1e
19
1
49
2
2
18
1b
1d
18
2e
61
1d
2 29
1d
25
Yong Chen, Ph.D.
88
61
Professor of Biostatistics in Biostatistics and Epidemiology
28
a3
3
75
Senior Fellow, Institute for Biomedical Informatics, Perelman School of Medicine, University of Pennsylvania
ac
Senior Scholar, Center for Evidence-Based Practice, Perelman Center for Advanced Medicine, University of Pennsylvania
b5
Senior Statistician, Center for Evidence-based Practice, The Perelman Center for Advanced Medicine, University of Pennsylvania
79
Senior Statistician, Penn Center for Cancer Care Innovation (PC3I)
bd
Founding Director, The Center for Health AI and Synthesis of Evidence (CHASE), Perelman School of Medicine, University of Pennsylvania
11
Department: Biostatistics and Epidemiology
4
1
23
1f
Graduate Group Affiliations
8
a
b
1d
46
Contact information
6e
4
3
3
3
2
4
b
1f
6e
602 Blockley Hall, 423 Guardian Drive
Philadelphia, PA 19104
26
Philadelphia, PA 19104
2e
Office: 215-746-8155
30
85
30
Email:
ychen123@upenn.edu
12
ychen123@upenn.edu
13
Education:
21 8 BSc 18 (Mathematics) c
60 University of Science and Technology of China, Hefei, Anhui, P.R. China, 2003.
21 7 MA 18 (Mathematics) c
44 The Johns Hopkins University, Baltimore, MD, 2005.
21 8 PhD 1a (Biostatistics) c
44 The Johns Hopkins University, Baltimore, MD, 2010.
c
3
3
3
3
8d
Permanent link21 8 BSc 18 (Mathematics) c
60 University of Science and Technology of China, Hefei, Anhui, P.R. China, 2003.
21 7 MA 18 (Mathematics) c
44 The Johns Hopkins University, Baltimore, MD, 2005.
21 8 PhD 1a (Biostatistics) c
44 The Johns Hopkins University, Baltimore, MD, 2010.
c
2 29
21
1e
1d
24
2b
29
27
23
e2 Chen Y, Ning J, Cai C: Regression analysis of longitudinal data with irregular and informative observation times. Biostatistics 16(4): 727-739, Oct 2015.
e8 Liu Y, Chen Y and Chu H: A unification of models for meta-analysis of diagnostic accuracy studies without a gold standard. Biometrics 71(2): 538-547, Jun 2015.
bc Chen Y and Li T: Book review on "Applied Meta-analysis for Social Science Research" The American Statistician 2015.
eb Chen Y, Hong C and Riley R: An alternative pseudolikelihood method for multivariate random-effects meta-analysis. Statistics in Medicine 34(3): 361-380, Feb 2015.
129 Chen Y, Liu Y, Ning J, Cormier J and Chu H: A hybrid model for combining case-control and cohort studies in systematic reviews of diagnostic tests. Journal of the Royal Statistical Society: Series C 64(3): 469-489, Apr 2015.
f8 Ning J, Chen Y, Cai C, Huang X and Wang MC: On the dependence structure of bivariate recurrent event processes: Inference and estimation. Biometrika 102(2): 345-358, Jun 2015.
d1 Luo S, Chen Y, Su X and Chu H: mmeta: An R package for multivariate meta-analysis. Journal of Statistical Software 56(11): 11, Jan 2014.
1a1 Xu C, Wallace M, Yang J, Jiang L, Zhai Q, Zhang Y, Hong C, Chen Y, Frank T, Stauffer J, Asbun H, Raimondo M, Woodward T, Li Z, Guha S, Zheng L and Li M: ZIP4 is a novel diagnostic and prognostic marker in human pancreatic cancer: A systemic comparison between EUS-FNA and surgical specimens. Current Molecular Medicine 14(3): 309-315, Mar 2014.
e3 Chen Y and Liang KY: On the asymptotic behaviour of the pseudolikelihood ratio test statistic with boundary problems. Biometrika 97(3): 603-620, Sep 2010.
13f Nie L, Chen Y and Chu H: Asymptotic variances of maximum likelihood estimator for the correlation coefficient from a BVN distribution with one variable subject to censoring. Journal of Statistical Planning and Inference 141(1): 392-401, Jan 2011.
10d Chen Y, Ning Y, Hong C and Wang S: Semiparametric tests for identifying differentially methylated loci with case-control designs using Illumina arrays. Genetic Epidemiology 38(1): 42-50, Jan 2014.
e6 Tong P, Chen Y, Su X and Coombes K: SIBER: Systematic identification of bimodally expressed genes using RNAseq data. Bioinformatics 29(5): 605-613, Mar 2013.
