10.1038/s44271-023-00027-8.
Adeeti Aggarwal, Jennifer Luo, Helen Chung, Diego Contreras, Max B Kelz, Alex Proekt: Neural assemblies coordinated by cortical waves are associated with waking and hallucinatory brain states. bioarxiv MAY 2023 Notes: currently in revision at Cell Reports.
Richard Lennertz, Kane O. Pryor, Aeyal Raz, Maggie Parker, Vincent Bonhomme, Peter Schuller, Gerhard Schneider, Matt Moore, Mark Coburn, James C. Root, Jacqueline M. Emerson, Alexandra L. Hohmann, Haya Azaria, Neta Golomb, Aline Defresne, Javier Montupil, Stefanie Pilge, David P. Obert, Hanna van Waart, Marta Seretny, Rolf Rossaint, Ana Kowark, Alexander Blair, Bryan Krause, Alex Proekt, Max Kelz, Jamie Sleigh, Amy Gaskell, Robert D. Sanders: Connected consciousness after tracheal intubation in young adults: an international multicentre cohort study. British Journal of Anesthesia 130(2): e217-e224, FEB 2023 Notes: doi: 10.1016/j.bja.2022.04.010. Epub 2022 May 23.
Brennan C, Aggarwal A, Pei R, Sussillo D, Proekt A: One dimensional approximations of neuronal dynamics reveal computational strategy. PLoS Computational Biology 19(1), JAN 2023 Notes: https://doi.org/10.1371/journal.pcbi.1010784.
J Cichon, AZ Wasilczuk, LL Looger, D Contreras, MB Kelz, A Proekt: Ketamine triggers a switch in excitatory neuronal activity across neocortex. Nature Neuroscience 26: 39-52, NOV 2022.
Ethan B Blackwood, Brenna P Shortal, Alex Proekt: Weakly Correlated Local Cortical State Switches under Anesthesia Lead to Strongly Correlated Global States. Journal of Neuroscience 42(48): 8980-8996, NOV 2022 Notes: doi: 10.1523/JNEUROSCI.0123-22.2022. Epub 2022 Oct 26.
Adeeti Aggarwal, Connor Brennan, Jennifer Luo, Helen Chung, Diego Contreras, Max B Kelz, Alex Proekt: Visual evoked feedforward–feedback traveling waves organize neural activity across the cortical hierarchy in mice. Nature Communications 13(1): 1-6, AUG 2022.
Ashwin G Ramayya, Andrew I Yang, Vivek P Buch, John F Burke, Andrew G Richardson, Cameron Brandon, Joel M Stein, Kathryn A Davis, H Isaac Chen, Alexander Proekt, Max B Kelz, Brian Litt, Joshua I Gold, Timothy H Lucas: Theta synchrony is increased near neural populations that are active when initiating instructed movement eNeuro 8(1), FEB 2021 Notes: doi: 10.1523/ENEURO.0252-20.2020. Print 2021 Jan-Feb.
A Proekt, MB Kelz: Explaining anaesthetic hysteresis with effect-site equilibration British Journal of Anaesthesia 126(1): 265-278, 2021.