Daniel S Herman, MD, PhD

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Assistant Professor of Pathology and Laboratory Medicine at the Hospital of the University of Pennsylvania
Department: Pathology and Laboratory Medicine

Contact information
3400 Spruce St. 7103 Founders Blvd.
Philadelphia, PA 19104
Office: 215.662.6575
Fax: 215.662.7529
Lab: 215.662.6577
BS (Bachelor of Science in Biology)
Massachusetts Institute of Technology, 2004.
PhD (Doctorate of Philosophy in Genetics)
Harvard Medical School, Division of Medical Sciences (MSTP), 2011.
MD (Doctorate of Medicine)
Harvard Medical School, Health Sciences and Technology (MSTP), 2013.
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Description of Clinical Expertise

Laboratory Medicine, Cardiac Biomarkers, Clinical Chemistry, and Pathology Informatics.

Description of Research Expertise

My research interests are in the prediction and prevention of cardiovascular disease and in developing systems to improve the interpretation of clinical laboratory results. Current areas of research include:

1) Leveraging electronic health record data to screen for specific causes of secondary hypertension and to inform selection of antihypertensive medications

2) Developing and implementing computational tools to improve the quality of clinical laboratory results and facilitate context-dependent interpretation

3) Improving the diagnosis of acute myocardial infarction by developing new biomarker-based strategies for testing and interpretation

4) Improving the prediction of primary cardiovascular disease by assessing the gap between existing biomarkers and the clinical needs

Selected Publications

Herman DS, Ranjitkar P, Yamaguchi D, Grenache DG, Greene DN.: Endogenous alkaline phosphatase interference in cardiac troponin I and other sensitive chemiluminescence immunoassays that use alkaline phosphatase activity for signal amplification. Clin Biochem 49(15): 1118-1121, Oct 2016 Notes: Epub ahead of Print 2016/June 16.

Daniel Herman: Automated approaches to wrangling wayward troponins. The American Association for Clinical Chemistry Annual Meeting, Atlanta, GA Jul 2015 Notes: Poster presentation.

Fatkin D, Lam L, Herman DS, Benson CC, Felkin LE, Barton PJR, Walsh R, Candan S, Ware JS, Roberts AM, Chung WK, Smoot L, Bornaun H, Keogh AM, Macdonald PS, Hayward CS, Seidman JG,Roberts AE, Cook SA, Seidman CE. : Titin truncating mutations: A rare cause of dilated cardiomyopathy in the young. Progress in Pediatric Cardiology. 40(1): 41-45, Mar 2016 Notes: Epub 18 January 2016. doi:10.1016/j.ppedcard.2016.01.003.

Silgard E, Fang M, Estey E, Herman DS: Automated parsing and risk classification of karyotypes for acute myeloid leukemia. American Society of Hematology Annual Meeting, Orlando, FL. Dec 2015 Notes: Poster presentation.

Roberts AM*, Ware JS*, Herman DS*, Schafer S, Baksi J, Bick AG, Buchan RJ, Walsh R, John S, Wilkinson S, Mazzarotto F, Felkin LE, Gong S, MacArthur JA, Cunningham F, Flannick J, Gabriel SB, Altshuler DM, Macdonald PS, Heinig M, Keogh AM, Hayward CS, Banner NR, Pennell DJ, O'Regan DP, San TR, de Marvao A, Dawes TJ, Gulati A, Birks EJ, Yacoub MH, Radke M, Gotthardt M, Wilson JG, O'Donnell CJ, Prasad SK, Barton PJ, Fatkin D, Hubner N, Seidman JG, Seidman CE, Cook SA.: Integrated allelic, transcriptional, and phenomic dissection of the cardiac effects of titin truncations in health and disease. Sci Transl Med 7(270): 270ra6, Jan 2015 Notes: * Authors did equal work on article. doi: 10.1126/scitranslmed.3010134.

Bick AG, Flannick J, Ito K, Cheng S, Ramachandran VS, Parfenov MG, Herman DS, DePalma SR, Gupta N, Gabriel S, Funke BH, Rehm HL, Benjamin E, Aragam J, Taylor HA, Fox ER, Newton-Cheh C, Kathiresan S, O’Donnell C, Wilson JG, Altshuler DL, Hirschhorn JN, Seidman JG, Seidman C.: Burden of rare sarcomere gene variants in the Framingham and Jackson Heart Study Cohorts. Am J Hum Gen 91(3): 513-9, Sept 2012.

Herman DS, Lam L, Taylor MR, Wang L, Teekakirikul P, Christodoulou D, Conner L, DePalma SR, McDonough B, Sparks E, Teodorescu DL, Cirino AL, Banner NR, Pennell DJ, Graw S, Merlo M, Di Lenarda A, Sinagra G, Bos JM, Ackerman MJ, Mitchell RN, Murry CE, Lakdawala NK, Ho CY, Barton PJ, Cook SA, Mestroni L, Seidman JG, Seidman CE.: Truncations of Titin Causing Dilated Cardiomyopathy. N Engl J Med. 366(7): 619-28, Feb 2012.

Herman DS, Hovingh GK, Iartchouk O, Rehm HL, Kucherlapati R, Seidman JG, Seidman CE.: Filter-based hybridization capture of subgenomes enables resequencing and copy-number detection. Nat Methods 6(7): 507-10, Jul 2009 Notes: E-published ahead of print 2009, June 21. doi: 10.1038/nmeth.1343.

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Last updated: 11/13/2018
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