Alexander Proekt, M.D. Ph.D.

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Assistant Professor of Anesthesiology and Critical Care
Department: Anesthesiology and Critical Care
Graduate Group Affiliations

Contact information
Anesthesiology and Critical Care
University of Pennsylvania
331 John Morgan Building
Philadelphia, PA 19104
Lab: 215 746 2370
B.S. (Biological Sciences)
Carnegie Mellon University, 1998.
M.D. Ph.D. (Neuroscience/Medicine)
Mount Sinai School of Medicine, 2006.
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Description of Clinical Expertise

General Anesthesia, Anesthesia for Neurosurgery, Neuromonitoring during Anesthesia

Description of Research Expertise

Neuroscience, Neurophysiology, Computational Neuroscience, Systems Neuroscience

Selected Publications

McKinstry-Wu AR, Wasilczuk AZ, Harrison BA, Bedell VM, Sridharan MJ, Breig JJ, Pack M, Kelz MB, Proekt A: Analysis of stochastic fluctuations in responsiveness is a critical step toward personalized anesthesia. eLife DEC 2019 Notes: Electronic Journal,

Proekt A., Hemmings H.: Mechanisms of Drug Action. Pharmacology and Physiology for Anesthesia, 2nd Ed. Hemmings H., Egan T. (eds.). Elsevier, Page: 2-18, NOV 2019.

Shortal B.P., Hickman L.B., Mak-McCully R.A., Wang W., Brennan C., Ung H., Litt B., Tarnal V., Janke E., Picton P., Blain-Moraes S., Maybrier H.R., Muench M.R., Lin N., Avidan M.S., Mashour G.A., McKinstry-Wu A.R., Kelz M.B., Palanca B.J., Proekt A.: Duration of EEG suppression does not predict recovery time or degree of cognitive impairment after general anaesthesia in human volunteers. British Journal of Anaesthesia 123(2): 206-218, AUG 2019.

Gao S., Proekt A., Renier N., Calderon D., Pfaff D. : Activating an anterior nucleus gigantocellularis subpopulation triggers emergence from pharmacologically-induced coma in rodents. Nature Communications 10(1), JUL 2019.

Brennan C., Proekt A: A quantitative model of conserved macroscopic dynamics predicts future motor commands. eLife July 2019.

Aggarwal A., Brennan C., Shortal B., Contreras D., Kelz M.B., Proekt A.: Coherence of Visual-Evoked Gamma Oscillations Is Disrupted by Propofol but Preserved Under Equipotent Doses of Isoflurane. Frontiers in Systems Neuroscience 13, MAY 2019 Notes: eCollection;

Proekt A.: Emergence Delirium: A New Hypothesis for an Old Problem. Perioperative Neurocognitive Disorders. Eckenhoff and Terrando (eds.). Cambridge University Press, New York NY, Page: 1-8, MAR 2019 Notes: Chapter 1.

Alonso L.M., Solovey G., Yanagawa T., Proekt A., Cecchi G.A., Magnasco M.O.: Single-trial classification of awareness state during anesthesia by measuring critical dynamics of global brain activity. Scientific Reports 9(1), MAR 2019.

Proekt A., Hudson A.E. : A stochastic basis for neural inertia in emergence from general anaesthesia. British Journal of Anaesthesia 121(1): 86-94, JUL 2018.

Shortal B.P., Reitz S.L., Aggarwal A., Meng Q.C., McKinstry-Wu A.R., Kelz M.B., Proekt A.: Development and validation of brain target controlled infusion of propofol in mice. PLOS One 13(4), APR 2018 Notes: eCollection;

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Last updated: 06/04/2020
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