Alexia Vite, PhD
Research Assistant Professor of Medicine (Cardiovascular Medicine)
Research Associate of Medicine, University of Pennsylvania School of Medicine
Department: Medicine
Contact information
11th Floor Smillow Building
34th Civic Center Blvd.
Philadelphia, PA 19104
34th Civic Center Blvd.
Philadelphia, PA 19104
Education
Master (Physiology/Physiopathology)
Pierre et Marie Curie University , 2009.
PhD
Pierre et Marie Curie University , 2013.
Permanent linkMaster (Physiology/Physiopathology)
Pierre et Marie Curie University , 2009.
PhD
Pierre et Marie Curie University , 2013.
Description of Research Expertise
I am a Research Assistant Professor with particular expertise in cardiac myocyte biology and genetic cardiomyopathies. My experience and training in these areas are extensive including studies addressing the consequences of mutations causing inherited cardiomyopathies, studies of cardiovascular development and physiology, tissue engineering, cell physiology, stem cells, and human tissue research to investigate clinically relevant inquiries. Currently, my lab is focusing on identifying the causes of reduced glucose utilization in the context of insulin resistance. This research aims to develop strategies to prevent energy starvation, which contributes to the progression of cardiomyopathies. This multi-component project studies the role of mechanical stress in insulin resistance and glucose utilization impairment in adult cardiomyocytes as well as cardiac tissues. A notable feature of my research is the complementary experimental approaches, which combine bioengineering and classic molecular biology techniques.Selected Publications
Alexia Vite, Tony Guo, Nesrine Bouhrira, Deborah M. Eaton, Kenneth C. Bedi Jr., Claire F. Brady, Jonathan J. Edwards, Bea Duric, Keita Uchida, Cassidy Olsen, Lola Dong, Benjamin L. Prosser, Zoltan Arany, Kenneth B. Margulies: Stiffness-Induced Impairment of GLUT4 Trafficking in Adult Cardiomyocytes. Cell Reports July 2026.Michael Ibrahim, Blanca Pamias-Lopez, Vasiliki Courelli, Lan Cheng, Leo Song, Alexia Vite, Omar Toubat, Fotios Pitoulis, Benjamin Prosser, Kenneth Margulies: T-tubular remodeling occurs in a cardiomyocyte-autonomous manner following pathological mechanical stiffness exposure. Journal of Molecular and Cellular Cardiology Plus March 2026.
Nesrine Bouhrira, Alexia Vite, Deborah Eaton, Kenneth Bedi, Kenneth Margulies: Mechanisms driving mechanical memory in adult rat and human Cardiomyocytes. Journal of Molecular and Cellular Cardiology Plus June 2025.
Ali H. Lateef,Nesrine Bouhrira, Jia-Jye Lee, Alexia Vite, Kenneth B. Margulies,Elise A. Corbin: Micropatterned Magneto-Rheological Elastomers to Drive Changes in Cardiomyocyte Alignment JOVE Jan 2025.
Ali H. Lateef,Nesrine Bouhrira, Jia-Jye Lee, Alexia Vite, Kenneth B. Margulies,Elise A. Corbin: Micropatterned Magneto-Rheological Elastomers to Drive Changes in Cardiomyocyte Alignment. JOVE Jan 2025.
Zheng Cao, Andy T Clark, Alexia Vite, Elise A Corbin: A Dynamic Gradient Stiffness Material Platform to Manipulate Cardiac Fibroblasts' Spatio‐Temporal Behavior. Advanced Functional Materials Sept 2024.
Eaton DM, Lee BW, Caporizzo MA, Iyengar A, Chen CY, Uchida K, Marcellin G, Lannay Y, Vite A, Bedi KC Jr, Brady CF, Smolyak JN, Meldrum D, Dominic J, Weingarten N, Patel M, Belec A, Hached K, Atluri P, Van Der Laan S, Prosser BL, Margulies KB.: Vasohibin inhibition improves myocardial relaxation in a rat model of heart failure with preserved ejection fraction. Sci Transl Med. 16(756): eadm8842, Jul 2024 Notes: DOI: 10.1126/scitranslmed.adm8842
Bouhrira N, Vite A, Margulies KB.: Distinct cytoskeletal regulators of mechanical memory in cardiac fibroblasts and cardiomyocytes. Basic Res Cardiol. 119(2): 277-289, Apr 2024.
Lee BW, Caporizzo MA, Chen CY, Bedi KC Jr, Peyster EG, Prosser BL, Margulies KB, Vite A.: Adult human cardiomyocyte mechanics in osteogenesis imperfecta. Am J Physiol Heart Circ Physiol. 325(4): H814-H821, Oct 2023.
Vite A, Matsuura TR, Bedi KC, Flam EL, Arany Z, Kelly DP, Margulies KB.: Functional Impact of Alternative Metabolic Substrates in Failing Human Cardiomyocytes. JACC Basic Transl Sci. 9(1): 1-15, Sep 2023.