Leonid Roshkovan, MD
Assistant Professor of Clinical Radiology
Active , Phoenixville Hospital
Active Medical Staff, Department of Radiology, Pennsylvania Hospital
Active Medical Staff, Department of Radiology, Penn Presbyterian Medical Center
Attending, Department of Radiology, Hospital of the University of Pennsylvania
Instructor, Department of Radiology, University of Pennsylvania Perelman School of Medicine
Active Medical Staff, Department of Radiology, Chester County Hospital
Department: Radiology
Contact information
Department of Radiology
Hospital of the University of Pennsylvania
1 Silverstein Building, 3400 Spruce Street
Philadelphia, PA 19104
Hospital of the University of Pennsylvania
1 Silverstein Building, 3400 Spruce Street
Philadelphia, PA 19104
Office: 215-662-3036
Education:
MD
University of Debrecen, Medical and Health Sciences Centre, Hungary, 2010.
Permanent linkMD
University of Debrecen, Medical and Health Sciences Centre, Hungary, 2010.
Description of Clinical Expertise
Dr. Roshkovan has expertise in thoracic radiology and abdominal imaging with special clinical focus on lung cancer and pleural malignancy.Description of Other Expertise
Selected Research Publications:Berger I, Cengel KA, Simone CB 2nd, Alley EW, Roshkovan L, Haas AR, Patel AM, Khalid U, Culligan MJ, McNulty S, Singhal S, Friedberg JS, Katz SI.: Lymphangitic carcinomatosis: A common radiographic manifestation of local failure following extended pleurectomy/decortication in patients with malignant pleural mesothelioma. Lung Cancer 132: 94-98, Jun 2019.
Roshkovan L, Thompson JC, Katz SI, Deshpande C, Jenkins T, Nowak AK, Francis R, Dennie C, Fabre D, Singhal S, Galperin-Aizenberg M.: Alveolar adenoma of the lung: multidisciplinary case discussion and review of the literature. J Thorac Dis 12: 6847-6853, Nov 2020. PMCID: PMC7711389
Berger I, Simpson S, Friedberg JS, Culligan MJ, Wileyto EP, Alley EW, Sterman D, Patel AM, Khalid U, Simone CB 2nd, Cengel KA, Katz SI, Roshkovan L.: CT for detection of malignant posterior intercostal lymph nodes in patients undergoing pre-operative staging for malignant pleural mesothelioma. Lung Cancer 152: 34-38, Dec 2020.
Patel A, Roshkovan L, McNulty S, Alley E, Torigian DA, Nachiappan AC, Galperin-Aizenberg M, Barbosa EM Jr, DiRienzi J, Berger I, Khalid U, Haas AR, Singhal S, Wileyto EP, Cengel KA, Katz SI.: Delayed-Phase Enhancement for Evaluation of Malignant Pleural Mesothelioma on Computed Tomography: A Prospective Cohort Study. Clin Lung Cancer lin Lung Cancer, 2020.
Roshkovan L, Katz, SI, Berger, I, Friedberg, J, Alley, E, Simone, CB, Haas, A, Cengal, K, Albelda. SM. : "Serum soluble mesothelin-related protein (SMRP) and fibulin-3 levels correlate with malignant pleural mesothelioma (MPM) tumor volumes." Lung Cancer(under review) 2020.
Roshkovan, L, Singhal, S, Katz, SI, and Galperin-Aizenberg, M. : "Clinical Perspectives: Surgicel, an important multimodality imaging mimic of post-operative complication." British Journal of Radiology (under review) 2020.
Roshkovan, L, Thompson, JC, Galperin-Aizenberg, M, Katz, SI. : "Clinical Pearls: A 53 year-old male presents to the emergency department with shortness of breath, cough and fever." Chest (in press) 2020.
Roshkovan, L, Thompson, JC, Galperin-Aizenberg, M, Katz, SI. : "Clinical Pearls: A 53 year-old male presents to the emergency department with shortness of breath, cough and fever." Chest (under review) 2020.
Yousefi, B., Katz, SI, Roshkovan, L. : Invited commentary "Radiomics-AI: A path forward to predicting immunotherapy response for NSCLC" Radiology: Artificial Intelligence(in press) 2020.
Roshkovan L, Litt H.: State-of-the-Art Imaging for the Evaluation of Pulmonary Embolism. Curr Treat Options Cardiovasc Med 20: 71, Aug 2018.
Roshkovan L, Chatterjee N, Galperin-Aizenberg M, Gupta N, Shah R, Barbosa EM Jr, Simpson S, Cook T, Nachiappan A, Knollmann F, Litt H, Desjardins B, Jha S, Panebianco N, Baston C, Thompson JC, Katz SI.: The Role of Imaging in the Management of Suspected or Known COVID-19 Pneumonia: A Multidisciplinary Perspective. Ann Am Thorac Soc nn Am Thorac Soc, 2020.
