Thomas T. Joseph, MD, PhD

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Assistant Professor of Anesthesiology and Critical Care at the Hospital of the University of Pennsylvania
Department: Anesthesiology and Critical Care

Contact information
Department of Anesthesiology and Critical Care
John Morgan Building, 319A
3620 Hamilton Walk
Philadelphia, PA 19104
Education:
BS (Computer Science; Biology)
Washington University in St. Louis, 2003.
PhD (Computational Biology)
Icahn School of Medicine at Mount Sinai, 2011.
MD (Medical Scientist Training Program)
Icahn School of Medicine at Mount Sinai, 2012.
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Description of Clinical Expertise

Anesthesiology

Description of Research Expertise

Computational biophysics and molecular dynamics simulation.

Anesthesia and medical informatics.

Selected Publications

McKinstry-Wu Andrew, Woll Kellie A, Joseph Thomas, Bu Weiming, White E Railey, Bhanu Natarajan V, Garcia Benjamin A, Brannigan Grace, Dailey William P, Eckenhoff Roderic G: Azi-medetomidine: Synthesis and Characterization of a Novel α2 Adrenergic Photoaffinity Ligand. ACS Chemical Neuroscience Oct 2019.

Salari R, Joseph T, Lohia R, Hénin J, Brannigan G: A streamlined, general approach for computing ligand binding free energies and its application to GPCR-bound cholesterol. Journal of Chemical Theory and Computation Oct 2018.

Kass JL, Lakha S, Levin MA, Joseph T, Lin H-M, Genden EM, Teng MS, Miles BA, DeMaria S: Intraoperative hypotension and flap loss in free tissue transfer surgery of the head and neck. Head and Neck Sep 2018.

Joseph TT, DiMeglio M, Huffenberger A, Laudanski KF: Behavioural patterns of electrolyte repletion in intensive care units: lessons from a large electronic dataset. Scientific Reports 8: Article number: 11915, August 2018.

Flaherty D, Kim S, Zerillo J, Park C, Joseph T, Hill B, Lin H-M, Li J, Hamsher C, Weiner MM, DeMaria S: Preoperative QTc Interval is Not Associated With Intraoperative Cardiac Events or Mortality in Liver Transplantation Patients. Journal of Cardiothoracic and Vascular Anesthesia Page: pii: S1053-0770(18)30389-6, July 2018.

Wax DB, McCormick PJ, Joseph TT, Levin MA: An Automated Critical Event Screening and Notification System to Facilitate Preanesthesia Record Review. Anesthesia and Analgesia 126(2): 606-610, Feb 2018.

Levin MA, Joseph TT, Jeff JM, Nadukuru R, Ellis SB, Bottinger EP, Kenny EE: iGAS: A framework for using electronic intraoperative medical records for genomic discovery. Journal of Biomedical Informatics 67: 80-89, Mar 2017.

Joseph TT, Hénin J: Molecular mechanics parameterization of anesthetic molecules. Methods in Enzymology 602: 61-76, March 2018.

Tabrizian P, Joseph TT, Radkani P, Cohen E, Facciuto M: Liver Transplantation in an Adult Recipient With Situs Inversus Totalis: Case Report and Review of the Literature. Transplantation Proceedings 48(9): 3163-3166, Nov 2016.

Joseph TT, Mincer JS: Common Internal Allosteric Network Links Anesthetic Binding Sites in a Pentameric Ligand-Gated Ion Channel. PLOS ONE 11(7): e0158795, 2016.

Joseph TT, Gal JS, DeMaria S, Lin H-M, Levine AI, Hyman JB: A Retrospective Study of Success, Failure, and Time Needed to Perform Awake Intubation. Anesthesiology 125(1): 105-14, Jul 2016.

Joseph TT, Osman R: Thermodynamic basis of selectivity in guide-target-mismatched RNA interference. Proteins 80(5): 1283-98, May 2012.

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Last updated: 08/08/2020
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