Ping Wang, PhD, DABCC, FAACC

faculty photo
Professor of Pathology and Laboratory Medicine at the Hospital of the University of Pennsylvania
Chief of Clinical Chemistry Section, Hospital of University of Pennsylvania
Director of Core Laboratory, Hospital of University of Pennsylvania
Director of William Pepper Laboratory George Woodward Fellowship Program in Physiological Chemistry , University of Pennsylvania
Department: Pathology and Laboratory Medicine
Graduate Group Affiliations

Contact information
Chief of Clinical Chemistry
Director of Core Laboratory
Hospital of University of Pennsylvania
Professor of Pathology and Laboratory Medicine
University of Pennsylvania
3400 Spruce St.
Founders 7.103
Philadelphia, PA 19104
Office: 215-614-6062
Lab: 215-400-1526 (cell)
Education:
BS (Biological Sciences & Biotechnology)
Tsinghua University, China, 2000.
PhD (Molecular & Cellular Pharmacology)
University of Wisconsin-Madison, 2005.
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Description of Clinical Expertise

Dr. Wang's clinical expertise focuses on in vitro diagnostics. She is a member of the FDA Medical Devices Advisory Committee. Her areas of clinical expertise includes Clinical Chemistry, Automation, Point-of-care Testing, Toxicology, Clinical Mass Spectrometry and Molecular Diagnostics.

Description of Other Expertise

Dr. Wang is on Scientific Advisory Boards of major and startup diagnostics companies. She works with industry partners to translate diagnostic tools in development into clinical applications, by way of pre-submission clinical studies and clinical trials.

Description of Research Expertise

Seventy percent of healthcare decisions rely on in vitro diagnostics results, for disease diagnosis, prognosis and monitoring. One of the fields where diagnostics play important roles is Precision Medicine. However, high-performing diagnostics that generate highly sensitive and specific information are only available in highly resourced and specialized settings, resulting in limited clinical and societal impact. We focus on translational research by partnering with clinicians, engineers and other partners to develop, validate and translate innovative diagnostics technologies that enable wide and equitable access to diagnostics and inform rapid and efficient medical decision making in all kinds of settings. We take unmet clinical needs observed in our daily practice to research labs to develop novel technology solutions, which are then tested and validated in the intended use setting in iterations. The ultimate goal of our research is to benefit patients and improve outcomes by making these novel technologies available to a wide variety of populations.

Selected Publications

Wang P. and O'Kane M.: Point-of-care Testing. Tietz Textbook of Clinical Chemistry and Molecular Diagnostics, 7th Edition. Nader Rifai (eds.). Elsevier, 2022 Notes: Chapter.

Chen H, Feng S, Zhou W, Li Z, Richard-Greenblatt M and Wang P: Pretreatment Methods for Human Nasopharyngeal Swabs to Increase Signal to Noise Ratio of High Sensitivity Immunoassays. ACS Measurement Science Au 2(5): 414, 2022 Notes: DOI 10.1021/acsmeasuresciau.2c00024.

Wang P.: Point-of-care Testing. Tietz Fundamentals of Clinical Chemistry and Molecular Diagnostics, 9th Edition. Nader Rifai (eds.). Elsevier, 2022 Notes: Chapter.

Pritt BS, Wang P, Nuzzo J, Zimmermann S and Burnham CA : Deadly Pathogens, Transformative Technologies, and Protracted Pandemics: Challenges and Opportunities in Laboratory Medicine. Clin Chem 68(1): 1-3, January 2022.

Reece JT, Milone MC, Wang P, Herman D and Shaw LM: A Biomarker for Concussion: The Good, the Bad and the Unknown. The Journal of Applied Laboratory Medicine 5(1): 170-82, January 2020.

Daniell H, Nair SK, Guan H, Guo Y, Kulchar RJ, Torres MDT, Shahed-Al-Mahmud, Liu Y,Graham-Wooten J,Zhou W, Wang P,Mante F, Fuente-Nunez C, Ma C, Ricciardi R, Collman R,Wolff MS: Debulking different Corona (SARS-COV-2 delta, omicron, OC43) and Influenza (H1N1, H3N2) virus strains by plant viral trap proteins in chewing gums to decrease infection and transmission. Biomaterials 288: 121671, 2022.

