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Dennis J. Dlugos, MD, MSCE
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Professor of Neurology at the Children's Hospital of Philadelphia
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Director, Pediatric Epilepsy Program, Division of Neurology, The Children's Hospital of Philadelphia
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Associate Dean for UME Science and Discovery Curriculum, Perelman School of Medicine at the University of Pennsylvania
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Department: Neurology
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Contact information
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Division of Neurology
2b Children's Hospital of Philadelphia
29 34th Street and Civic Center Blvd
2a The Hub for Clinical Collaboration
39 10th floor, Room 10537
Philadelphia, PA 19104
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2b Children's Hospital of Philadelphia
29 34th Street and Civic Center Blvd
2a The Hub for Clinical Collaboration
39 10th floor, Room 10537
Philadelphia, PA 19104
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Office: 215-590-1719
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Email:
dlugos@email.chop.edu
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dlugos@email.chop.edu
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Education:
21 9 B.A. 15 (Theology) c
45 Loyola Marymount University, Los Angeles, CA, 1983.
21 9 M.D. 15 (Medicine) c
5b Columbia University College of Physicians & Surgeons, New York, NY, 1988.
21 c M.S.C.E 22 (Clinical Epidemiology) c
bc Master’s of Science in Clinical Epidemiology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA, 2002.
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Permanent link21 9 B.A. 15 (Theology) c
45 Loyola Marymount University, Los Angeles, CA, 1983.
21 9 M.D. 15 (Medicine) c
5b Columbia University College of Physicians & Surgeons, New York, NY, 1988.
21 c M.S.C.E 22 (Clinical Epidemiology) c
bc Master’s of Science in Clinical Epidemiology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA, 2002.
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19 Epilepsy Genetics
21 Clinical Prediction Models
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19 Epilepsy Genetics
18 Epilepsy Surgery
b EEG
1f Clinical Neurophysiology
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Description of Research Expertise
26 Epilepsy Epidemiology19 Epilepsy Genetics
21 Clinical Prediction Models
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Description of Clinical Expertise
23 Pediatric Epilepsy19 Epilepsy Genetics
18 Epilepsy Surgery
b EEG
1f Clinical Neurophysiology
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162 Chen Z, Okafor CM, Gopaul MT, Kanner AM, Altalib HH, for the Human Epilepsy Project Investigators (including Dlugos DJ): The Trajectory of Quality of Life in Newly Diagnosed vs Chronic Refractory Focal Epilepsy: A Prospective Multicenter Study. Neurol Open Access 2: e000066, 2026.
15a Dlugos DJ, Scheffer IE, French JA, Vossler DG, Orevillo C, Polega S, Kaye R, and the LP352-201 Study Investigators: Bexicaserin for the Treatment of Seizures in Developmental and Epileptic Encephalopathies: A Phase 1b/2a Trial. Epilepsia Page: DOI: 10.1111/epi.18689, 2025.
25e Sullivan J, Perry MS, Scheffer IE, Wheless J, Boronat S, Brunklaus A, Laux L, Patel A, Roberts C, Dlugos D, Holder D, Knupp K, Lallas M, Phillips S, Segal E, Lal D, Wirrell E, Zuberi S, Gioia G, Shaffer R, Berl MM, Wojnaroski M, Christensen M, King A, James E, Vila MC, Huang N, Gofshteyn JS, Rico S: Cognitive Stagnation and Executive Function Challenges in Young Children with SCN1A+ Dravet Syndrome: Detailed Characterization of Onset, Progression, and Impact in the ENVISION Natural History Study. Epilepsia Page: in press, 2025.
87 Shah D, Villanueva V, Dlugos J, Benitez A, Taylor Y, Olsen S, Connolly H, Lai S, Andrews JS 104 : Non-Seizure Symptoms and Broader Seizure Impacts in Patients with Dravet Syndrome and Lennox-Gastaut Syndrome in Clinical Practice Settings: Results From a Multi-National Survey. Epilepsia Open doi.org/10.1002/epi4.70118, 2025.
168 Dlugos D, Lozano M, DiVentura B, Farfel G, Shellhaas RA, Sullivan JE, Thio LL, Kessler SK, Sadleir L, French J: Appropriate selection of participants in pediatric developmental and epileptic encephalopathy trials: Lessons learned and future opportunities. Epilepsia 66: e121-e126, 2025.
16a Omurtag A, Abdulbaki S, Thesen T, Waechter R, Landon B, Evans R, Dlugos D, Chari G, LaBeaud AD, Hassan YI, Fernandes M, Blackmon K: Disruption of functional network development in children with prenatal Zika virus exposure revealed by resting-state EEG. Scientific Reports 15: 6346, 2025.
1fa Alkofer M, Yang C, Ganglberger W, Beal J, Hegde M, Kang JY, Yoo JY, Gelfand MA, Thio LL, Kutluay E, Campbell Z, Schmitt S, Gleichgerrcht E, Waterhouse E, Lopez MR, Eisenschenk S, Galanti M, Singh RK, Wills KE, Meulenbrugge EJ, Dlugos D, Dean B, Halford J, Goldenholz D, Jing J, Thomas R, Westover MB: Automated detection of interictal epileptiform discharges with few electroencephalographic channels. Epilepsia 66: e114-e120, 2025.
b5 Ferrer M, Jandhyala N, Pellinen J, Greenwood H, Thio LL, Dlugos D, Park KL, Kanner AM, French J, for Human Epilepsy Project Investigators a8 : Delayed Diagnosis in Adolescent-Onset Focal Epilepsy: Impact on Morbidity and Mental Health. Epilepsia doi.org/10.1111/epi.18434, 2025.