118 Huang J, Chen Y, Swartz M and Ionita-Laza I: Comparing the power of family-based association test for sequence data with applilcations in the GAW 18 simulated data. BMC Proceedings 8(Suppl 1): S27, Jun 2014.
129 Chen Y, Liu Y, Ning J, Nie L, Zhu H and Chu H: A composite likelihood method for bivariate meta-analysis of sensitivity and specificity in diagnostic reviews. Statistical Methods in Medical Research 26(2): 914-930, Apr 2017.
113 Chen Y, Chu H, Luo S, Nie L, Chen S: Bayesian analysis on meta-analysis of case-control studies accounting for within-study correlation. Statistical Methods in Medical Research 24(6): 836-855, Dec 2015.
11c Chen Y, Luo S, Chu H, Su X, and Nie L: An empirical Bayes method for multivariate meta-analysis with application in clinical trials. Communications in Statistics - Theory and Methods 43(16): 3536-3551, Jul 2014.
14c Ma X, Chen Y, Cole S and Chu H: A hybrid Bayesian hierarchical model combining cohort and case-control studies for meta-analysis of diagnostic tests: accounting for partial verification bias. Statistical Methods in Medical Research 25(6): 3015-3037, Dec 2016.
125 Chen Y, Luo S, Chu H and Wei P: Bayesian inference on risk differences: an application to multivariate meta-analysis of adverse events in clinical trials. Statistics in Biopharmaceutical Research 5(2): 142-155, May 2013.
135 Nie L, Soon G, Qi K, Chen Y and Chu HT: A note on partial covariate-adjustment and design considerations in noninferiority trials when patient-level data are not available. Journal of Biopharmaceutical Statistics 23(5): 1042-1053, 2013.
14e Chu H, Nie L, Chen Y, Huang Y and Sun W: Bivariate random effects models for meta-analysis of comparative studies with binary outcomes: methods for the absolute risk difference and relative risk. Statistical Methods in Medical Research 21(6): 621-633, Dec 2012.
125 Chen Y and Luo S: A few remarks on 'Statistical distribution of the difference of two proportions' by Nadarajah and Kotz, Statistics in Medicine 2007; 26(18):3518-3523. Statistics in Medicine 30(15): 1913-1915, Jul 2011.
12b Lin Y, Chen Y, Wang Y, Yang J, Zhu V, Liu Y, Cui X, Yan W, Jiang T, Hergenroeder G, Fletcher S, Levine J, Kim D, Tandon N, Zhu J and Li M: ZIP4 is a novel molecular marker for glioma. Neuro-Oncology 15(8): 1008-1016, Aug 2013.
178 Zhang Y, Yang J, Cui X, Chen Y, Zhu V, Hagan J, Wang H, Yu X, Hodges S, Fang J, Chiao P, Logsdon C, Fisher W, Brunicardi F, Chen C, Yao Q, Fernandez-Zapico M and Li M: A novel epigenetic CREB-miR 373 axis mediates ZIP4-induced pancreatic cancer growth. EMBO Molecular Medicine 5(9): 1322-1334, Sep 2013.
12a Lin Y, Zhang G, Zhang J, Gao C, Li M, Chen Y, Wang J, Li G, Song S, Wang Y and Jiang T: A panel of four cytokines predicts the prognosis of patients with malignant gliomas. Journal of Neuro-Oncology 114(2): 199-208, Sep 2013.
1ac Go VF, Frangakis C, Minh N, Latkin C, Ha T, Mo T, Sripaipan T, Davis W, Zelaya C, Chen Y, Celentano D and Quan V: Effects of an HIV peer prevention intervention on sexual and injecting risk behaviors among injecting drug users and their risk partners in Thai Nguyen, Vietnam: a randomized controlled trial. Social Science & Medicine 96: 154-164, Nov 2013.
1eb Nestadt G, Wang Y, Grados MA, Riddle MA, Greenberg BD, Knowles JA, Fyer AJ, McCracken JT, Rauch SL, Murphy DL, Rasmussen SA Cullen B, Piacentini J, Geller D, Pauls D, Bienvenu OJ, Chen Y, Liang KY, Goes FS, Maher B, Pulver AE, Shugart YY, Valle D, Samuels JF and Chang YC: Homeobox genes in obsessive-compulsive disorder. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 159B(1): 53-60, Jan 2012.
111 Blom RM, Samuels JF, Grados MA, Chen Y, Bienvenu OJ, Riddle MA, Liang KY, Brandt J and Nestadt G: Cognitive functioning in compulsive hoarding. Journal of Anxiety Disorders 25(8): 1139-1144, Dec 2011.
155 Frangakis CE, Geschwind J, Kim D, Chen Y, Koteish A, Hong K, Liapi E and Georgiades CS: Chemoembolization decreases drop-off risk of hepatocellular carcinoma patients on the liver transplant list. Cardiovascular and Interventional Radiology 34(6): 1254-1261, Dec 2011.
