Alexia Vite, PhD

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Research Assistant Professor of Medicine (Cardiovascular Medicine)
Research Associate of Medicine, University of Pennsylvania School of Medicine
Department: Medicine

Contact information
11th Floor Smillow Building
34th Civic Center Blvd.
Philadelphia, PA 19104
Education:
Master (Physiology/Physiopathology)
Pierre et Marie Curie University , 2009.
PhD
Pierre et Marie Curie University , 2013.
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Description of Research Expertise

I am a Research Assistant Professor with particular expertise in cardiac myocyte biology and genetic cardiomyopathies. My experience and training in these areas are extensive including studies addressing the consequences of mutations causing inherited cardiomyopathies, studies of cardiovascular development and physiology, tissue engineering, cell physiology, stem cells, and human tissue research to investigate clinically relevant inquiries. Currently, my lab is focusing on identifying the causes of reduced glucose utilization in the context of insulin resistance. This research aims to develop strategies to prevent energy starvation, which contributes to the progression of cardiomyopathies. This multi-component project studies the role of mechanical stress in insulin resistance and glucose utilization impairment in adult cardiomyocytes as well as cardiac tissues. A notable feature of my research is the complementary experimental approaches, which combine bioengineering and classic molecular biology techniques.

Selected Publications

Eaton DM, Lee BW, Caporizzo MA, Iyengar A, Chen CY, Uchida K, Marcellin G, Lannay Y, Vite A, Bedi KC Jr, Brady CF, Smolyak JN, Meldrum D, Dominic J, Weingarten N, Patel M, Belec A, Hached K, Atluri P, Van Der Laan S, Prosser BL, Margulies KB.: Vasohibin inhibition improves myocardial relaxation in a rat model of heart failure with preserved ejection fraction. Sci Transl Med. 16(756): eadm8842, Jul 2024 Notes: DOI: 10.1126/scitranslmed.adm8842

Bouhrira N, Vite A, Margulies KB.: Distinct cytoskeletal regulators of mechanical memory in cardiac fibroblasts and cardiomyocytes. Basic Res Cardiol. 119(2): 277-289, Apr 2024.

Lee BW, Caporizzo MA, Chen CY, Bedi KC Jr, Peyster EG, Prosser BL, Margulies KB, Vite A.: Adult human cardiomyocyte mechanics in osteogenesis imperfecta. Am J Physiol Heart Circ Physiol. 325(4): H814-H821, Oct 2023.

Vite A, Matsuura TR, Bedi KC, Flam EL, Arany Z, Kelly DP, Margulies KB.: Functional Impact of Alternative Metabolic Substrates in Failing Human Cardiomyocytes. JACC Basic Transl Sci. 9(1): 1-15, Sep 2023.

Ramachandran A, Livingston CE, Vite A, Corbin EA, Bennett AI, Turner KT, Lee BW, Lam CK, Wu JC, Margulies KB.: Biomechanical Impact of Pathogenic MYBPC3 Truncation Variant Revealed by Dynamically Tuning In Vitro Afterload. J Cardiovasc Transl Res. 16(4): 828-841, Aug 2023.

Vite A, Caporizzo MA, Corbin EA, Brandimarto J, McAfee Q, Livingston CE, Prosser BL, Margulies KB.: Extracellular stiffness induces contractile dysfunction in adult cardiomyocytes via cell-autonomous and microtubule-dependent mechanisms. Basic Res Cardiol. 117(1): 41, Aug 2022.

Vite A, Gandjbakhch E, Hery T, Fressart V, Gary F, Simon F, Varnous S, Hidden Lucet F, Charron P, Villard E: Desmoglein-2 mutations in propeptide cleavage-site causes arrhythmogenic right ventricular cardiomyopathy/dysplasia by impairing extracellular 1-dependent desmosomal interactions upon cellular stress. Europace 22(2): 320-329, Feb 2020

Martí-Pàmies Í, Thoonen R, Seale P, Vite A, Caplan A, Tamez J, Graves L, Han W, Buys ES, Bloch DB, Scherrer-Crosbie M : Deficiency of bone morphogenetic protein-3b induces metabolic syndrome and increases adipogenesis. Am J Physiol Endocrinol Metab 319(2): E363-E375, Aug 2020.

Vite A, Matsuura T, Bedi K, Snyder N, Brandimarto J, Ramachandran A, Margulies KB: Effect of Substrate on Adult Human Cardiomyocytes Contractility. Journal of cardiac failure 25(8): S113, Aug 2019.

Corbin EA*, Vite A*, Peyster EG, Bhoopalam M, Brandimarto J, Wang X, Bennett AI, Clark AT, Cheng X, Turner KT, Musunuru K, Margulies KB: Tunable and Reversible Substrate Stiffness Reveals a Dynamic Mechanosensitivity of Cardiomyocytes. ACS Appl Mater Interfaces 11(23): 20603-20614, Jun 2019 Notes: *Authors contributed equally to this work"

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Last updated: 11/11/2024
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