Daniell1 H, Nair1 S, Esmaeili1 N, Wakade1 G, Schad D, Gerbrick K, Kulp J, Shepley-McTaggart A, Feng S,Islam R, Nuth M, Nunez Cruz S, Graham-Wooten J, Streatfield S, Lopez RM, Kaznica P, Mawson M, Green B, Gurdon C, R. Ricciardi,1 Milone M,Harty R,Wang P and Collman R: Debulking SARS-COV-2 in Saliva using Angiotensin Converting Enzyme 2 in the Chewing Gum to Decrease Oral Virus Transmission and Infection. Molecular Therapy 30: 1-13, 2022.

Chen H, Li Z, Feng S, Richard-Greenblatt M, Hutson E, Andrianus S, Glaser LJ, Rodino KG, Qian J, Jayaraman D, Collman RG, Glascock A, Bushman FD, Lee JS, Cherry S, Fausto A, Weiss SR, Koo H, Corby PM, O’Doherty U, Garfall AL, Vogl DT, Stadtmauer EA, Wang P: Femtomolar SARS-CoV-2 Antigen Detection Using the Microbubbling Digital Assay with Smartphone Readout Enables Antigen Burden Quantitation and Tracking. Clin Chem 68(1): 230, 2021.

Feng S, Rutledge TJ, Manzoni M, Le T, Gardiner J, Milone M, Shaw L, Wang P: Performance of Two Fentanyl Immunoassays Against a Liquid Chromatography-Tandem Mass Spectrometry Method. J Anal Tox 45(2): 117-123, March 2021.

Li Z and Wang P: Point of Care Drugs of Abuse Testing in the Opioid Epidemic. Arch Pathol Lab Med 144(11): 1325-34, 2020 Notes: https://doi.org/10.5858/arpa.2020-0055-RA.

Wang P, Anderson N, Pan Y, Poon L, Charlton C, Zelyas N, Persing D, Rhoads D and Babcock H: The SARS-CoV-2 Outbreak: Diagnosis, Infection Prevention, and Public Perception. Clinical Chemistry May 2020 Notes: Published online ahead-of-print: https://academic.oup.com/clinchem/advance-article/doi/10.1093/clinchem/hvaa080/5802466?guestAccessKey=1bb6c088-57e7-4cc9-8c37-0b6e95a8d6b0.

Wang P.: Point-of-care Testing. NEJM/AACC Learning Lab March 2019 Notes: https://www.aacc.org/education-and-career/learning-lab.

Li Z., Chen H., Feng S., Liu K. and Wang P.: Development and Clinical Validation of a Sensitive Lateral Flow Assay for Rapid Urine Fentanyl Screening in the Emergency Department. Clinical Chemistry 66(2): 324-32, February 2020.

Herman D., Cobani E., Baraban E., Bagg A., and Wang P.: Falsely Increased Plasma Lactate Dehydrogenase without Hemolysis following Transport through Pneumatic Tube System. Journal of Applied Laboratory Medicine 4(3): 433-438, July 2019 Notes: doi: 10.1373/jalm.2018.028928. Epub 2019 Aug 13.

Chen H., Liu K., Li Z. and Wang P.: Point-of-care Testing for Infectious Diseases. Clinica Chimica Acta 493: 138-147, June 2019 Notes: No issue. doi: 10.1016/j.cca.2019.03.008. Epub 2019 Mar 8.

Li Z., Chen H. and Wang P.: Lateral Flow Assay Ruler for Quantitative and Rapid Point-of-care Testing. Analyst 144(10): 3314-22, May 2019 Notes: DOI: 10.1039/C9AN00374F

Chen H., Li Z., Zhang L., Sawaya P., Shi J., Wang P.: Quantitation of Femtomolar Protein Biomarkers Using a Simple Microbubbling Digital Assay via Bright-field Smartphone Imaging. Angewandte Chemie International Edition 58(39): 2-9, July 2019 Notes: Featured by 360Dx: https://www.360dx.com/infectious-disease/upenn-targeting-ultrasensitive-protein-detection-poc-microbubbling-digital-assay#.XWa0mOhKgdU.

Rosenbaum MW, Flood JG, Melanson SEF, Baumann NA, Marzinke MA, Rai AJ, Hayden J, Wu A, Ladror M, Lifshitz MS, Palmer SM, Bowen R, Babic N, Sobhani K, Giacherio D, Bocsi G, Herman DS, Wang P, Toffaletti J, Handel E, Kelly KA, Albeiroti S, Wang S, Zimmer M, Driver B, Yi X, Wilburn C, Lewandowski KB: Quality Control Practices for Chemistry and Immunochemistry in a Cohort of 21 Large Academic Medical Centers. American Journal of Clinical Pathology 150(2): 1-9, July 2018.

