Kiran Musunuru, MD, PhD, MPH, ML

faculty photo
Professor of Medicine (Cardiovascular Medicine)
Director, Penn Cardiovascular Institute's Genetic and Epigenetic Origins of Disease Program, Perelman School of Medicine at the University of Pennsylvania
Scientific Director, Penn Center for Inherited Cardiovascular Disease, Hospital of the University of Pennsylvania
Department: Medicine
Graduate Group Affiliations

Contact information
3400 Civic Center Blvd, Bldg 421
11-104 Smilow Center for Translational Research
Philadelphia, PA 19104
Office: 215-573-4717
AB (Biochemical Sciences)
Harvard College, Cambridge, MA, 1997.
PhD (Biomedical Sciences)
The Rockefeller University, New York, NY, 2003.
MD (Medicine)
Weill-Cornell Medical College, New York, NY, 2004.
MPH (Epidemiology)
Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, 2009.
ML (Law)
University of Pennsylvania Law School, Philadelphia, PA, 2019.
Permanent link
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Selected Publications

Brooks DL, Whittaker MN, Said H, Dwivedi G, Qu P, Musunuru K, Ahrens-Nicklas RC, Alameh MG, Wang X.: A base editing strategy using mRNA-LNPs for in vivo correction of the most frequent phenylketonuria variant. HGG Adv 5: 100253, Jan 2024.

Brooks DL, Whittaker MN, Qu P, Musunuru K, Ahrens-Nicklas RC, Wang X.: Efficient in vivo prime editing corrects the most frequent phenylketonuria variant, associated with high unmet medical need. Am J Hum Genet 110: 2003-2014, Dec 2023.

Musunuru K.: Playing the genetic lottery: an interview with Kiran Musunuru. Dis Model Mech 16: dmm050508, Oct 2023.

Whittaker MN, Testa LC, Quigley A, Jindal I, Cortez-Alvarado SV, Qu P, Yang Y, Alameh MG, Musunuru K, Wang X.: Epigenome editing durability varies widely across cardiovascular disease target genes. Arterioscler Thromb Vasc Biol 43: 2075-2077, Oct 2023.

Allyse MA, Meagher KM, Michie M, Isasi R, Ormond KE, Bonhomme N, Bombard Y, Howard H, Musunuru K, Riggan KA, Rubeck S.: Translational justice in human gene editing: bringing end user engagement and policy together. Am J Bioeth 23: 55-58, Jul 2023.

Testa LC, Musunuru K.: Base editing and prime editing: potential therapeutic options for rare and common diseases. BioDrugs 37: 453-462, Jul 2023.

Brooks DL, Carrasco MJ, Qu P, Peranteau WH, Ahrens-Nicklas RC, Musunuru K, Alameh MG, Wang X.: Rapid and definitive treatment of phenylketonuria in variant-humanized mice with corrective editing. Nat Commun 14: 3451, Jun 2023.

Gawronski KAB, Bone WP, Park Y, Pashos EE, Wenz BM, Dudek MF, Wang X, Yang W, Rader DJ, Musunuru K, Voight BF, Brown CD.: Evaluating the contribution of cell type-specific alternative splicing to variation in lipid levels. Circ Genom Precis Med 16: 248-257, Jun 2023.

Kasiewicz LN, Biswas S, Beach A, Ren H, Dutta C, Mazzola AM, Rohde E, Chadwick A, Cheng C, Garcia SP, Iyer S, Matsumoto Y, Khera AV, Musunuru K, Kathiresan S, Malyala P, Rajeev KG, Bellinger AM.: GalNAc-Lipid nanoparticles enable non-LDLR dependent hepatic delivery of a CRISPR base editing therapy. Nat Commun 14: 2776, May 2023.

Davis JR, Banskota S, Levy JM, Newby GA, Wang X, Anzalone AV, Nelson AT, Chen PJ, Hennes AD, An M, Roh H, Randolph PB, Musunuru K, Liu DR.: Efficient prime editing in mouse brain, liver and heart with dual AAVs. Nat Biotechnol May 2023.

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Last updated: 01/30/2024
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