Lei Dong, Ph.D.

faculty photo
Professor of Radiation Oncology at the Hospital of the University of Pennsylvania
Director of Medical Physics Division, The Hospital of University of Pennsylvania, Department of Radiation Oncology
Vice Chair of Radiation Oncology, the Hospital of University of Pennsylvania, Department of Radiation Oncology
Department: Radiation Oncology

Contact information
Perelman Center for Advanced Medicine
Department of Radiation Oncology
3400 Civic Center Blvd
Philadelphia, PA 19104
B.S. (Engineering Physics)
Tsinghua University, 1985.
M.S. (Modern Applied Physics)
Tsinghua University, 1987.
Ph.D. (Biomedical Sciences/Medical Physics Program)
University of Texas Graduate School of Biomedical Sciences, 1995.
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Description of Clinical Expertise

Dr.Dong is familiar with radiation dosimetry and use of images in radiation oncology for setup (IGRT) and treatment planning. He was involved in several auto-segmentation projects using deformable image registration or machine learning methods. In addition, Dr.Dong worked extensively in the technical commissioning in three proton therapy centers (Hitachi Synchrotron at MD Anderson Cancer Center in 2005-2008, Varian first ProBeam pencil beam scanning at Scripps Health in 2012-2016, and IBA multi-room cyclotron-based system with upgraded dedicated pencil beam scanning technology since 2017).

Description of Research Expertise

My research interests are always motivated by clinical needs. As a medical physicist, the use of advanced technologies to improve clinical outcomes or clinical efficiencies is always interesting to me. Throughout the years, I have been interested in intensity-modulated radiation therapy, which includes proton therapy and automated treatment planning; I am interested in adaptive radiotherapy beyond anatomical changes of patient’s anatomy; I am interested in imaging, which provides rich information about the patient (spatially or biologically); I am interested in novel treatment techniques, which includes the recent hot topic on ultra-high dose-rate radiation therapy (FLASH). I have published over 220 peer-reviewed papers and 15 book chapters. My publication h-index is around 62. I plan to continue my innovative research through close collaboration with researchers internally and around the world.

Selected Publications

Zou, W., Zhang, R., Schueler, E., Taylor, P. A., Mascia, A. E., Diffenderfer, E. S., Zhao, T., Ayan, A. S., Sharma, M., Yu, S. J., Lu, W., Bosch, W. R., Tsien, C., Surucu, M., Pollard-Larkin, J. M., Schuemann, J., Moros, E. G., Bazalova-Carter, M., Gladstone, D. J., Li, H., Simone, C. B., 2nd, Petersson, K., Kry, S. F., Maity, A., Loo, B. W., Jr., Dong, L., Maxim, P. G., Xiao, Y., Buchsbaum, J. C.: Framework for Quality Assurance of Ultra-High Dose Rate Clinical Trials Investigating FLASH Effects and Current Technology Gaps. International Journal of Radiation Oncology*Biology*Physics 2023.

Schofield, D. L., Conroy, L., Harmsen, W. S., Johnson, J. L., Wells, M. C., Dong, L., Fong de Los Santos, L. E.: AAPM task group report 275.S: Survey strategy and results on plan review and chart check practices in US and Canada. Journal of Applied Clinical Medical Physics. 24(4): e13952, 2023.

Tan, H. S., Teo, B. K., Dong, L., Friberg, A., Koumenis, C., Diffenderfer, E., Zou, J. W.: Modeling ultra-high dose rate electron and proton FLASH effect with the physicochemical approach. Phys Med Biol 2023.

AA Kassaee, H Lin, L Xu, S Philbrook, L Dong, D Carlson, T Li: SBRT on Halcyon Linear Accelerator: Exploring Dosimetric Impact of Residual Rotational Error after Correcting for Translational Setup Errors. Cureus Journal of Medical Science 14(2), 11 2022.

Zou, W., Kim, H., Diffenderfer, E. S., Carlson, D. J., Koch, C. J., Xiao, Y., Teo, B. K., Kim, M. M., Metz, J. M., Fan, Y., Maity, A., Koumenis, C., Busch, T. M., Wiersma, R., Cengel, K. A., Dong, L.: A phenomenological model of proton FLASH oxygen depletion effects depending on tissue vasculature and oxygen supply. Front Oncol 12: 1004121, 2022.

Li, H., Dong, L., Bert, C., Chang, J., Flampouri, S., Jee, K. W., Lin, L., Moyers, M., Mori, S., Rottmann, J., Tryggestad, E., Vedam, S.: AAPM Task Group Report 290: Respiratory motion management for particle therapy. Med Phys 49(4): e50-e81, 2022.

Lin, H., Dong, L., Jimenez, R. B.: Emerging Technologies in Mitigating the Risks of Cardiac Toxicity From Breast Radiotherapy. Seminars in Radiation Oncology 32(3): 270-281, 2022.

Pakela, J. M., Knopf, A., Dong, L., Rucinski, A., Zou, W.: Management of Motion and Anatomical Variations in Charged Particle Therapy: Past, Present, and Into the Future. Front Oncol 12: 806153, 2022.

Yeom, Y. S., Griffin, K. T., Mille, M. M., Lee, C., O'Reilly, S., Dong, L., Jung, J. W., Lee, C.: Fetal dose from proton pencil beam scanning craniospinal irradiation during pregnancy: a Monte Carlo study. Phys Med Biol 67(3), 2022.

Velalopoulou, A., Karagounis, I. V., Cramer, G. M., Kim, M. M., Skoufos, G., Goia, D., Hagan, S., Verginadis,, II, Shoniyozov, K., Chiango, J., Cerullo, M., Varner, K., Yao, L., Qin, L., Hatzigeorgiou, A. G., Minn, A. J., Putt, M., Lanza, M., Assenmacher, C. A., Radaelli, E., Huck, J., Diffenderfer, E., Dong, L., Metz, J., Koumenis, C., Cengel, K. A., Maity, A., Busch, T. M.: FLASH proton radiotherapy spares normal epithelial and mesenchymal tissues while preserving sarcoma response. Cancer Research 2021.

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Last updated: 09/25/2023
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