Anupma Nayak, MBBS, MD
Associate Professor of Pathology and Laboratory Medicine at the Hospital of the University of Pennsylvania
Attending Pathologist, Hospital of the University of Pennsylvania
Director, Breast Pathology Fellowship Program, Department of Pathology and Laboratory Medicine,Perelman School of Medicine and Hospital of the University of Pennsylvania
Director, Tumor Tissue and Biobank (TTAB), Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania
Associate Vice Chair of Translational and Clinical Research, Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania
Department: Pathology and Laboratory Medicine
Contact information
Associate Professor
Dept. of Pathology and Laboratory Medicine
Hospital of the University of Pennsylvania
Perelman School of Medicine
3400 Spruce St.
6 Founders
Philadelphia, PA 19104
Dept. of Pathology and Laboratory Medicine
Hospital of the University of Pennsylvania
Perelman School of Medicine
3400 Spruce St.
6 Founders
Philadelphia, PA 19104
Office: 2156624899
Publications
Education
MBBS (Medicine)
King George Medical College, Lucknow, India, 1997.
Permanent linkMBBS (Medicine)
King George Medical College, Lucknow, India, 1997.
Description of Clinical Expertise
Breast PathologyDescription of Research Expertise
Breast CancerSelected Publications
Boruah N, Hoyos D, Moses R, Hausler R, Desai H, Le AN, Good M, Kelly G, Raghavakaimal A, Tayeb M, Narasimhamurthy M, Doucette A, Gabriel P, Feldman MJ, Park J, Lopez de Rodas M, Schalper KA, Goldfarb SB, Nayak A, Levine AJ, Greenbaum BD, Maxwell KN. : Distinct genomic and immunologic tumor evolution in germline TP53-driven breast cancers. Nat Commun. Nature, 17(1): 7300, May 2026.Sreekumar A, Blankemeyer E, Sterner CJ, Pan TC, Pant DK, Acolatse S, Turkistani H, Belka GK, Nayak A, Carlin SD, Assenmacher CA, Sellmyer MA, Mankoff DA, Chodosh LA.: Residual Breast Cancer Cells Co-opt SOX5-Driven Endochondral Ossification to Maintain Dormancy. Cancer Discov. Page: 781-799, April 2026.
Akamandisa MP, Xia M, Cheah W, Wubbenhorst B, D'Andrea KP, Fan M, Shilan JS, Pueschl D, Nayak A, McKenzie H, Tapper W, Copson ER, Cutress RI, Domchek SM, Eccles DM, Nathanson KL. : Comparative analysis of distinct genomic landscapes in young-onset gBRCA1/2 breast cancer. JCI Insight 11(12): e203005. April 2026.
Budina A, Vergara N, Navarro FE, Morrissette JJD, Nayak A. High-Grade Urothelial Carcinoma with Divergent Prostatic Differentiation Mimicking a Collision Tumor in a Bladder Diverticulum. Int J Surg Pathol. 2026 Mar 31:10668969261429079. doi: 10.1177/10668969261429079. Epub ahead of print. PMID: 41918088.: High-Grade Urothelial Carcinoma with Divergent Prostatic Differentiation Mimicking a Collision Tumor in a Bladder Diverticulum. Int J Surg Pathol. March 2026.
Yuan M, Jin K, Yan H, Schroeder A, Luo C, Yao S, Dumoulin B, Levinsohn J, Luo T, Clemenceau JR, Jang I, Kim M, Liu Y, Deng M, Furth EE, Wilson P, Nayak A, Lubo I, Solis Soto LM, Wang L, Park JH, Susztak K, Hwang TH, Li M. : Smart spatial omics (S2-omics) optimizes region of interest selection to capture molecular heterogeneity in diverse tissues. Nat Cell Biol. Nature, 27(12): 2225-2238, December 2025.
DeMichele A, Clark A, Shea E, Bayne L, Sterner C, Rohn K, Eberle-Dwyer S, Pan T-C, Nivar I, Chen Y, Wileyto EP, Berry L, DeLuca S, Savage J, Makhlin I, Pant D, Egunsola A, Mears N, Goodspeed B, Chislock E, Graves J, Wang J, Shih N, Belka G, Berry D, Nayak A, Feldman M, Martin H, Chodosh L.: Targeting Dormant Tumor Cells to Prevent Recurrent Breast Cancer: a randomized phase 2 trial. Nature Medicine Sept 2025.
Griffin B. Spychalski1, Andrew A. Lin, Stephanie J. Yang, Hanfei Shen, Jean Rosario, Kyle Tien, Kate French, Miriyam Ghali, Stephanie Yee, Melinda Yin, Michael D. Feldman, Emily F. Conant, Susan P. Weinstein, Erica L. Carpenter, David Issadore, Anupma Nayak: miRNA Panel from HER2+ and CD24+ Plasma Extracellular Vesicle Subpopulations as Biomarkers of Early-stage Breast Cancer. Breast Cancer Res. Springer Nature, 27(1): 90, May 2025.
Narasimhamurthy M, Le A, Boruah N, Moses R, Kelly G, Bleiweiss I, Maxwell KN, Nayak A. : Clinicopathologic Features of Breast Tumors in Germline TP53 Variant-Associated Li-Fraumeni Syndrome. Am J Surg Pathol. 49(3): 195-205, March 2025.
Kaitlin Demarest, Arravinth Anantharajah, Kara N. Maxwell1, Mersedeh Rohanizadegan, Angela Bradbury, Katherine L Nathanson, Susan Domchek, Anupma Nayak, Payal D. Shah: Pathogenic Germline Variants in Patients with Metaplastic Breast Cancer. JAMA Network Open 8(2), Feb 2025.
Young AJ, Pantel AR, Kiani M, Doot RK, Bagheri S, Pryma DA, Farwell MD, Li S, Lee H, Schubert EK, Secreto A, Zuckerman SP, Nayak A, Choi H, Carlin S, DeMichele A, Mankoff DA, Zhou R, Mach RH, McDonald ES. : Kinetic Analysis and Metabolism of Poly(Adenosine Diphosphate-Ribose) Polymerase-1-Targeted 18F-Fluorthanatrace PET in Breast Cancer. J Nucl Med. 65((12)): 1862-68, Dec 2024.