Fengqi Chang, Ph.D.
Principal Scientist, Children's Hospital of Philadelphia
Contact information
The Children's Hospital of Philadelphia
Colket Translational Research Building
3501 Civic Center Blvd
Philadelphia, PA 19104
Colket Translational Research Building
3501 Civic Center Blvd
Philadelphia, PA 19104
Email:
fengqic@email.chop.edu
fengqic@email.chop.edu
Education:
B.S. (Biology)
Liaocheng University, P.R.China , 1997.
M.S. (Physiology and Biochemistry)
Life Science College, Beijing Normal University, P.R.China , 2000.
Ph.D. (Molecular Biology)
Institute of Botany, Chinese Academy of Sciences, P.R.China , 2003.
Permanent linkB.S. (Biology)
Liaocheng University, P.R.China , 1997.
M.S. (Physiology and Biochemistry)
Life Science College, Beijing Normal University, P.R.China , 2000.
Ph.D. (Molecular Biology)
Institute of Botany, Chinese Academy of Sciences, P.R.China , 2003.
Selected Publications
Lin F*, Cao K*, Chang F*, Oved JH, Luo M, Fan Z, Schubert j, Wu J, Zhong Y, Gallo DJ, Denenberg EH, Chen J, Fanning EA, Lambert MP, Paessler ME, Surrey LF, Zelley K, MacFarland S, Kurre P, Olson TS, Li MM: Uncovering the genetic etiology of inherited bone marrow failure syndromes using a custom-designed next-generation sequencing panel J Mol Diagn 26(3): 191-201, Mar 2024 Notes: *Contributed equally to this study.Tian W, Sun L, Zhang Q, Zhao J, Guo Y, Zhong W, Liu L, Meirelles K, Tang S, Zhang J, Huang Y, Yin Y, Zhang N, Zhao Z, Li Q, Wu N, Fang P, Chang* F, Wu Z: Activating PIK3CA postzygotic mutations in segmental overgrowth of muscles with bone involvement in the body extremities. Mol Genet Genomics 297(2): 387-96, Mar 2022 Notes: *Corresponding author.
Yang L, Wei Z, Chen X, Hu L, Peng X, Wang J, Lu C, Kong Y, Dong X, Ni Q, Lu Y, Wu B, Wang H, Meirelles K, Tian X, Zhang J, Chang F, Liu L, Li C, You W, Cheng G, Wang L, Cao Y, Chen C, Fang P, Tang S, Zhou W: Use of medical exome sequencing for identification of underlying defects in NICU: experience in a cohort of 2303 neonates in China. Clin Genet 101(1): 101-109, Jan 2022.
Chang F, Lin F, Cao K, Surrey LF, Aplenc R, Bagatell R, Santi M, Storm JB, Tasian SK, Waanders AJ, Hunger SP, Li M: Development and clinical validation of a large fusion gene panel for pediatric cancers. J Mol Diagn 21(5): 873-883, Sep 2019.
Surrey LF, MacFarland SP, Chang F, Cao K, Rathi KS, Akgumus GT, Gallo D, Lin F, Gleason A, Raman P, Aplenc R, Bagatell R, Minturn J, Mosse Y, Santi M, Tasian SK, Waanders AJ, Sarmady M, Maris JM, Hunger SP, Li M: Clinical Utility of Custom-designed NGS Panel Testing in Pediatric Tumors. Genome Med 11(1): 32, May 2019.
Yang Y Ding, Julie W Stern, Tracey F Jubelirer, Gerald BW Wertheim, Fumin Lin, Fengqi Chang, Zhaohui Gu, Charles G Mullighan, Yong Li, Richard C Harvey, I-Ming Chen, Cheryl L Willman, Stephen P Hunger, Marilyn M Li and Sarah K Tasian: Clinical efficacy of Ruxolitinib and chemotherapy in a child with Philadelphia chromosome-like acute lymphoblastic leukemia with GOLGA5-JAK2 fusion and induction failure. Haematologica 103(9): e427-431, Sep 2018.
Chang F, Liu L, Fang E, Zhang G, Chen T, Cao K, Li Y, Li M: Molecular Diagnosis of Mosaic Overgrowth Syndromes Using a Custom-Designed Next-Generation Sequencing Panel. J Mol Diagn 19(4): 613-624, Jul 2017.
Gozde Akgumus, Fengqi Chang, Marilyn M. Li: Overgrowth syndromes caused by somatic mutations in PI3K/AKT/mTOR pathway. Journal of Molecular Diagnostics 19(4): 487-497, Jul 2017.
Lea F. Surrey, Minjie Luo, Fengqi Chang, Marilyn M. Li : The genomic era of clinical oncology: integrated genomic analysis for precision cancer care. Cytogenet Genome Res 150(3-4): 162-175, 2016.
Fengqi Chang, Geoffrey L. Liu, Cindy J. Liu, Marilyn M. Li: Somatic Diseases (Cancer): Amplification-based NGS. Clinical Genomics: A Guide to Clinical Next Generation Sequencing Shashikant Kulkarni, Somak Roy (eds.). Elsevier/Academic Press, Page: 297-319, 2015.