178 Wible BC, Rilling WS, Drescher P, Hieb RA, Saeian K, Frangakis CE, Chen Y, Eastwood D and Kim HS: Longitudinal quality of life assessment of patients with hepatocellular carcinoma after primary transarterial chemoembolization. Journal of Vascular and Interventional Radiology 21(7): 1024-1030, Jul 2010.
156 Buijs M, Vossen JA, Frangakis CE, Hong K, Georgiades C, Chen Y, Liapi E and Geschwind JF: Nonresectable hepatocellular carcinoma: long-term toxicity in patients treated with transarterial chemoembolization--single-center experience. Radiology 249(1): 346-354, Oct 2008.
2c
7
1d
1f
Selected Publications
1b0 Liu L, Xu H, Wang W, Wu C, Chen Y, Yang J, Cen P, Xu J, Liu C, Long J, Guha S, Fu D, Ni Q, Jatoi A, Chari S, McCleary-Wheeler A, Fernandez-Zapico M, Li M and Yu X: A preoperative serum signature of CEA +/ CA125 +/ CA19-9 >= 1,000 U/mL indicates poor outcome to pancreatectomy for pancreatic cancer. International Journal of Cancer 136(9): 2216-2227, May 2015.e2 Chen Y, Ning J, Cai C: Regression analysis of longitudinal data with irregular and informative observation times. Biostatistics 16(4): 727-739, Oct 2015.
e8 Liu Y, Chen Y and Chu H: A unification of models for meta-analysis of diagnostic accuracy studies without a gold standard. Biometrics 71(2): 538-547, Jun 2015.
bc Chen Y and Li T: Book review on "Applied Meta-analysis for Social Science Research" The American Statistician 2015.
eb Chen Y, Hong C and Riley R: An alternative pseudolikelihood method for multivariate random-effects meta-analysis. Statistics in Medicine 34(3): 361-380, Feb 2015.
129 Chen Y, Liu Y, Ning J, Cormier J and Chu H: A hybrid model for combining case-control and cohort studies in systematic reviews of diagnostic tests. Journal of the Royal Statistical Society: Series C 64(3): 469-489, Apr 2015.
f8 Ning J, Chen Y, Cai C, Huang X and Wang MC: On the dependence structure of bivariate recurrent event processes: Inference and estimation. Biometrika 102(2): 345-358, Jun 2015.
d1 Luo S, Chen Y, Su X and Chu H: mmeta: An R package for multivariate meta-analysis. Journal of Statistical Software 56(11): 11, Jan 2014.
1a1 Xu C, Wallace M, Yang J, Jiang L, Zhai Q, Zhang Y, Hong C, Chen Y, Frank T, Stauffer J, Asbun H, Raimondo M, Woodward T, Li Z, Guha S, Zheng L and Li M: ZIP4 is a novel diagnostic and prognostic marker in human pancreatic cancer: A systemic comparison between EUS-FNA and surgical specimens. Current Molecular Medicine 14(3): 309-315, Mar 2014.
e3 Chen Y and Liang KY: On the asymptotic behaviour of the pseudolikelihood ratio test statistic with boundary problems. Biometrika 97(3): 603-620, Sep 2010.
13f Nie L, Chen Y and Chu H: Asymptotic variances of maximum likelihood estimator for the correlation coefficient from a BVN distribution with one variable subject to censoring. Journal of Statistical Planning and Inference 141(1): 392-401, Jan 2011.
10d Chen Y, Ning Y, Hong C and Wang S: Semiparametric tests for identifying differentially methylated loci with case-control designs using Illumina arrays. Genetic Epidemiology 38(1): 42-50, Jan 2014.
e6 Tong P, Chen Y, Su X and Coombes K: SIBER: Systematic identification of bimodally expressed genes using RNAseq data. Bioinformatics 29(5): 605-613, Mar 2013.
118 Huang J, Chen Y, Swartz M and Ionita-Laza I: Comparing the power of family-based association test for sequence data with applilcations in the GAW 18 simulated data. BMC Proceedings 8(Suppl 1): S27, Jun 2014.
129 Chen Y, Liu Y, Ning J, Nie L, Zhu H and Chu H: A composite likelihood method for bivariate meta-analysis of sensitivity and specificity in diagnostic reviews. Statistical Methods in Medical Research 26(2): 914-930, Apr 2017.
113 Chen Y, Chu H, Luo S, Nie L, Chen S: Bayesian analysis on meta-analysis of case-control studies accounting for within-study correlation. Statistical Methods in Medical Research 24(6): 836-855, Dec 2015.
