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Vera Moiseenkova-Bell, PhD
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Professor of Pharmacology
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Faculty Director, Electron Microscopy Resource Laboratory and Beckman Center for Cryo Electron Microscopy, University of Pennsylvania
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Department: Systems Pharmacology and Translational Therapeutics
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Graduate Group Affiliations
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Contact information
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Department of Systems Pharmacology and Translational Therapeutics
3f University of Pennsylvania, Perelman School of Medicine
37 10-124 Smilow Center for Translational Research
51 3400 Civic Center Boulevard, Building 421
Philadelphia, PA 19104-5158
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3f University of Pennsylvania, Perelman School of Medicine
37 10-124 Smilow Center for Translational Research
51 3400 Civic Center Boulevard, Building 421
Philadelphia, PA 19104-5158
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Office: 215 898-1154
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Email:
vmb@pennmedicine.upenn.edu
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vmb@pennmedicine.upenn.edu
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Publications
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Education:
21 7 MS 1d (Laser Biophysics) c
3f M.V. Lomonosov Moscow State University, 1999.
21 8 PhD 37 (Cellular Physiology & Molecular Biophysics) c
3f The University of Texas Medical Branch, 2004.
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Permanent link21 7 MS 1d (Laser Biophysics) c
3f M.V. Lomonosov Moscow State University, 1999.
21 8 PhD 37 (Cellular Physiology & Molecular Biophysics) c
3f The University of Texas Medical Branch, 2004.
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e9 Moiseenkova-Bell V.Y., Delemotte L., Minor Jr D.L: Ion channels: Intersection of Structure, Function, and Pharmacology. Journal of Molecular Biology June 2021.
ec Fluck E.C., Pumroy R.A., Moiseenkova-Bell V.Y. : Production and purification of TRPV2 and TRPV5 for structural and functional studies. Methods Enzymology May 2021.
244 3. Conde J., Pumroy R.A., Baker C., Rodrigues T., Guerreiro A., Sousa B., Marques M.C., de Almeida B.P., Lee S., Leites E., Picard D., Samanta A., Vaz S.H., Sieglitz F., Langini M., Remke M., Roque R., Weiss T., Weller M., Liu Y., Han S., Corzana F., Morais V., Faria C.C., Carvalho T., Filippakopoulos P., Snijder B., Barbosa-Morais N.L., Moiseenkova-Bell V.Y., Bernardes G.J.L. : Allosteric Antagonist Modulation of TRPV2 by Piperlongumine Impairs Glioblastoma Progression. ACS Central Science April 2021.
c7 Zhao Y., McVeigh B., Moiseenkova-Bell V.Y. : Structural Pharmacology of TRP Channels. Journal of Molecular Biology March 2021.
152 Asangani I., Blair I.A., van Duyne G., Hilser V., Moiseenkova-Bell V.Y., Plymate S., Sprenger C., Wand J., Penning T.M. : Using biochemistry and biophysics to extinguish Androgen Receptor signaling in prostate cancer. Journal of Biological Chemistry January 2021.
120 Pumroy R.A., Fluck E.C., Ahmed T., Moiseenkova-Bell V.Y. : Structural insights into the gating mechanisms of TRPV channels. Cell Calcium 87: 102168, May 2020 Notes: doi: 10.1016/j.ceca.2020.102168. Epub 2020 Jan 24.
230 Xu Z., Wise M.C., Chokkalingam N., Walker S., Tello-Ruiz E., Elliott S., Perales-Puchalt A., Xiao P., Zhu X., Pumroy R.A., Fisher P.D., Schultheis K., Schade E., Menis S., Guzman S., Andersen H., Broderick K.E., Humeau L.M., Muthumani K., Moiseenkova-Bell V.Y., Schief W.R., Weiner D.B., Kulp D.W. : Achieved through Synergy of Structure‐Based Protein Engineering and Synthetic DNA Generates Enhanced Adaptive Immunity. Advanced Science Feb 2020 Notes: doi.org/10.1002/advs.201902802.
1bd Fricke T.C., Echtermeyer F., Zielke J., de la Roche J., Filipovic M.R., Claverol S., Herzog C., Tominaga M., Pumroy R.A., Moiseenkova-Bell V.Y., Zygmunt P., Leffler A., Eberhardt M.J. : Oxidation of methionine residues activates the high-threshold heat-sensitive ion channel TRPV2. PNAS 116(48): 24359-24365, Nov 2019 Notes: doi: 10.1073/pnas.1904332116. Epub 2019 Nov 12.
