Amelia J. Eisch, Ph.D.

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Professor of Anesthesiology and Critical Care
Department: Anesthesiology and Critical Care
Graduate Group Affiliations

Contact information
Abramson Research Center, Room 402D
3615 Civic Center Drive
Philadelphia, PA 19104-4399
B.A. (Psychology/Biology)
Yale University, 1990.
Ph.D. (Biological Sciences )
University of California, Irvine, 1997.
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Description of Other Expertise

In addition to my neuroscience expertise, I have extensive experience mentoring trainees. From 2000 until my move to PennMed/CHOP in 2016, I trained 11 postdoctoral, 13 predoctoral, 26 undergraduates, and 29 high school students in the laboratory. At UT Southwestern, I was Principal Investigator from 2008 until 2016 (when I moved to PennMed/CHOP) of a NIDA T32 training grant (DA T32007290) which provided training for 6 predoctoral and 5 postdoctoral trainees each year in basic translational research. Since having moved my group to PennMed/CHOP, I have hosted predoctoral trainees for rotation experiences, as well as undergraduate/high school students for summer research experiences. I have also been named co-Director of an NINDS T32 training grant on neurodevelopmental disorders (Director: Mike Robinson), and been appointed to the Executive Committee for the PennMed Neuroscience Graduate Group. These activities demonstrate my commitment to training the next generation of neuroscientists.

Description of Research Expertise

I am neuroscientist with a broad interest in how molecular and cellular changes – such as the changes in the number of neurons generated in the hippocampus, a brain region important for learning/memory and regulation of anxiety and the stress response – influence both normal behavior and cognitive functioning. I am interested in how developmental and adult neurogenesis in particular and dentate gyrus plasticity in general contribute to abnormal functioning with relevance to developmental, psychiatric, and neurological disorders. Current Eisch Lab projects span genetic, molecular, cellular, circuit, and functional/behavioral levels, and are funded by NASA and NIH (both the National Institute on Drug Abuse and National Institute on Mental Health).

Selected Publications

Zanni G*, Robinson-Drummer PA*, Dougher AA, Deutsch HM, DeSalle MJ, Teplitsky D, Vemulapalli A, Sullivan RM, Eisch AJ^, Barr GA^. *equal contribution, ^co-corresponding and senior authors: Maternal Continuous Oral Oxycodone Self-Administration Alters Pup Affective/Social Communication but not Spatial Learning or Sensory-Motor Function. Drug Addiction and Dependence 221: 108628, April 2021.

Clark LR, Yun S, Acquah NK, Kumar PL, Metheny HE, Paixao RCC, Cohen AS, Eisch AJ.: Mild traumatic brain injury induces transient, sequential increases in proliferation, neurogenesis, and cell survival: a time course study in the male mouse dentate gyrus. Frontiers in Neuroscience. Part of special issue “New Insights into Adult Neurogenesis and Neurodegeneration: Challenges for Brain Repair”. January 2021.

Tran FH*, Spears SL*, Ahn KJ, Eisch AJ, Yun S.*equal contribution.: Does chronic systemic injection of the DREADD agonists clozapine-N-oxide or compound 21 change behavior relevant to locomotion, exploration, anxiety, and depression in male non-DREADD-expressing mice? Neuroscience Letters November 2020.

Simmons SJ, Greenbaum RE, Haury WH, Phillips HM, Muñoz Rodríguez PA, Deutsch HM, Eisch AJ. : Effects of intravenous oxycodone self-administration and contextual renewal of oxycodone-seeking behavior on ultrasonic vocalizations (USVs) in rats. International Behavioral Neuroscience Society, Virtual August 2020 Notes: Poster Presentation.

Zanni G, DeSalle MJ, Deutsch HM, Barr GA^, Eisch AJ^. ^co-corresponding authors: Female and male rats readily consume and prefer oxycodone to water in a chronic, continuous access, two-bottle oral voluntary paradigm. Neuropharmacology. May 2020.

Tran FH*, Spears S*, Ahn KA, Eisch AJ, Yun S. *equal contribution.: Chronic systemic injection of DREADD agonists Clozapine-N-oxide and Compound 21 does not change behavior relevant to locomotion, exploration, anxiety, or affect in male mice. bioRxiv. May 2020.

Kiffer FC, Guzman CS, Soler I, Tran FH, Yang E, Ahn KJ, Luitel KB, Shay JW, Yun S, Eisch AJ: Exposure to Galactic Cosmic Radiation impairs simple rule-based acquisition behavior in female mice which is prevented by antioxidant CDDO-EA. Second Annual Touchscreen Symposium, Virtual April 2020 Notes: Poster Presentation.

Soler I, Tran FH, Reynolds RP, DeSalle MJ, Yun S, Eisch AJ : Multi-domain cognitive assessment of mature C57BL/6J female mice shows space radiation improves pattern separation and extinction learning while impairing stimulus-response habit learning. Second Annual Touchscreen Symposium, Virtual April 2020 Notes: Poster Presentation.

Ortega SB*, Torres VO*, Latchney SE, Whoolery CW, Noorbhai IZ, Poinsatte K, Selvaraj UM, Benson MA, Meeuwissen AJM, Plautz EJ, Kong X, Ramirez DM, Ajay AD, Meeks JP, Goldberg MP, Monson NL, Eisch AJ, Stowe AM. *equal contribution: B cells migrate into remote brain areas and support neurogenesis and functional recovery after focal stroke in mice. Proceedings of the National Academy of Sciences USA. March 2020.

Bulin SE*, Simmons SJ*, Richardson DR, Latchney SE, Deutsch HM, Yun S, Eisch AJ. *equal contribution: Indices of dentate gyrus neurogenesis are unaffected immediately after or following withdrawal from morphine self-administration compared to saline self-administering control male rats. Behavioural Brain Research. March 2020.

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Last updated: 09/23/2021
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