Xu X, Gao D, Wang P, Chen J, Ruan J, Xu J, and Xia X: Efficient homology-directed gene editing by CRISPR/Cas9 in human stem and primary cells using tube electroporation. Nature Scientific Reports 8(1): 11649, August 2018.

Liu Z, Chen R; Li Y; Liu J; Wang P*; Xia X* and Qin L* : Integrated microfluidic chip for efficient isolation and deformability analysis of circulating tumor cells. Advanced Biosystems 2(10): https://doi.org/10.1002/adbi.201800200, September 2018 Notes: *Equal corresponding authors

Wang P* and Kricka LJ : Current and Emerging Trends in Point-of-care Technology and Strategies for Clinical Validation and Implementation. Clinical Chemistry 64(10): 1439-52, October 2018 Notes: *Corresponding author Cover article Featured by Diagnostics World News: http://www.diagnosticsworldnews.com/2019/05/22/how-point-of-care-can-bridge-the-gap-between-engineering-and-medicine.aspx.

Wang P, Panatdasirisuk W, Zhang M, Stoltzfus A, Dion G, Yang S: Wearable Knitted Bands For Sweat Glucose Sensing and Quantitation in Telemedicine. 27th Critical and Point of Care Testing International Symposium, Anaheim, CA September 2018.

Wang L, Naudé N, Chang Y, Crivaro A, Kamoun M, Wang P*, and Li L* : A Ultra-low Cost Smartphone Octochannel Spectrometer for Mobile Health Diagnostics. Journal of Biophotonics 11(8): doi:10.1002/jbio.201700382, August 2018 Notes: *Equal corresponding authors Highlighted on AdvancedScienceNews.com https://www.advancedsciencenews.com/new-ultra%E2%80%90low%E2%80%90cost-smartphone-sensor-to-diagnose-autoimmune-disease/

Wang L, Naudé N, Demissie M, Crivaro A, Kamoun M, Wang P*, Li L* : Analytical Validation of an Ultra Low-cost Mobile Phone Microplate Reader for Infectious Disease Testing. Clinica Chimica Acta 482: 21-26, July 2018 Notes: *Equal corresponding authors. No issue.

Wilburn C.R., Bernard D.W., Zieske A.W, Andrieni J., Miller T. and Wang P. : The Prevalence and Role of Hemoglobin Variants in Biometric Screening of a Multiethnic Population: One Large Health System’s experience. American Journal of Clinical Pathology 147(6): 589-95, June 2017.

Li Y, Uddayasankar U, He B, Wang P* and Qin L* : Fast, Sensitive and Quantitative Point-of-care Platform for the Assessment of Drugs of Abuse in Urine, Serum and Whole Blood. Analytical Chemistry 89(16): 8273-8281, August 2017 Notes: *Equal corresponding authors.

Li Y, Xuan J, Song Y, Qi W, Wang P*, Qin L* : Nanoporous Glass Integrated in Volumetric Bar-chart Chip for Point-of-care Diagnostics of Non-small Cell Lung Cancer. ACS Nano 10(1): 1640-47, Jan 2016 Notes: *Equal corresponding authors. doi: 10.1021/acsnano.5b07357. Epub 2015 Dec 28.

Song Y., Wang Y., Qi W., Li Y., Xuan J., Wang P*., Qin L* : Integrative volumetric bar-chart chip for rapid and quantitative point-of-care detection of myocardial infarction biomarker. Lab on a Chip 16(15): 2955-62, August 2016 Notes: *Equal corresponding authors.

Li Y, Xuan J, Song Y, Li Y, Wang P*, Qin L* : A Microfluidic Platform with Digital Readout and Ultra-Low Detection Limit for Quantitative Point-of-Care Diagnostics. Lab on a Chip 15(16): 3300-06, Aug 2015 Notes: *Equal corresponding authors. doi: 10.1039/c5lc00529a.

Zhang Y, Wu M, Han X, Wang P*, and Qin L* : High Throughput, Label-free Isolation of Cancer Stem Cells on the Basis of Cell Adhesion Capacity. Angewandte Chemie International Edition 127(37): 1-6, Sep 2015 Notes: *Equal corresponding authors. doi: 10.1002/anie.201505294. Epub 2015 Jul 15

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Last updated: 01/28/2023
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