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Simone S. Riedel, PhD
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Research Assistant Professor of Pediatrics (Oncology)
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Department: Pediatrics
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Contact information
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Children's Hospital of Philadelphia
39 3501 Civic Center Blvd
Philadelphia, PA 19104
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39 3501 Civic Center Blvd
Philadelphia, PA 19104
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Education:
21 9 M.S. 14 (Biology) c
45 Kaiserslautern Technical University, Germany, 2007.
21 8 PhD 17 (Immunology) c
36 Wuerzburg University, Germany, 2013.
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Permanent link21 9 M.S. 14 (Biology) c
45 Kaiserslautern Technical University, Germany, 2007.
21 8 PhD 17 (Immunology) c
36 Wuerzburg University, Germany, 2013.
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17c Sung PJ, Selvam M, Riedel SS, Xie HM, Bryant K, Manning B, Wertheim GB, Kulej K, Pham L, Bowman RL, Peresie J, Nemeth MJ, Levine RL, Garcia BA, Meyer SE, Sidoli S, Bernt KM, Carroll M.: FLT3 tyrosine kinase inhibition modulates PRC2 and promotes differentiation in acute myeloid leukemia. Leukemia Feb 2024.
175 Huijuan Lin, Keren Cheng, Hiroshi Kubota, Yemin Lan, Simone S Riedel, Kazue Kakiuchi, Kotaro Sasaki, Kathrin M Bernt, Marisa S Bartolomei, Mengcheng Luo, P Jeremy Wang: Histone methyltransferase DOT1L is essential for self-renewal of germline stem cells. Genes & Development 1(36): 752-763, Jun 2022.
192 Simone S Riedel, Congcong Lu, Hongbo M Xie, Kevin Nestler, Marit W Vermunt, Alexandra Lenard, Laura Bennett, Nancy A Speck, Ichiro Hanamura, Julie A Lessard, Gerd A Blobel, Benjamin A Garcia, Kathrin M Bernt: Intrinsically disordered Meningioma-1 stabilizes the BAF complex to cause AML. Molecular cell 81(11): 2332-48, Jun 2021.
168 Clara Libbrecht, Hongbo M Xie, Molly C Kingsley, Jessica N Haladyna, Simone S Riedel, Fatemeh Alikarami, Alexandra Lenard, Gerard M McGeehan, Patricia Ernst, Kathrin M Bernt: Menin is necessary for long term maintenance of meningioma-1 driven leukemia. Leukemia 35(5): 1405-17, May 2021.
20e Carina A Bäuerlein, Musga Qureischi, Zeinab Mokhtari, Paula Tabares, Christian Brede, Ana-Laura Jordán Garrote, Simone S Riedel, Martin Chopra, Simone Reu, Anja Mottok, Estibaliz Arellano-Viera, Carolin Graf, Miriam Kurzwart, Katharina Schmiedgen, Hermann Einsele, Matthias Wölfl, Paul-Gerhardt Schlegel, Andreas Beilhack: A T-Cell Surface Marker Panel Predicts Murine Acute Graft-Versus-Host Disease. Frontiers in immunology 11(5): 593321, Jan 2021.
1a8 Pamela J. Sung, Simone Sidoli, Simone S. Riedel, Katarzyna Kulej, Hongbo Xie, Bryan Manning, Daniel Tsai, Gerald Wertheim, Benjamin A. Garcia, Sara E. Meyer, Kathrin M. Bernt, Martin P. Carroll: FLT3 Inhibition Downregulates EZH2 in AML and Promotes Myeloid Differentiation. 63rd ASH Annual Meeting and Exposition, Atlanta, GA, USA 138(1): 785, 2021.
197 Molly C Kingsley, Hongbo M Xie, Bo-Rui Chen, Simone S Riedel, Taylor Pastuer, Madelyn K Bollig, Tyler Shank, Clara Libbrecht, Sally P Stabler, Aniruddha J Deshpande, Andrew M Intlekofer, Kathrin M Bernt: Specific patterns of H3K79 methylation influence genetic interaction of oncogenes in AML. Blood advances 4(13): 3109-22, Jul 2020.
168 Alexandra Lenard, Hongbo Michael Xie, Taylor Pastuer, Tyler Shank, Clara Libbrecht, Molly Kingsley, Simone S Riedel, Zuo-Fei Yuan, Nan Zhu, Tobias Neff, Kathrin M Bernt: Epigenetic regulation of protein translation in KMT2A-rearranged AML. Experimental hematology 85(1): 57-69, May 2020.
10b SS Riedel, A Lenard, K Nestler, C Lu, HM Xie, B Garcia, KM Bernt: SWI/SNF Dysregulation through a Prion-like Domain Causes AML. 61st ASH Annual Meeting and Exposition, Orlando, FL, USA Dec 2019.
