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Daniel S. Lefler, MD

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Assistant Professor of Clinical Medicine (Hematology-Oncology)
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Assistant Program Director of the Hematology/Oncology Fellowship Program, Hospital of the University of Pennsylvania
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Associate Clinical Director of Sarcoma Medical Oncology, Abramson Cancer Center
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Medical Director, PCAM 3
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Department: Medicine
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Perelman Center for Advanced Medicine
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38 10-145 South Pavilion
Philadelphia, PA 19104
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Email: daniel.lefler@pennmedicine.upenn.edu
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13 Education:
21 7 BS 36 (Neuroscience (Minor in Religious Studies)) c
36 The College of William & Mary, 2012.
 21 7 MD 16 (Medicine ) c
43 Cooper Medical School of Rowan University , 2016.
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Selected Publications

21b Daniel S Lefler, Andrew Elliott, Wei Jiang, Ubaldo Martinez-Outschoorn, Jude Al-Sabah, Daniel M Freed, Caitlin M King, Robert G Maki, Richard F Riedel, Jaime F Modiano, Daniel Hübschmann, Hanno Glimm, Stefan Fröhling, Matthew Oberley, Sosipatros A Boikos, Atrayee Basu Mallick: Pansarcoma Analysis of Cyclin-Dependent Kinase and Cyclin Outlier Gene Expression Highlights CDK7 as a Potential Therapeutic Target in Chordoma. JCO Precis Oncol 9: e2500149. July 2025.

 14d Mohammad S Farooq, Neha Shafique, Gracia M Vargas, Jennifer Guo, John T Miura, Daniel S Lefler, Giorgos C Karakousis: Neoadjuvant Immunotherapy for Resectable Dedifferentiated Liposarcoma: A National Cohort Analysis. J Surg Oncol 131(8): 1683-1691. June 2025.

 188 Gabriel Aleixo, Lee Hartner, Mark Diamond, Lazlo Nziga, Daniel Lefler: Liposomal vs conventional doxorubicin as first-line therapy in advanced soft tissue sarcomas: A tertiary US center’s 8.5-year experience. The American Society of Clinical Oncology Annual Meeting, Chicago, IL. May 2025 Notes: "Poster Presentation"

 193 Lefler, D.S., Maki, R.G., Somaiah, N.,…Basu Mallick, A.: Characterizing the genomic landscape of perivascular epithelioid cell family of tumors in a real-world patient population using the Foundation Medicine genomic database. Connective Tissue Oncology Society Annual Meeting, San Diego, CA. Nov 2024 Notes: "Oral presentation"

 139 Lefler, D.S., Moding, E.J., Basu Mallick, A: mTOR activity: a biomarker for chemo- and immunotherapy response and outcomes in sarcomas. Connective Tissue Oncology Society Annual Meeting, San Diego, CA. Nov 2024 Notes: "Poster Presentation"

17a Lefler, D.S., Elliott, A., Blomain, E.S.,…Basu Mallick, A: Characterizing patterns of mTORC1 activation across sarcomas using single-sample gene set enrichment analysis (ssGSEA) and a national biomarker database. American Society of Clinical Oncology Annual Meeting, Chicago,IL June 2024 Notes: "Poster"

 11a Jirka GW, Lefler DS, Russo J, Bashir B.: Colon adenocarcinoma and Birt-Hogg-Dubé syndrome in a young patient: case report and exploration of pathologic implications. Cancer Biol Ther 24(1): 2184153, Dec 2023.

 111 Lefler DS, Manobianco SA, Bashir B.: Immunotherapy resistance in solid tumors: mechanisms and potential solutions. Cancer Biol Ther 25(1): 2315655, Dec 2023 Notes: doi: 10.1080/15384047.2024.2315655.

152 Robbins J, Halegoua-DeMarzio D, Basu Mallick A, Vijayvergia N, Ganetzky R, Lavu H, Giri VN, Miller J, Maley W, Shah AP, DiMeglio M, Ambelil M, Yu R, Sato T, Lefler DS: Liver Transplantation in a Woman with Mahvash Disease. N Engl J Med 389(21): 1972-1978, Nov 2023.

 134 Lefler, D.S., Elliott, A., Maki, R.G.,…Basu Mallick, A.: Overexpression of cyclin dependent kinases and cyclins across sarcomas beyond CDK4. Connective Tissue Oncology Society Annual Meeting, Dublin, Ireland Nov 2023 Notes: "Poster"

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