John T. Seykora, M.D., Ph.D
Professor of Dermatology
Member, Abramson Cancer Center, Hospital of the University of Pennsylvania
Department: Dermatology
Graduate Group Affiliations
Contact information
Department of Dermatology
Room 1011, Biomedical Research Building
421 Curie Blvd
Philadelphia, PA 19104-6142
Room 1011, Biomedical Research Building
421 Curie Blvd
Philadelphia, PA 19104-6142
Office: 2158980170
Fax: 2155732143
Lab: 215 573 5063
Fax: 2155732143
Lab: 215 573 5063
Publications
Education:
M.S. (Biochemistry)
University of Chicago, 1986.
B.A. (Biology with Honors)
University of Chicago, 1986.
Ph.D. (Cell Biology)
Rockefeller University, 1992.
M.D. (Medicine)
Cornell University Medical College, 1993.
Permanent linkM.S. (Biochemistry)
University of Chicago, 1986.
B.A. (Biology with Honors)
University of Chicago, 1986.
Ph.D. (Cell Biology)
Rockefeller University, 1992.
M.D. (Medicine)
Cornell University Medical College, 1993.
Description of Research Expertise
1. Keratinocyte growth and differentiation-mechanisms of growth control2. Skin cancer-squamous cell carcinoma, SCCIS, Actinic keratoses
3. Signal transduction-tyrosine kinases and adaptor molecules
4. Murine models of human diseases.
5. Use of organotypic cultures to model disease.
6. Effects of UVB on keratinocytes
7. Psoriasis
8. Dermatopathology-alopecia, appendageal tumors, cancer.
Description of Clinical Expertise
Dermatopathology1. Alopecias-including analysis via horizontal sections or the HoVert Technique
2. Appendageal neoplasms
3. Melanocytic lesions
4. Molecular analysis of biopsy tissue
Selected Publications
Natale CA, Mercado S, Zhuang R, Aguirre-Portolés C, Olayide I, Arnatt CK, Seykora JT, Garyantes TK, Luke W, Ridky TW. : An enantiomerically pure agonist of the G protein-coupled estrogen receptor suitable for clinical development. Cancer Res Commun. Mar. 2025.Zhu X, Xu M, Portal C, Lin Y, Ferdinand A, Peng T, Morrisey EE, Dlugosz AA, Castellano JM, Lee V, Seykora JT, Wong SY, Iomini C, Millar SE.: Identification of Meibomian gland stem cell populations and mechanisms of aging. Nat Commun. Feb. 2025.
Nguyen PTT, Shiue M, Kuprasertkul N, Costa-Pinheiro P, Izzo LT, Pinheiro LV, Affronti HA, Gugiu G, Ghaisas S, Liu JY, Harris JC, Bradley CW, Seykora JT, Yang X, Kambayashi T, Mesaros C, Capell BC, Wellen KE.: Acetyl-CoA synthesis in the skin is a key determinant of systemic lipid homeostasis. Cell Rep. Feb. 2025.
Hoffman CL, Bharathan NK, Shibata Y, Giang W, Gudjonsson JE, Seykora JT, Prouty SM, Stahley SN, Payne AS, Kowalczyk AP.: Pemphigus Vulgaris Autoantibodies Induce an Endoplasmic Reticulum Stress Response. J Invest Dermatol. Feb. 2025.
Yu H, Nagi SS, Usoskin D, Hu Y, Kupari J, Bouchatta O, Yan H, Cranfill SL, Gautam M, Su Y, Lu Y, Wymer J, Glanz M, Albrecht P, Song H, Ming GL, Prouty S, Seykora J, Wu H, Ma M, Marshall A, Rice FL, Li M, Olausson H, Ernfors P, Luo W: Leveraging deep single-soma RNA sequencing to explore the neural basis of human somatosensation. Nat Neurosci Dec. 2024.
Grice EA, Brennan-Crispi D, Rodriguez N, Margolis DJ, Seykora JT, Cotsarelis G, Taylor SC, Shuda J. : Penn Academy for Skin Health (PASH): An Experiential Pipeline Program in Skin Biology and Dermatology for High-School Students. J Invest Dermatol. Oct. 2024.
Abbott JJ, Jiang AJ, Godse R, Ahmed S, Senft SC, Wilson MA, Cohen JV, Mitchell TC, Ogunleye TA, Higgins HW 2nd, Shin TM, Miller CJ, Roth JJ, Priore SF, Castelo-Soccio L, Elenitsas R, Seykora JT, Nathanson KL, Chu EY: Inherited Basaloid Neoplasms Associated With SUFU Pathogenic Variants. JAMA Dermatol. Sept. 2024.
Sati S, Huang J, Kersh AE, Jones P, Ahart O, Murphy C, Prouty SM, Hedberg ML, Jain V, Gregory SG, Leung DH, Seykora JT, Rosenbach M, Leung TH: Recruitment of CXCR4+ type 1 innate lymphoid cells distinguishes sarcoidosis from other skin granulomatous diseases. J Clin Invest. Sept. 2024.
Maeno H, Suzuki-Horiuchi Y, Funakoshi A, Chumsakul O, Sato Y, Ishii T, Seykora JT: miR-4521-A novel biomarker for human lentigos. Exp Dermatol. 2024 33(6), June 2024.
Harris JC, Prouty SM, Nelson MA, Sung DC, Nelson AM, Seykora JT, Kambayashi T, Grice EA.: Laser Capture Microdissection-based RNAseq for Profiling Mouse and Human Sebaceous Gland Transcriptomes. J Invest Dermatol 144, May 2024.