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Selected Publications
180 Alikarami F, Xie HM, Riedel SS, Goodrow HT, Barrett DR, Mahdavi L, Lenard A, Chen C, Yamauchi T, Danis E, Cao Z, Tran VL, Jung MM, Li Y, Huang H, Shi J, Tan K, Teachey DT, Bresnick EH, Neff TA, Bernt KM.: GATA2 links stemness to chemotherapy resistance in acute myeloid leukemia. Blood 145: 2179-2195, May 2025.17c Sung PJ, Selvam M, Riedel SS, Xie HM, Bryant K, Manning B, Wertheim GB, Kulej K, Pham L, Bowman RL, Peresie J, Nemeth MJ, Levine RL, Garcia BA, Meyer SE, Sidoli S, Bernt KM, Carroll M.: FLT3 tyrosine kinase inhibition modulates PRC2 and promotes differentiation in acute myeloid leukemia. Leukemia Feb 2024.
175 Huijuan Lin, Keren Cheng, Hiroshi Kubota, Yemin Lan, Simone S Riedel, Kazue Kakiuchi, Kotaro Sasaki, Kathrin M Bernt, Marisa S Bartolomei, Mengcheng Luo, P Jeremy Wang: Histone methyltransferase DOT1L is essential for self-renewal of germline stem cells. Genes & Development 1(36): 752-763, Jun 2022.
192 Simone S Riedel, Congcong Lu, Hongbo M Xie, Kevin Nestler, Marit W Vermunt, Alexandra Lenard, Laura Bennett, Nancy A Speck, Ichiro Hanamura, Julie A Lessard, Gerd A Blobel, Benjamin A Garcia, Kathrin M Bernt: Intrinsically disordered Meningioma-1 stabilizes the BAF complex to cause AML. Molecular cell 81(11): 2332-48, Jun 2021.
168 Clara Libbrecht, Hongbo M Xie, Molly C Kingsley, Jessica N Haladyna, Simone S Riedel, Fatemeh Alikarami, Alexandra Lenard, Gerard M McGeehan, Patricia Ernst, Kathrin M Bernt: Menin is necessary for long term maintenance of meningioma-1 driven leukemia. Leukemia 35(5): 1405-17, May 2021.
20e Carina A Bäuerlein, Musga Qureischi, Zeinab Mokhtari, Paula Tabares, Christian Brede, Ana-Laura Jordán Garrote, Simone S Riedel, Martin Chopra, Simone Reu, Anja Mottok, Estibaliz Arellano-Viera, Carolin Graf, Miriam Kurzwart, Katharina Schmiedgen, Hermann Einsele, Matthias Wölfl, Paul-Gerhardt Schlegel, Andreas Beilhack: A T-Cell Surface Marker Panel Predicts Murine Acute Graft-Versus-Host Disease. Frontiers in immunology 11(5): 593321, Jan 2021.
1a8 Pamela J. Sung, Simone Sidoli, Simone S. Riedel, Katarzyna Kulej, Hongbo Xie, Bryan Manning, Daniel Tsai, Gerald Wertheim, Benjamin A. Garcia, Sara E. Meyer, Kathrin M. Bernt, Martin P. Carroll: FLT3 Inhibition Downregulates EZH2 in AML and Promotes Myeloid Differentiation. 63rd ASH Annual Meeting and Exposition, Atlanta, GA, USA 138(1): 785, 2021.
197 Molly C Kingsley, Hongbo M Xie, Bo-Rui Chen, Simone S Riedel, Taylor Pastuer, Madelyn K Bollig, Tyler Shank, Clara Libbrecht, Sally P Stabler, Aniruddha J Deshpande, Andrew M Intlekofer, Kathrin M Bernt: Specific patterns of H3K79 methylation influence genetic interaction of oncogenes in AML. Blood advances 4(13): 3109-22, Jul 2020.
168 Alexandra Lenard, Hongbo Michael Xie, Taylor Pastuer, Tyler Shank, Clara Libbrecht, Molly Kingsley, Simone S Riedel, Zuo-Fei Yuan, Nan Zhu, Tobias Neff, Kathrin M Bernt: Epigenetic regulation of protein translation in KMT2A-rearranged AML. Experimental hematology 85(1): 57-69, May 2020.
10b SS Riedel, A Lenard, K Nestler, C Lu, HM Xie, B Garcia, KM Bernt: SWI/SNF Dysregulation through a Prion-like Domain Causes AML. 61st ASH Annual Meeting and Exposition, Orlando, FL, USA Dec 2019.
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