John T. Seykora, M.D., Ph.D

faculty photo
Associate Professor of Dermatology
Department: Dermatology
Graduate Group Affiliations

Contact information
Department of Dermatology
421 Curie Blvd
Room 1011 BRB II/III
Philadelphia, PA 19104-6142
Office: 2158980170
Fax: 2155732143
Education:
M.S. (Biochemistry)
University of Chicago, 1986.
B.A. (Biology with Honors)
University of Chicago, 1986.
Ph.D. (Cell Biology)
Rockefeller University, 1992.
M.D. (Medicine)
Cornell University Medical College, 1993.
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Description of Research Expertise

1. Keratinocyte growth and differentiation-mechanisms of growth control
2. Skin cancer-squamous cell carcinoma
3. Signal transduction-tyrosine kinases and adaptor molecules
4. Murine models of human diseases.
5. Use of organotypic cultures to model disease.
6. Effects of UVB on keratinocytes
7. Psoriasis
8. Dermatopathology-alopecia, appendageal tumors, cancer.

Description of Clinical Expertise

Dermatopathology
1. Alopecias-including analysis via horizontal sections
2. Appendageal neoplasms
3. Melanocytic lesions
4. Molecular analysis of biopsy tissue

Selected Publications

Lee V, Yang X, Prouty S, Dentchev T, Marshall C, Maeno H, Bashir H, O'Day C, Seykora JT. : Srcasm regulates tyrosine kinases in skin cancer: Implications for precision medicine. Journal of Investigative Dermatology Symp Proc. 19(2): S103-S105, December 2018 Notes: Doi: 10.1016/j.jisp.2018.10.006.

Seykora, J.T.: Introduction to the 2016 JID Beijing Workshop: Precision Medicine in Dermatology. Journal of Investigative Dermatology Symp Proc. 10(2): S65-S68, December 2018 Notes: Doi: 10.1016/j.jisp.2018.09.001.

Stewart CL, Cornejo CM, Wanat KA, Sander I, Samimi S, Prouty S, Seykora J. Zhang P, Rosenbach M, Kim EJ, Micheletti RG. : The immune reconstitution of the skin following sex-mismatched allogeneic haematopoietic stem cell transplant: A prospective case series utilizing fluorescence in situ hybridization and immunohistochemistry. Br J Dermatol. 178(1): e55-e56, January 2018 Notes: Doi: 10.1111/bjd.15878. Epub 2018 Jan 8.

Dou Z, Ghosh K, Vizioli MG, Zhu J, Sen P, Wangensteen KJ, Simithy J, Lan Y, Lin Y, Zhou Z, Capell BC, Xu C, Xu M, Kieckhaefer JE, Jiang T, Shoshkes-Carmel M, Tanim KMAA, Barber GN, Seykora JT, Millar SE, Kaestner KH, Garcia BA, Adams PD, Berger SL: Cytoplasmic chromatin triggers inflammation in senescence and cancer. Journal of Investigative Dermatology Symp Proc. 550(7676): 402-406, October 2017 Notes: Doi: 10.1038/nature24050.Epub 2017 Oct 4.

Dou Z, Ghosh K, Vixioli MG, Zhu J, Sen P, Wangensteen KJ, Simithy J, Lan Y, Lin Y, Zhou Z, Capell BC, Xu C, Xu M, Kieckhaefer JE, Jiang T, Shoshkes-Carmel M. Tanim KMAA, Barber GN, Seykora JT, Millar SE, Kaestner KH, Garcia BA, Adams PD, Berger SL.: Cytoplasmic chromatin triggers inflammation in senescence and cancer. Nature. 550(7676): 402-406, October 2017.

Ma S, Imadojemu S, Beer K, Seykora JT. : Inflammatory features of frontal fibrosing alopecia. Journal of Cutaneous Pathology 44(8): 672-676, August 2017 Notes: Doi: 10.1111/cup.12955. Epub 2017 Jun 1.

Xu M, Horrell J, Snitow M, Cui J, Gochnauer H, Syrett CM, Kallish S, Seykora JT, Liu F, Gaillard D, Katz JP, Kestner KH, Levin B, Mansfield C, Douglas JE, Cowart BJ, Tordoff M, Liu F, Zhu X, Barlow LA, Rubin AI, McGrath JA, Morrisey EE, Chu EY, Millar SE. : WNT10A mutation causes ectodermal dysplasia by impairing progenitor cell proliferation and KLF4-mediated differentiation. Nat Commun. June 7, 2017; 8; 15397. doi: 10.1028/ncomms15397. PubMed PMID: 28589954; PubMed Central PMCID: PMCID: PMC5467248. 8: 15397, June 2017 Notes: Doi: 10.1038/ncomms15397.

Taylor LA, O'Day C, Dentchev T, Hood K, Chu EY, Ridky TW, Seykora JT.: p15 expression differentiates nevus from melanoma. American Journal of Pathology 186(12), December 2016 Notes: Doi: 10.1016/j.ajpath.2016.08.009. Epub 2016 Nov 14.

Gui J, Gober M, Yang X, Katlinski KV, Marshall CM, Sharma M, Werth VP, Baker DP, Rui H, Seykora JT, Fuchs SY.: Therapeutic elimination of the Type 1 interferon receptor for treating psoriatic skin inflammation. J Invest Dermatol. 136(10): 1990-2002, October 2016 Notes: Doi: 10.1016/j.jid.2016.06.608. Epub 2016 Jun 29.

Ellebrecht CT, Bhoj VG, Nace A, Choi EJ, Mao X, Cho MJ, Di Zenzo G, Lanzavecchia A, Seykora JT, Cotsarelis G, Milone MC, Payne AS.: Reengineering chimeric antigen receptor T cells for targeted therapy of autoimmune disease. Science. 353(6295): 179-84, July 2016 Notes: Doi: 10.1126/science.aaf6756. Epub 2016 Jun 30.

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Last updated: 01/14/2019
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