Thomas T. Joseph, MD, PhD
John Morgan Building, 319A
3620 Hamilton Walk
Philadelphia, PA 19104
BS (Computer Science; Biology)
Washington University in St. Louis, 2003.
PhD (Computational Biology)
Icahn School of Medicine at Mount Sinai, 2011.
MD (Medical Scientist Training Program)
Icahn School of Medicine at Mount Sinai, 2012.
Description of Clinical ExpertiseAnesthesiology
Description of Research ExpertiseComputational biophysics and molecular dynamics simulation.
Anesthesia and medical informatics.
Selected PublicationsMcKinstry-Wu Andrew, Woll Kellie A, Joseph Thomas, Bu Weiming, White E Railey, Bhanu Natarajan V, Garcia Benjamin A, Brannigan Grace, Dailey William P, Eckenhoff Roderic G: Azi-medetomidine: Synthesis and Characterization of a Novel α2 Adrenergic Photoaffinity Ligand. ACS Chemical Neuroscience Oct 2019.
Salari R, Joseph T, Lohia R, Hénin J, Brannigan G: A streamlined, general approach for computing ligand binding free energies and its application to GPCR-bound cholesterol. Journal of Chemical Theory and Computation Oct 2018.
Kass JL, Lakha S, Levin MA, Joseph T, Lin H-M, Genden EM, Teng MS, Miles BA, DeMaria S: Intraoperative hypotension and flap loss in free tissue transfer surgery of the head and neck. Head and Neck Sep 2018.
Joseph TT, DiMeglio M, Huffenberger A, Laudanski KF: Behavioural patterns of electrolyte repletion in intensive care units: lessons from a large electronic dataset. Scientific Reports 8: Article number: 11915, August 2018.
Flaherty D, Kim S, Zerillo J, Park C, Joseph T, Hill B, Lin H-M, Li J, Hamsher C, Weiner MM, DeMaria S: Preoperative QTc Interval is Not Associated With Intraoperative Cardiac Events or Mortality in Liver Transplantation Patients. Journal of Cardiothoracic and Vascular Anesthesia Page: pii: S1053-0770(18)30389-6, July 2018.
Wax DB, McCormick PJ, Joseph TT, Levin MA: An Automated Critical Event Screening and Notification System to Facilitate Preanesthesia Record Review. Anesthesia and Analgesia 126(2): 606-610, Feb 2018.
Levin MA, Joseph TT, Jeff JM, Nadukuru R, Ellis SB, Bottinger EP, Kenny EE: iGAS: A framework for using electronic intraoperative medical records for genomic discovery. Journal of Biomedical Informatics 67: 80-89, Mar 2017.
Joseph TT, Hénin J: Molecular mechanics parameterization of anesthetic molecules. Methods in Enzymology 602: 61-76, March 2018.
Tabrizian P, Joseph TT, Radkani P, Cohen E, Facciuto M: Liver Transplantation in an Adult Recipient With Situs Inversus Totalis: Case Report and Review of the Literature. Transplantation Proceedings 48(9): 3163-3166, Nov 2016.
Joseph TT, Mincer JS: Common Internal Allosteric Network Links Anesthetic Binding Sites in a Pentameric Ligand-Gated Ion Channel. PLOS ONE 11(7): e0158795, 2016.
Joseph TT, Gal JS, DeMaria S, Lin H-M, Levine AI, Hyman JB: A Retrospective Study of Success, Failure, and Time Needed to Perform Awake Intubation. Anesthesiology 125(1): 105-14, Jul 2016.
Joseph TT, Osman R: Thermodynamic basis of selectivity in guide-target-mismatched RNA interference. Proteins 80(5): 1283-98, May 2012.