130 Hughes T.E.T., del Rosario J., Kapoor A., Yazici A.T., Fluck E.C., Filizola M., Rohacs T., Moiseenkova-Bell V.Y. : Structure-based discovery of novel TRPV5 inhibitors. eLife 8, Oct 2019 Notes: pii: e49572. doi: 10.7554/eLife.49572.
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Selected Publications
147 Swanson N. A., Lokareddy R. K., Li F., Hou C-F., Leptihn S., Pavlenok M., Neiderweis M., Pumroy R. A., Moiseenkova-Bell V. Y., Cingolani G. : Cryo-EM structure of the periplasmic tunnel of T7 DNA-ejectosome at 2.7 Å resolution. Molecular Cell July 2021.e9 Moiseenkova-Bell V.Y., Delemotte L., Minor Jr D.L: Ion channels: Intersection of Structure, Function, and Pharmacology. Journal of Molecular Biology June 2021.
ec Fluck E.C., Pumroy R.A., Moiseenkova-Bell V.Y. : Production and purification of TRPV2 and TRPV5 for structural and functional studies. Methods Enzymology May 2021.
244 3. Conde J., Pumroy R.A., Baker C., Rodrigues T., Guerreiro A., Sousa B., Marques M.C., de Almeida B.P., Lee S., Leites E., Picard D., Samanta A., Vaz S.H., Sieglitz F., Langini M., Remke M., Roque R., Weiss T., Weller M., Liu Y., Han S., Corzana F., Morais V., Faria C.C., Carvalho T., Filippakopoulos P., Snijder B., Barbosa-Morais N.L., Moiseenkova-Bell V.Y., Bernardes G.J.L. : Allosteric Antagonist Modulation of TRPV2 by Piperlongumine Impairs Glioblastoma Progression. ACS Central Science April 2021.
c7 Zhao Y., McVeigh B., Moiseenkova-Bell V.Y. : Structural Pharmacology of TRP Channels. Journal of Molecular Biology March 2021.
152 Asangani I., Blair I.A., van Duyne G., Hilser V., Moiseenkova-Bell V.Y., Plymate S., Sprenger C., Wand J., Penning T.M. : Using biochemistry and biophysics to extinguish Androgen Receptor signaling in prostate cancer. Journal of Biological Chemistry January 2021.
120 Pumroy R.A., Fluck E.C., Ahmed T., Moiseenkova-Bell V.Y. : Structural insights into the gating mechanisms of TRPV channels. Cell Calcium 87: 102168, May 2020 Notes: doi: 10.1016/j.ceca.2020.102168. Epub 2020 Jan 24.
230 Xu Z., Wise M.C., Chokkalingam N., Walker S., Tello-Ruiz E., Elliott S., Perales-Puchalt A., Xiao P., Zhu X., Pumroy R.A., Fisher P.D., Schultheis K., Schade E., Menis S., Guzman S., Andersen H., Broderick K.E., Humeau L.M., Muthumani K., Moiseenkova-Bell V.Y., Schief W.R., Weiner D.B., Kulp D.W. : Achieved through Synergy of Structure‐Based Protein Engineering and Synthetic DNA Generates Enhanced Adaptive Immunity. Advanced Science Feb 2020 Notes: doi.org/10.1002/advs.201902802.
1bd Fricke T.C., Echtermeyer F., Zielke J., de la Roche J., Filipovic M.R., Claverol S., Herzog C., Tominaga M., Pumroy R.A., Moiseenkova-Bell V.Y., Zygmunt P., Leffler A., Eberhardt M.J. : Oxidation of methionine residues activates the high-threshold heat-sensitive ion channel TRPV2. PNAS 116(48): 24359-24365, Nov 2019 Notes: doi: 10.1073/pnas.1904332116. Epub 2019 Nov 12.
130 Hughes T.E.T., del Rosario J., Kapoor A., Yazici A.T., Fluck E.C., Filizola M., Rohacs T., Moiseenkova-Bell V.Y. : Structure-based discovery of novel TRPV5 inhibitors. eLife 8, Oct 2019 Notes: pii: e49572. doi: 10.7554/eLife.49572.
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