Description of Research Expertise
Dr. Roshkovan completed a Thoracic Radiology fellowship and Abdominal Imaging fellowship at the University of Pennsylvania Perelman School of Medicine. His primary research focus in developing improved measures of cancer detection and therapy response assessment in thoracic oncology. His work centers on functioning as an active member of an interdisciplinary research team dedicated to advances in thoracic oncology including therapeutic clinical trials and development of novel radiomic signatures for non-small cell therapy response prediction and improving therapy response assessment in NSCLC and mesothelioma.In addition, Dr. Roshkovan is actively engaged in research efforts at the institutional level at Penn as well as the national level where he is an integral part of teams tasked to procure and curate COVID-19 imaging and clinical data so as to accelerate innovation and discovery in improved ways of detecting and characterizing COVID-19 pneumonia. He is also lead in a research project at Penn evaluating utilization of computed tomography (CT) in patients suspected of COVID-19 pneumonia.
He is a member of the Penn Thoracic Oncology Radiomics Working Group, the iMig Pleural Expert Panel and the ACR COVID-19 Registry Steering Committee
Selected Publications
Jyotsna Natarajan BS , Nikhil Yegya-Raman MD , Timothy P. Kegelman MD, PhD , Michael J. Kallan MS , Leonid Roshkovan MD , Sharyn Katz MD , Bonnie Ky MD , Michael Fradley MD , Ying Xiao PhD, DABR , Sang Ho Lee PhD , Zheng Zhang PhD , Corey Langer MD , Charu Aggarwal MD, MPH , Roger Cohen MD , Keith Cengel MD, PhD , William Levin MD , Abigail T. Berman MD, MSCE , Steven J. Feigenberg MD : Cardiovascular Substructure Dose and Cardiac Events following Proton- and Photon-Based Chemoradiotherapy for Non-Small Cell Lung Cancer. Advances in Radiation Oncology. Elsevier, 8(5), September 2023.Leonid Roshkovan, MD, Corey Langer, MD, Melina Marmarelis, MD, Keith Cengel, MD, PhD, Sharyn Katz, MD, MTR. : Nodal predominant pattern of failure in malignant pleural mesothelioma receiving immunotherapy. 16th International Conference of the international Mesothelioma interest group (iMig 2023) June 2023.
Leonid Roshkovan, MD and Sharyn Katz, MD, MTR : Malignant pleural mesothelioma mimicking a complex parapneumonic effusion: a case report. 16th International Conference of the international Mesothelioma interest group (iMig 2023) June 2023.
Sharyn Katz MD, MTR, Leonid Roshkovan, MD, Christopher M. Straus, MD, and Samuel G. Armato III, PhD: International Group Consensus Statement Offers Technical Guidance for MPM Imaging. IASLC lung cancer news June 2023.
Marmarelis ME, Wang X, Roshkovan L, Grady CB, Miura JT, Ginsberg MS, Ciunci CA, Egger J, Walker S, Cercek A, Foote MB, Litzky LA, Nash G, Haas AR, Karakousis GC, Cengel KA, Katz SI, Zauderer MG, Langer CJ, Offin M.: Clinical Outcomes Associated With Pembrolizumab Monotherapy Among Adults With Diffuse Malignant Peritoneal Mesothelioma. JAMA Netw Open 6: e232526, Mar 2023.
Shapira N, Donovan K, Mei K, Geagan M, Roshkovan L, Gang GJ, Abed M, Linna NB, Cranston CP, O'Leary CN, Dhanaliwala AH, Kontos D, Litt HI, Stayman JW, Shinohara RT, Noël PB.: Three-dimensional printing of patient-specific computed tomography lung phantoms: a reader study. PNAS Nexus 2: pgad026, Feb 2023.
Leonid Roshkovan, Sharyn Katz: Radiologic assessment of tumor response to immunotherapy and its complications. Book- NK Cells in Cancer Immunotherapy: Successes and Challenges. Anahid Jewett,Yuman Fong (eds.). Academic Press, Page: 239-261, January 2023.
Apurva Singh, Hannah Horng, Leonid Roshkovan, Sharyn I. Katz, Despina Kontos, Jeffrey C. Thompson: Radiomics analysis to diagnose tumor invasiveness of pulmonary sub-solid nodules from longitudinal pre-surgical CT scans. SPIE Medical Imaging, 2023, San Diego, California, 2023.
Kai Mei, Leonid Roshkovan, Pouyan Pasyar, Nadav Shapira, Grace J. Gang, J. Webster Stayman, Michael Geagan, Peter B. Noël: PixelPrint: a collection of three-dimensional printed CT phantoms of different respiratory diseases. SPIE Medical Imaging, 2023, San Diego, California 2023.
Katz SI, Straus CM, Roshkovan L, Blyth KG, Frauenfelder T, Gill RR, Lalezari F, Erasmus J, Nowak AK, Gerbaudo VH, Francis RJ, Armato SG 3rd.: Considerations for Imaging of Malignant Pleural Mesothelioma: A Consensus Statement from the International Mesothelioma Interest Group. J Thorac Oncol Dec 2022.