John T. Seykora, M.D., Ph.D

faculty photo
Associate Professor of Dermatology
Department: Dermatology
Graduate Group Affiliations

Contact information
Department of Dermatology
Room 1011, Biomedical Research Building
421 Curie Blvd
Philadelphia, PA 19104-6142
Office: 2158980170
Fax: 2155732143
B.A. (Biology with Honors)
University of Chicago, 1986.
M.S. (Biochemistry)
University of Chicago, 1986.
Ph.D. (Cell Biology)
Rockefeller University, 1992.
M.D. (Medicine)
Cornell University Medical College, 1993.
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Description of Research Expertise

1. Keratinocyte growth and differentiation-mechanisms of growth control
2. Skin cancer-squamous cell carcinoma
3. Signal transduction-tyrosine kinases and adaptor molecules
4. Murine models of human diseases.
5. Use of organotypic cultures to model disease.
6. Effects of UVB on keratinocytes
7. Psoriasis
8. Dermatopathology-alopecia, appendageal tumors, cancer.

Description of Clinical Expertise

1. Alopecias-including analysis via horizontal sections
2. Appendageal neoplasms
3. Melanocytic lesions
4. Molecular analysis of biopsy tissue

Selected Publications

Flamm A, Moshiri AS, Roche F, Onyekaba G, Nguyen J, James AJ, Taylor S and Seykora J. : “Characterization of the Inflammatory Features of Central Centrifugal Cicatricial Alopecia” J Cutan Pathol Jan 2020 Notes: In press.

Chandrasekaran S, Sasaki M, Scharer CD, Kissick HT, Patterson DG, Magliocca KR, Seykora JT, Sapkota B, Gutman DA, Cooper LA, Lesinski GB, Waller EK, Thomas SN, Kotenko SV, Boss JM, Moreno CS, Swerlick RA, Pollack BP. : Phosphoinositide 3-Kinase Signaling Can Modulate MHC Class I and II Expression. Mol Cancer Res. 17(12): 2395-2409, Dec 2019 Notes: doi: 10.1158/1541-7786.MCR-19-0545. Epub 2019 Sep 23.

Lee V, Gober MD, Bashir H, O’Day C, Blair IA, Mesaros C, Weng L, Huang A, Chen A, Tang R, Anagnos V, Li JL, Roling S, Sagaityte E, Wang A, Lin C, Yeh C, Atillasoy C, Marshall C, Dentchev T, Ridky T, and Seykora JT.: “Voriconazole enhances UV-induced DNA damage by inhibiting catalase and promoting oxidative stress.” Exp Dermatol Sept 13 2019 Notes: doi: 10.1111/exd.14038. [Epub ahead of print]

Micheletti RG, Chansky PB, Haun PL, Seykora JT, Dekerlegand J, Sultan LR, Schultz SM, Sehgal CM, Sobanko JF: “Ablative fractional laser resurfacing for treatment of sclerosis and contractures in chronic graft-versus-host disease: A pilot study.” J Am Acad Dermatol July 30 2019 Notes: pii: S0190-9622(19)32477-6. doi: 10.1016/j.jaad.2019.07.084. [Epub ahead of print]

Ma SA, O'Day CP, Dentchev T, Takeshita J, Ridky TW, Seykora JT, Chu EY: Expression of p15 in a spectrum of spitzoid melanocytic neoplasms. J Cutan Pathol 46(5): 310-16, May 2019 Notes: doi: 10.1111/cup.13424.

Yang X, Daifallah AEM Shankar S, Beer J, Marshall C, Dentchev T, Seykora F, D'Armas S, Hahn J, Lee V, Sabry HH, Farag AM, Seykora JT: Topical kinase inhibitors induce regression of cutaneous squamous cell carcinoma. Exp Dermatol 28(5): 609-13, May 2019 Notes: doi: 10.1111/exd.13902.

Lee V, Yang X, Prouty S, Dentchev T, Marshall C, Maeno H, Bashir H, O'Day C, Seykora JT. : Srcasm regulates tyrosine kinases in skin cancer: Implications for precision medicine. Journal of Investigative Dermatology Symp Proc. 19(2): S103-S105, December 2018 Notes: Doi: 10.1016/j.jisp.2018.10.006.

Stewart CL, Cornejo CM, Wanat KA, Sander I, Samimi S, Prouty S, Seykora JT. Zhang P, Rosenbach M, Kim EJ, Micheletti RG. : The immune reconstitution of the skin following sex-mismatched allogeneic haematopoietic stem cell transplant: A prospective case series utilizing fluorescence in situ hybridization and immunohistochemistry. Br J Dermatol. 178(1): e55-e56, Jan 2018 Notes: Doi: 10.1111/bjd.15878. Epub 2018 Jan 8.

Dou Z, Ghosh K, Vixioli MG, Zhu J, Sen P, Wangensteen KJ, Simithy J, Lan Y, Lin Y, Zhou Z, Capell BC, Xu C, Xu M, Kieckhaefer JE, Jiang T, Shoshkes-Carmel M. Tanim KMAA, Barber GN, Seykora JT, Millar SE, Kaestner KH, Garcia BA, Adams PD, Berger SL.: Cytoplasmic chromatin triggers inflammation in senescence and cancer. Nature. 550(7676): 402-406, October 2017.

Ma S, Imadojemu S, Beer K, Seykora JT. : Inflammatory features of frontal fibrosing alopecia. Journal of Cutaneous Pathology 44(8): 672-676, August 2017 Notes: Doi: 10.1111/cup.12955. Epub 2017 Jun 1.

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Last updated: 02/12/2020
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