Karthik Rajasekaran, MD, FACS

faculty photo
Associate Professor of Otorhinolaryngology: Head and Neck Surgery at the Hospital of the University of Pennsylvania
Head/Neck Oncology Leadership Meeting Member, Cancer Service Line, Hospital of the University of Pennsylvania, Philadelphia, PA
Director of Facial Trauma, University of Pennsylvania
Director of Quality Improvement Education, University of Pennsylvania
Senior Fellow of the Leonard Davis Institute of Health Economics , University of Pennsylvania
Co-Director of Head and Neck Oncology and Microvascular Reconstruction Fellowship, University of Pennsylvania
Advisory Dean, Perelman School of Medicine
Department: Otorhinolaryngology: Head and Neck Surgery

Contact information
800 Walnut St, 18th Floor
Department of Otorhinolaryngology
Penn Medicine
Philadelphia, PA 19107
Office: 2158295180
Education:
B.A. (Biology, Health and Society)
University of Rochester, 2005.
M.D. (Doctor of Medicine)
Chicago Medical School at Rosalind Franklin University of Medicine and Science, 2011.
Permanent link
 
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Selected Publications

Park SL, Painter MM, Manne S, Alcalde V, McLaughlin M, Sullivan MA, Mathew D, Torres L, Huang YJ, Reeg DB, Douek NR, Campos T, Klapholz M, Cardenas MA, Fang V, Ngiow SF, Kc W, Goel RR, Baxter AE, Wu JE, Tan M, Berry CT, Ellebrecht CT, Alexander HC, Papazian E, Liu Y, Rajasekaran K, Brody RM, Thaler ER, Basu D, Diab A, Giles JR, Wherry EJ: Tissue-resident exhausted and memory CD8+ T cells have distinct ontogeny, function and role in disease. Nat Immunol 27(1): 110-125, Jan 2026.

Moss W, Muralidhar A, Girela M, Rajasekaran K, Moreira A: Pediatric laryngeal trauma: An epidemiological study using the National Trauma Data Bank. Int J Pediatr Otorhinolaryngol Dec 2025 Notes: doi: 10.1016/j.ijporl.2025.112618.

Fu BJ, Potter AL, Pipkorn P, Kraimer KL, Chen MM, Rajasekaran K, Yang CJ, Lee JJ: Differences in Survival Following Surgery Versus Chemoradiotherapy for Clinical Stage T4a Laryngeal Squamous Cell Carcinoma: A Propensity Score-Matched Analysis. Head Neck Dec 2025 Notes: doi: 10.1002/hed.70114. Epub ahead of print.

Barrette LX, Gentile M, Rajasekaran K. Contralateral Tonsil in p16-Positive Tonsil Squamous Cell Carcinoma: Contralateral Tonsil in p16-Positive Tonsil Squamous Cell Carcinoma. JAMA Otolaryngol Head Neck Surg 151(12): 1115-1116, Dec 2025.

Halle TR, Cao AC, Naik AG, Weinstein GS, Lee JJ, Gobillot TA, Kaye ER, Brody RM, Basu D, O'Malley BW Jr, Farwell DG, Cannady SB, Lin A, Lukens J, Gentile M, Newman JG, Chalian AA, Rasskeh CH, Rajasekaran K: Risk of Occult Contralateral Neck Metastasis in Early-Stage HPV-Related Lateralized Cancer of the Base of the Tongue. Head Neck Dec 2025 Notes: doi: 10.1002/hed.70117. Epub ahead of print.

Trifoi MD, Morales KV, Frankel D, Lin SK, Deitermann AM, Haynes D, Lubeck M, Etzkorn JR, Sobanko JF, Giordano CN, Walker JL, Zhang J, Lewis DJ, Higgins HW 2nd, Miura JT, Karakousis GC, Rajasekaran K, Cannady SB, Brody RM, Mitchell TC, Amaravadi RK, Lukens JN, Miller CJ.: Compliance with guidelines and timeliness of sentinel lymph node biopsy for Merkel cell carcinoma treated with Mohs micrographic surgery versus conventional excision at a tertiary academic center. J Am Acad Dermatol Oct 2025 Notes: doi: 10.1016/j.jaad.2025.10.053. Epub ahead of print.

Lam D, Herpin L, Campe L, Brody RM, Rajasekaran K, Mirza N: Medialization Thyroplasty with Tensor Fascia Lata for Immunocompromised or Irradiated Patients. J Voice Oct 2025 Notes: doi: 10.1016/j.jvoice.2025.10.009. Epub ahead of print.

Kaki P, Lam D, Sangal NR, Carey RM, Rajasekaran K, Chalian A, Brody RM, Weinstein GS, Cannady SB: Comparing Functional Outcomes Following TORS With Free Flap Reconstruction Using a Radial Forearm vs. Anterolateral Thigh Flap. Head Neck Sep 2025 Notes: doi: 10.1002/hed.70039. Epub ahead of print.

Veerabagu SA, Nugent ST, Geng Z, Yanes AF, Fischer JP, Kovell R, Kuntz AF, Rajasekaran K, VanderBeek BL, Miller CJ, Etzkorn JR, Sobanko JF, Higgins HW 2nd, Walker J, Zhang J, Giordano CN: National opioid prescription decline across outpatient specialty surgeries: a claims database study. J Am Acad Dermatol 93(3): 733-741, Sep 2025.

Deng J, Murphy BA, Andersen LP, McMenamin E, Lukens JN, Cohn JC, Rajasekaran K, Quinn RJ, Spinelli BA, Lin A: Feasibility and preliminary efficacy of a lymphedema and fibrosis self-management program for head and neck cancer survivors: a pilot randomized controlled trial. Oral Oncol Aug 2025 Notes: doi: 10.1016/j.oraloncology.2025.107556. [Epub ahead of print]

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Last updated: 01/06/2026
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