Nathaniel Dyment, PhD

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Assistant Professor of Orthopaedic Surgery
Department: Orthopaedic Surgery

Contact information
McKay Orthopaedic Research Laboratory
330A Stemmler Hall
3450 Hamilton Walk
Philadelphia, PA 19104-6081
Office: 215-746-8138
Fax: 215-573-2133
Lab: 215-746-8167
B.S. (Materials Science and Engineering)
University of Illinois at Urbana-Champaign , 2005.
Ph.D. (Biomedical Engineering)
University of Cincinnati, 2011.
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Description of Research Expertise

My primary research goals are directed towards understanding the genetic, cellular, and mechanical mechanisms that regulate normal development, disease (e.g., chronic tendon pathologies, osteoarthritis, psoriatic arthritis, ankylosing spondylitis), and repair of tissues in the joint. My current research focuses on 1) identifying the resident progenitor populations that contribute to normal growth, healing and repair, 2) characterizing the mechanisms that control the expansion and differentiation of these cells, and 3) ascertaining the phenotypical markers that define the stages of differentiation from early stem/progenitors to mature tendon/ligament fibroblasts and chondrocytes. These goals in combination will guide future therapeutic strategies and provide success criteria to assess efficacy moving forward.

Selected Publications

Yu W, Zhong L, Yao L, Wei Y, Gui T, Li Z, Kim H, Holdreith N, Jiang X, Tong W, Dyment NA, Liu XS, Yang S, Choi Y, Ahn J, Qin L: Bone marrow adipogenic lineage precursors promote osteoclastogenesis in bone remodeling and pathologic bone loss. J Clin Invest January 2021.

Ashley K. Fung; Nathaniel A. Dyment; David E. Birk; Louis J. Soslowsky: Collagen XII Regulates Tendon Dynamic Mechanical Properties And Collagen Fiber Realignment. Orthopaedic Research Society Annual Meeting 2021.

Tonia K. Tsinman, Saima Ahmed, Aurélie Levillain, Yuming Huang, Niamh C. Nowlan, Nathaniel A. Dyment, Robert L. Mauck: Morphogenesis of Fibrous Structures in the Embryonic Knee is Severely Disrupted by a Lack of Muscle Contraction. Orthopaedic Research Society Annual Meeting 2021.

Ryan Leiphart; Brittany Taylor; Stephanie Weiss; Nathaniel Dyment; Louis Soslowsky: Collagen V Knockdown During Phases Of Tendon Healing Differentially Impacts Gene Expression. Orthopaedic Research Society Annual Meeting 2021.

Wei Yu; Leilei Zhong; Lutian Yao; Yulong Wei; Tao Gui; Ziqing Li; Hyunsoo Kim; Nicholas Holdreith; Xi Jiang; Wei Tong; Nathaniel Dyment; Xiaowei S. Liu; Shuying Yang; Yongwon Choi; Jaimo Ahn; Ling Qin: MALPs Promote Osteoclastogenesis In Bone Remodeling And Pathologic Bone Loss. Orthopaedic Research Society Annual Meeting 2021.

Timur B. Kamalitdinov; Keitaro Fujino; Xi Jiang; Mary Kate Evans; Miltiadis H. Zgonis; Andrew F. Kuntz; Nathaniel A. Dyment: Leveraging Hedgehog Signaling To Improve Tendon-to-Bone Repair. Orthopaedic Research Society Annual Meeting 2021.

Wenzheng Wang; Tala Azar; Nathaniel Dyment; X. Sherry Liu: Contributions Of Modeling- Vs. Remodeling-based Bone Formation To An Anabolic Window Upon Early Withdrawal From Parathyroid Hormone(PTH) And PTH Related Peptide (PTHrP) Treatments. Orthopaedic Research Society Annual Meeting 2021.

Catherine A. Bautista; Mary Kate Evans; Tonia K. Tsinman; Nathaniel A. Dyment: Tendon Resident Macrophages Internalize Type 1 Collagen And Express Trophic Signaling Factors. Orthopaedic Research Society Annual Meeting 2021.

Yeonju Lee; Na Rae Park; Nathaniel A Dyment; Kyu Sang Joeng: Scaffold-free 3D Tendon Cell Culture Using Mouse Tendon Cells. Orthopaedic Research Society Annual Meeting 2021.

Ryan J Leiphart, Stephanie N Weiss, Louis J Soslowsky, Nathaniel A Dyment: Collagen V Knockdown in Mature Murine Tendons Causes Sex-Dependent Expression Changes. Orthopaedic Research Society Annual Meeting 2021.

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Last updated: 03/22/2021
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