John T. Seykora, M.D., Ph.D

faculty photo
Professor of Dermatology
Member, Abramson Cancer Center, Hospital of the University of Pennsylvania
Department: Dermatology
Graduate Group Affiliations

Contact information
Department of Dermatology
Room 1011, Biomedical Research Building
421 Curie Blvd
Philadelphia, PA 19104-6142
Office: 2158980170
Fax: 2155732143
M.S. (Biochemistry)
University of Chicago, 1986.
B.A. (Biology with Honors)
University of Chicago, 1986.
Ph.D. (Cell Biology)
Rockefeller University, 1992.
M.D. (Medicine)
Cornell University Medical College, 1993.
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Description of Research Expertise

1. Keratinocyte growth and differentiation-mechanisms of growth control
2. Skin cancer-squamous cell carcinoma
3. Signal transduction-tyrosine kinases and adaptor molecules
4. Murine models of human diseases.
5. Use of organotypic cultures to model disease.
6. Effects of UVB on keratinocytes
7. Psoriasis
8. Dermatopathology-alopecia, appendageal tumors, cancer.

Description of Clinical Expertise

1. Alopecias-including analysis via horizontal sections
2. Appendageal neoplasms
3. Melanocytic lesions
4. Molecular analysis of biopsy tissue

Selected Publications

Roche FC, Fischer AS, Gaddis KJ, Dentchev T, Taylor SC, Cotsarelis G, Seykora JT: Fibrotic Trochanters: A Potential Mechanism for Stem Cell Depletion in Scarring Alopecias J Cutan Pathol August 2020 Notes: doi: 10.1111/cup.13855. Epub ahead of print.

Ramakrishnan MS, Lee V, Seykora JT, Briceño CA: Lupus Miliaris Disseminatus Faciei of the Posterior Eyelids: A Case Report Ophthalmic Plast Reconstr Surg 36(4): e90-e91, July 2020 Notes: doi: 10.1097/IOP.0000000000001603.

Micheletti RG, Chansky PB, Haun PL, Seykora JT, Dekerlegand J, Sultan LR, Schultz SM, Sehgal CM, Sobanko JF: Ablative fractional laser resurfacing for treatment of sclerosis and contractures in chronic graft-versus-host disease: A pilot study. J Am Acad Dermatol 82(4): 984-986, April 2020 Notes: doi: 10.1016/j.jaad.2019.07.084. Epub 2019 Jul 30.

Natale C, Li J, Dentchev T, Capell B, Seykora J, Stanger B, Ridky T: Pharmacologic Activation of G Protein-Coupled Estrogen Receptor Inhibits Pancreatic Ductal Adenocarcinoma Cellular and Molecular Gastroenterology and Hepatology In Press, April 2020 Notes: doi: In Press.

Cuong, N., Gaddis, K., Stephens, M., Seykora, J.T., Chu, E.Y.: An intra-patient concordance study of mismatch repair protein immunohistochemical staining patterns in patients with Muir-Torre syndrome. JAMA Dermatol In Press, April 2020.

Flamm A, Moshiri AS, Roche F, Onyekaba G, Nguyen J, James AJ, Taylor S and Seykora J: Characterization of the Inflammatory Features of Central Centrifugal Cicatricial Alopecia J Cutan Pathol February 2020 Notes: doi: 10.1111/cup.13666. [Epub ahead of print].

Lee V, Gober MD, Bashir H, O’Day C, Blair IA, Mesaros C, Weng L, Huang A, Chen A, Tang R, Anagnos V, Li JL, Roling S, Sagaityte E, Wang A, Lin C, Yeh C, Atillasoy C, Marshall C, Dentchev T, Ridky T, and Seykora JT: Voriconazole enhances UV-induced DNA damage by inhibiting catalase and promoting oxidative stress. Exp Dermatol 29(1): 29-38, January 2020 Notes: doi: 10.1111/exd.14038. Epub 2019 Oct 29.

Zheng Q, Capell B, Parekh V, O’Day C, Atillasoy C, Bashir HM, Yeh C, Shim EH, Prouty S, Dentchev T, Lee V, Wushanley L, Kweon Y, Suzuki-Horiuchi Y, Pear W, Grice E and Seykora, JT: Whole exome and transcriptome analysis of UV-exposed epidermis and carcinoma in situ reveals early drivers of carcinogenesis J Invest Dermatol S0022-202X(20 (1736-X)), 2020 Notes: [published online ahead of print, 2020 Jul 7]. doi:10.1016/j.jid.2020.05.116.

Szigety KM, Liu F, Yuan CY, Moran DJ, Horrell J, Gochnauer HR, Cohen RN, Katz JP, Kaestner KH, Seykora JT, Tobias JW, Lazar MA, Xu M, and Millar, SE : HDAC3 ensures stepwise epidermal stratification via NCoR/SMRT-reliant mechanisms independent of its histone deacetylase activity. Genes and Development 2020 Notes: In Press.

Chandrasekaran S, Sasaki M, Scharer CD, Kissick HT, Patterson DG, Magliocca KR, Seykora JT, Sapkota B, Gutman DA, Cooper LA, Lesinski GB, Waller EK, Thomas SN, Kotenko SV, Boss JM, Moreno CS, Swerlick RA, Pollack BP : Phosphoinositide 3-Kinase Signaling Can Modulate MHC Class I and II Expression. Mol Cancer Res 17(12): 2395-2409, December 2019 Notes: doi: 10.1158/1541-7786.MCR-19-0545. Epub 2019 Sep 23.

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Last updated: 01/14/2021
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