Amelia J. Eisch, Ph.D.

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Professor of Anesthesiology and Critical Care
Department: Anesthesiology and Critical Care
Graduate Group Affiliations

Contact information
Abramson Research Center, Room 402F
3615 Civic Center Drive
Philadelphia, PA 19104-4399
B.A. (Psychology/Biology)
Yale University, 1990.
Ph.D. (Biological Sciences )
University of California, Irvine, 1997.
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Description of Other Expertise

In addition to my neuroscience expertise, I have extensive experience mentoring trainees. From 2000 until my move to PennMed/CHOP in 2016, I trained 11 postdoctoral, 13 predoctoral, 26 undergraduates, and 29 high school students in the laboratory. At UT Southwestern, I was Principal Investigator from 2008 until 2016 (when I moved to PennMed/CHOP) of a NIDA T32 training grant (DA T32007290) which provided training for 6 predoctoral and 5 postdoctoral trainees each year in basic translational research. Since having moved my group to PennMed/CHOP, I have hosted predoctoral trainees for rotation experiences, as well as undergraduate/high school students for summer research experiences. I have also been named co-Director of an NINDS T32 training grant on neurodevelopmental disorders (Director: Mike Robinson), and been appointed to the Executive Committee for the PennMed Neuroscience Graduate Group. These activities demonstrate my commitment to training the next generation of neuroscientists.

Description of Research Expertise

I am neuroscientist with a broad interest in how molecular and cellular changes – such as the changes in the number of neurons generated in the hippocampus, a brain region important for learning/memory and regulation of anxiety and the stress response – influence both normal behavior and cognitive functioning. I am interested in how developmental and adult neurogenesis in particular and dentate gyrus plasticity in general contribute to abnormal functioning with relevance to developmental, psychiatric, and neurological disorders. Current Eisch Lab projects span genetic, molecular, cellular, circuit, and functional/behavioral levels, and are funded by NASA and NIH (both the National Institute on Drug Abuse and National Institute on Mental Health).

Selected Publications

Yun S, Reynolds RP, Petrof I, White A. Rivera PD, Segev A, Gibson AD, Suarez M, Desalle MJ, Ito N, Mukherjee S, Richardson DR, Kang CE, Ahrens-Nicklas RC, Soler I, Chetkovich DM, Kourrich S, Coulter DA, Eisch AJ. : Stimulation of entorhinal cortex-dentate gyrus circuitry is antidepressive. Nature Medicine 24(5): 658-666 April 2018.

Ochoa Escamilla C*, Filonova I*, Walker AK, Xuan Z, Holehonnur R, Espinosa F, Liu S, Thyme SB, Lopez-Garcia IA, Mendoza DB, Usui N, Ellegood J, Eisch AJ, Konopka G, Lerch JP, Schier AF, Speed HE, Powell CM. : Kctd13 deletion reduces synaptic transmission via increased RhoA. Nature 9(551): 227-231, November 2017.

Bulin SE, Mendoza ML, Richardson DR, Song KH, Solberg TD, Yun S, Eisch AJ: Dentate Gyrus Neurogenesis Ablation via Cranial Irradiation Enhances Morphine Self-administration and Locomotor Sensitization. Addiction Biology 2017.

Whoolery CW, Walker AK, Richardson DR, Rivera PD, Reynolds RP, Chen BPC, Eisch AJ: Unexpected enhancement in hippocampal-dependent pattern separation: Evidence from both aversive and appetitive learning paradigms. Human Research Program: Investigator's Workshop, Frontiers in Human Space Exploration Research, Galveston, TX 2017 Notes: Oral Presentation.

Reynolds RP, Walker AK, Whoolery CW, Richardson DR, Beddow DH, Shih H-Y, LeBlanc JA, Cole MG, Amaral WZ, Zhang S, Ahn F, Bulin SE, DeCarolis NA, Rivera PD, Chen BPC, Eisch AJ: 28Si irradiation transiently reduces proliferation but persistently decreases neurogenesis in the mouse dentate gyrus and interferes with contextual fear conditioning. Human Research Program: Investigator's Workshop, Frontiers in Human Space Exploration Research, Galveston, TX 2017 Notes: Poster Presentation.

Whoolery CW, Walker AK, Lucero MJ, Richardson DR, Reynolds RP, Beddow DH, Clark KL, Shih H-Y, LeBlanc JA, Cole MG, Amaral WZ, Mukherjee S, Zhang S, Ahn F, Bulin SE, DeCarolis NA, Rivera PD, Chen BPC, Yun S, Eisch AJ. : Whole Body Exposure to 28Si Radiation Dose-Dependently Disrupts Dentate Gyrus Neurogenesis and Proliferation in the Short-Term and New Neuron Survival and Contextual Fear Conditioning in the Long-Term. Radiation Research 2017.

Reynolds RP, Whoolery CW, Lucero MJ, Ito N, Redfield RL, Richardson DR, Palchik G, Mukherjee S, Rivera PD, Birnbaum SG, Chen BPC, Yun S, Eisch AJ.: Exposure to space radiation reduces neurogenesis but enhances pattern separation in both aversive and appetitive testing platforms in mature mice. Annual Meeting of the Society for Neuroscience, Washington, DC 2017.

Clark KL, Yun S, Metheny HE, Zanni G, Cohen AS, Eisch AJ: Adult hippocampal neurogenesis following mild traumatic brain injury. Annual Meeting of the Society for Neuroscience, Washington, DC 2017.

Whoolery CW, Yun S, Lucero MJ, Walker AK, Ito N, Redfield RL, Richardson DR, Reynolds RP, Palchik G, Mukherjee S, Shih H-Y, Rivera PD, Birnbaum SG, Chen BPC, Stowe AM, Eisch AJ: Enhanced pattern separation following space radiation exposure in maturity: neural and molecular underpinnings. Annual meeting of the Society for Radiation Research, Cancun, Mexico 2017.

Celen C, Chuang J-C, Luo X, Walker AK, Nijem N, Chung A, Nguyen LH, Nassour I, Budhipramono A, Sun X, Zhang S, Bok LA, McEntagart M, Gevers E, Birnbaum SG, Eisch AJ, Santen G.W.E., Chahrour M, Zhu H: Arid1b haploinsufficient mice reveal neuropsychiatric phenotypes and reversible causes of growth impairment. eLife 2017.

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Last updated: 10/31/2018
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