11c Chen Y, Luo S, Chu H, Su X, and Nie L: An empirical Bayes method for multivariate meta-analysis with application in clinical trials. Communications in Statistics - Theory and Methods 43(16): 3536-3551, Jul 2014.
14c Ma X, Chen Y, Cole S and Chu H: A hybrid Bayesian hierarchical model combining cohort and case-control studies for meta-analysis of diagnostic tests: accounting for partial verification bias. Statistical Methods in Medical Research 25(6): 3015-3037, Dec 2016.
125 Chen Y, Luo S, Chu H and Wei P: Bayesian inference on risk differences: an application to multivariate meta-analysis of adverse events in clinical trials. Statistics in Biopharmaceutical Research 5(2): 142-155, May 2013.
135 Nie L, Soon G, Qi K, Chen Y and Chu HT: A note on partial covariate-adjustment and design considerations in noninferiority trials when patient-level data are not available. Journal of Biopharmaceutical Statistics 23(5): 1042-1053, 2013.
14e Chu H, Nie L, Chen Y, Huang Y and Sun W: Bivariate random effects models for meta-analysis of comparative studies with binary outcomes: methods for the absolute risk difference and relative risk. Statistical Methods in Medical Research 21(6): 621-633, Dec 2012.
125 Chen Y and Luo S: A few remarks on 'Statistical distribution of the difference of two proportions' by Nadarajah and Kotz, Statistics in Medicine 2007; 26(18):3518-3523. Statistics in Medicine 30(15): 1913-1915, Jul 2011.
12b Lin Y, Chen Y, Wang Y, Yang J, Zhu V, Liu Y, Cui X, Yan W, Jiang T, Hergenroeder G, Fletcher S, Levine J, Kim D, Tandon N, Zhu J and Li M: ZIP4 is a novel molecular marker for glioma. Neuro-Oncology 15(8): 1008-1016, Aug 2013.
178 Zhang Y, Yang J, Cui X, Chen Y, Zhu V, Hagan J, Wang H, Yu X, Hodges S, Fang J, Chiao P, Logsdon C, Fisher W, Brunicardi F, Chen C, Yao Q, Fernandez-Zapico M and Li M: A novel epigenetic CREB-miR 373 axis mediates ZIP4-induced pancreatic cancer growth. EMBO Molecular Medicine 5(9): 1322-1334, Sep 2013.
12a Lin Y, Zhang G, Zhang J, Gao C, Li M, Chen Y, Wang J, Li G, Song S, Wang Y and Jiang T: A panel of four cytokines predicts the prognosis of patients with malignant gliomas. Journal of Neuro-Oncology 114(2): 199-208, Sep 2013.
1ac Go VF, Frangakis C, Minh N, Latkin C, Ha T, Mo T, Sripaipan T, Davis W, Zelaya C, Chen Y, Celentano D and Quan V: Effects of an HIV peer prevention intervention on sexual and injecting risk behaviors among injecting drug users and their risk partners in Thai Nguyen, Vietnam: a randomized controlled trial. Social Science & Medicine 96: 154-164, Nov 2013.
1eb Nestadt G, Wang Y, Grados MA, Riddle MA, Greenberg BD, Knowles JA, Fyer AJ, McCracken JT, Rauch SL, Murphy DL, Rasmussen SA Cullen B, Piacentini J, Geller D, Pauls D, Bienvenu OJ, Chen Y, Liang KY, Goes FS, Maher B, Pulver AE, Shugart YY, Valle D, Samuels JF and Chang YC: Homeobox genes in obsessive-compulsive disorder. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 159B(1): 53-60, Jan 2012.
111 Blom RM, Samuels JF, Grados MA, Chen Y, Bienvenu OJ, Riddle MA, Liang KY, Brandt J and Nestadt G: Cognitive functioning in compulsive hoarding. Journal of Anxiety Disorders 25(8): 1139-1144, Dec 2011.
155 Frangakis CE, Geschwind J, Kim D, Chen Y, Koteish A, Hong K, Liapi E and Georgiades CS: Chemoembolization decreases drop-off risk of hepatocellular carcinoma patients on the liver transplant list. Cardiovascular and Interventional Radiology 34(6): 1254-1261, Dec 2011.
178 Wible BC, Rilling WS, Drescher P, Hieb RA, Saeian K, Frangakis CE, Chen Y, Eastwood D and Kim HS: Longitudinal quality of life assessment of patients with hepatocellular carcinoma after primary transarterial chemoembolization. Journal of Vascular and Interventional Radiology 21(7): 1024-1030, Jul 2010.
156 Buijs M, Vossen JA, Frangakis CE, Hong K, Georgiades C, Chen Y, Liapi E and Geschwind JF: Nonresectable hepatocellular carcinoma: long-term toxicity in patients treated with transarterial chemoembolization--single-center experience. Radiology 249(1): 346-354, Oct 2008.
2c