Hayley M. Knollman, M.D.

faculty photo
Assistant Professor of Clinical Medicine (Hematology-Oncology)
Attending, Hospital of the University of Pennsylvania
Department: Medicine

Contact information
Perelman Center for Advanced Medicine
3400 Civic Center Blvd
10th Floor, South Pavilion
Philadelphia, PA 19104
Education:
BS (Chemistry )
Purdue University , 2006.
MD
Indiana University School of Medicine, 2010.
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Selected Publications

Jung W, Hubbard RA, Smith AM, Ko K, Huang A, Wang J, Isaacs JM, Zhang L, Liu PP, Chen Z, Shah PD, Mintzer D, Bhattacharya S, Knollman HM, Clark AS, Koropeckyj-Cox D, Messinger M, Wilcox NS, Xia C, Narayan V, Upshaw JN, Armenian SH, Ky B.: Risk-guided cardioprotection with carvedilol in patients with breast cancer (CCT guide): a phase 1 randomized clinical trial. Breast Cancer Res Treat 211(2): 293-305, Jun 2025.

Emily Xu, James M Schuster, Anish Butala, Gabrielle W Peters, Alvand Hassankhani, Hayley M Knollman, Colbey W Freeman, Neil R Malhotra. : Disparities in patient enrollment of spinal oncology clinical trials. Neurooncol Pract 12(5): 892-900, Jun 2025.

Berlin E, Ko K, Ma L, Messing I, Hollawell C, Smith AM, Taunk NK, Narayan V, Upshaw JN, Clark AS, Shah PD, Knollman H, Bhattacharya S, Koropeckyj-Cox D, Wang J, Yegya-Raman N, Han IS, Lefebvre B, Li T, Wilcox NS, Jung W, Chen J, Freedman GM, Ky B.: Cardiac Effects of Modern Breast Radiation Therapy in Patients Receiving Systemic Cancer Therapy. JACC CardioOncol 7(3): 219-230, April 2025.

Emily Xu, Ritesh Karsalia, Ellie Gabriel, Alan Napole, Claudia Hejazi-Garcia, Jason Kost, Scott D McClintock, James M Schuster, Anish Butala, Gabrielle W Peters, Alvand Hassankhani, Hayley M Knollman, Colbey W Freeman, Neil R Malhotra. : Preoperative prediction of postoperative needs after spinal tumor surgery. Clin Neurol Neurosurg 250: 108752. Mar 2025.

Julia Tchou, Amy Clark, Neil Taunk, Gary Freedman, Nucleus Xu, Andy Minn, Angela Bradbury, Angela Demichele Gross, Susan Domchek, Hayley Knollman, Rachel Jankowitz, Payal Shah, Oluwadamilola Fayanju, Anupma Nayak, Joseph Fraietta and Alexander Huang: Major pathologic response after a single radiotherapy fraction + a single pembrolizumab dose given preoperatively in patients with cT1N0 triple negative breast cancer (TNBC) – preliminary results of a phase 1b/2 study (NCT04454528). Journal for ImmunoTherapy of Cancer, Society for Immunotherapy of Cancer, Denver, CO 10: A674-A674, Mar 2023 Notes: "Poster Presentation"

Alexandra Torres; Carey Kokkonen; Mary Oladeji; Kurt D'Andrea; Rosemarie Mick; Vivek Narayan; Michael Mallamaci; Gayle Ewing; Hayley Knollman; Nadine M. Tung; Mark Robson; Katherine L. Nathanson; Susan Domchek; Payal D. Shah: Harnessing olaparib, palbociclib, and endocrine therapy (HOPE): Phase I/II trial of olaparib, palbociclib and fulvestrant in patients with BRCA1/2-associated, hormone receptor-positive, HER2-negative metastatic breast cancer San Antonio Breast Cancer Symposium, San Antonio, TX. 82, Feb 2022 Notes: "Poster Presentation"

Lauren Bayne; Isoris Nivar; Brooke Goodspeed; Shannon Deluca; E. Paul Wileyto; Natalie Shih; Anupma Nayak; Michael D Feldman; Joshua Edwards; Kevin Fox; Jennifer M. Matro; Susan Domchek; Hayley Knollman; Rachel Jankowitz; Angela Bradbury; Payal D. Shah; Jewell Graves; George Woodfield; Elizabeth Chislock; Jianping Wang; George Belka; Lewis A. Chodosh; Amy S. Clark; Angela DeMichele: Identifying breast cancer survivors with dormant disseminated tumor cells: The PENN-SURMOUNT screening study. Cancer Research, San Antonio Breast Cancer Symposium, San Antonio, TX. 81, Dec 2021 Notes: "Poster Presentation"

Igor Makhlin; Amy S Clark; Paul Wileyto; Noah Goodman; John Ndicu; Shannon DeLuca; Candace Clark; S. William Stavropoulos; Natalie Shih; Michael D Feldman; Susan M Domchek; Jennifer M Matro; Payal D Shah; Hayley M Knollman; Kevin R Fox; Kara N Maxwell; Lewis A Chodosh; Angela DeMichele: Investigating the clinical utility of tumor mutational burden in predicting rapid progression and death in patients with metastatic breast cancer. Cancer Research/San Antonio Breast Cancer Symposium, San Antonio, TX. 81, Dec 2021 Notes: "Poster Presentation"

Biniyam G.Demissei, Srinath Adusumalli, Rebecca A.Hubbard, Srinivas Denduluri, Vivek Narayan, Amy S. Clark, Payal Shah, Hayley Knollman, Kelly D. Getz, Richard Aplenc, Joseph R. Carver, Bonnie Ky: Cardiology Involvement in Patients With Breast Cancer Treated With Trastuzumab. JACC CardioOncology 2(2): 179-189, Jun 2020.

Biniyam G. Demissei, Rebecca A. Hubbard, Liyong Zhang, Amanda M. Smith, Karyn Sheline, Caitlin McDonald, Vivek Narayan, Susan M. Domchek, Angela DeMichele, Payal Shah, Amy S. Clark, Kevin Fox, Jennifer Matro, Angela R. Bradbury, Hayley Knollman, Kelly D. Getz, Saro H. Armenian, James L. Januzzi, W. H. Wilson Tang, Peter Liu, and Bonnie Ky: Changes in Cardiovascular Biomarkers with Breast Cancer Therapy and Associations with Cardiac Dysfunction. Journal of the American Heart Association 9(2): e014708. Jan 2020.

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Last updated: 01/08/2026
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