140 Greenwood H, Ferrer M, Jandhyala N, Dlugos D, Park K, Thio L, Pellinen J, Kanner A, French J: Prevalence of Suicidality in Adolescents with Newly Diagnosed Focal Epilepsy at Diagnosis and over the Following 36 Months. Neurology 103: e209397, 2024.
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Selected Publications
225 Scheffer IE, Perry MS, Sullivan J, Boronat S, Wheless J, Brunklaus A, Laux L, Patel AD, Roberts C, Dlugos D, Holder D, Knupp K, Lallas M, Phillips S, Segal E, Lal D, Wirrell E, Zuberi SM, Shaffer R, Wojnaroski M, Berl MM, Christensen S, James ES, Vila MC, Huang N, Gofshteyn JS, Rico S : Characterizing early behavioral and social–emotional problems in young children with SCN1A+ Dravet syndrome: Findings from the ENVISION prospective natural history study. Epilepsia 2026.162 Chen Z, Okafor CM, Gopaul MT, Kanner AM, Altalib HH, for the Human Epilepsy Project Investigators (including Dlugos DJ): The Trajectory of Quality of Life in Newly Diagnosed vs Chronic Refractory Focal Epilepsy: A Prospective Multicenter Study. Neurol Open Access 2: e000066, 2026.
15a Dlugos DJ, Scheffer IE, French JA, Vossler DG, Orevillo C, Polega S, Kaye R, and the LP352-201 Study Investigators: Bexicaserin for the Treatment of Seizures in Developmental and Epileptic Encephalopathies: A Phase 1b/2a Trial. Epilepsia Page: DOI: 10.1111/epi.18689, 2025.
25e Sullivan J, Perry MS, Scheffer IE, Wheless J, Boronat S, Brunklaus A, Laux L, Patel A, Roberts C, Dlugos D, Holder D, Knupp K, Lallas M, Phillips S, Segal E, Lal D, Wirrell E, Zuberi S, Gioia G, Shaffer R, Berl MM, Wojnaroski M, Christensen M, King A, James E, Vila MC, Huang N, Gofshteyn JS, Rico S: Cognitive Stagnation and Executive Function Challenges in Young Children with SCN1A+ Dravet Syndrome: Detailed Characterization of Onset, Progression, and Impact in the ENVISION Natural History Study. Epilepsia Page: in press, 2025.
87 Shah D, Villanueva V, Dlugos J, Benitez A, Taylor Y, Olsen S, Connolly H, Lai S, Andrews JS 104 : Non-Seizure Symptoms and Broader Seizure Impacts in Patients with Dravet Syndrome and Lennox-Gastaut Syndrome in Clinical Practice Settings: Results From a Multi-National Survey. Epilepsia Open doi.org/10.1002/epi4.70118, 2025.
168 Dlugos D, Lozano M, DiVentura B, Farfel G, Shellhaas RA, Sullivan JE, Thio LL, Kessler SK, Sadleir L, French J: Appropriate selection of participants in pediatric developmental and epileptic encephalopathy trials: Lessons learned and future opportunities. Epilepsia 66: e121-e126, 2025.
16a Omurtag A, Abdulbaki S, Thesen T, Waechter R, Landon B, Evans R, Dlugos D, Chari G, LaBeaud AD, Hassan YI, Fernandes M, Blackmon K: Disruption of functional network development in children with prenatal Zika virus exposure revealed by resting-state EEG. Scientific Reports 15: 6346, 2025.
1fa Alkofer M, Yang C, Ganglberger W, Beal J, Hegde M, Kang JY, Yoo JY, Gelfand MA, Thio LL, Kutluay E, Campbell Z, Schmitt S, Gleichgerrcht E, Waterhouse E, Lopez MR, Eisenschenk S, Galanti M, Singh RK, Wills KE, Meulenbrugge EJ, Dlugos D, Dean B, Halford J, Goldenholz D, Jing J, Thomas R, Westover MB: Automated detection of interictal epileptiform discharges with few electroencephalographic channels. Epilepsia 66: e114-e120, 2025.
b5 Ferrer M, Jandhyala N, Pellinen J, Greenwood H, Thio LL, Dlugos D, Park KL, Kanner AM, French J, for Human Epilepsy Project Investigators a8 : Delayed Diagnosis in Adolescent-Onset Focal Epilepsy: Impact on Morbidity and Mental Health. Epilepsia doi.org/10.1111/epi.18434, 2025.
140 Greenwood H, Ferrer M, Jandhyala N, Dlugos D, Park K, Thio L, Pellinen J, Kanner A, French J: Prevalence of Suicidality in Adolescents with Newly Diagnosed Focal Epilepsy at Diagnosis and over the Following 36 Months. Neurology 103: e209397, 2024.
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