Thomas T. Joseph, MD, PhD
Assistant Professor of Anesthesiology and Critical Care at the Hospital of the University of Pennsylvania
Attending Anesthesiologist, The Hospital of the University of Pennsylvania
Attending Anesthesiologist, Penn Presbyterian Medical Center
Department: Anesthesiology and Critical Care
Contact information
Department of Anesthesiology and Critical Care
John Morgan Building, 319A
3620 Hamilton Walk
Philadelphia, PA 19104
John Morgan Building, 319A
3620 Hamilton Walk
Philadelphia, PA 19104
Publications
Education:
BS (Computer Science; Biology)
Washington University in St. Louis, 2003.
PhD (Computational Biology)
Icahn School of Medicine at Mount Sinai, 2011.
MD (Medical Scientist Training Program)
Icahn School of Medicine at Mount Sinai, 2012.
Permanent linkBS (Computer Science; Biology)
Washington University in St. Louis, 2003.
PhD (Computational Biology)
Icahn School of Medicine at Mount Sinai, 2011.
MD (Medical Scientist Training Program)
Icahn School of Medicine at Mount Sinai, 2012.
Description of Clinical Expertise
AnesthesiologyDescription of Research Expertise
Computational biophysics and molecular dynamics simulation.Anesthesia and medical informatics.
Selected Publications
Johanna Becker-Baldus, Alexei Yeliseev, Thomas T. Joseph, Snorri Th. Sigurdsson, Lioudmila Zoubak, Kirk Hines, Malliga R. Iyer, Arjen van den Berg, Sam Stepnowski, Jon Zmuda, Klaus Gawrisch, and Clemens Glaubitz: Probing the Conformational Space of the Cannabinoid Receptor 2 and a Systematic Investigation of DNP-Enhanced MAS NMR Spectroscopy of Proteins in Detergent Micelles. ACS Omega 8(36): 32963-32976, Aug 2023 Notes: DOI: 10.1021/acsomega.3c04681.Joseph TT, Bu W, Lin W, Zoubak L, Yeliseev A, Liu R, Eckenhoff RG, Brannigan G: Ketamine Metabolite (2R,6R)-Hydroxynorketamine Interacts with μ and κ Opioid Receptors. ACS Chem Neurosci Apr 2021 Notes: doi:10.1021/acschemneuro.0c00741.
John T Petroff, Noah M Dietzen, Ezry Santiago-McRae, Brett Deng, Maya S Washington, Lawrence J Chen, K Trent Moreland, Zengqin Deng, Michael Rau, James AJ Fitzpatrick, Peng Yuan, Thomas T Joseph, Jérôme Hénin, Grace Brannigan, Wayland WL Cheng: Open-channel structure of a pentameric ligand-gated ion channel reveals a mechanism of leaflet-specific phospholipid modulation. Nature Communications 13(1): 7017, 11 2022 Notes: DOI: 10.1038/s41467-022-34813-5.
Wague A, Joseph TT, Woll KA, Bu W, Vaidya KA, Bhanu NV, Garcia B, Nimigean CM, Eckenhoff RG, Riegelhaupt PM: Mechanistic insights into volatile anesthetic modulation of K2P channels. eLife. eLife Sciences, Dec 2020 Notes: doi:10.7554/eLife.59839.
Joseph TT: Best practices for resilient automation of biomolecular simulations. Methods in Cell Biology. Elsevier, 169, 2022 Notes: https://doi.org/10.1016/bs.mcb.2021.12.004. In press.
Yeliseev A, Iyer MR, Joseph TT, Coffey NJ, Cinar R, Zoubak L, Kunos G, Gawrisch K: Cholesterol as a modulator of cannabinoid receptor CB2 signaling. Scientific Reports. Springer Nature, 11(Article number: 3706), Feb 2021.
Wenric S, Jeff JM, Joseph T, Yee M-C, Belbin GM, Owusu Obeng A, Ellis SB, Bottinger EP, Gottesman O, Levin MA, Kenny EE: Rapid response to the alpha-1 adrenergic agent phenylephrine in the perioperative period is impacted by genomics and ancestry. Pharmacogenomics J Nov 2020 Notes: doi: 10.1038/s41397-020-00194-5.
Thomas T Joseph, David B Wax, Raymond Goldstein, Jia Huang, Patrick J McCormick, Matthew A Levin: A Web-Based Perioperative Dashboard as a Platform for Anesthesia Informatics Innovation. Anesthesia and Analgesia. LWW, Sep 2020.
McKinstry-Wu Andrew, Woll Kellie A, Joseph Thomas, Bu Weiming, White E Railey, Bhanu Natarajan V, Garcia Benjamin A, Brannigan Grace, Dailey William P, Eckenhoff Roderic G: Azi-medetomidine: Synthesis and Characterization of a Novel α2 Adrenergic Photoaffinity Ligand. ACS Chemical Neuroscience Oct 2019.
Salari R, Joseph T, Lohia R, Hénin J, Brannigan G: A streamlined, general approach for computing ligand binding free energies and its application to GPCR-bound cholesterol. Journal of Chemical Theory and Computation Oct 2018.
Kass JL, Lakha S, Levin MA, Joseph T, Lin H-M, Genden EM, Teng MS, Miles BA, DeMaria S: Intraoperative hypotension and flap loss in free tissue transfer surgery of the head and neck. Head and Neck Sep 2018.
Flaherty D, Kim S, Zerillo J, Park C, Joseph T, Hill B, Lin H-M, Li J, Hamsher C, Weiner MM, DeMaria S: Preoperative QTc Interval is Not Associated With Intraoperative Cardiac Events or Mortality in Liver Transplantation Patients. Journal of Cardiothoracic and Vascular Anesthesia Page: pii: S1053-0770(18)30389-6, July 2018.