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Christoforos Thomas, PhD
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Adjunct Assistant Professor of Radiation Oncology
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Senior Research Investigator, University of Pennsylvania, Department of Radiation Oncology
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Department: Radiation Oncology
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Contact information
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University of Pennsylvania, Perelman School of Medicine
28 Department of Radiation Oncology
4b Smilow Center for Translational Research
Philadelphia, PA 19104
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28 Department of Radiation Oncology
4b Smilow Center for Translational Research
Philadelphia, PA 19104
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Education:
21 8 BS 14 (Biology) c
43 Aristotle University, Thessaloniki, Greece, 1995.
21 a Ph.D. 29 (Tumor Biology and Physiology) c
61 Laboratory of Physiology, University of Ioannina, Medical School, Greece, 2004.
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Permanent link21 8 BS 14 (Biology) c
43 Aristotle University, Thessaloniki, Greece, 1995.
21 a Ph.D. 29 (Tumor Biology and Physiology) c
61 Laboratory of Physiology, University of Ioannina, Medical School, Greece, 2004.
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139 Bado Igor, Nikolos Fotis, Rajapaksa Gayani, Gustafsson Jan-Åke, Thomas Christoforos: ERβ decreases the invasiveness of triple-negative breast cancer cells by regulating mutant p53 oncogenic function. Oncotarget 7(12): 13599-611, Mar 2016.
102 Thomas Christoforos, Gustafsson Jan-Åke: Estrogen receptor mutations and functional consequences for breast cancer. Trends in endocrinology and metabolism: TEM 26(9): 467-76, Sep 2015.
102 Rajapaksa G, Nikolos F, Bado I, Clarke R, Gustafsson J-Å, Thomas C: ERβ decreases breast cancer cell survival by regulating the IRE1/XBP-1 pathway. Oncogene 34(31): 4130-41, Jul 2015.
186 Said Rabih, Ye Yang, Hong David S, Janku Filip, Fu Siqing, Naing Aung, Wheler Jennifer J, Kurzrock Razelle, Thomas Christoforos, Palmer Gary A, Hess Kenneth R, Aldape Kenneth, Tsimberidou Apostolia M: Characteristics and survival of patients with advanced cancer and p53 mutations. Oncotarget 5(11): 3871-9, Jun 2014.
11f Nikolos Fotis, Thomas Christoforos, Rajapaksa Gayani, Bado Igor, Gustafsson Jan-Åke: ERβ regulates NSCLC phenotypes by controlling oncogenic RAS signaling. Molecular cancer research : MCR 12(6): 843-54, Jun 2014.
1b5 Thomas Christoforos, Rajapaksa Gayani, Nikolos Fotis, Hao Ruixin, Katchy Anne, McCollum Catherine W, Bondesson Maria, Quinlan Phil, Thompson Alastair, Krishnamurthy Savitri, Esteva Francisco J, Gustafsson Jan-Åke: ERbeta1 represses basal breast cancer epithelial to mesenchymal transition by destabilizing EGFR. Breast cancer research : BCR 14(6): R148, Nov 2012.
f5 Thomas Christoforos, Gustafsson Jan-Åke: Targeting PES1 for restoring the ERα/ERβ ratio in breast cancer. The Journal of clinical investigation 122(8): 2771-3, Aug 2012.
d0 Thomas CG, Gustafsson, JA: Not enough evidence to include ESR1 amplification. Nat Rev Cancer 11: 823, Nov 2011 Notes: Epub 24 Oct 2011.
16f Alvarez-Baron Claudia P, Jonsson Philip, Thomas Christoforos, Dryer Stuart E, Williams Cecilia: The two-pore domain potassium channel KCNK5: induction by estrogen receptor alpha and role in proliferation of breast cancer cells. Molecular endocrinology (Baltimore, Md.) 25(8): 1326-36, Aug 2011.
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Selected Publications
117 Rajapaksa Gayani, Thomas Christoforos, Gustafsson Jan-Åke: Estrogen signaling and unfolded protein response in breast cancer. The Journal of steroid biochemistry and molecular biology 163: 45-50, Oct 2016.139 Bado Igor, Nikolos Fotis, Rajapaksa Gayani, Gustafsson Jan-Åke, Thomas Christoforos: ERβ decreases the invasiveness of triple-negative breast cancer cells by regulating mutant p53 oncogenic function. Oncotarget 7(12): 13599-611, Mar 2016.
102 Thomas Christoforos, Gustafsson Jan-Åke: Estrogen receptor mutations and functional consequences for breast cancer. Trends in endocrinology and metabolism: TEM 26(9): 467-76, Sep 2015.
102 Rajapaksa G, Nikolos F, Bado I, Clarke R, Gustafsson J-Å, Thomas C: ERβ decreases breast cancer cell survival by regulating the IRE1/XBP-1 pathway. Oncogene 34(31): 4130-41, Jul 2015.
186 Said Rabih, Ye Yang, Hong David S, Janku Filip, Fu Siqing, Naing Aung, Wheler Jennifer J, Kurzrock Razelle, Thomas Christoforos, Palmer Gary A, Hess Kenneth R, Aldape Kenneth, Tsimberidou Apostolia M: Characteristics and survival of patients with advanced cancer and p53 mutations. Oncotarget 5(11): 3871-9, Jun 2014.
11f Nikolos Fotis, Thomas Christoforos, Rajapaksa Gayani, Bado Igor, Gustafsson Jan-Åke: ERβ regulates NSCLC phenotypes by controlling oncogenic RAS signaling. Molecular cancer research : MCR 12(6): 843-54, Jun 2014.
1b5 Thomas Christoforos, Rajapaksa Gayani, Nikolos Fotis, Hao Ruixin, Katchy Anne, McCollum Catherine W, Bondesson Maria, Quinlan Phil, Thompson Alastair, Krishnamurthy Savitri, Esteva Francisco J, Gustafsson Jan-Åke: ERbeta1 represses basal breast cancer epithelial to mesenchymal transition by destabilizing EGFR. Breast cancer research : BCR 14(6): R148, Nov 2012.
f5 Thomas Christoforos, Gustafsson Jan-Åke: Targeting PES1 for restoring the ERα/ERβ ratio in breast cancer. The Journal of clinical investigation 122(8): 2771-3, Aug 2012.
d0 Thomas CG, Gustafsson, JA: Not enough evidence to include ESR1 amplification. Nat Rev Cancer 11: 823, Nov 2011 Notes: Epub 24 Oct 2011.
16f Alvarez-Baron Claudia P, Jonsson Philip, Thomas Christoforos, Dryer Stuart E, Williams Cecilia: The two-pore domain potassium channel KCNK5: induction by estrogen receptor alpha and role in proliferation of breast cancer cells. Molecular endocrinology (Baltimore, Md.) 25(8): 1326-36, Aug 2011.
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