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Laura Almasy, Ph.D.
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Professor of Genetics
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Department: Genetics
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Graduate Group Affiliations
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Contact information
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1016C Abramson Research Center
3e 3615 Civic Center Boulevard
Philadelphia, PA 19104
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3e 3615 Civic Center Boulevard
Philadelphia, PA 19104
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Office: 215-590-3031
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Email:
almasyl@upenn.edu
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almasyl@upenn.edu
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Education:
21 9 B.A. 23 (Biology and Psychology) c
2b Swarthmore College, 1990.
21 c M.Phil. 15 (Genetics) c
28 Yale University, 1992.
21 a Ph.D. 15 (Genetics) c
28 Yale University, 1996.
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Permanent link21 9 B.A. 23 (Biology and Psychology) c
2b Swarthmore College, 1990.
21 c M.Phil. 15 (Genetics) c
28 Yale University, 1992.
21 a Ph.D. 15 (Genetics) c
28 Yale University, 1996.
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14f Kazem S, Kumar K, Jean-Louis M, Huguet G, Renne T, Saci Z, Engchuan W, Shanta O, Thiruvahindrapuram B, MacDonald JR, Greenwood CMT, Scherer SW, Almasy L, Sebat J, Glahn DC, Dumas G, Jacquemont S.: Gene dosage architecture across complex traits. medRxiv Feb 2025.
164 Rupert PE, Roalf DR, Prasad KM, Kuo SS, Musket CW, Wood J, Gur RC, Almasy L, Gur RE, Nimgaonkar VL, Pogue-Geile MF.: Genetic risk for schizophrenia and brain activation during the Penn Conditional Exclusion Test: A multiplex extended pedigree study. J Psychopathol Clin Sci Feb 2025.
152 Rodrigue AL, Knowles EEM, Mollon J, Mathias SR, Peralta JM, Leandro AC, Fox PT, Kochunov P, Olvera RL, Almasy L, Curran JE, Blangero J, Glahn DC.: Genetic Associations Among Inflammation, White Matter Architecture, and Extracellular Free Water. Hum Brain Mapp 2025.
15a Hill SY, Edenberg HJ, Corvin A, Thorgeirsson T, Below JE, Goldman D, Leal S, Almasy L, Cox NJ, Daly M, Neale B, Vrieze S, Zoghbi H.: Whole Genome Sequencing of Pedigrees With High Density of Substance Use and Psychiatric Disorders: A Meeting Report. Genes Brain Behav 2025.
217 Huguet G, Renne T, Poulain C, Dubuc A, Kumar K, Kazem S, Engchuan W, Shanta O, Douard E, Proulx C, Jean-Louis M, Saci Z, Mollon J, Schultz LM, Knowles EEM, Cox SR, Porteous D, Davies G, Redmond P, Harris SE, Schumann G, Dumas G, Labbe A, Pausova Z, Paus T, Scherer SW, Sebat J, Almasy L, Glahn DC, Jacquemont S.: Effects of gene dosage on cognitive ability: A function-based association study across brain and non-brain processes. Cell Genom 4: 100721, Dec 2024.
53b Huffman JE, Nicholas J, Hahn J, Heath AS, Raffield LM, Yanek LR, Brody JA, Thibord F, Almasy L, Bartz TM, Bielak LF, Bowler RP, Carrasquilla GD, Chasman DI, Chen MH, Emmert DB, Ghanbari M, Haessler J, Hottenga JJ, Kleber ME, Le NQ, Lee J, Lewis JP, Li-Gao R, Luan J, Malmberg A, Mangino M, Marioni RE, Martinez-Perez A, Pankratz N, Polasek O, Richmond A, Rodriguez BAT, Rotter JI, Steri M, Suchon P, Trompet S, Weiss S, Zare M, Auer P, Cho MH, Christofidou P, Davies G, de Geus E, Deleuze JF, Delgado GE, Ekunwe L, Faraday N, Gögele M, Greinacher A, Gao H, Howard T, Joshi PK, Kilpeläinen TO, Lahti J, Linneberg A, Naitza S, Noordam R, Paüls-Vergés F, Rich SS, Rosendaal FR, Rudan I, Ryan KA, Souto JC, van Rooij FJA, Wang H, Zhao W, Becker LC, Beswick A, Brown MR, Cade BE, Campbell H, Cho K, Crapo JD, Curran JE, de Maat MPM, Doyle M, Elliott P, Floyd JS, Fuchsberger C, Grarup N, Guo X, Harris SE, Hou L, Kolcic I, Kooperberg C, Menni C, Nauck M, O'Connell JR, Orrù V, Psaty BM, Räikkönen K, Smith JA, Soria JM, Stott DJ, van Hylckama Vlieg A, Watkins H, Willemsen G, Wilson PWF, Ben-Shlomo Y, et al.: Whole-genome analysis of plasma fibrinogen reveals population-differentiated genetic regulators with putative liver roles. Blood 144: 2248-2265, Nov 2024.
120 Schultz LM, Knighton A, Huguet G, Saci Z, Jean-Louis M, Mollon J, Knowles EEM, Glahn DC, Jacquemont S, Almasy L.: Copy-number variants differ in frequency across genetic ancestry groups. HGG Adv 5: 100340, Oct 2024.
11f Dudek MF, Wenz BM, Brown CD, Voight BF, Almasy L, Grant SFA.: Characterization of non-coding variants associated with transcription factor binding through ATAC-seq-defined footprint QTLs in liver. bioRxiv Sep 2024.
182 Sun KY, Schmitt JE, Moore TM, Barzilay R, Almasy L, Schultz LM, Mackey AP, Kafadar E, Sha Z, Seidlitz J, Mallard TT, Cui Z, Li H, Fan Y, Fair DA, Satterthwaite TD, Keller AS, Alexander-Bloch A.: Polygenic Risk Underlies Youth Psychopathology and Personalized Functional Brain Network Topography. medRxiv Sep 2024.
