Alexander Proekt, M.D. Ph.D.

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Associate Professor of Anesthesiology and Critical Care
Department: Anesthesiology and Critical Care
Graduate Group Affiliations

Contact information
Anesthesiology and Critical Care
University of Pennsylvania
331 John Morgan Building
Philadelphia, PA 19104
Lab: 215 746 2370
B.S. (Biological Sciences)
Carnegie Mellon University, 1998.
M.D. Ph.D. (Neuroscience/Medicine)
Mount Sinai School of Medicine, 2006.
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Description of Clinical Expertise

General Anesthesia, Anesthesia for Neurosurgery, Neuromonitoring during Anesthesia

Description of Research Expertise

Neuroscience, Neurophysiology, Computational Neuroscience, Systems Neuroscience

Selected Publications

A Proekt, MB Kelz: Explaining anaesthetic hysteresis with effect-site equilibration British Journal of Anaesthesia 126(1): 265-278, 2021.

Sarah L.Reitz, Andrzej Z.Wasilczuk, Gretel H.Beh, Alex Proekt, Max B.Kelz: Activation of Preoptic Tachykinin 1 Neurons Promotes Wakefulness over Sleep and Volatile Anesthetic-Induced Unconsciousness. Current Biology 31(2), 2021.

AR McKinstry-Wu, A Proekt, MB Kelz: Neural inertia: a sticky situation for anesthesia. Journal of Neurosurgical Anesthesiology 32(3), 2020.

Ashwin G Ramayya, Andrew I Yang, Vivek P Buch, John F Burke, Andrew G Richardson, Cameron Brandon, Joel M Stein, Kathryn A Davis, H Isaac Chen, Alexander Proekt, Max B Kelz, Brian Litt, Joshua I Gold, Timothy H Lucas: Theta synchrony is increased near neural populations that are active when initiating instructed movement eNeuro 2020.

Andrzej Z Wasilczuk, Benjamin A Harrison, Paula Kwasniewska, Bo Ku, Max B Kelz, Andrew R McKinstry-Wu, Alex Proekt: Resistance to state transitions in responsiveness is differentially modulated by different volatile anaesthetics in male mice. British Journal of Anaesthesia 125(3), 2020.

Connor Brennan, Alex Proekt: LOOPER: Inferring computational algorithms enacted by neuronal population dynamics. arxiv ( arXiv preprint arXiv:2003.09976, 2020) 2020.

McKinstry-Wu AR, Wasilczuk AZ, Harrison BA, Bedell VM, Sridharan MJ, Breig JJ, Pack M, Kelz MB, Proekt A: Analysis of stochastic fluctuations in responsiveness is a critical step toward personalized anesthesia. eLife 8: e50143 DEC 2019 Notes: Electronic Journal;

Proekt A, Hemmings H: Mechanisms of Drug Action. Pharmacology and Physiology for Anesthesia, 2nd Ed. Hemmings H, Egan T (eds.). Elsevier, Page: 2-18, NOV 2019.

Shortal BP, Hickman LB, Mak-McCully RA, Wang W, Brennan C, Ung H, Litt B, Tarnal V, Janke E, Picton P, Blain-Moraes S, Maybrier HR, Muench MR, Lin N, Avidan MS, Mashour GA, McKinstry-Wu AR, Kelz MB, Palanca BJ, Proekt A: Duration of EEG suppression does not predict recovery time or degree of cognitive impairment after general anaesthesia in human volunteers. British Journal of Anaesthesia 123(2): 206-218, AUG 2019.

Gao S, Proekt A, Renier N, Calderon D, Pfaff D : Activating an anterior nucleus gigantocellularis subpopulation triggers emergence from pharmacologically-induced coma in rodents. Nature Communications 10(1), JUL 2019.

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Last updated: 02/23/2021
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