Nathaniel Dyment, PhD
Assistant Professor of Orthopaedic Surgery
Member, Penn Center for Musculoskeletal Disorders
Member, Institute for Regenerative Medicine
Department: Orthopaedic Surgery
Contact information
McKay Orthopaedic Research Laboratory
330A Stemmler Hall
3450 Hamilton Walk
Philadelphia, PA 19104-6081
330A Stemmler Hall
3450 Hamilton Walk
Philadelphia, PA 19104-6081
Office: 215-746-8138
Fax: 215-573-2133
Lab: 215-746-8167
Fax: 215-573-2133
Lab: 215-746-8167
Education:
B.S. (Materials Science and Engineering)
University of Illinois at Urbana-Champaign , 2005.
Ph.D. (Biomedical Engineering)
University of Cincinnati, 2011.
Permanent linkB.S. (Materials Science and Engineering)
University of Illinois at Urbana-Champaign , 2005.
Ph.D. (Biomedical Engineering)
University of Cincinnati, 2011.
Description of Research Expertise
My primary research goals are directed towards understanding the genetic, cellular, and mechanical mechanisms that regulate normal development, disease (e.g., chronic tendon pathologies, osteoarthritis, psoriatic arthritis, ankylosing spondylitis), and repair of tissues in the joint. My current research focuses on 1) identifying the resident progenitor populations that contribute to normal growth, healing and repair, 2) characterizing the mechanisms that control the expansion and differentiation of these cells, and 3) ascertaining the phenotypical markers that define the stages of differentiation from early stem/progenitors to mature tendon/ligament fibroblasts and chondrocytes. These goals in combination will guide future therapeutic strategies and provide success criteria to assess efficacy moving forward.Selected Publications
Madhura Nijsure, Gabrielle Tanner, Miriam Baitner, Annemarie Lang, Yasaman Moharrer, Dakota Jones, Annapurna Pranatharthi-Haran, Nathaniel Dyment, Joel Boerckel: YAP activates and represses defined transcriptional programs to promote periosteal activation for fracture repair. Orthopaedic Research Society Annual Meeting February 2023.Bryan Kwok, Mingyue Fan, David Birk, Robert Mauck, Nathaniel Dyment, Eiki Koyama, Lin Han: Type V Collagen Plays An Essential Role In The Development Of Knee Articular Cartilage And Meniscus. Orthopaedic Research Society Annual Meeting February 2023.
Joseph Collins, Nathaniel Dyment, Ling Qin, Joel Boerckel: Yap And Taz Regulate Vessel-associated Osteoblast Precursors And Angiogenic Coupling In Embryonic Bone. Orthopaedic Research Society Annual Meeting February 2023.
Alexander J. Bein, Ashley K. Fung, Stephanie N. Weiss, Nathaniel A. Dyment, Lou J. Soslowsky: Inducible Rosa, But Not Alpha-SMA Or Scx, Cre Driven Excision Achieves Substantial Col12a1 Knockdown In Tendon Healing. Orthopaedic Research Society Annual Meeting February 2023.
Natalie L. Fogarty, Talayah Johnson, Bryan Kwok, Alisia Lin, Tonia K. Tsinman, Xi Jiang, Eiki Koyama, Lin Han, Josh Baxter, Robert Mauck, Nathaniel Dyment: Reduction In Post-natal Load Bearing Has Negligible Impact On Murine Meniscus Maturation. Orthopaedic Research Society Annual Meeting February 2023.
Leilei Zhong, Jiawei Lu, Jiankang Fang, Lutian Yao, Wei Yu, Nicholas Holdreith, Catherine Bautista, Yongwon Choi, Jean Jiang, Shuying Yang, Wei Tong, Nathaniel Dyment, Ling Qin: Csf1 From Marrow Adipogenic Precursors Is Required For Osteoclast Formation And Hematopoiesis In Bone. Orthopaedic Research Society Annual Meeting February 2023.
Thomas P. Leahy, Srish S. Chenna, Lou Soslowsky, Nathaniel Dyment: The Mechanosensor Focal Adhesion Kinase Regulates Cell Shape And Tendon Development. Orthopaedic Research Society Annual Meeting February 2023.
Sinaia Keith Lang, Keitaro Fujino, Timur Kamalitdinov, Xi Jiang, Andrew Kuntz, Nathaniel Dyment: The Role Of Tunnel Size In Tendon-to-Bone Integration And Fluid Effusion Following ACL Reconstruction. Orthopaedic Research Society Annual Meeting February 2023.
Rashad Madi, Jonathan Marcelin, Timur Kamalitdinov, Xi Jiang, Sereen Assi, Dong Hwa Kim, Sinaia Keith Lang, Robert Mauck, Andrew Kuntz, Nathaniel Dyment: Localized Release Of A Hedgehog Signaling Agonist For Improving Tendon-to-Bone Integration. Orthopaedic Research Society Annual Meeting February 2023.
Yujia Zhang, Saeed Ahmed, Parisha Shah, Rajan Jain, Robert Mauck, Nathaniel Dyment, Su-Jin Heo: Roles Of H3k4me3 And H3k27me3 In Regulating Cellular Phenotype And Homeostasis Of Murine Tenocytes During Tendon Development. Orthopaedic Research Society Annual Meeting February 2023.