Steven C. Pugliese, MD

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Associate Professor of Clinical Medicine (Pulmonary, Allergy and Critical Care)
Associate Director Chronic Thromboembolic Pulmonary Hypertension Program, PENN/HUP
Director of Pulmonary Embolism Response Team, PENN/HUP
Department: Medicine

Contact information
923 E Gates Building, 3400 Spruce Street
Philadelphia, PA 19104
Lab: Appointments: 215 662 8766
Education:
BS (Biology)
Ursinus College, 2003.
MD (Medicine)
Drexel University, 2008.
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Description of Clinical Expertise

I joined the faculty at Penn in 2017 after being on faculty at the University of Colorado since 2015. At the University of Colorado I completed a fellowship in pulmonary and critical care medicine and a sub-fellowship in pulmonary vascular disease. During my fellowship and while on faculty at University of Colorado I studied the role of macrophages in the development of hypoxic pulmonary hypertension with a clinical focus on pulmonary hypertension and pulmonary embolism. Since joining Penn, I’ve transitioned to a clinical role. I spend my time in the hospital as an intensive care unit physician and I also attend on our inpatient pulmonary hypertension service as well as the pulmonary embolism response team (PERT). My outpatient focus has been in care of patients with all aspects of pulmonary vascular disease including pulmonary hypertension, hepatopulmonary syndrome, hereditary hemorrhagic telangiectasia (HHT), and acute and chronic pulmonary embolism. I am the director of PERT at the Hospital University of Pennsylvania and co-direct the comprehensive pulmonary embolism program at Penn with Christian Bermudez from cardiothoracic surgery. A large part of my outpatient practice is the follow up care of patients who suffered acute pulmonary embolism as well as patients with chronic thromboembolic pulmonary hypertension (CTEPH). I work closely with a multidisciplinary team including interventional cardiology, hematology, interventional radiology, diagnostic radiology, and cardiothoracic surgery. I am particularly interested in the transition of care in post pulmonary embolism patients, patients who experience ongoing shortness of breath following an acute pulmonary embolism, as well as patients seeking a second opinion for unexplained shortness of breath. In addition to my clinical and administrator roles, I enjoy teaching about pulmonary vascular disease and cardio-pulmonary physiology.

Selected Publications

De la Fuente JRO, Buckley LK, Kawut SM, Pugliese SC.: Unexplained Dyspnea: Hepatopulmonary Syndrome without Cirrhosis? Ann Am Thorac Soc. August 2023.

Steven Pugliese and Mahir Elder: PE Centers of Excellence™: The Next Big Innovation in Pulmonary Embolism Care. Endovascular Today 2023.

Taisei Kobayashi MD,, Steven Pugliese MDc, Sanjum S Sethi, MD MPHd, Sahil A Parikh, MDd, Joshua Goldberg, MDe, Fahad Alkhafan MD, MPHf, Clara Vitarello MPHf, Kenneth Rosenfieldg, MD, Robert Lookstein, MDh, Brent Keeling, MDi, Andrew Klein, MDj, C. Michael Gibson MS MDf, k, Lauren Glassmoyer, MD, Sameer Khandhar MDa, Eric Secemsky MDk, Jay Giri MD MPH : Contemporary Management and Outcomes of Patients with High-Risk Pulmonary Embolism. JACC 2023.

McCormick A, Krishnan A, Badesch D, Benza RL, Bull TM, De Marco T, Feldman J, Hemnes AR, Hirsch R, Horn E, Kennedy J, Mathai SC, McConnell W, Pugliese SC, Sager JS, Shlobin OA, Simon MA, Lammi MR.: Pulmonary artery compliance in different forms of pulmonary hypertension. Heart 2023.

Breanne E McCarthy, Robyn L McClelland, Dina H Appleby, Jude S Moutchia, Jasleen K Minhas, Jeff Min, Jeremy A Mazurek, K Akaya Smith, Jason S Fritz, Steven C Pugliese, Ryan J Urbanowicz, John H Holmes, Harold I Palevsky, Steven M Kawut, Nadine Al-Naamani: BMI and Treatment Response in Patients With Pulmonary Arterial Hypertension: A Meta-analysis. Chest 162(2): 436-437, Aug 2022.

Lapatra, T; Baird, GL; Goodman, R; Pinder, D; DiGregorio, R; Normandin, B; Klinger, JR; Palevsky, HI; Fritz, JS; Mullin, CJ; Pugliese, S; Smith, A; Mazurek, JA; Whittenhall, ME; Al-Naamani, N; Kawut, SM; Ventetuolo, CE: Remote Six-Minute Walk Tests in Pulmonary Hypertension. AJRCCM May 2022 Notes: poster presentation.

Min, J; Goodman, R; Provine, C; Archer-Chicko, CL; Pugliese, S; Mazurek, JA; Smith, A; Fritz, JS; Palevsky, HI; Kawut, SM; Al-Naamani, N: Deep Phenotyping of Insulin Resistance in Pulmonary Arterial Hypertension. AJRCCM May 2022 Notes: poster presentation.

Hsieh, J Goodman, R Mazurek, JA Smith, A Palevsky, HI ; Fritz, JS; Pugliese, S ;Archer-Chicko, C. L Provine, C Kawut, SM : Low Physical Activity Is Associated with More Visceral Fat in Pulmonary Arterial Hypertension. AJRCCM conference May 2022 Notes: poster presentation.

Steven C Pugliese, MD and Hari M Shankar MD: Pulmonary Embolic Disorders: Thrombus, Air, and Fat. Principles of Critical Care, 5th Ed. Hall, Schmidt, Wood Page: Chapt 39, 2022 Notes: Published on-line ebook.

Jeff Min 1, Dina H Appleby 2, Robyn L McClelland 3, Jasleen Minhas 4, John H Holmes 5, Ryan J Urbanowicz 6, Steven C Pugliese 7, Jeremy A Mazurek 8, K Akaya Smith 9, Jason S Fritz 7, Harold I Palevsky 7, Jude Moutchia Suh 6, Nadine Al-Naamani 9, Steven M Kawut : Secular and Regional Trends among Pulmonary Arterial Hypertension Clinical Trial Participants. Ann Am Thorac Soc 19(6): 952-961, Dec 2021.

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Last updated: 10/31/2023
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