Marielle Scherrer-Crosbie, MD, PhD
Professor of Medicine (Cardiovascular Medicine) at the Hospital of the University of Pennsylvania
Attending Physician, Hospital of the University of Pennsylvania
Director Echocardiography, Hospital of the University of Pennsylvania
Director, Echocardiography, Penn Cardiovascular Institute
Department: Medicine
Contact information
Perelman Center for Advanced Medicine
Cardiovascular Medicine Division
11th Floor - South Tower
3400 Civic Center Boulevard
Philadelphia, PA 19104
Cardiovascular Medicine Division
11th Floor - South Tower
3400 Civic Center Boulevard
Philadelphia, PA 19104
Office: 215-662-3569
Education:
D.E.A. (Cardiovascular Physiology)
Paris VI University, France, 1991.
D.E.S.C (Nuclear Medicine)
INSTN, Paris, France, 1992.
M.D. (Medicine)
Paris XII University, France, 1993.
D.U. (Echocardiography)
Paris XII University, France, 1996.
Ph.D. (Cardiovascular Physiology)
Paris XII University, France, 2003.
Permanent linkD.E.A. (Cardiovascular Physiology)
Paris VI University, France, 1991.
D.E.S.C (Nuclear Medicine)
INSTN, Paris, France, 1992.
M.D. (Medicine)
Paris XII University, France, 1993.
D.U. (Echocardiography)
Paris XII University, France, 1996.
Ph.D. (Cardiovascular Physiology)
Paris XII University, France, 2003.
Description of Research Expertise
ISCHEMIA Research Group. Initial Invasive or Conservative Strategy for Stable Coronary Artery Disease. N Engl J Med. 2020 Apr 9;382(15):1395-1407. doi: 10.1056/NEJMoa1915922. Epub 2020 Mar 30.PMID: 32227755 Clinical Trial.ISCHEMIA Research Group. Health-Status Outcomes with Invasive or Conservative Care in Corionary Disease. N Engl J Med. 2020 Apr 9;382(15):1408-1419. doi: 10.1056/NEJMoa1916370. Epub 2020 Mar 30.PMID: 32227753 Clinical Trial.
Symptomatic Heart Failure in Acute Leukemia Patients Treated with Anthracyclines. JACC CardioOncol. 2019 Dec;1(2):208-217. doi: 10.1016/j.jaccao.2019.10.008. Epub 2019 Dec 17.PMID: 32905430
State of the Art: Imaging for Myocardial Viability: A Scientific Statement from the American heart Association. American Heart Association Council on Cardiovascular Radiology and Intervention and Council on Clinical Cardiology.Circ Cardiovasc Imaging. 2020 Jul;13(7):e000053. doi: 10.1161/HCI.0000000000000053. Epub 2020 Jul 13.PMID: 32833510
Cardioavscular Effects of CAR T Cell Therapy: A Retrospective Study. JACC CardioOncol. 2020 Jun;2(2):193-203. doi: 10.1016/j.jaccao.2020.04.012. Epub 2020 Jun 16.PMID: 32776016
Deficiency of bone morphogenetic protein-3b induces metabolic syndrome and increases adipogenesis. Am J Physiol Endocrinol Metab. 2020 Aug 1;319(2):E363-E375. doi: 10.1152/ajpendo.00362.2019. Epub 2020 Jun 30.PMID: 32603262
Selected Publications
Makhlin I, Demissei BG, D'Agostino R, Hundley WG, Baleanu-Gogonea C, Wilcox NS, Chen A, Smith AM, O'Connell NS, Januzzi JL, Lesser GJ, Scherrer-Crosbie M, Ibáñez B, Tang WHW, Ky B: Statins Do Not Significantly Affect Oxidative Nitrosative Stress Biomarkers in the PREVENT Randomized Clinical Trial. Clin Cancer Res. June 2024.Cotella J, Randazzo M, Maurer MS, Helmke S, Scherrer-Crosbie M, Soltani M, Goyal A, Zareba K, Cheng R, Kirkpatrick JN, Yogeswaran V, Kitano T, Takeuchi M, Fernandes F, Tiemi Hotta V, Campos Vieira ML, Elissamburu P, Ronderos R, Prado A, Koutroumpakis E, Deswal A, Pursnani A, Sarswat N, Addetia K, Mor-Avi V, Asch FM, Slivnick JA, Lang RM: Limitations of apical sparing pattern in cardiac amyloidosis: a multicentre echocardiographic study. Eur Heart J Cardiovasc Imaging May 2024.
Pracoń R, Spertus JA, Broderick S, Bangalore S, Rockhold FW, Ruzyllo W, Demchenko E, Nageh T, Grossman GB, Mavromatis K, Manjunath CN, Smanio PEP, Stone GW, Mancini GBJ, Boden WE, Newman JD, Reynolds HR, Hochman JS, Maron DJ: ISCHEMIA Research Group. Factors Associated With Coronary Angiography Performed Within 6 Months of Randomization to the Conservative Strategy in the ISCHEMIA Trial. Circ Cardiovasc Interv April 2024.
Nemec R, Scherrer-Crosbie M, Abramson JS, Redd R, Gilman HK, Ho T, Wu J, Heemelaar J, Neuberg D, Hochberg EP, Barnes JA, Armand P, Jacobsen ED, Jacobson CA, Kim AI, Friedman RS, LaCasce AS, Neilan TG, Soumerai JD: Effect of atorvastatin versus placebo on efficacy in patients with diffuse large B-cell lymphoma receiving R-CHOP. Leuk Lymphoma. February 2024.
Vakilpour A, Lefebvre B, Lai C, Scherrer-Crosbie M. : Heartbreaker: Detection and prevention of cardiotoxicity in hematological malignancies. Blood Rev. 2024 December 2023.
Dos Santos JM, Joiakim A, Putt DA, Scherrer-Crosbie M, Kim H: 14,15-Dihydroxyeicosatrienoic acid, a soluble epoxide hydrolase metabolite in blood, is a predictor of anthracycline-induced cardiotoxicity - a hypothesis generating study. Cardiooncology December 2023.
Onoue T, Kang Y, Lefebvre B, Smith AM, Denduluri S, Fradley MG, Chittams J, Carver JR, Scherrer-Crosbie M: Impact of Atrial Fibrillation on Heart Failure in Patients Treated With Anthracycline Chemotherapy. Am J Cardiol November 2023.
Lefebvre B, Kang Y, Vakilpour A, Onoue T, Frey NV, Brahmbhatt P, Huang B, Oladuja K, Koropeckyj-Cox D, Wiredu C, Smith AM, Chittams J, Carver J, Scherrer-Crosbie M. : Incidence of MACE in Patients Treated With CAR-T Cell Therapy: A Prospective Study. JACC CardioOncol. October 2023.
Cheng KH, Tu HP, Cheng KC, Scherrer-Crosbie M, Hsu TY: Cardiovascular and Neurological Outcomes in Patients Treated with Edoxaban for Atrial Fibrillation and Characteristics in Patients with Cancer. medRxiv October 2023.
Avula V, Sharma G, Kosiborod MN, Vaduganathan M, Neilan TG, Lopez T, Dent S, Baldassarre L, Scherrer-Crosbie M, Barac A, Liu J, Deswal A, Khadke S, Yang EH, Ky B, Lenihan D, Nohria A, Dani SS, Ganatra S. : SGLT2 Inhibitor Use and Risk of Clinical Events in Patients With Cancer Therapy-Related Cardiac Dysfunction. JACC Heart Fail. October 2023.