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Selected Publications
1c0 Thompson EW, Dong NJ, Kim JS, Bhattaru A, Vu P, Hu F, Shinohara RT, Swago S, Donnelly E, Zhang X, Loth A, Vuthuri L, Lanzilotta K, Whitehead KK, Duda J, Gee J, Almasy L, Goldmuntz E, Fogel MA, Witschey WR.: Cardiovascular Magnetic Resonance Imaging Traits Associated with Adverse Right Ventricular Remodeling in Repaired Tetralogy of Fallot. J Cardiovasc Magn Reson Feb 2025.14f Kazem S, Kumar K, Jean-Louis M, Huguet G, Renne T, Saci Z, Engchuan W, Shanta O, Thiruvahindrapuram B, MacDonald JR, Greenwood CMT, Scherer SW, Almasy L, Sebat J, Glahn DC, Dumas G, Jacquemont S.: Gene dosage architecture across complex traits. medRxiv Feb 2025.
164 Rupert PE, Roalf DR, Prasad KM, Kuo SS, Musket CW, Wood J, Gur RC, Almasy L, Gur RE, Nimgaonkar VL, Pogue-Geile MF.: Genetic risk for schizophrenia and brain activation during the Penn Conditional Exclusion Test: A multiplex extended pedigree study. J Psychopathol Clin Sci Feb 2025.
152 Rodrigue AL, Knowles EEM, Mollon J, Mathias SR, Peralta JM, Leandro AC, Fox PT, Kochunov P, Olvera RL, Almasy L, Curran JE, Blangero J, Glahn DC.: Genetic Associations Among Inflammation, White Matter Architecture, and Extracellular Free Water. Hum Brain Mapp 2025.
15a Hill SY, Edenberg HJ, Corvin A, Thorgeirsson T, Below JE, Goldman D, Leal S, Almasy L, Cox NJ, Daly M, Neale B, Vrieze S, Zoghbi H.: Whole Genome Sequencing of Pedigrees With High Density of Substance Use and Psychiatric Disorders: A Meeting Report. Genes Brain Behav 2025.
217 Huguet G, Renne T, Poulain C, Dubuc A, Kumar K, Kazem S, Engchuan W, Shanta O, Douard E, Proulx C, Jean-Louis M, Saci Z, Mollon J, Schultz LM, Knowles EEM, Cox SR, Porteous D, Davies G, Redmond P, Harris SE, Schumann G, Dumas G, Labbe A, Pausova Z, Paus T, Scherer SW, Sebat J, Almasy L, Glahn DC, Jacquemont S.: Effects of gene dosage on cognitive ability: A function-based association study across brain and non-brain processes. Cell Genom 4: 100721, Dec 2024.
53b Huffman JE, Nicholas J, Hahn J, Heath AS, Raffield LM, Yanek LR, Brody JA, Thibord F, Almasy L, Bartz TM, Bielak LF, Bowler RP, Carrasquilla GD, Chasman DI, Chen MH, Emmert DB, Ghanbari M, Haessler J, Hottenga JJ, Kleber ME, Le NQ, Lee J, Lewis JP, Li-Gao R, Luan J, Malmberg A, Mangino M, Marioni RE, Martinez-Perez A, Pankratz N, Polasek O, Richmond A, Rodriguez BAT, Rotter JI, Steri M, Suchon P, Trompet S, Weiss S, Zare M, Auer P, Cho MH, Christofidou P, Davies G, de Geus E, Deleuze JF, Delgado GE, Ekunwe L, Faraday N, Gögele M, Greinacher A, Gao H, Howard T, Joshi PK, Kilpeläinen TO, Lahti J, Linneberg A, Naitza S, Noordam R, Paüls-Vergés F, Rich SS, Rosendaal FR, Rudan I, Ryan KA, Souto JC, van Rooij FJA, Wang H, Zhao W, Becker LC, Beswick A, Brown MR, Cade BE, Campbell H, Cho K, Crapo JD, Curran JE, de Maat MPM, Doyle M, Elliott P, Floyd JS, Fuchsberger C, Grarup N, Guo X, Harris SE, Hou L, Kolcic I, Kooperberg C, Menni C, Nauck M, O'Connell JR, Orrù V, Psaty BM, Räikkönen K, Smith JA, Soria JM, Stott DJ, van Hylckama Vlieg A, Watkins H, Willemsen G, Wilson PWF, Ben-Shlomo Y, et al.: Whole-genome analysis of plasma fibrinogen reveals population-differentiated genetic regulators with putative liver roles. Blood 144: 2248-2265, Nov 2024.
120 Schultz LM, Knighton A, Huguet G, Saci Z, Jean-Louis M, Mollon J, Knowles EEM, Glahn DC, Jacquemont S, Almasy L.: Copy-number variants differ in frequency across genetic ancestry groups. HGG Adv 5: 100340, Oct 2024.
11f Dudek MF, Wenz BM, Brown CD, Voight BF, Almasy L, Grant SFA.: Characterization of non-coding variants associated with transcription factor binding through ATAC-seq-defined footprint QTLs in liver. bioRxiv Sep 2024.
182 Sun KY, Schmitt JE, Moore TM, Barzilay R, Almasy L, Schultz LM, Mackey AP, Kafadar E, Sha Z, Seidlitz J, Mallard TT, Cui Z, Li H, Fan Y, Fair DA, Satterthwaite TD, Keller AS, Alexander-Bloch A.: Polygenic Risk Underlies Youth Psychopathology and Personalized Functional Brain Network Topography. medRxiv Sep 2024.
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